{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:53:25Z","timestamp":1762674805146,"version":"3.40.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Hypertens"],"DOI":"10.1038\/s41371-025-00995-w","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T12:59:10Z","timestamp":1740747550000},"page":"293-300","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CITED2 is highly-expressed and PRX4 is poorly-expressed in preeclampsia and have diagnostic values"],"prefix":"10.1038","volume":"39","author":[{"given":"Caixia","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7175-4191","authenticated-orcid":false,"given":"Zhiying","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"995_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101535","volume":"73","author":"EC Miller","year":"2022","unstructured":"Miller EC, Wilczek A, Bello NA, Tom S, Wapner R, Suh Y. Pregnancy, preeclampsia and maternal aging: from epidemiology to functional genomics. Ageing Res Rev. 2022;73:101535.","journal-title":"Ageing Res Rev"},{"key":"995_CR2","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.preghy.2021.09.008","volume":"27","author":"LA Magee","year":"2022","unstructured":"Magee LA, Brown MA, Hall DR, Gupte S, Hennessy A, Karumanchi SA, et al. The 2021 international society for the study of hypertension in pregnancy classification, diagnosis & management recommendations for international practice. Pregnancy Hypertens. 2022;27:148\u201369.","journal-title":"Pregnancy Hypertens"},{"key":"995_CR3","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3390\/biom10060953","volume":"10","author":"MK Jena","year":"2020","unstructured":"Jena MK, Sharma NR, Petitt M, Maulik D, Nayak NR. Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta. Biomolecules. 2020;10:953.","journal-title":"Biomolecules"},{"key":"995_CR4","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.2215\/CJN.15121219","volume":"15","author":"K Wiles","year":"2020","unstructured":"Wiles K, Chappell LC, Lightstone L, Bramham K. Updates in diagnosis and management of preeclampsia in women with CKD. Clin J Am Soc Nephrol. 2020;15:1371\u201380.","journal-title":"Clin J Am Soc Nephrol"},{"key":"995_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202300118","volume":"46","author":"M Kuna","year":"2024","unstructured":"Kuna M, Soares MJ. Cited2 is a key regulator of placental development and plasticity. Bioessays. 2024;46:e2300118.","journal-title":"Bioessays"},{"key":"995_CR6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2213622120","volume":"120","author":"M Kuna","year":"2023","unstructured":"Kuna M, Dhakal P, Iqbal K, Dominguez EM, Kent LN, Muto M, et al. CITED2 is a conserved regulator of the uterine-placental interface. Proc Natl Acad Sci USA. 2023;120:e2213622120.","journal-title":"Proc Natl Acad Sci USA"},{"key":"995_CR7","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.2147\/IJGM.S475310","volume":"17","author":"X Lu","year":"2024","unstructured":"Lu X, Lan X, Fu X, Li J, Wu M, Xiao L, et al. Screening preeclampsia genes and the effects of CITED2 on trophoblastic function. Int J Gen Med. 2024;17:3493\u2013509.","journal-title":"Int J Gen Med"},{"key":"995_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2023.102355","volume":"76","author":"SF Villar","year":"2023","unstructured":"Villar SF, Ferrer-Sueta G, Denicola A. The multifaceted nature of peroxiredoxins in chemical biology. Curr Opin Chem Biol. 2023;76:102355.","journal-title":"Curr Opin Chem Biol"},{"key":"995_CR9","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1146\/annurev-biochem-060815-014431","volume":"86","author":"SG Rhee","year":"2017","unstructured":"Rhee SG, Kil IS. Multiple functions and regulation of mammalian peroxiredoxins. Annu Rev Biochem. 2017;86:749\u201375.","journal-title":"Annu Rev Biochem"},{"key":"995_CR10","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/pin.12634","volume":"68","author":"S Yamada","year":"2018","unstructured":"Yamada S, Guo X. Peroxiredoxin 4 (PRDX4): its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease. Pathol Int. 2018;68:91\u2013101.","journal-title":"Pathol Int"},{"key":"995_CR11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/978-1-4939-1441-8_22","volume":"1208","author":"B Gharesi-Fard","year":"2015","unstructured":"Gharesi-Fard B. Preoxiredoxin family members (Prx3 and Prx4) and pregnancy disorder (recurrent pregnancy loss). Methods Mol Biol. 2015;1208:299\u2013311.","journal-title":"Methods Mol Biol"},{"key":"995_CR12","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.preghy.2020.12.004","volume":"23","author":"S Mazloomi","year":"2021","unstructured":"Mazloomi S, Khodadadi I, Alizadeh N, Shafiee G. Association of glutamate cystein ligase (GCL) activity Peroxiredoxin 4 (prxR4) and apelin levels in women with preeclampsia. Pregnancy Hypertens. 