{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:30:02Z","timestamp":1793413802990,"version":"4.5.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000057","name":"U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM121334"],"award-info":[{"award-number":["P20GM121334"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Hypertens"],"DOI":"10.1038\/s41371-025-01042-4","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T04:40:28Z","timestamp":1751949628000},"page":"549-558","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of ventricular-arterial coupling in early stage middle-aged hypertensives"],"prefix":"10.1038","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9916-0706","authenticated-orcid":false,"given":"Andrea","family":"Vitali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe Biondi","family":"Zoccai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Booz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Altara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"1042_CR1","doi-asserted-by":"publisher","unstructured":"Vitali A, Zouein FA, Booz GW, Altara R Prognostic utility of assessing ventricular-arterial coupling in arterial hypertension and cardiovascular diseases. Minerva Cardiol Angiol 2025. https:\/\/doi.org\/10.23736\/S2724-5683.24.06655-9","DOI":"10.23736\/S2724-5683.24.06655-9"},{"key":"1042_CR2","doi-asserted-by":"publisher","unstructured":"Vitali A, Zouein FA, Booz GW, Altara R Clinical utility of myocardial work assessment in arterial hypertension and cardiovascular diseases. Minerva Cardiol Angiol 2025. https:\/\/doi.org\/10.23736\/S2724-5683.24.06654-7","DOI":"10.23736\/S2724-5683.24.06654-7"},{"key":"1042_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/FJC.0000000000001508","volume":"83","author":"MS Kelly","year":"2024","unstructured":"Kelly MS, Dacey A, Siana A, Ojeda J. Efficacy and safety of a polypill to reduce cardiovascular events: a review of clinical trials. J Cardiovasc Pharmacol. 2024;83:8\u201315.","journal-title":"J Cardiovasc Pharmacol"},{"key":"1042_CR4","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1097\/FJC.0000000000001602","volume":"84","author":"Y Zhao","year":"2024","unstructured":"Zhao Y, Wang L, Huang Y, Evans PC, Little PJ, Tian X, et al. Anthocyanins in vascular health and disease: mechanisms of action and therapeutic potential. J Cardiovasc Pharmacol. 2024;84:289\u2013302.","journal-title":"J Cardiovasc Pharmacol"},{"key":"1042_CR5","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1097\/FJC.0000000000001556","volume":"83","author":"MR Chilbert","year":"2024","unstructured":"Chilbert MR, Woodruff AE, Rogers KC. A practical guide to understanding and treating peripheral artery disease. J Cardiovasc Pharmacol. 2024;83:565\u201379.","journal-title":"J Cardiovasc Pharmacol"},{"key":"1042_CR6","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s10554-020-01969-4","volume":"37","author":"F Loncaric","year":"2021","unstructured":"Loncaric F, Marciniak M, Nunno L, Mimbrero M, Fernandes JF, Fabijanovic D, et al. Distribution of myocardial work in arterial hypertension: insights from non-invasive left ventricular pressure-strain relations. Int J Cardiovasc Imaging. 2021;37:145\u201354.","journal-title":"Int J Cardiovasc Imaging"},{"key":"1042_CR7","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1093\/eurheartj\/ehs016","volume":"33","author":"K Russell","year":"2012","unstructured":"Russell K, Eriksen M, Aaberge L, Wilhelmsen N, Skulstad H, Remme EW, et al. A novel clinical method for quantification of regional left ventricular pressure-strain loop area: a non-invasive index of myocardial work. Eur Heart J. 2012;33:724\u201333.","journal-title":"Eur Heart J"},{"key":"1042_CR8","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1016\/j.jcmg.2022.07.001","volume":"15","author":"FA Flachskampf","year":"2022","unstructured":"Flachskampf FA, Chandrashekar Y. Myocardial work and work index: related but different for clinical usage. JACC Cardiovasc Imaging. 2022;15:1521\u20133.","journal-title":"JACC Cardiovasc Imaging"},{"key":"1042_CR9","doi-asserted-by":"publisher","first-page":"3912","DOI":"10.1093\/eurheartj\/ehae178","volume":"45","author":"JW McEvoy","year":"2024","unstructured":"McEvoy JW, McCarthy CP, Bruno RM, Brouwers S, Canavan MD, Ceconi C, et al. 2024 ESC guidelines for the management of elevated blood pressure and hypertension. Eur Heart J. 2024;45:3912\u20134018.","journal-title":"Eur Heart J"},{"key":"1042_CR10","first-page":"H498","volume":"236","author":"H Suga","year":"1979","unstructured":"Suga H. Total mechanical energy of a ventricle model and cardiac oxygen consumption. Am J Physiol. 1979;236:H498\u2013505.","journal-title":"Am J Physiol"},{"key":"1042_CR11","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mcna.2016.08.013","volume":"101","author":"W Nadruz","year":"2017","unstructured":"Nadruz W, Shah AM, Solomon SD. Diastolic dysfunction and hypertension. Med Clin North Am. 2017;101:7\u201317.","journal-title":"Med Clin North Am"},{"key":"1042_CR12","doi-asserted-by":"publisher","first-page":"795","DOI":"10.21037\/atm.2020.04.10","volume":"8","author":"MI Monge Garcia","year":"2020","unstructured":"Monge Garcia MI, Santos A. Understanding ventriculo-arterial coupling. Ann Transl Med. 2020;8:795.","journal-title":"Ann Transl Med"},{"key":"1042_CR13","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1081\/CEH-200031982","volume":"26","author":"GM London","year":"2004","unstructured":"London GM, Marchais SJ, Guerin AP, Pannier B. Arterial stiffness: pathophysiology and clinical impact. Clin Exp Hypertens. 