{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:37:19Z","timestamp":1775129839465,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Hypertens"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1038\/s41371-020-0312-x","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T17:16:06Z","timestamp":1581959766000},"page":"65-73","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hypertensive disorders of pregnancy and risks of adverse pregnancy outcomes: a retrospective cohort study of 2368 patients"],"prefix":"10.1038","volume":"35","author":[{"given":"Xun","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weishe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zujing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yincheng","family":"Teng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingrui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaozhen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxiu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiejie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangqun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingming","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanqiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiefeng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifang","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingfei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"312_CR1","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","volume":"376","author":"EA Steegers","year":"2010","unstructured":"Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre-eclampsia. Lancet 2010;376:631\u201344.","journal-title":"Lancet"},{"key":"312_CR2","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.bpobgyn.2011.01.006","volume":"25","author":"JA Hutcheon","year":"2011","unstructured":"Hutcheon JA, Lisonkova S, Joseph KS. Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. Best Pract Res Clin Obstet. 2011;25:391\u2013403.","journal-title":"Best Pract Res Clin Obstet"},{"key":"312_CR3","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/hr.2016.126","volume":"40","author":"M Umesawa","year":"2017","unstructured":"Umesawa M, Kobashi G. Epidemiology of hypertensive disorders in pregnancy: prevalence, risk factors, predictors and prognosis. Hypertens Res. 2017;40:213\u201320.","journal-title":"Hypertens Res."},{"key":"312_CR4","doi-asserted-by":"publisher","first-page":"ix-xiv","DOI":"10.1081\/PRG-100104165","volume":"20","author":"MA Brown","year":"2001","unstructured":"Brown MA, Lindheimer MD, de Swiet M, Assche AV, Moutquin J-M. The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy. 2001;20:ix-xiv.","journal-title":"Hypertens Pregnancy."},{"key":"312_CR5","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.preghy.2014.02.001","volume":"4","author":"AL Tranquilli","year":"2014","unstructured":"Tranquilli AL, Dekker G, Magee L, Roberts J, Sibai BM, Steyn W, et al. The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP. Hypertens Pregnancy. 2014;4:97\u2013104.","journal-title":"Hypertens Pregnancy."},{"key":"312_CR6","doi-asserted-by":"publisher","first-page":"544.e1","DOI":"10.1016\/j.ajog.2013.08.019","volume":"209","author":"S Lisonkova","year":"2013","unstructured":"Lisonkova S, Joseph KS. Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease. Am J Obstet Gynecol. 2013;209:544.e1\u201312.","journal-title":"Am J Obstet Gynecol"},{"key":"312_CR7","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/S0002-9378(10)02322-7","volume":"204","author":"MG Tuuli","year":"2011","unstructured":"Tuuli MG, Rampersad R, Stamilio D, Macones G, Odibo AO. Perinatal outcomes in women with preeclampsia and superimposed preeclampsia: do they differ? Am J Obstet Gynecol. 2011;204:e1\u20137.","journal-title":"Am J Obstet Gynecol"},{"key":"312_CR8","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1042\/CS20150702","volume":"130","author":"AC Harmon","year":"2016","unstructured":"Harmon AC, Cornelius DC, Amaral LM, Faulkner JL, Cunningham MW Jr., Wallace K, et al. The role of inflammation in the pathology of preeclampsia. Clin Sci. 2016;130:409\u201319.","journal-title":"Clin Sci"},{"key":"312_CR9","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.2215\/CJN.12081115","volume":"11","author":"E Phipps","year":"2016","unstructured":"Phipps E, Prasanna D, Brima W, Jim B. Preeclampsia: updates in pathogenesis, definitions, and guidelines. Clin J Am Soc Nephrol. 2016;11:1102\u201313.","journal-title":"Clin J Am Soc Nephrol"},{"key":"312_CR10","doi-asserted-by":"publisher","first-page":"l2381","DOI":"10.1136\/bmj.l2381","volume":"366","author":"GJ Burton","year":"2019","unstructured":"Burton GJ, Redman CW, Roberts JM, Moffett A. Pre-eclampsia: pathophysiology and clinical implications. BMJ. 2019;366:l2381.","journal-title":"BMJ."},{"key":"312_CR11","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1081\/PRG-120021060","volume":"22","author":"P von Dadelszen","year":"2003","unstructured":"von Dadelszen P, Magee LA, Roberts JM. Subclassification of preeclampsia. Hypertens Pregnancy. 2003;22:143\u20138.","journal-title":"Hypertens Pregnancy."