{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:14Z","timestamp":1789171214557,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009750","name":"Familjen Kamprads Stiftelse","doi-asserted-by":"publisher","award":["20170102"],"award-info":[{"award-number":["20170102"]}],"id":[{"id":"10.13039\/501100009750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009750","name":"Familjen Kamprads Stiftelse","doi-asserted-by":"publisher","award":["20170102"],"award-info":[{"award-number":["20170102"]}],"id":[{"id":"10.13039\/501100009750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009750","name":"Familjen Kamprads Stiftelse","doi-asserted-by":"publisher","award":["20170102"],"award-info":[{"award-number":["20170102"]}],"id":[{"id":"10.13039\/501100009750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009750","name":"Familjen Kamprads Stiftelse","doi-asserted-by":"publisher","award":["20170102"],"award-info":[{"award-number":["20170102"]}],"id":[{"id":"10.13039\/501100009750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20170251 \/ 20200507"],"award-info":[{"award-number":["20170251 \/ 20200507"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20170251 \/ 20200507"],"award-info":[{"award-number":["20170251 \/ 20200507"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20170251 \/ 20200507"],"award-info":[{"award-number":["20170251 \/ 20200507"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20170251 \/ 20200507"],"award-info":[{"award-number":["20170251 \/ 20200507"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018-02648"],"award-info":[{"award-number":["2018-02648"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018-02648"],"award-info":[{"award-number":["2018-02648"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018-02648"],"award-info":[{"award-number":["2018-02648"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018-02648"],"award-info":[{"award-number":["2018-02648"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Hypertens"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Blood pressure variability (BPV) represents a cardiovascular risk factor, regardless of mean level of blood pressure (BP). In this post-hoc analysis from the PERson-centredness in Hypertension management using Information Technology (PERHIT) study, we aimed to explore BPV in daily home measurements in hypertensive patients from primary care, to identify factors associated with high BPV and to investigate whether estimated glomerular filtration rate (eGFR) and pulse pressure, as markers of target organ damage (TOD), are associated with BPV. For eight consecutive weeks, 454 participants reported their daily BP and heart rate in their mobile phone, along with reports of lifestyle and hypertension-related factors. Systolic BP (SBP) values were used to calculate BPV with coefficient of variation (CV) as primary estimate. Background characteristics and self-reports were tested between fifths of CV in a linear regression model, adjusted for age and sex. Associations between BPV and eGFR and pulse pressure were tested with linear and logistic regression models. Higher home BPV was associated with higher age, BP, heart rate, and smoking. BPV was lower for participants with low alcohol consumption and treatment with calcium channel blockers. There was a significant association between BPV and pulse pressure (<jats:italic>P<\/jats:italic>\u2009=\u20090.015), and between BPV and eGFR (<jats:italic>P<\/jats:italic>\u2009=\u20090.049). Participants with high BPV reported more dizziness and palpitations. In conclusion, pulse pressure and eGFR were significantly associated with home BPV. Older age, high BP, heart rate, and smoking were associated with high BPV, but treatment with calcium channel blockers and low alcohol consumption was associated with low BPV. Trial registration: The study was registered with ClinicalTrials.gov [NCT03554382].