2021;23:163\u20138.","journal-title":"Pregnancy Hypertens"},{"key":"995_CR13","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/aji.12042","volume":"69","author":"B Gharesi-Fard","year":"2013","unstructured":"Gharesi-Fard B, Jafarzadeh L, Ghaderi-shabankareh F, Zolghadri J, Kamali-Sarvestani E. Presence of autoantibody against two placental proteins, peroxiredoxin 3 and peroxiredoxin 4, in sera of recurrent pregnancy loss patients. Am J Reprod Immunol. 2013;69:248\u201355.","journal-title":"Am J Reprod Immunol"},{"key":"995_CR14","doi-asserted-by":"publisher","first-page":"7468","DOI":"10.1074\/jbc.M110.179242","volume":"286","author":"A Sengupta","year":"2011","unstructured":"Sengupta A, Molkentin JD, Paik JH, DePinho RA, Yutzey KE. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem. 2011;286:7468\u201378.","journal-title":"J Biol Chem"},{"key":"995_CR15","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.1182\/blood-2011-10-387902","volume":"119","author":"J Du","year":"2012","unstructured":"Du J, Chen Y, Li Q, Han X, Cheng C, Wang Z, et al. HIF-1alpha deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency. Blood. 2012;119:2789\u201398.","journal-title":"Blood"},{"key":"995_CR16","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.3390\/cimb45020114","volume":"45","author":"FA Kose","year":"2023","unstructured":"Kose FA, Pabuccuoglu A, Karakoyun M, Aydogdu S. Peroxiredoxins and hypoxia-inducible factor-1alpha in duodenal tissue: emerging factors in the pathophysiology of pediatric celiac disease patients. Curr Issues Mol Biol. 2023;45:1779\u201393.","journal-title":"Curr Issues Mol Biol"},{"key":"995_CR17","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s10735-024-10197-2","volume":"55","author":"J Li","year":"2024","unstructured":"Li J, Li W, Li L, Wang W, Zhang M, Tang X. Induction of peroxiredoxin 1 by hypoxia promotes cellular autophagy and cell proliferation in oral leukoplakia via HIF-1alpha\/BNIP3 pathway. J Mol Histol. 2024;55:403\u201313.","journal-title":"J Mol Histol"},{"key":"995_CR18","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1111\/jch.14893","volume":"26","author":"J Peng","year":"2024","unstructured":"Peng J, Zhao Q, Pang W, Li Y, Dong X. Changes of coagulation function and platelet parameters in preeclampsia and their correlation with pregnancy outcomes. J Clin Hypertens. 2024;26:1181\u20137.","journal-title":"J Clin Hypertens"},{"key":"995_CR19","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/ajo.12320","volume":"55","author":"SA Lowe","year":"2015","unstructured":"Lowe SA, Bowyer L, Lust K, McMahon LP, Morton M, North RA, et al. SOMANZ guidelines for the management of hypertensive disorders of pregnancy 2014. Aust N Z J Obstet Gynaecol. 2015;55:e1\u201329.","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"995_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2020.101123","volume":"25","author":"M Ma\u2019ayeh","year":"2020","unstructured":"Ma\u2019ayeh M, Costantine MM. Prevention of preeclampsia. Semin Fetal Neonatal Med. 2020;25:101123.","journal-title":"Semin Fetal Neonatal Med"},{"key":"995_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2024.102683","volume":"41","author":"J Zhang","year":"2024","unstructured":"Zhang J, Yin B, Xi Y, Bai Y. Triglyceride-glucose index: a promising biomarker for predicting risks of adverse pregnancy outcomes in Hangzhou, China. Prev Med Rep. 2024;41:102683.","journal-title":"Prev Med Rep"},{"key":"995_CR22","doi-asserted-by":"publisher","first-page":"12371","DOI":"10.3390\/ijms252212371","volume":"25","author":"M Pehlic","year":"2024","unstructured":"Pehlic M, Dumancic S, Radan M, Galic J, Gruica B, Marijan S, et al. Untargeted urinary volatilomics reveals hexadecanal as a potential biomarker for preeclampsia. Int J Mol Sci. 2024;25:12371.","journal-title":"Int J Mol Sci"},{"key":"995_CR23","doi-asserted-by":"publisher","first-page":"3479","DOI":"10.1007\/s00018-019-03104-6","volume":"76","author":"M Knofler","year":"2019","unstructured":"Knofler M, Haider S, Saleh L, Pollheimer J, Gamage T, James J. Human placenta and trophoblast development: key molecular mechanisms and model systems. Cell Mol Life Sci. 2019;76:3479\u201396.","journal-title":"Cell Mol Life Sci"},{"key":"995_CR24","doi-asserted-by":"publisher","first-page":"6707","DOI":"10.18632\/oncotarget.24158","volume":"9","author":"GP Collett","year":"2018","unstructured":"Collett GP, Redman CW, Sargent IL, Vatish M. Endoplasmic reticulum stress stimulates the release of extracellular vesicles carrying danger-associated molecular pattern (DAMP) molecules. Oncotarget. 