{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:24:31Z","timestamp":1789273471571,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"This work was supported by a South Dakota State University Research Scholarship Support award (Van Guilder, G.P.)."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Hypertens"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1038\/s41371-020-00440-0","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T16:06:37Z","timestamp":1604937997000},"page":"870-879","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Reduced effect of ischemic preconditioning against endothelial ischemia-reperfusion injury with cardiovascular risk factors in humans"],"prefix":"10.1038","volume":"35","author":[{"given":"Tiffany E.","family":"Trachte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Hemenway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-1903","authenticated-orcid":false,"given":"Gary P.","family":"Van Guilder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,9]]},"reference":[{"key":"440_CR1","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1177\/1074248411405990","volume":"16","author":"RA Kloner","year":"2011","unstructured":"Kloner RA. No-reflow phenomenon: maintaining vascular integrity. J Cardiovasc Pharm Ther. 2011;16:244\u201350.","journal-title":"J Cardiovasc Pharm Ther"},{"key":"440_CR2","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1161\/01.CIR.0000118496.44135.A7","volume":"109","author":"L Bolognese","year":"2004","unstructured":"Bolognese L, Carrabba N, Parodi G, Santoro GM, Buonamici P, Cerisano G, et al. Impact of microvascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction. Circulation 2004;109:1121\u20136.","journal-title":"Circulation"},{"key":"440_CR3","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.jcin.2010.04.009","volume":"3","author":"R McGeoch","year":"2010","unstructured":"McGeoch R, Watkins S, Berry C, Steedman T, Davie A, Byrne J, et al. The index of microcirculatory resistance measured acutely predicts the extent and severity of myocardial infarction in patients with ST-segment elevation myocardial infarction. JACC Cardiovasc Inter. 2010;3:715\u201322.","journal-title":"JACC Cardiovasc Inter"},{"key":"440_CR4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jcin.2010.09.016","volume":"4","author":"M Valgimigli","year":"2011","unstructured":"Valgimigli M, Campo G, Malagutti P, Anselmi M, Bolognese L, Ribichini F, et al. Persistent coronary no flow after wire insertion is an early and readily available mortality risk factor despite successful mechanical intervention in acute myocardial infarction: a pooled analysis from the STRATEGY (Single High-Dose Bolus Tirofiban and Sirolimus-Eluting Stent Versus Abciximab and Bare-Metal Stent in Acute Myocardial Infarction) and MULTISTRATEGY (Multicenter Evaluation of Single High-Dose Bolus Tirofiban Versus Abciximab With Sirolimus-Eluting Stent or Bare-Metal Stent in Acute Myocardial Infarction Study) trials. JACC Cardiovasc Inter. 2011;4:51\u201362.","journal-title":"JACC Cardiovasc Inter"},{"key":"440_CR5","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.1161\/01.CIR.0000043806.51912.9B","volume":"106","author":"RK Kharbanda","year":"2002","unstructured":"Kharbanda RK, Mortensen UM, White PA, Kristiansen SB, Schmidt MR, Hoschtitzky JA, et al. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation. 2002;106:2881\u20133.","journal-title":"Circulation."},{"key":"440_CR6","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.ijcard.2006.11.079","volume":"122","author":"K Zhou","year":"2007","unstructured":"Zhou K, Yang B, Zhou X-M, Tan C-M, Zhao Y, Huang C, et al. Effects of remote ischemic preconditioning on the flow pattern of the left anterior descending coronary artery in normal subjects. Int J Cardiol. 2007;122:250\u20131.","journal-title":"Int J Cardiol"},{"key":"440_CR7","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.lfs.2016.03.021","volume":"151","author":"S Aggarwal","year":"2016","unstructured":"Aggarwal S, Randhawa PK, Singh N, Jaggi AS. Preconditioning at a distance: involvement of endothelial vasoactive substances in cardioprotection against ischemia-reperfusion injury. Life Sci. 2016;151:250\u20138.","journal-title":"Life Sci"},{"key":"440_CR8","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.yjmcc.2012.04.001","volume":"53","author":"RM Bell","year":"2012","unstructured":"Bell RM, Yellon DM. Conditioning the whole heart\u2013not just the cardiomyocyte. J Mol Cell Cardiol. 