{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:04:22Z","timestamp":1791867862975,"version":"4.3.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100007846","name":"Yunnan Provincial Department of Education","doi-asserted-by":"publisher","award":["2024J0329 to Y.C-X"],"award-info":[{"award-number":["2024J0329 to Y.C-X"]}],"id":[{"id":"10.13039\/501100007846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011635","name":"CAMS | Fuwai Hospital, Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2024RCTJ-XK003 to Z.W"],"award-info":[{"award-number":["2024RCTJ-XK003 to Z.W"]}],"id":[{"id":"10.13039\/501100011635","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011635","name":"CAMS | Fuwai Hospital, Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2024RCTJ-XK002 to Z.Y-J"],"award-info":[{"award-number":["2024RCTJ-XK002 to Z.Y-J"]}],"id":[{"id":"10.13039\/501100011635","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Hypertens"],"DOI":"10.1038\/s41371-025-01006-8","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T19:13:19Z","timestamp":1752693199000},"page":"652-657","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Age- and sex-specific reference intervals for renin and aldosterone in healthy individuals in Yunnan Province, China"],"prefix":"10.1038","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0060-8644","authenticated-orcid":false,"given":"CaiYan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9004-2746","authenticated-orcid":false,"given":"ZiHong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChunXiu","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1562-441X","authenticated-orcid":false,"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1155-1804","authenticated-orcid":false,"given":"YaJing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"1006_CR1","first-page":"24","volume":"24","author":"Writing Group of Chinese Guidelines for the Management of Hypertension CHL, Chinese Society of Cardiology, Chinese Medical Doctor Association Hypertension Committee, Hypertension Branch of China International Exchange, Medical PAf, Health Care HBoCGMA","year":"2019","unstructured":"Writing Group of Chinese Guidelines for the Management of Hypertension CHL, Chinese Society of Cardiology, Chinese Medical Doctor Association Hypertension Committee, Hypertension Branch of China International Exchange, Medical PAf, Health Care HBoCGMA. 2018 Chinese guidelines for the management of hypertension. Chin J Cardiovasc Med. 2019;24:24\u201356.","journal-title":"Chin J Cardiovasc Med"},{"key":"1006_CR2","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.peptides.2012.09.016","volume":"38","author":"PM Abadir","year":"2012","unstructured":"Abadir PM, Walston JD, Carey RM. Subcellular characteristics of functional intracellular renin-angiotensin systems. Peptides. 2012;38:437\u201345.","journal-title":"Peptides"},{"key":"1006_CR3","first-page":"269","volume":"2013","author":"R Ferrari","year":"2013","unstructured":"Ferrari R. RAAS inhibition and mortality in hypertension. Glob Cardiol Sci Pract. 2013;2013:269\u201378.","journal-title":"Glob Cardiol Sci Pract"},{"key":"1006_CR4","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/jch.14612","volume":"25","author":"EM Al-Hashedi","year":"2023","unstructured":"Al-Hashedi EM, Zhao X, Mohammed AA, Juvenal H, Yu J. Serum aldosterone effect on left ventricular structure and diastolic function in essential hypertension. J Clin Hypertens (Greenwich). 2023;25:213\u201322.","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"1006_CR5","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s12872-020-01579-x","volume":"20","author":"Y Liu","year":"2020","unstructured":"Liu Y, Lin Y, Zhang MM, Li XH, Liu YY, Zhao J, et al. The relationship of plasma renin, angiotensin, and aldosterone levels to blood pressure variability and target organ damage in children with essential hypertension. BMC Cardiovasc Disord. 2020;20:296.","journal-title":"BMC Cardiovasc Disord"},{"key":"1006_CR6","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/cen.13741","volume":"89","author":"S Monticone","year":"2018","unstructured":"Monticone S, Losano I, Tetti M, Buffolo F, Veglio F, Mulatero P. Diagnostic approach to low-renin hypertension. Clin Endocrinol (Oxf). 2018;89:385\u201396.