<\/jats:p>","DOI":"10.1038\/s41371-023-00874-2","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T16:03:06Z","timestamp":1700064186000},"page":"212-220","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Variability in home blood pressure and its association with renal function and pulse pressure in patients with treated hypertension in primary care"],"prefix":"10.1038","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5331-3348","authenticated-orcid":false,"given":"Ulrika","family":"Andersson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5652-8459","authenticated-orcid":false,"given":"Peter M.","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2764-3095","authenticated-orcid":false,"given":"Karin","family":"Kjellgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2444-2869","authenticated-orcid":false,"given":"Katie","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-0580","authenticated-orcid":false,"given":"John","family":"Chalmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Ekholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-8731","authenticated-orcid":false,"given":"Patrik","family":"Midl\u00f6v","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"874_CR1","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1097\/HJH.0000000000003363","volume":"41","author":"G Parati","year":"2023","unstructured":"Parati G, Bilo G, Kollias A, Pengo M, Ochoa JE, Castiglioni P, et al. Blood pressure variability: methodological aspects, clinical relevance and practical indications for management - a European Society of Hypertension position paper \u2217. J Hypertens. 2023;41:527\u201344.","journal-title":"J Hypertens"},{"key":"874_CR2","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","volume":"39","author":"B Williams","year":"2018","unstructured":"Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC\/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018;39:3021\u2013104.","journal-title":"Eur Heart J"},{"key":"874_CR3","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1093\/eurheartj\/ehx760","volume":"39","author":"MH Mehlum","year":"2018","unstructured":"Mehlum MH, Liest\u00f8l K, Kjeldsen SE, Julius S, Hua TA, Rothwell PM, et al. Blood pressure variability and risk of cardiovascular events and death in patients with hypertension and different baseline risks. Eur Heart J. 2018;39:2243\u201351.","journal-title":"Eur Heart J"},{"key":"874_CR4","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1093\/ageing\/afz178","volume":"49","author":"TO Smith","year":"2020","unstructured":"Smith TO, Sillito JA, Goh CH, Abdel-Fattah AR, Einarsson A, Soiza RL, et al. Association between different methods of assessing blood pressure variability and incident cardiovascular disease, cardiovascular mortality and all-cause mortality: a systematic review. Age Ageing. 2020;49:184\u201392.","journal-title":"Age Ageing"},{"key":"874_CR5","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1097\/HJH.0000000000002922","volume":"39","author":"G Parati","year":"2021","unstructured":"Parati G, Stergiou GS, Bilo G, Kollias A, Pengo M, Ochoa JE, et al. Home blood pressure monitoring: methodology, clinical relevance and practical application: a 2021 position paper by the working group on blood pressure monitoring and cardiovascular variability of the European Society of Hypertension. J Hypertens. 2021;39:1742\u201367.","journal-title":"J Hypertens"},{"key":"874_CR6","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1161\/HYPERTENSIONAHA.117.10385","volume":"71","author":"S Hoshide","year":"2018","unstructured":"Hoshide S, Yano Y, Mizuno H, Kanegae H, Kario K. Day-by-day variability of home blood pressure and incident cardiovascular disease in clinical practice. Hypertension. 2018;71:177\u201384.","journal-title":"Hypertension"},{"key":"874_CR7","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/hr.2014.2","volume":"37","author":"GS Stergiou","year":"2014","unstructured":"Stergiou GS, Ntineri A, Kollias A, Ohkubo T, Imai Y, Parati G. Blood pressure variability assessed by home measurements: a systematic review. Hypertens Res. 2014;37:565\u201372.","journal-title":"Hypertens Res"},{"key":"874_CR8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/s41371-018-0129-z","volume":"33","author":"N Takashima","year":"2019","unstructured":"Takashima N, Ohkubo T, Miura K, Okayama A, Okuda N, Nakagawa H, et al. Factors associated with intra-individual visit-to-visit variability of blood pressure in four countries: the INTERMAP study. J Hum Hypertens. 