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We aimed to evaluate changes in 24-h ambulatory blood pressure (BP) monitoring (ABPM) following tumor resection. Individuals with evidence of pheochromocytoma\/paraganglioma prospectively underwent 24-h ABPM and plasma and urine catecholamine measurement 2\u20133 weeks before and 6\u20138 weeks after pathologically-confirmed tumor resection. Patients with metastatic disease were excluded. Changes in office, 24-h, daytime, and nighttime mean systolic and diastolic BP and heart rate, 24-h BP and heart rate average real variability, and rates of controlled, sustained, white coat, and masked hypertension were assessed in paired analyses. There were 34 participants who completed 24-h ABPM before and after tumor resection. Mean age was 55\u2009\u00b1\u200913 years, with 21 (62%) women, median duration of hypertension of 3 years, and 6 (18%) participants with coronary artery disease. Serum and urine catecholamines normalized following tumor resection and participants were prescribed 1\u2009\u00b1\u20090.2 fewer antihypertensive medications. Office BP declined by a mean 10\u2009\u00b1\u200916\/7\u2009\u00b1\u20099\u2009mmHg, 24-h BP declined by 8\u2009\u00b1\u200914\/4\u2009\u00b1\u200910\u2009mmHg, with greater improvement in nighttime (9\u2009\u00b1\u200918\/5\u2009\u00b1\u200913\u2009mmHg) than daytime (7\u2009\u00b1\u200914\/4\u2009\u00b1\u20099) ambulatory BP. Systolic BP variability and heart rate variability significantly improved. While the frequency of controlled hypertension increased (4 [12%] to 11 [32%]; <jats:italic>p<\/jats:italic>\u2009=\u20090.008), there was no significant change in masked hypertension (9 [26%] to 12 [35%]; <jats:italic>p<\/jats:italic>\u2009=\u20090.366). In conclusion, pheochromocytoma\/paraganglioma resection was associated with improvement in 24-h BP and BP variability, particularly nighttime BP. ABPM may be useful following tumor resection to identify patients with unrecognized residual cardiovascular risk.<\/jats:p>","DOI":"10.1038\/s41371-025-01008-6","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T20:15:16Z","timestamp":1743020116000},"page":"369-375","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ambulatory blood pressure monitoring before and after resection of catecholamine-secreting pheochromocytoma or paraganglioma"],"prefix":"10.1038","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4649-079X","authenticated-orcid":false,"given":"Jordana B.","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liann","family":"Abu Salman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonita J.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie L.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"1008_CR1","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.jamcollsurg.2009.09.022","volume":"209","author":"MA Guerrero","year":"2009","unstructured":"Guerrero MA, Schreinemakers JM, Vriens MR, Suh I, Hwang J, Shen WT, et al. 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DLC reports no conflicts of interest; she is supported by the National Institutes of Health (NIH) U24-DK060990 and an American Heart Association Bugher Award. She also reports funding for research and a consultant for Medtronic and Recor and DSMB for Metavention.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}