2012;53:24\u201332.","journal-title":"J Mol Cell Cardiol"},{"key":"440_CR9","doi-asserted-by":"publisher","first-page":"321","DOI":"10.15171\/apb.2015.045","volume":"5","author":"R Badalzadeh","year":"2015","unstructured":"Badalzadeh R, Mohammadi M, Yousefi B, Farajnia S, Najafi M, Mohammadi S. Involvement of Glycogen Synthase Kinase-3beta and Oxidation Status in the Loss of Cardioprotection by Postconditioning in Chronic Diabetic Male Rats. Adv Pharm Bull. 2015;5:321\u20137.","journal-title":"Adv Pharm Bull"},{"key":"440_CR10","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.bbrc.2015.01.084","volume":"458","author":"N Wu","year":"2015","unstructured":"Wu N, Zhang X, Jia P, Jia D. Hypercholesterolemia abrogates the protective effect of ischemic postconditioning by induction of apoptosis and impairment of activation of reperfusion injury salvage kinase pathway. Biochem Biophys Res Commun. 2015;458:148\u201353.","journal-title":"Biochem Biophys Res Commun"},{"key":"440_CR11","doi-asserted-by":"publisher","first-page":"R920","DOI":"10.1152\/ajpregu.00520.2006","volume":"292","author":"PV Katakam","year":"2007","unstructured":"Katakam PV, Jordan JE, Snipes JA, Tulbert CD, Miller AW, Busija DW. Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance. Am J Physiol Regul Integr Comp Physiol. 2007;292:R920\u20136.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"440_CR12","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.exger.2007.04.005","volume":"42","author":"Z Ebrahim","year":"2007","unstructured":"Ebrahim Z, Yellon DM, Baxter GF. Ischemic preconditioning is lost in aging hypertensive rat heart: independent effects of aging and longstanding hypertension. Exp Gerontol. 2007;42:807\u201314.","journal-title":"Exp Gerontol"},{"key":"440_CR13","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.tcm.2009.03.001","volume":"19","author":"NM Hamburg","year":"2009","unstructured":"Hamburg NM, Benjamin EJ. Assessment of endothelial function using digital pulse amplitude tonometry. Trends Cardiovasc Med. 2009;19:6\u201311.","journal-title":"Trends Cardiovasc Med"},{"key":"440_CR14","unstructured":"Weihl FM, Van Guilder GP. Endothelial vasodilation after a high-volume training load and tapered training in collegiate female swimmers. J Strength Cond Res. 2018."},{"key":"440_CR15","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1152\/japplphysiol.01285.2005","volume":"101","author":"A Nohria","year":"2006","unstructured":"Nohria A, Gerhard-Herman M, Creager MA, Hurley S, Mitra D, Ganz P. Role of nitric oxide in the regulation of digital pulse volume amplitude in humans. J Appl Physiol (1985). 2006;101:545\u20138.","journal-title":"J Appl Physiol (1985)"},{"key":"440_CR16","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/S0002-8703(03)00094-2","volume":"146","author":"JT Kuvin","year":"2003","unstructured":"Kuvin JT, Patel AR, Sliney KA, Pandian NG, Sheffy J, Schnall RP, et al. Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. Am Heart J. 2003;146:168\u201374.","journal-title":"Am Heart J"},{"key":"440_CR17","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1016\/j.jacc.2004.08.062","volume":"44","author":"PO Bonetti","year":"2004","unstructured":"Bonetti PO, Pumper GM, Higano ST, Holmes DR Jr., Kuvin JT, Lerman A. Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. J Am Coll Cardiol. 2004;44:2137\u201341.","journal-title":"J Am Coll Cardiol"},{"key":"440_CR18","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1152\/japplphysiol.00585.2018","volume":"126","author":"EJ Paull","year":"2019","unstructured":"Paull EJ, Van Guilder GP. Remote Ischemic Preconditioning Increases Accumulated Oxygen Deficit in Middle-Distance Runners. J Appl Physiol (1985). 