2019;33:229\u201336.","journal-title":"J Hum Hypertens"},{"key":"874_CR9","doi-asserted-by":"publisher","first-page":"101677","DOI":"10.1016\/j.arr.2022.101677","volume":"80","author":"L Bencivenga","year":"2022","unstructured":"Bencivenga L, de Souto Barreto P, Rolland Y, Hanon O, Vidal JS, Cestac P, et al. Blood pressure variability: a potential marker of aging. Ageing Res Rev. 2022;80:101677.","journal-title":"Ageing Res Rev"},{"key":"874_CR10","doi-asserted-by":"publisher","first-page":"e21227","DOI":"10.1097\/MD.0000000000021227","volume":"99","author":"JS Park","year":"2020","unstructured":"Park JS, Shin JH, Park JB, Choi DJ, Youn HJ, Park CG, et al. Relationship between arterial stiffness and variability of home blood pressure monitoring. Medicine. 2020;99:e21227.","journal-title":"Medicine"},{"key":"874_CR11","doi-asserted-by":"publisher","first-page":"e012141","DOI":"10.1161\/JAHA.119.012141","volume":"8","author":"RS Vasan","year":"2019","unstructured":"Vasan RS, Short MI, Niiranen TJ, Xanthakis V, DeCarli C, Cheng S, et al. Interrelations between arterial stiffness, target organ damage, and cardiovascular disease outcomes. J Am Heart Assoc. 2019;8:e012141.","journal-title":"J Am Heart Assoc"},{"key":"874_CR12","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/s41371-019-0286-8","volume":"34","author":"M el Mokadem","year":"2020","unstructured":"el Mokadem M, Boshra H, Abd el Hady Y, Kasla A, Gouda A. Correlation between blood pressure variability and subclinical target organ damage in patients with essential hypertension. J Hum Hypertens. 2020;34:641\u20137.","journal-title":"J Hum Hypertens"},{"key":"874_CR13","doi-asserted-by":"publisher","first-page":"e003825","DOI":"10.1161\/JAHA.116.003825","volume":"5","author":"YC Chia","year":"2016","unstructured":"Chia YC, Lim HM, Ching SM. Long-term visit-to-visit blood pressure variability and renal function decline in patients with hypertension over 15 years. J Am Heart Assoc. 2016;5:e003825.","journal-title":"J Am Heart Assoc"},{"key":"874_CR14","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/s41440-021-00818-8","volume":"45","author":"T Kubozono","year":"2022","unstructured":"Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Makizako H, et al. The relationship between day-to-day variability in home blood pressure measurement and multiple organ function. Hypertens Res. 2022;45:474\u201382.","journal-title":"Hypertens Res"},{"key":"874_CR15","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1093\/ajh\/hpaa091","volume":"33","author":"D Suzuki","year":"2020","unstructured":"Suzuki D, Hoshide S, Kario K. Associations between day-by-day home blood pressure variability and renal function and albuminuria in patients with and without diabetes. Am J Hypertens. 2020;33:860\u20138.","journal-title":"Am J Hypertens"},{"key":"874_CR16","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1177\/2047487317747498","volume":"25","author":"C Mancusi","year":"2018","unstructured":"Mancusi C, Losi MA, Izzo R, Canciello G, Carlino MV, Albano G, et al. Higher pulse pressure and risk for cardiovascular events in patients with essential hypertension: The Campania Salute Network. Eur J Prev Cardiol. 2018;25:235\u201343.","journal-title":"Eur J Prev Cardiol"},{"key":"874_CR17","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1097\/HJH.0000000000003322","volume":"41","author":"U Andersson","year":"2023","unstructured":"Andersson U, Nilsson PM, Kjellgren K, Hoffmann M, Wennersten A, Midl\u00f6v P. PERson-centredness in Hypertension management using Information Technology: a randomized controlled trial in primary care. J Hypertens. 2023;41:246\u201353.","journal-title":"J Hypertens"},{"key":"874_CR18","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1080\/08037051.2019.1697177","volume":"29","author":"P Midl\u00f6v","year":"2020","unstructured":"Midl\u00f6v P, Nilsson PM, Bengtsson U, Hoffmann M, Wennersten A, Andersson U, et al. PERson-centredness in hypertension management using information technology (PERHIT): a protocol for a randomised controlled trial in primary health care. Blood Press. 