},{"key":"312_CR12","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1097\/AOG.0000000000000472","volume":"124","author":"S Lisonkova","year":"2014","unstructured":"Lisonkova S, Sabr Y, Mayer C, Young C, Skoll A, Joseph KS. Maternal morbidity associated with early-onset and late-onset preeclampsia. Obstet Gynecol. 2014;124:771\u201381.","journal-title":"Obstet Gynecol."},{"key":"312_CR13","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.preghy.2012.11.001","volume":"3","author":"AL Tranquilli","year":"2013","unstructured":"Tranquilli AL, Brown MA, Zeeman GG, Dekker G, Sibai BM. The definition of severe and early-onset preeclampsia. Statements from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Pregnancy Hypertens. 2013;3:44\u20137.","journal-title":"Pregnancy Hypertens"},{"key":"312_CR14","doi-asserted-by":"publisher","first-page":"90","DOI":"10.5152\/jtgga.2011.22","volume":"12","author":"G Yildirim","year":"2011","unstructured":"Yildirim G, Gungorduk K, Aslan H, Gul A, Bayraktar M, Ceylan Y. Comparison of perinatal and maternal outcomes of severe preeclampsia, eclampsia, and HELLP syndrome. J Turk Ger Gynecol Assoc. 2011;12:90\u20136.","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"312_CR15","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.preghy.2016.10.017","volume":"7","author":"S Rahmayanti","year":"2017","unstructured":"Rahmayanti S, Nurdiati DS. HELLP syndrome in severe preeclampsia: the perinatal outcomes. Pregnancy Hypertens. 2017;7:61.","journal-title":"Pregnancy Hypertens"},{"key":"312_CR16","first-page":"721","volume":"10","author":"Group of Obstetrics and Gynecology Chinese Medical Association.","year":"2015","unstructured":"Group of Obstetrics and Gynecology Chinese Medical Association. Guidelines for the diagnosis and treatment of hypertensive disorder complicating pregnancy (2015). Chin J Obstet Gynecol. 2015;10:721\u20138. [in Chinese]","journal-title":"Chin J Obstet Gynecol"},{"key":"312_CR17","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1097\/01.AOG.0000437382.03963.88","volume":"122","author":"American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy.","year":"2013","unstructured":"American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists\u2019 Task Force on hypertension in pregnancy. Obstet Gynecol. 2013;122:1122\u201331.","journal-title":"Obstet Gynecol."},{"key":"312_CR18","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/S1701-2163(15)30588-0","volume":"36","author":"LA Magee","year":"2014","unstructured":"Magee LA, Pels A, Helewa M, Rey E, von Dadelszen P. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary. J Obstet Gynaecol Can. 2014;36:416\u201341.","journal-title":"J Obstet Gynaecol Can"},{"key":"312_CR19","first-page":"58","volume":"7","author":"CW Redman","year":"2017","unstructured":"Redman CW. Early and late onset preeclampsia: Two sides of the same coin. Pregnancy Hypertens. 2017;7:58. (Abstract)","journal-title":"Pregnancy Hypertens"},{"key":"312_CR20","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ejogrb.2012.09.026","volume":"166","author":"U Abildgaard","year":"2013","unstructured":"Abildgaard U, Heimdal K. Pathogenesis of the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP): a review. Eur J Obstet Gynecol Reprod Biol. 2013;166:117\u201323.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"312_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.408","volume":"4","author":"K John","year":"2013","unstructured":"John K, Wielgosz S, Schulze-Osthoff K, Bantel H, Hass R. Increased plasma levels of CK-18 as potential cell death biomarker in patients with HELLP syndrome. Cell Death Dis. 2013;4:e886.","journal-title":"Cell Death Dis"},{"key":"312_CR22","doi-asserted-by":"publisher","first-page":"386.e1","DOI":"10.1016\/j.ajog.2008.11.035","volume":"200","author":"Y Purwosunu","year":"2009","unstructured":"Purwosunu Y, Sekizawa A, Okazaki S, Farina A, Wibowo N, Nakamura M, et al. Prediction of preeclampsia by analysis of cell-free messenger RNA in maternal plasma. Am J Obstet Gynecol. 2009;200:386.e1\u20137.","journal-title":"Am J Obstet Gynecol"},{"key":"312_CR23","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1097\/GRF.0000000000000255","volume":"60","author":"NE Ankumah","year":"2017","unstructured":"Ankumah NE, Sibai BM. Chronic hypertension in pregnancy: diagnosis, management, and outcomes. Clin Obstet Gynecol. 2017;60:206\u201314.","journal-title":"Clin Obstet Gynecol"},{"key":"312_CR24","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1097\/AOG.0000000000000205","volume":"123","author":"NA Ankumah","year":"2014","unstructured":"Ankumah NA, Cantu J, Jauk V, Biggio J, Hauth J, Andrews W, et al. Risk of adverse pregnancy outcomes in women with mild chronic hypertension before 20 weeks of gestation. Obstet Gynecol 2014;123:966\u201372.","journal-title":"Obstet Gynecol"},{"key":"312_CR25","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0140-6736(98)08049-0","volume":"355","author":"P von Dadelszen","year":"2000","unstructured":"von Dadelszen P, Ornstein MP, Bull SB, Logan AG, Koren G, Magee LA. Fall in mean arterial pressure and fetal growth restriction in pregnancy hypertension: a meta-analysis. Lancet. 