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1006_CR7","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/j.1365-2265.2007.02898.x","volume":"67","author":"P Mulatero","year":"2007","unstructured":"Mulatero P, Verhovez A, Morello F, Veglio F. Diagnosis and treatment of low-renin hypertension. Clin Endocrinol (Oxf). 2007;67:324\u201334.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1006_CR8","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1093\/ajh\/hpad032","volume":"36","author":"A Mansur","year":"2023","unstructured":"Mansur A, Vaidya A, Turchin A. Using renin activity to guide mineralocorticoid receptor antagonist therapy in patients with low renin and hypertension. Am J Hypertens. 2023;36:455\u201361.","journal-title":"Am J Hypertens"},{"key":"1006_CR9","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1097\/HJH.0000000000000880","volume":"34","author":"J Burrello","year":"2016","unstructured":"Burrello J, Monticone S, Buffolo F, Lucchiari M, Tetti M, Rabbia F, et al. Diagnostic accuracy of aldosterone and renin measurement by chemiluminescent immunoassay and radioimmunoassay in primary aldosteronism. J Hypertens. 2016;34:920\u20137.","journal-title":"J Hypertens"},{"key":"1006_CR10","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/cen.14199","volume":"93","author":"P Solanki","year":"2020","unstructured":"Solanki P, Gwini SM, Doery JCG, Choy KW, Shen J, Young MJ, et al. Age- and sex-specific reference ranges are needed for the aldosterone\/renin ratio. Clin Endocrinol (Oxf). 2020;93:221\u201328.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1006_CR11","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1210\/jc.2015-4061","volume":"101","author":"JW Funder","year":"2016","unstructured":"Funder JW, Carey RM, Mantero F, Murad MH, Reincke M, Shibata H, et al. The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2016;101:1889\u2013916.","journal-title":"J Clin Endocrinol Metab"},{"key":"1006_CR12","doi-asserted-by":"publisher","first-page":"5","DOI":"10.11613\/BM.2016.001","volume":"26","author":"Y Ozarda","year":"2016","unstructured":"Ozarda Y. Reference intervals: current status, recent developments and future considerations. Biochem Med (Zagreb). 2016;26:5\u201316.","journal-title":"Biochem Med (Zagreb)"},{"key":"1006_CR13","first-page":"e13353","volume":"73","author":"PM O\u2019Shea","year":"2019","unstructured":"O\u2019Shea PM, Griffin TP, Denieffe S, Fitzgibbon MC. The aldosterone to renin ratio in the diagnosis of primary aldosteronism: promises and challenges. Int J Clin Pract. 2019;73:e13353.","journal-title":"Int J Clin Pract"},{"key":"1006_CR14","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1055\/a-0672-0836","volume":"127","author":"K Schilbach","year":"2019","unstructured":"Schilbach K, Junnila RK, Bidlingmaier M. Aldosterone to renin ratio as screening tool in primary aldosteronism. Exp Clin Endocrinol Diabetes. 2019;127:84\u201392.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"1006_CR15","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.clinbiochem.2018.04.016","volume":"56","author":"L Deng","year":"2018","unstructured":"Deng L, Xiong Z, Li H, Lei X, Cheng L. Analytical validation and investigation on reference intervals of aldosterone and renin in Chinese Han population by using fully automated chemiluminescence immunoassays. Clin Biochem. 2018;56:89\u201394.","journal-title":"Clin Biochem"},{"key":"1006_CR16","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1258\/acb.2010.009230","volume":"47","author":"CA Dorrian","year":"2010","unstructured":"Dorrian CA, Toole BJ, Alvarez-Madrazo S, Kelly A, Connell JM, Wallace AM. A screening procedure for primary aldosteronism based on the Diasorin Liaison automated chemiluminescent immunoassay for direct renin. Ann Clin Biochem. 2010;47:195\u20139.","journal-title":"Ann Clin Biochem"},{"key":"1006_CR17","doi-asserted-by":"publisher","first-page":"605","DOI":"10.3109\/1354750X.2011.614015","volume":"16","author":"D Gruson","year":"2011","unstructured":"Gruson D, Maisin D, Lison P, Maiter D, Persu A. Two-site automated chemiluminescent assay for measurement of immunoreactive renin. Biomarkers. 