2020;29:149\u201356.","journal-title":"Blood Press"},{"key":"874_CR19","doi-asserted-by":"publisher","first-page":"e26143","DOI":"10.2196\/26143","volume":"23","author":"U Andersson","year":"2021","unstructured":"Andersson U, Bengtsson U, Ranerup A, Midl\u00f6v P, Kjellgren K. Patients and professionals as partners in hypertension care: qualitative substudy of a randomized controlled trial using an interactive web-based system via mobile phone. J Med Internet Res. 2021;23:e26143.","journal-title":"J Med Internet Res"},{"key":"874_CR20","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S0140-6736(10)60308-X","volume":"375","author":"PM Rothwell","year":"2010","unstructured":"Rothwell PM, Howard SC, Dolan E, O\u2019brien E, Dobson JE, Dahl\u00f6f B, et al. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet. 2010;375:895\u2013905.","journal-title":"Lancet"},{"key":"874_CR21","first-page":"e16347","volume":"98","author":"R del Giorno","year":"2019","unstructured":"del Giorno R, Balestra L, Heiniger PS, Gabutti L. Blood pressure variability with different measurement methods: reliability and predictors. A proof of concept cross sectional study in elderly hypertensive hospitalized patients. Med (US). 2019;98:e16347.","journal-title":"Med (US)"},{"key":"874_CR22","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3109\/00365513.2011.634023","volume":"72","author":"A Grubb","year":"2012","unstructured":"Grubb A, Nyman U, Bj\u00f6rk J. Improved estimation of glomerular filtration rate (GFR) by comparison of eGFR cystatin C and eGFR creatinine. Scand J Clin Lab Invest. 2012;72:73\u20137.","journal-title":"Scand J Clin Lab Invest"},{"key":"874_CR23","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1515\/cclm-2013-0741","volume":"52","author":"U Nyman","year":"2014","unstructured":"Nyman U, Grubb A, Larsson A, Hansson LO, Flodin M, Nordin G, et al. The revised Lund-Malm\u00f6 GFR estimating equation outperforms MDRD and CKD-EPI across GFR, age and BMI intervals in a large Swedish population. Clin Chem Lab Med. 2014;52:815\u201324.","journal-title":"Clin Chem Lab Med"},{"key":"874_CR24","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1038\/s41440-021-00736-9","volume":"44","author":"N Boubouchairopoulou","year":"2021","unstructured":"Boubouchairopoulou N, Ntineri A, Kollias A, Destounis A, Stergiou GS. Blood pressure variability assessed by office, home, and ambulatory measurements: comparison, agreement, and determinants. Hypertens Res. 2021;44:1617\u201324.","journal-title":"Hypertens Res"},{"key":"874_CR25","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3109\/10641963.2012.681087","volume":"34","author":"K Ishikura","year":"2012","unstructured":"Ishikura K, Obara T, Kato T, Kikuya M, Shibamiya T, Shinki T, et al. Associations between day-by-day variability in blood pressure measured at home and antihypertensive drugs: The J-HOME-morning study home. Clin Exp Hypertens. 2012;34:297\u2013304.","journal-title":"Clin Exp Hypertens"},{"key":"874_CR26","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1007\/s11906-012-0306-3","volume":"14","author":"S Reule","year":"2012","unstructured":"Reule S, Drawz PE. Heart rate and blood pressure: any possible implications for management of hypertension. Curr Hypertens Rep. 2012;14:478\u201384.","journal-title":"Curr Hypertens Rep"},{"key":"874_CR27","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s12012-022-09728-8","volume":"22","author":"CL Hwang","year":"2022","unstructured":"Hwang CL, Muchira J, Hibner BA, Phillips SA, Piano MR. Alcohol consumption: a new risk factor for arterial stiffness? Cardiovasc Toxicol. 2022;22:236\u201345.","journal-title":"Cardiovasc Toxicol"},{"key":"874_CR28","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.3390\/nu14061207","volume":"14","author":"R del Giorno","year":"2022","unstructured":"del Giorno R, Maddalena A, Bassetti S, Gabutti L. Association between alcohol intake and arterial stiffness in healthy adults: a systematic review. Nutrients. 