{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:02:14Z","timestamp":1789977734462,"version":"4.0.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Hypertens"],"DOI":"10.1038\/s41371-026-01224-8","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:02:33Z","timestamp":1789974153000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Can primary aldosteronism and acromegaly be etiological factors in non-obese patients with obstructive sleep apnea syndrome?"],"prefix":"10.1038","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5909-7327","authenticated-orcid":false,"given":"Esra","family":"Ercan Aktekin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-7612","authenticated-orcid":false,"given":"Zehra","family":"Erdemir K\u00f6yl\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6452-0492","authenticated-orcid":false,"given":"Utku O\u011fan","family":"Aky\u0131ld\u0131z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2887-6656","authenticated-orcid":false,"given":"\u0130mran","family":"Kurt \u00d6m\u00fcrl\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5035-9711","authenticated-orcid":false,"given":"Ay\u00e7a","family":"Tuzcu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9846-2016","authenticated-orcid":false,"given":"Engin","family":"G\u00fcney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6444-3500","authenticated-orcid":false,"given":"Mustafa","family":"\u00dcn\u00fcbol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"1224_CR1","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1513\/pats.200709-155MG","volume":"5","author":"NM Punjabi","year":"2008","unstructured":"Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc. 2008;5:136\u201343.","journal-title":"Proc Am Thorac Soc"},{"key":"1224_CR2","unstructured":"T\u00fcrk Toraks Derne\u011fi. T\u0131kay\u0131ci uyku apne sendromu tani ve tedavi kilavuzu. Ankara: T\u00fcrk Toraks Derne\u011fi; 2012."},{"key":"1224_CR3","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/MCP.0000000000000628","volume":"25","author":"PA Cistulli","year":"2019","unstructured":"Cistulli PA, Sutherland K. Obstructive sleep apnea and obesity. Curr Opin Pulm Med. 2019;25:594\u2013601.","journal-title":"Curr Opin Pulm Med"},{"key":"1224_CR4","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1378\/chest.109.3.659","volume":"109","author":"T Mooe","year":"1996","unstructured":"Mooe T, Rabben T, Wiklund U, Franklin KA, Eriksson P. Sleep-disordered breathing in men with coronary artery disease. Chest. 1996;109:659\u201363.","journal-title":"Chest"},{"key":"1224_CR5","first-page":"603","volume-title":"Principles and Practice of Sleep Medicine","author":"RW Robinson","year":"1994","unstructured":"Robinson RW, Zwillich CW. Drugs and sleep respiration. In: Kryger MH, Roth T, Dement WC, editors. Principles and Practice of Sleep Medicine. Philadelphia, PA: WB Saunders; 1994. p. 603\u201320."},{"key":"1224_CR6","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1378\/chest.97.5.1220","volume":"97","author":"JM Parish","year":"1990","unstructured":"Parish JM, Shepard JW Jr. Cardiovascular effects of sleep disorders. Chest. 1990;97:1220\u20136.","journal-title":"Chest"},{"key":"1224_CR7","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1600-0404.2007.00901.x","volume":"116","author":"T Saunam\u00e4ki","year":"2007","unstructured":"Saunam\u00e4ki T, Jehkonen M. Depression and anxiety in obstructive sleep apnea syndrome: a review. Acta Neurol Scand. 2007;116:277\u201388.","journal-title":"Acta Neurol Scand"},{"key":"1224_CR8","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1016\/j.ijporl.2006.06.002","volume":"70","author":"A Leiberman","year":"2006","unstructured":"Leiberman A, Stiller-Timor L, Tarasiuk A, Tal A. The effect of adenotonsillectomy on children suffering from obstructive sleep apnea syndrome (OSAS): the Negev perspective. Int J Pediatr Otorhinolaryngol. 2006;70:1675\u201382.","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"1224_CR9","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/j.1440-1843.2011.02081.x","volume":"17","author":"JC Lam","year":"2012","unstructured":"Lam JC, Mak JC, Ip MS. Obesity, obstructive sleep apnoea and metabolic syndrome. Respirology. 2012;17:223\u201336.","journal-title":"Respirology"},{"key":"1224_CR10","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","volume":"3","author":"R Heinzer","year":"2015","unstructured":"Heinzer R, Vat S, Marques-Vidal P, Marti-Soler H, Andries D, Tobback N, et al. Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study. Lancet Respir Med. 2015;3:310\u20138.","journal-title":"Lancet Respir Med"},{"key":"1224_CR11","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1001\/archinte.160.15.2289","volume":"160","author":"EO Bixler","year":"2000","unstructured":"Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Leiby BE, Vela-Bueno A, et al. Association of hypertension and sleep-disordered breathing. Arch Intern Med. 2000;160:2289\u201395.","journal-title":"Arch Intern Med"},{"key":"1224_CR12","doi-asserted-by":"crossref","unstructured":"Luyster FS, Kip KE, Aiyer AN, Reis SE, Strollo PJ Jr Relation of obstructive sleep apnea to coronary artery calcium in non-obese versus obese men and women aged 45\u201375 years. Am J Cardiol. 