2011;16:605\u20139.","journal-title":"Biomarkers"},{"key":"1006_CR18","first-page":"1970","volume":"17","author":"F Wang","year":"2017","unstructured":"Wang F, Ma WJ, Cong HY, Chen X, Cai J. The reference interval of plasma aldosterone and renin concentration detected by chemiluminescence immunoassay and the performance evaluation in screening primary aldosteronism. Mol Cardiol China. 2017;17:1970\u201373.","journal-title":"Mol Cardiol China"},{"key":"1006_CR19","doi-asserted-by":"publisher","first-page":"3474","DOI":"10.3390\/cells10123474","volume":"10","author":"X Gao","year":"2021","unstructured":"Gao X, Li F, Liu B, Wang Y, Wang Y, Zhou H. Cellular senescence in adrenocortical biology and its disorders. Cells. 2021;10:3474.","journal-title":"Cells"},{"key":"1006_CR20","doi-asserted-by":"publisher","first-page":"E340","DOI":"10.1210\/jc.2010-1355","volume":"96","author":"AH Ahmed","year":"2011","unstructured":"Ahmed AH, Gordon RD, Taylor PJ, Ward G, Pimenta E, Stowasser M. Are women more at risk of false-positive primary aldosteronism screening and unnecessary suppression testing than men? J Clin Endocrinol Metab. 2011;96:E340\u20136.","journal-title":"J Clin Endocrinol Metab"},{"key":"1006_CR21","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/HJH.0b013e32833266e3","volume":"28","author":"F Pizzolo","year":"2010","unstructured":"Pizzolo F, Raffaelli R, Memmo A, Chiecchi L, Pavan C, Guarini P, et al. Effects of female sex hormones and contraceptive pill on the diagnostic work-up for primary aldosteronism. J Hypertens. 2010;28:135\u201342.","journal-title":"J Hypertens"},{"key":"1006_CR22","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1111\/j.1472-8206.2010.00854.x","volume":"24","author":"K Komukai","year":"2010","unstructured":"Komukai K, Mochizuki S, Yoshimura M. Gender and the renin-angiotensin-aldosterone system. Fundam Clin Pharmacol. 2010;24:687\u201398.","journal-title":"Fundam Clin Pharmacol"},{"key":"1006_CR23","doi-asserted-by":"publisher","first-page":"R498","DOI":"10.1152\/ajpregu.00182.2014","volume":"307","author":"E O\u2019Donnell","year":"2014","unstructured":"O\u2019Donnell E, Floras JS, Harvey PJ. Estrogen status and the renin angiotensin aldosterone system. Am J Physiol Regul Integr Comp Physiol. 2014;307:R498\u2013500.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1006_CR24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/jvim.15661","volume":"34","author":"Y Sakamoto","year":"2020","unstructured":"Sakamoto Y, Sakai M, Sato K, Watari T. Plasma renin activity and aldosterone concentration in dogs with acquired portosystemic collaterals. J Vet Intern Med. 2020;34:139\u201344.","journal-title":"J Vet Intern Med"},{"key":"1006_CR25","first-page":"799","volume":"67","author":"H Yoshiji","year":"2009","unstructured":"Yoshiji H, Noguchi R, Fukui H. [RAAS inhibitors as therapeutic alternatives in the treatment of chronic liver diseases]. Nihon Rinsho. 2009;67:799\u2013806.","journal-title":"Nihon Rinsho"},{"key":"1006_CR26","doi-asserted-by":"publisher","first-page":"934","DOI":"10.5009\/gnl240038","volume":"18","author":"Y Gao","year":"2024","unstructured":"Gao Y, Liu X, Gao Y, Duan M, Hou B, Chen Y. Pharmacological interventions for cirrhotic ascites: from challenges to emerging therapeutic horizons. Gut Liver. 2024;18:934\u201348.","journal-title":"Gut Liver"}],"container-title":["Journal of Human Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41371-025-01006-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41371-025-01006-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41371-025-01006-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T10:03:11Z","timestamp":1757498591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41371-025-01006-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,16]]},"references-count":26,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["1006"],"URL":"https:\/\/doi.org\/10.1038\/s41371-025-01006-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4325558\/v1","asserted-by":"object"}]},"ISSN":["1476-5527"],"issn-type":[{"value":"1476-5527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,16]]},"assertion":[{"value":"25 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The Ethics Committee of Fu Wai Hospital examined and approved the study (ethics approval no.: 2020-1360). All methods were carried out in accordance with relevant guidelines and regulations. Informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}