2000;355:87\u201392.","journal-title":"Lancet."},{"key":"312_CR26","doi-asserted-by":"publisher","first-page":"301.e1","DOI":"10.1016\/j.ajog.2012.11.011","volume":"208","author":"H Orbach","year":"2013","unstructured":"Orbach H, Matok I, Gorodischer R, Sheiner E, Daniel S, Wiznitzer A, et al. Hypertension and antihypertensive drugs in pregnancy and perinatal outcomes. Am J Obstet Gynecol. 2013;208:301.e1\u20136.","journal-title":"Am J Obstet Gynecol"},{"key":"312_CR27","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.ajog.2005.10.813","volume":"194","author":"J Villar","year":"2006","unstructured":"Villar J, Carroli G, Wojdyla D, Abalos E, Giordano D, Ba\u2019aqeel H, et al. Preeclampsia, gestational hypertension and intrauterine growth restriction, related or independent conditions? Am J Obstet Gynecol. 2006;194:921\u201331.","journal-title":"Am J Obstet Gynecol"},{"key":"312_CR28","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1161\/HYPERTENSIONAHA.117.09246","volume":"70","author":"J Tooher","year":"2017","unstructured":"Tooher J, Thornton C, Makris A, Ogle R, Korda A, Hennessy A. All hypertensive disorders of pregnancy increase the risk of future cardiovascular disease. Hypertension. 2017;70:798\u2013803.","journal-title":"Hypertension."},{"key":"312_CR29","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1067\/mob.2001.112905","volume":"184","author":"JR Barton","year":"2001","unstructured":"Barton JR, O\u2019Brien JM, Bergauer NK, Jacques DL, Sibai BM. Mild gestational hypertension remote from term: progression and outcome. Am J Obstet Gynecol. 2001;184:979\u201383.","journal-title":"Am J Obstet Gynecol"},{"key":"312_CR30","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1111\/j.1471-0528.2007.01315.x","volume":"114","author":"LA Magee","year":"2007","unstructured":"Magee LA, von Dadelszen P, Chan S, Gafni A, Gruslin A, Helewa M, et al. The control of hypertension in pregnancy study pilot trial. BJOG. 2007;114:e13\u201320.","journal-title":"BJOG"},{"key":"312_CR31","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1097\/HJH.0b013e3282fcc36e","volume":"26","author":"LM Silva","year":"2008","unstructured":"Silva LM, Coolman M, Steegers EA, Jaddoe VW, Moll HA, Hofman A, et al. Low socioeconomic status is a risk factor for preeclampsia: the Generation R Study. J Hypertens. 2008;26:1200\u20138.","journal-title":"J Hypertens."},{"key":"312_CR32","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/S0002-9378(97)70004-8","volume":"177","author":"B Sibai","year":"1997","unstructured":"Sibai B, Ewell M, Levine R, Klebanoff M, Esterlitz J, Catalano P, et al. Risk factors associated with preeclampsia in healthy nulliparous women. Am J Obstet Gynecol. 1997;177:1003\u201310.","journal-title":"Am J Obstet Gynecol"},{"key":"312_CR33","doi-asserted-by":"publisher","first-page":"e0175914","DOI":"10.1371\/journal.pone.0175914","volume":"12","author":"M Shen","year":"2017","unstructured":"Shen M, Smith GN, Rodger M, White RR, Walker MC, Wen SW. Comparison of risk factors and outcomes of gestational hypertension and pre-eclampsia. PLoS ONE. 2017;12:e0175914.","journal-title":"PLoS ONE."},{"key":"312_CR34","doi-asserted-by":"publisher","first-page":"260.e1","DOI":"10.1016\/j.ajog.2011.06.033","volume":"205","author":"MO Cruz","year":"2011","unstructured":"Cruz MO, Gao W, Hibbard JU. Obstetrical and perinatal outcomes among women with gestational hypertension, mild preeclampsia, and mild chronic hypertension. Am J Obstet Gynecol. 2011;205:260.e1\u20139.","journal-title":"Am J Obstet Gynecol"},{"key":"312_CR35","first-page":"24","volume":"95","author":"JC Hauth","year":"2000","unstructured":"Hauth JC, Ewell MG, Levine RJ, Esterlitz JR, Sibai B, Curet LB, et al. Pregnancy outcomes in healthy nulliparas who developed hypertension. Calcium for Preeclampsia Prevention Study Group. Obstet Gynecol. 2000;95:24\u20138.","journal-title":"Obstet Gynecol."}],"container-title":["Journal of Human Hypertension"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41371-020-0312-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41371-020-0312-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41371-020-0312-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:24:48Z","timestamp":1684617888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41371-020-0312-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,17]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["312"],"URL":"https:\/\/doi.org\/10.1038\/s41371-020-0312-x","relation":{},"ISSN":["0950-9240","1476-5527"],"issn-type":[{"value":"0950-9240","type":"print"},{"value":"1476-5527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,17]]},"assertion":[{"value":"9 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was reviewed and approved by the Medical Ethics Committee of the Xiangya Hospital, Center South University (reference number: 20170527). The requirement for written informed consent was waived by the Ethics Committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}