2014;114:1690-4.","DOI":"10.1016\/j.amjcard.2014.08.040"},{"key":"1224_CR13","first-page":"31","volume":"50","author":"E Gaudette","year":"2010","unstructured":"Gaudette E, Kimoff RJ. Pathophysiology of OSA. Eur Respir Mon. 2010;50:31\u201350.","journal-title":"Eur Respir Mon"},{"key":"1224_CR14","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s11886-020-1257-y","volume":"22","author":"R Shulman","year":"2020","unstructured":"Shulman R, Cohen JB. Obstructive sleep apnea, hypertension, and cardiovascular risk: epidemiology, pathophysiology, and management. Curr Cardiol Rep. 2020;22:6.","journal-title":"Curr Cardiol Rep"},{"key":"1224_CR15","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41371-019-0208-9","volume":"33","author":"M Li","year":"2019","unstructured":"Li M, Ge Q, Sheng CS, Zhang J, Li H, Niu W, et al. Clinical characteristics of snoring patients with primary aldosteronism and obstructive sleep apnea-hypopnea syndrome. J Hum Hypertens. 2019;33:693\u2013700","journal-title":"J Hum Hypertens"},{"key":"1224_CR16","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1530\/EJE-08-0442","volume":"159","author":"MV Davi","year":"2008","unstructured":"Davi MV, Dalle Carbonare L, Giustina A, Ferrari M, Frigo A, Lo Cascio V, et al. Sleep apnoea syndrome is highly prevalent in acromegaly and only partially reversible after biochemical control of the disease. Eur J Endocrinol. 2008;159:533\u201340.","journal-title":"Eur J Endocrinol"},{"key":"1224_CR17","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1007\/s40618-015-0338-z","volume":"38","author":"F Ceccato","year":"2015","unstructured":"Ceccato F, Bernkopf E, Scaroni C. Sleep apnea syndrome in endocrine clinics. J Endocrinol Invest. 2015;38:827\u201334.","journal-title":"J Endocrinol Invest"},{"key":"1224_CR18","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1210\/jc.2015-4061","volume":"101","author":"JW Funder","year":"2016","unstructured":"Funder JW, Carey RM, Mantero F, Murad MH, Reincke M, Shibata H, et al. The management of primary aldosteronism: case detection, diagnosis, and treatment\u2014an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2016;101:1889\u2013916.","journal-title":"J Clin Endocrinol Metab"},{"key":"1224_CR19","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1210\/clinem\/dgaf284","volume":"110","author":"GK Adler","year":"2025","unstructured":"Adler GK, Stowasser M, Correa RR, Khan N, Kline G, McGowan MJ, et al. Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2025;110:2453\u201395. https:\/\/doi.org\/10.1210\/clinem\/dgaf284.","journal-title":"J Clin Endocrinol Metab"},{"key":"1224_CR20","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1161\/HYPERTENSIONAHA.111.179788","volume":"58","author":"RP Pedrosa","year":"2011","unstructured":"Pedrosa RP, Drager LF, Gonzaga CC, Sousa MG, de Paula LK, Amaro AC, et al. Obstructive sleep apnea: the most common secondary cause of hypertension associated with resistant hypertension. Hypertension. 2011;58:811\u20137.","journal-title":"Hypertension"},{"key":"1224_CR21","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/jhh.2013.32","volume":"27","author":"E Florczak","year":"2013","unstructured":"Florczak E, Prejbisz A, Szwench-Pietrasz E, Sliwi\u0144ski P, Biele\u0144 P, Klisiewicz A, et al. Clinical characteristics of patients with resistant hypertension: the RESIST-POL study. J Hum Hypertens. 2013;27:678\u201385.","journal-title":"J Hum Hypertens"},{"key":"1224_CR22","doi-asserted-by":"publisher","first-page":"363","DOI":"10.5664\/jcsm.27878","volume":"6","author":"CC Gonzaga","year":"2010","unstructured":"Gonzaga CC, Gaddam KK, Ahmed MI, Pimenta E, Thomas SJ, Harding SM, et al. Severity of obstructive sleep apnea is related to aldosterone status in subjects with resistant hypertension. J Clin Sleep Med. 2010;6:363\u20138.","journal-title":"J Clin Sleep Med"},{"key":"1224_CR23","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1055\/s-0043-122887","volume":"49","author":"A Prejbisz","year":"2017","unstructured":"Prejbisz A, Ko\u0142odziejczyk-Kruk S, Lenders JWM, Januszewicz A. Primary aldosteronism and obstructive sleep apnea: is this a bidirectional relationship? Horm Metab Res. 2017;49:969\u201376.","journal-title":"Horm Metab Res"},{"key":"1224_CR24","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/jhh.2009.96","volume":"24","author":"K Gaddam","year":"2010","unstructured":"Gaddam K, Pimenta E, Thomas SJ, Cofield SS, Oparil S, Harding SM, et al. Spironolactone reduces severity of obstructive sleep apnoea in patients with resistant hypertension: a preliminary report. J Hum Hypertens. 