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The potential contribution of low-grade systemic inflammation to PPA\u2014particularly in the context of overweight and obesity (OW\/OB)\u2014remains unclear, especially in young adults. We assessed differences in PPA and inflammatory markers (leptin, interleukin-6, interleukin-8, tumour necrosis factor-\u03b1, adiponectin, interleukin-10, and C-reactive protein) in young adults stratified by body composition. We further determined the relationship of PPA and inflammatory markers within these groups. This cross-sectional study included 1202 adults aged between 20-30 years. Participants were stratified into groups with underweight (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200982) healthy weight (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009598), overweight (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009326) and obesity (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009196). PPA was defined as the ratio of brachial pulse pressure to central pulse pressure. Inflammatory biomarkers were measured in serum. PPA was lower in the OW and OB groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), while the inflammatory profile (tumour necrosis factor-\u03b1, adiponectin, leptin and C-reactive protein) was also more adverse in the OW and OB groups (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In multivariate adjusted regression analysis, PPA was adversely associated with tumour necrosis factor-\u03b1, adiponectin, leptin and C-reactive protein in the OW or OB groups only (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.025). In young adults, a higher BMI is associated with a lower PPA and higher levels of inflammatory markers. Adverse associations between PPA as a measure of arterial function and several inflammatory markers are also seen in the setting of increased adiposity, highlighting inflammation as a potential mechanistic link between adiposity and changes in arterial function.\n                  <\/jats:p>","DOI":"10.1038\/s41371-026-01126-9","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T09:24:10Z","timestamp":1772184250000},"page":"281-287","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Associations between pulse pressure amplification and inflammation in young adults according to body composition: The African-PREDICT study"],"prefix":"10.1038","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5067-8387","authenticated-orcid":false,"given":"Yolandi","family":"Breet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2238-2612","authenticated-orcid":false,"given":"Christian","family":"Delles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7970-3643","authenticated-orcid":false,"given":"Paul","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-3341","authenticated-orcid":false,"given":"Catharina MC","family":"Mels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"1126_CR1","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/00001573-200007000-00009","volume":"15","author":"M Safar","year":"2000","unstructured":"Safar M. 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