{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T22:29:15Z","timestamp":1786400955093,"version":"build-2736575974"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Hypertens"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Non-invasive blood pressure (BP) measurement is performed by the inflation of an upper-arm cuff, which itself could induce a reactive BP response and potentially influence BP management. The aim of this study was to determine if cuff inflation was associated with reactive BP responses. Beat-to-beat invasive aortic BP was measured continuously before and during inflation of an automated upper-arm cuff in 234 participants (61\u2009\u00b1\u200910 years, 31% female) undergoing coronary angiography. Reactive responses were calculated as invasive aortic systolic BP immediately post cuff inflation minus baseline aortic systolic BP immediately pre-cuff inflation. Three groups were defined based on an increase (\u2265\u20095\u2009mmHg), decrease (\u2264 \u22125 mmHg) or no response (&gt;\u22125\u2013&lt;5\u2009mmHg) in aortic systolic BP. Cuff inflation was associated with an average increase in aortic systolic BP of 9.8\u2009\u00b1\u20095.1\u2009mmHg in 28 (12%) participants, an average decrease of 9.2\u2009\u00b1\u20095.4\u2009mmHg in 43 (18%) participants, and no response in 163 (70%) participants (\u22120.3\u2009\u00b1\u20092.4\u2009mmHg). Cuff and baseline aortic systolic BP were higher in participants who exhibited a reactive response and BP variability was greater among the decrease group (ANOVA p\u2009&lt;\u20090.05). No clinical characteristics were associated with reactive responses. Similar findings were observed for diastolic BP, mean arterial pressure and pulse pressure. Approximately one-third of participants exhibited a substantial reactive systolic BP response (increase or decrease) to upper-arm cuff inflation as determined from invasive BP measurements. Whether this could influence the accuracy of cuff BP measures, and consequent hypertension management, should be determined in future, prospectively designed studies.<\/jats:p>","DOI":"10.1038\/s41371-026-01172-3","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:44:13Z","timestamp":1781711053000},"page":"663-669","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Invasive observation of reactive systolic blood pressure responses to upper-arm cuff inflation"],"prefix":"10.1038","volume":"40","author":[{"given":"Louisa F.","family":"Morris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3948-2452","authenticated-orcid":false,"given":"Matthew K.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-0811","authenticated-orcid":false,"given":"James E.","family":"Sharman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3458-1811","authenticated-orcid":false,"given":"Martin G.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Andrew","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan B.","family":"Dwyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5777-6331","authenticated-orcid":false,"given":"Philip","family":"Roberts-Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heath","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-1937","authenticated-orcid":false,"given":"St\u00e9phane G.","family":"Carlier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4760-1634","authenticated-orcid":false,"given":"Dean S.","family":"Picone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"1172_CR1","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","volume":"396","author":"Global Burden of Disease Risk Factors Collaborators","year":"2020","unstructured":"Global Burden of Disease Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396:1223\u201349.","journal-title":"Lancet"},{"key":"1172_CR2","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1016\/S0140-6736(21)00590-0","volume":"397","author":"Blood Pressure Lowering Treatment Trialists Collaboration","year":"2021","unstructured":"Blood Pressure Lowering Treatment Trialists Collaboration. Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis. Lancet. 2021;397:1625\u201336.","journal-title":"Lancet"},{"key":"1172_CR3","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1111\/jch.13005","volume":"19","author":"E O\u2019Brien","year":"2017","unstructured":"O\u2019Brien E, Stergiou GS. 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