2018;9:6707\u201317.","journal-title":"Oncotarget"},{"key":"995_CR25","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.fertnstert.2015.12.137","volume":"105","author":"Y Fang","year":"2016","unstructured":"Fang Y, Shang W, Wei DL, Zeng SM. Cited2 protein level in cumulus cells is a biomarker for human embryo quality and pregnancy outcome in one in vitro fertilization cycle. Fertil Steril. 2016;105:1351\u20139.e4.","journal-title":"Fertil Steril"},{"key":"995_CR26","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.radonc.2007.04.026","volume":"83","author":"T van den Beucken","year":"2007","unstructured":"van den Beucken T, Magagnin MG, Savelkouls K, Lambin P, Koritzinsky M, Wouters BG. Regulation of Cited2 expression provides a functional link between translational and transcriptional responses during hypoxia. Radiother Oncol. 2007;83:346\u201352.","journal-title":"Radiother Oncol"},{"key":"995_CR27","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.placenta.2009.08.003","volume":"30","author":"RM Gobble","year":"2009","unstructured":"Gobble RM, Groesch KA, Chang M, Torry RJ, Torry DS. Differential regulation of human PlGF gene expression in trophoblast and nontrophoblast cells by oxygen tension. Placenta. 2009;30:869\u201375.","journal-title":"Placenta"},{"key":"995_CR28","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ydbio.2014.04.023","volume":"392","author":"JL Moreau","year":"2014","unstructured":"Moreau JL, Artap ST, Shi H, Chapman G, Leone G, Sparrow DB, et al. Cited2 is required in trophoblasts for correct placental capillary patterning. Dev Biol. 2014;392:62\u201379.","journal-title":"Dev Biol"},{"key":"995_CR29","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/nature21705","volume":"543","author":"RB Berlow","year":"2017","unstructured":"Berlow RB, Dyson HJ, Wright PE. Hypersensitive termination of the hypoxic response by a disordered protein switch. Nature. 2017;543:447\u201351.","journal-title":"Nature"},{"key":"995_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.767684","volume":"12","author":"FJ Valenzuela-Melgarejo","year":"2021","unstructured":"Valenzuela-Melgarejo FJ, Lagunas C, Carmona-Pasten F, Jara-Medina K, Delgado G. Supraphysiological role of melatonin over vascular dysfunction of pregnancy, a new therapeutic agent? Front Physiol. 2021;12:767684.","journal-title":"Front Physiol"},{"key":"995_CR31","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9949753","volume":"2021","author":"S Mazloomi","year":"2021","unstructured":"Mazloomi S, Sheikh N, Sanoee Farimani M, Pilehvari S. Association of Prx4, total oxidant status, and inflammatory factors with insulin resistance in polycystic ovary syndrome. Int J Endocrinol. 2021;2021:9949753.","journal-title":"Int J Endocrinol"},{"key":"995_CR32","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.21037\/atm-20-397","volume":"8","author":"Q Yi","year":"2020","unstructured":"Yi Q, Meng C, Cai LB, Cui YG, Liu JY, Meng Y. Peroxiredoxin 4, a new oxidative stress marker in follicular fluid, may predict in vitro fertilization and embryo transfer outcomes. Ann Transl Med. 2020;8:1049.","journal-title":"Ann Transl Med"},{"key":"995_CR33","doi-asserted-by":"publisher","first-page":"9779","DOI":"10.1039\/D4FO02720E","volume":"15","author":"C Jiang","year":"2024","unstructured":"Jiang C, Chen Z, Xiong H, Yang X, Liao W, Chen G, et al. Lycium barbarum berry extract improves female fertility against aging-related oxidative stress in the ovary. Food Funct. 2024;15:9779\u201395.","journal-title":"Food Funct"}],"container-title":["Journal of Human Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41371-025-00995-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41371-025-00995-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41371-025-00995-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T21:03:53Z","timestamp":1744319033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41371-025-00995-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,27]]},"references-count":33,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["995"],"URL":"https:\/\/doi.org\/10.1038\/s41371-025-00995-w","relation":{},"ISSN":["1476-5527"],"issn-type":[{"type":"electronic","value":"1476-5527"}],"subject":[],"published":{"date-parts":[[2025,2,27]]},"assertion":[{"value":"29 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}