2010;24:532\u20137.","journal-title":"J Hum Hypertens"},{"key":"1224_CR25","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1161\/HYPERTENSIONAHA.110.154427","volume":"56","author":"O Friedman","year":"2010","unstructured":"Friedman O, Bradley TD, Chan CT, Parkes R, Logan AG. Relationship between overnight rostral fluid shift and obstructive sleep apnea in drug-resistant hypertension. Hypertension. 2010;56:1077\u201382.","journal-title":"Hypertension"},{"key":"1224_CR26","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1097\/HJH.0000000000000047","volume":"32","author":"T Kasai","year":"2014","unstructured":"Kasai T, Bradley TD, Friedman O, Logan AG. Effect of intensified diuretic therapy on overnight rostral fluid shift and obstructive sleep apnoea in patients with uncontrolled hypertension. J Hypertens. 2014;32:673\u201380.","journal-title":"J Hypertens"},{"key":"1224_CR27","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1161\/HYPERTENSIONAHA.119.13833","volume":"74","author":"F Buffolo","year":"2019","unstructured":"Buffolo F, Li Q, Monticone S, Heinrich DA, Mattei A, Pieroni J, et al. Primary aldosteronism and obstructive sleep apnea: a cross-sectional multi-ethnic study. Hypertension. 2019;74:1532\u201340.","journal-title":"Hypertension"},{"key":"1224_CR28","first-page":"333","volume":"13","author":"ZN Jin","year":"2016","unstructured":"Jin ZN, Wei YX. Meta-analysis of effects of obstructive sleep apnea on the renin\u2013angiotensin\u2013aldosterone system. J Geriatr Cardiol. 2016;13:333\u201343.","journal-title":"J Geriatr Cardiol"},{"key":"1224_CR29","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1177\/1470320310366581","volume":"11","author":"A Di Murro","year":"2010","unstructured":"Di Murro A, Petramala L, Cotesta D, Zinnamosca L, Crescenzi E, Marinelli C, et al. Renin\u2013angiotensin\u2013aldosterone system in patients with sleep apnoea: prevalence of primary aldosteronism. J Renin Angiotensin Aldosterone Syst. 2010;11:165\u201372.","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"1224_CR30","doi-asserted-by":"publisher","first-page":"629","DOI":"10.5664\/jcsm.8960","volume":"17","author":"P Dobrowolski","year":"2021","unstructured":"Dobrowolski P, Ko\u0142odziejczyk-Kruk S, Warcho\u0142-Celi\u0144ska E, Kabat M, Ambroziak U, Wr\u00f3bel A, et al. Primary aldosteronism is highly prevalent in patients with hypertension and moderate to severe obstructive sleep apnea. J Clin Sleep Med. 2021;17:629\u201337.","journal-title":"J Clin Sleep Med"},{"key":"1224_CR31","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/BF03343767","volume":"23","author":"V Weiss","year":"2000","unstructured":"Weiss V, Sonka K, Pretl M, Dost\u00e1lov\u00e1 S, Klozar J, Rambousek P, et al. Prevalence of sleep apnea syndrome in the acromegaly population. J Endocrinol Invest. 2000;23:515\u20139.","journal-title":"J Endocrinol Invest"},{"key":"1224_CR32","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s12020-018-1538-z","volume":"60","author":"DA Heinrich","year":"2018","unstructured":"Heinrich DA, Reinholz C, Bauer M, Tufman A, Frohner R, Schopohl J, et al. IGF-1-based screening reveals a low prevalence of acromegaly in patients with obstructive sleep apnea. Endocrine. 2018;60:60\u201367.","journal-title":"Endocrine"},{"key":"1224_CR33","first-page":"161","volume":"175","author":"L Galerneau","year":"2016","unstructured":"Galerneau L, Thibaud E, Chapurlat RD, Chanson P. Prevalence of acromegaly in patients with obstructive sleep apnea. Eur J Endocrinol. 2016;175:161\u20136.","journal-title":"Eur J Endocrinol"},{"key":"1224_CR34","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1530\/ERC-17-0253","volume":"24","author":"P Petrossians","year":"2017","unstructured":"Petrossians P, Daly AF, Natchev E, Maione L, Blijdorp K, Sahnoun-Fathallah M, et al. Acromegaly at diagnosis in 3173 patients from the Li\u00e8ge Acromegaly Survey (LAS) Database. Endocr Relat Cancer. 2017;24:505\u201318. https:\/\/doi.org\/10.1530\/ERC-17-0253.","journal-title":"Endocr Relat Cancer"}],"container-title":["Journal of Human Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41371-026-01224-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41371-026-01224-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41371-026-01224-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:02:36Z","timestamp":1789974156000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41371-026-01224-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":34,"alternative-id":["1224"],"URL":"https:\/\/doi.org\/10.1038\/s41371-026-01224-8","relation":{},"ISSN":["1476-5527"],"issn-type":[{"value":"1476-5527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"assertion":[{"value":"14 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"Ethics committee approval was obtained prior to the initiation of the study. Written informed consent was obtained from all participants. All methods were performed in accordance with the relevant guidelines and regulations.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Ethics"}}]}}