2019;126:1193\u2013203.","journal-title":"J Appl Physiol (1985)"},{"key":"440_CR19","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.1093\/eurheartj\/ehv463","volume":"36","author":"I Eitel","year":"2015","unstructured":"Eitel I, Stiermaier T, Rommel KP, Fuernau G, Sandri M, Mangner N, et al. Cardioprotection by combined intrahospital remote ischaemic perconditioning and postconditioning in ST-elevation myocardial infarction: the randomized LIPSIA CONDITIONING trial. Eur Heart J. 2015;36:3049\u201357.","journal-title":"Eur Heart J"},{"key":"440_CR20","doi-asserted-by":"publisher","first-page":"331","DOI":"10.2165\/11587190-000000000-00000","volume":"28","author":"K Przyklenk","year":"2011","unstructured":"Przyklenk K. Efficacy of cardioprotective \u2018conditioning\u2019 strategies in aging and diabetic cohorts: the co-morbidity conundrum. Drugs Aging. 2011;28:331\u201343.","journal-title":"Drugs Aging"},{"key":"440_CR21","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.jcin.2014.05.015","volume":"8","author":"SK White","year":"2015","unstructured":"White SK, Frohlich GM, Sado DM, Maestrini V, Fontana M, Treibel TA, et al. Remote ischemic conditioning reduces myocardial infarct size and edema in patients with ST-segment elevation myocardial infarction. JACC Cardiovasc Inter. 2015;8:178\u201388.","journal-title":"JACC Cardiovasc Inter"},{"key":"440_CR22","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1152\/ajpheart.00054.2013","volume":"304","author":"I van den Munckhof","year":"2013","unstructured":"van den Munckhof I, Riksen N, Seeger J, Schreuder T, Borm G, Eijsvogels T, et al. Aging attenuates the protective effect of ischemic preconditioning against endothelial ischemia-reperfusion in humans. Am J Physiol Heart Circ Physiol. 2013;304:1727\u201332.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"440_CR23","doi-asserted-by":"publisher","first-page":"e006923","DOI":"10.1136\/bmjopen-2014-006923","volume":"5","author":"AD Sloth","year":"2015","unstructured":"Sloth AD, Schmidt MR, Munk K, Schmidt M, Pedersen L, Sorensen HT, et al. Impact of cardiovascular risk factors and medication use on the efficacy of remote ischaemic conditioning: post hoc subgroup analysis of a randomised controlled trial. BMJ Open. 2015;5:e006923.","journal-title":"BMJ Open"},{"key":"440_CR24","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.jcin.2013.05.011","volume":"6","author":"G Crimi","year":"2013","unstructured":"Crimi G, Pica S, Raineri C, Bramucci E, De Ferrari GM, Klersy C, et al. Remote ischemic post-conditioning of the lower limb during primary percutaneous coronary intervention safely reduces enzymatic infarct size in anterior myocardial infarction: a randomized controlled trial. JACC Cardiovasc Inter. 2013;6:1055\u201363.","journal-title":"JACC Cardiovasc Inter"},{"key":"440_CR25","doi-asserted-by":"publisher","first-page":"H1727","DOI":"10.1152\/ajpheart.00054.2013","volume":"304","author":"I van den Munckhof","year":"2013","unstructured":"van den Munckhof I, Riksen N, Seeger JP, Schreuder TH, Borm GF, Eijsvogels TM, et al. Aging attenuates the protective effect of ischemic preconditioning against endothelial ischemia-reperfusion injury in humans. Am J Physiol Heart Circ Physiol. 2013;304:H1727\u201332.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"440_CR26","doi-asserted-by":"publisher","first-page":"H1685","DOI":"10.1152\/ajpheart.01281.2007","volume":"294","author":"GP Van Guilder","year":"2008","unstructured":"Van Guilder GP, Stauffer BL, Greiner JJ, Desouza CA. Impaired endothelium-dependent vasodilation in overweight and obese adult humans is not limited to muscarinic receptor agonists. Am J Physiol Heart Circ Physiol. 2008;294:H1685\u201392.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"440_CR27","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1056\/NEJMoa1413534","volume":"373","author":"DJ Hausenloy","year":"2015","unstructured":"Hausenloy DJ, Candilio L, Evans R, Ariti C, Jenkins DP, Kolvekar S, et al. Remote Ischemic Preconditioning and Outcomes of Cardiac Surgery. N Engl J Med. 2015;373:1408\u201317.","journal-title":"N Engl J Med"},{"key":"440_CR28","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1056\/NEJMoa1413579","volume":"373","author":"P Meybohm","year":"2015","unstructured":"Meybohm P, Bein B, Brosteanu O, Cremer J, Gruenewald M, Stoppe C, et al. A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery. N Engl J Med. 2015;373:1397\u2013407.","journal-title":"N Engl J Med"},{"key":"440_CR29","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S0140-6736(13)61450-6","volume":"382","author":"M Thielmann","year":"2013","unstructured":"Thielmann M, Kottenberg E, Kleinbongard P, Wendt D, Gedik N, Pasa S, et al. Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: a single-centre randomised, double-blind, controlled trial. Lancet 2013;382:597\u2013604.","journal-title":"Lancet"},{"key":"440_CR30","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1097\/FJC.0b013e3182760c4d","volume":"61","author":"C Wagner","year":"2013","unstructured":"Wagner C, Ebner B, Tillack D, Strasser RH, Weinbrenner C. Cardioprotection by ischemic postconditioning is abrogated in hypertrophied myocardium of spontaneously hypertensive rats. J Cardiovasc Pharm. 2013;61:35\u201341.","journal-title":"J Cardiovasc Pharm"},{"key":"440_CR31","doi-asserted-by":"publisher","first-page":"H1580","DOI":"10.1152\/ajpheart.00379.2008","volume":"295","author":"O Bouhidel","year":"2008","unstructured":"Bouhidel O, Pons S, Souktani R, Zini R, Berdeaux A, Ghaleh B. Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob\/ob mice. Am J Physiol Heart Circ Physiol. 2008;295:H1580\u20136.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"440_CR32","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1111\/j.1582-4934.2009.00796.x","volume":"14","author":"V Sivaraman","year":"2010","unstructured":"Sivaraman V, Hausenloy DJ, Wynne AM, Yellon DM. Preconditioning the diabetic human myocardium. J Cell Mol Med. 2010;14:1740\u20136.","journal-title":"J Cell Mol Med"},{"key":"440_CR33","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1210\/jc.2002-020904","volume":"88","author":"TM Lee","year":"2003","unstructured":"Lee TM, Chou TF. Impairment of myocardial protection in type 2 diabetic patients. J Clin Endocrinol Metab. 2003;88:531\u20137.","journal-title":"J Clin Endocrinol Metab"},{"key":"440_CR34","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1161\/01.CIR.103.12.1624","volume":"103","author":"RK Kharbanda","year":"2001","unstructured":"Kharbanda RK, Peters M, Walton B, Kattenhorn M, Mullen M, Klein N, et al. Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation. 2001;103:1624\u201330.","journal-title":"Circulation."},{"key":"440_CR35","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1161\/hc4601.099485","volume":"104","author":"T Heitzer","year":"2001","unstructured":"Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001;104:2673\u20138.","journal-title":"Circulation"},{"key":"440_CR36","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/S0735-1097(03)00927-6","volume":"42","author":"SY Chan","year":"2003","unstructured":"Chan SY, Mancini GBJ, Kuramoto L, Schulzer M, Frohlich J, Ignaszewski A. The prognostic importance of endothelial dysfunction and carotid atheromaburden in patients with coronary artery disease. J Am Coll Cardiol. 2003;42:1037\u201343.","journal-title":"J Am Coll Cardiol"},{"key":"440_CR37","first-page":"1175","volume":"8","author":"Y Kono","year":"2014","unstructured":"Kono Y, Fukuda S, Hanatani A, Nakanishi K, Otsuka K, Taguchi H, et al. Remote ischemic conditioning improves coronary microcirculation in healthy subjects and patients with heart failure. Drug Des Devel Ther. 2014;8:1175\u201381.","journal-title":"Drug Des Devel Ther"}],"container-title":["Journal of Human Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41371-020-00440-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41371-020-00440-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41371-020-00440-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T23:04:25Z","timestamp":1633907065000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41371-020-00440-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,9]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["440"],"URL":"https:\/\/doi.org\/10.1038\/s41371-020-00440-0","relation":{},"ISSN":["0950-9240","1476-5527"],"issn-type":[{"value":"0950-9240","type":"print"},{"value":"1476-5527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,9]]},"assertion":[{"value":"21 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}