2004;26:689\u201399.","journal-title":"Clin Exp Hypertens"},{"key":"1042_CR14","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/s41371-021-00509-4","volume":"36","author":"F Sahiti","year":"2022","unstructured":"Sahiti F, Morbach C, Cejka V, Tiffe T, Wagner M, Eichner FA, et al. Impact of cardiovascular risk factors on myocardial work-insights from the STAAB cohort study. J Hum Hypertens. 2022;36:235\u201345.","journal-title":"J Hum Hypertens"},{"key":"1042_CR15","doi-asserted-by":"publisher","first-page":"H362","DOI":"10.1152\/ajpheart.00179.2023","volume":"325","author":"H Holm","year":"2023","unstructured":"Holm H, Kruger R, Jujic A, Lamiral Z, Uys AS, Girerd N, et al. Ventricular-arterial coupling and cardiovascular risk among young adults: the African-PREDICT study. Am J Physiol Heart Circ Physiol. 2023;325:H362\u201371.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1042_CR16","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1097\/HJH.0000000000001007","volume":"34","author":"G de Simone","year":"2016","unstructured":"de Simone G, Izzo R, Losi MA, Stabile E, Rozza F, Canciello G, et al. Depressed myocardial energetic efficiency is associated with increased cardiovascular risk in hypertensive left ventricular hypertrophy. J Hypertens. 2016;34:1846\u201353.","journal-title":"J Hypertens"},{"key":"1042_CR17","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13049","volume":"49","author":"I Ikonomidis","year":"2019","unstructured":"Ikonomidis I, Katsanos S, Triantafyllidi H, Parissis J, Tzortzis S, Pavlidis G, et al. Pulse wave velocity to global longitudinal strain ratio in hypertension. Eur J Clin Invest. 2019;49:e13049.","journal-title":"Eur J Clin Invest"},{"key":"1042_CR18","first-page":"7024","volume":"26","author":"G Stoichescu-Hogea","year":"2022","unstructured":"Stoichescu-Hogea G, Buleu FN, Nicusor Pop G, Duda-Seiman D, Ember A, Tudor A, et al. Ventricular-arterial coupling assessed by PWV\/GLS ratio in hypertensive patients. Eur Rev Med Pharmacol Sci. 2022;26:7024\u201335.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1042_CR19","first-page":"608","volume":"16","author":"E Aslanger","year":"2016","unstructured":"Aslanger E, Assous B, Bihry N, Beauvais F, Logeart D, Cohen-Solal A. Association between baseline cardiovascular mechanics and exercise capacity in patients with coronary artery disease. Anatol J Cardiol. 2016;16:608\u201313.","journal-title":"Anatol J Cardiol"},{"key":"1042_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.842554","volume":"9","author":"S Andrei","year":"2022","unstructured":"Andrei S, Nguyen M, Longrois D, Popescu BA, Bouhemad B, Guinot PG. Ventriculo-arterial coupling is associated with oxygen consumption and tissue perfusion in acute circulatory failure. Front Cardiovasc Med. 2022;9:842554.","journal-title":"Front Cardiovasc Med"},{"issue":"Suppl E","key":"1042_CR21","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1093\/eurheartj\/13.suppl_E.85","volume":"13","author":"H Takaoka","year":"1992","unstructured":"Takaoka H, Takeuchi M, Odake M, Yokoyama M. Assessment of myocardial oxygen consumption (Vo2) and systolic Pressure-Volume Area (PVA) in human hearts. Eur Heart J. 1992;13(Suppl E):85\u201390.","journal-title":"Eur Heart J"},{"key":"1042_CR22","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1093\/ehjci\/jez203","volume":"21","author":"R Manganaro","year":"2020","unstructured":"Manganaro R, Marchetta S, Dulgheru R, Sugimoto T, Tsugu T, Ilardi F, et al. Correlation between non-invasive myocardial work indices and main parameters of systolic and diastolic function: results from the EACVI NORRE study. Eur Heart J Cardiovasc Imaging. 2020;21:533\u201341.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"1042_CR23","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1097\/HJH.0b013e32834fa8b0","volume":"30","author":"LM Van Bortel","year":"2012","unstructured":"Van Bortel LM, Laurent S, Boutouyrie P, Chowienczyk P, Cruickshank JK, De Backer T, et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens. 2012;30:445\u20138.","journal-title":"J Hypertens"}],"container-title":["Journal of Human Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41371-025-01042-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41371-025-01042-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41371-025-01042-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:03:14Z","timestamp":1774519394000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41371-025-01042-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,8]]},"references-count":23,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["1042"],"URL":"https:\/\/doi.org\/10.1038\/s41371-025-01042-4","relation":{},"ISSN":["1476-5527"],"issn-type":[{"value":"1476-5527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,8]]},"assertion":[{"value":"9 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In this article the statement in the Funding information section should have read 'No specific grant is associated with this work.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All methods were performed in accordance with the relevant guidelines and regulations. No experiments involving human participants were performed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}]}}