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The aim of this study was to explore the impact of non-dipping status and nocturnal hypertension on TOD in untreated WCH subjects. A cross-sectional study of 547 individuals with WCH was conducted at a single institution. Patients underwent a thorough clinical examination, including medical history, office BP measurements, echocardiography, carotid artery ultrasonography, serum creatinine level measurements, and ambulatory blood pressure monitoring. Left ventricular hypertrophy (LVH), intima-media thickness of the common carotid artery (IMT-CCA) and estimated Glomerular Filtration Rate (eGFR) were used as TOD indices. The patients were divided into dippers and non-dippers, as well as nocturnal hypertensives and normotensives. Among WCH patients, 49.9% were non-dippers and 33.6% had nocturnal hypertension. Dippers had a significantly lower risk of left ventricular hypertrophy (OR: 0.68, 95%CI: 0.48 \u2013 0.97) and higher mean expected eGFR values (b\u2009=\u20097.03, 95%CI: 3.12 \u2013 10.94) than non-dippers. For IMT-CCA, office systolic and diastolic BP were the only significant predictors (b\u2009=\u20090.02, 95%CI: 0.00 \u2013 0.03 and b\u2009=\u2009-0.03, 95%CI: -0.05 \u2013 -0.01). Office systolic BP was also significantly associated with eGFR (b\u2009=\u2009-1.68, 95%CI: -2.84 \u2013 -0.52). The results of this study indicate that non-dipping status is a significant risk factor for LVH and renal function in WCH subjects. Therefore, nighttime BP patterns, especially non-dipping, should be examined in patients with WCH.<\/jats:p>","DOI":"10.1038\/s41371-026-01152-7","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:11:52Z","timestamp":1777050712000},"page":"475-480","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood pressure determinants of target organ damage among adults with white coat hypertension with a focus on nocturnal hypertension and blood pressure dipping"],"prefix":"10.1038","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5591-8703","authenticated-orcid":false,"given":"Ionas","family":"Papasotiriou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotiria","family":"Spiliopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-9638","authenticated-orcid":false,"given":"Gerasimos","family":"Barlas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damianos","family":"Dragonas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Rizogiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios","family":"Manios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"1152_CR1","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1161\/HYPERTENSIONAHA.113.01275","volume":"62","author":"SS Franklin","year":"2013","unstructured":"Franklin SS, Thijs L, Hansen TW, O\u2019Brien E, Staessen JA. 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