2022;14:1207.","journal-title":"Nutrients"},{"key":"874_CR29","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/hr.2012.177","volume":"36","author":"M Fukui","year":"2013","unstructured":"Fukui M, Ushigome E, Tanaka M, Hamaguchi M, Tanaka T, Atsuta H, et al. Home blood pressure variability on one occasion is a novel factor associated with arterial stiffness in patients with type 2 diabetes. Hypertens Res. 2013;36:219\u201325.","journal-title":"Hypertens Res"},{"key":"874_CR30","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1093\/ajh\/hpaa060","volume":"33","author":"JW Lee","year":"2020","unstructured":"Lee JW, Choi E, Son JW, Youn YJ, Ahn SG, Ahn MS, et al. Comparison of blood pressure variability between losartan and amlodipine in essential hypertension (COMPAS-BPV). Am J Hypertens. 2020;33:748\u201355.","journal-title":"Am J Hypertens"},{"key":"874_CR31","doi-asserted-by":"publisher","first-page":"156","DOI":"10.2174\/1573402115666191023111351","volume":"16","author":"GM Lin","year":"2019","unstructured":"Lin GM, Tsai KZ, Lin CS, Han CL. Physical fitness and long-term blood pressure variability in young male military personnel. Curr Hypertens Rev. 2019;16:156\u201360.","journal-title":"Curr Hypertens Rev"},{"key":"874_CR32","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1152\/ajpheart.00600.2003","volume":"286","author":"ALT Uusitalo","year":"2004","unstructured":"Uusitalo ALT, Laitinen T, V\u00e4is\u00e4nen SB, L\u00e4nsimies E, Rauramaa R. Physical training and heart rate and blood pressure variability: a 5-yr randomized trial. Am J Physiol Heart Circ Physiol. 2004;286:1821\u20136.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"874_CR33","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1093\/ajh\/hpx034","volume":"30","author":"A Maseli","year":"2017","unstructured":"Maseli A, Aeschbacher S, Schoen T, Fischer A, Jung M, Risch M, et al. Healthy lifestyle and blood pressure variability in young adults. Am J Hypertens. 2017;30:690\u20139.","journal-title":"Am J Hypertens"},{"key":"874_CR34","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nrcardio.2017.155","volume":"15","author":"ME Safar","year":"2018","unstructured":"Safar ME. Arterial stiffness as a risk factor for clinical hypertension. Nat Rev Cardiol. 2018;15:97\u2013105.","journal-title":"Nat Rev Cardiol"},{"key":"874_CR35","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1080\/08037050802584313","volume":"17","author":"A Mokhtari","year":"2008","unstructured":"Mokhtari A, Bellinetto-Ford L, Melander O, Nilsson PM. Determinants of increasing pulse pressure during 23 years\u2019 follow-up as a marker of arterial stiffness and vascular ageing. Blood Press. 2008;17:291\u20137.","journal-title":"Blood Press"},{"key":"874_CR36","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1016\/S0895-7061(97)00277-X","volume":"10","author":"Y Imai","year":"1997","unstructured":"Imai Y, Aihara A, Ohkubo T, Nagai K, Tsuji I, Minami N, et al. Factors that affect blood pressure variability a community-based study in Ohasama, Japan. Am J Hypertens Ltd AJH. 1997;10:1281\u20139.","journal-title":"Am J Hypertens Ltd AJH"}],"container-title":["Journal of Human Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41371-023-00874-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41371-023-00874-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41371-023-00874-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T10:07:05Z","timestamp":1710410825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41371-023-00874-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,15]]},"references-count":36,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["874"],"URL":"https:\/\/doi.org\/10.1038\/s41371-023-00874-2","relation":{},"ISSN":["1476-5527"],"issn-type":[{"value":"1476-5527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,15]]},"assertion":[{"value":"17 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors report no conflicts of interest. Mikael Ekholm has received grants from FORSS Grants, Medical Research Council of Southeast Sweden. John Chalmers reports a Program Grant from the National Health and Medical Research Council (NHMRC) of Australia.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The PERHIT-project was approved by the Regional Ethics Review Board in Lund (2017\/311 and 2019\/00036). The study was registered with ClinicalTrials.gov [NCT03554382]. The participants were given oral and written information about the study prior to entering the study. All patients who agreed to participate signed a consent document.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}