{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:26:47Z","timestamp":1792204007489,"version":"4.4.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1038\/s41372-017-0033-3","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T15:44:00Z","timestamp":1514994240000},"page":"197-202","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Selenium: implications for outcomes in extremely preterm infants"],"prefix":"10.1038","volume":"38","author":[{"given":"Rachael","family":"Tindell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trent","family":"Tipple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"33_CR1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1177\/000456329002700301","volume":"27","author":"J Lunec","year":"1990","unstructured":"Lunec J. Free radicals: their involvement in disease processes. Ann Clin Biochem. 1990;27:173\u201382.","journal-title":"Ann Clin Biochem."},{"key":"33_CR2","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1442-200X.2008.02662.x","volume":"51","author":"N Nassi","year":"2009","unstructured":"Nassi N, Ponziani V, Becatti M, Galvan P, Donzelli G. Anti-oxidant enzymes and related elements in term and preterm newborns. Pediatr Int. 2009;51:183\u20137.","journal-title":"Pediatr Int."},{"key":"33_CR3","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.nut.2014.09.008","volume":"31","author":"H Leite","year":"2015","unstructured":"Leite H, Noguiera P, Iglesias S. Increased plasma selenium is associated with better outcomes in children with systemic inflammation. Nutrition. 2015;31:485\u201390.","journal-title":"Nutrition."},{"key":"33_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/10715769009148569","volume":"9","author":"B Halliwell","year":"1990","unstructured":"Halliwell B. How to characterize a biological antioxidant. Free Radic Res Commun. 1990;9:1\u201332.","journal-title":"Free Radic Res Commun."},{"key":"33_CR5","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1164\/ajrccm\/136.2.478","volume":"136","author":"H Sies","year":"1987","unstructured":"Sies H. Antioxidant activity in cells and organs. Am Rev Respir Dis. 1987;136:478\u201380.","journal-title":"Am Rev Respir Dis."},{"key":"33_CR6","doi-asserted-by":"crossref","unstructured":"Allingstrup M, Afshari A Selenium supplementation for critically ill adults. Cochrane Datab, Syst. Rev. CD003703 (2015).","DOI":"10.1002\/14651858.CD003703.pub3"},{"key":"33_CR7","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1183\/09031936.93.06091317","volume":"6","author":"FH Hawker","year":"1993","unstructured":"Hawker FH, Ward HE, Stewart PM, Wynne LA, Snitch PJ. Selenium deficiency augments the pulmonary toxic effects of oxygen exposure in the rat. Eur Respir J. 1993;6:1317\u201323.","journal-title":"Eur Respir J."},{"key":"33_CR8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1385\/BTER:106:2:097","volume":"106","author":"AM Mentro","year":"2005","unstructured":"Mentro AM, Smith AM, Moyer-Mileur L. Plasma and erythrocyte selenium and glutathione peroxidase activity in preterm infants at risk for bronchopulmonary dysplasia. Biol Trace Elem Res. 2005;106:97\u2013106.","journal-title":"Biol Trace Elem Res."},{"key":"33_CR9","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1203\/00006450-199208000-00013","volume":"32","author":"KB Sluis","year":"1992","unstructured":"Sluis KB, Darlow BA, George PM, Mogridge N, Dolamore BA, Winterbourn CC. Selenium and glutathione peroxidase levels in premature infants in a low selenium community (Christchurch, New Zealand). Pediatr Res. 1992;32:189\u201394.","journal-title":"Pediatr Res."},{"key":"33_CR10","doi-asserted-by":"publisher","first-page":"2025S","DOI":"10.3945\/ajcn.2009.27230F","volume":"89","author":"K Ashton","year":"2009","unstructured":"Ashton K, Hooper L, Harvey LJ, Hurst R, Casgrain A, Fairweather-Tait SJ. Methods of assessment of selenium status in humans: a systematic review. Am J Clin Nutr. 2009;89:2025S\u20132039S.","journal-title":"Am J Clin Nutr."},{"key":"33_CR11","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1093\/ajcn\/88.1.70","volume":"88","author":"L Daniels","year":"2008","unstructured":"Daniels L, Gibson RA, Simmer K, Van Dael P, Makrides M. Selenium status of term infants fed selenium-supplemented formula in a randomized dose-response trial. Am J Clin Nutr. 2008;88:70\u201376.","journal-title":"Am J Clin Nutr."},{"key":"33_CR12","first-page":"129","volume-title":"Nutritional Care of Preterm Infants: Scientific Basis and Practical Guidelines","author":"M Domellof","year":"2014","unstructured":"Domellof M. Nutritional Care of Premature Infants: Microminerals. In: Koletzko B, Poindexter B, Uauy R, (eds). Nutritional Care of Preterm Infants: Scientific Basis and Practical Guidelines. Basel: Karger; 2014. p. 129\u201330. vol. 110"},{"key":"33_CR13","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1590\/S0103-05822014000100019","volume":"32","author":"R Freitas","year":"2014","unstructured":"Freitas R, Nogueira R, Antonio M. Selenium Deficiency and the effects of supplementation on preterm infants. Rev Paul De Pediatr. 2014;32:126\u201335.","journal-title":"Rev Paul De Pediatr."},{"key":"33_CR14","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.clnu.2003.08.004","volume":"23","author":"IR Makhoul","year":"2004","unstructured":"Makhoul IR, Sammour RN, Diamond E, Shohat I, Tamir A, Shamir R. Selenium concentrations in maternal and umbilical cord blood at 24-42 weeks of gestation: basis for optimization of selenium supplementation to premature infants. Clin Nutr. 2004;23:373\u201381.","journal-title":"Clin Nutr."},{"key":"33_CR15","first-page":"125","volume":"9","author":"L Nazemi","year":"2015","unstructured":"Nazemi L, Shariat M, Chamari M. Comparison of Maternal and Umbilical Cord Blood Selenium Levels in low and normal birth weight infants. J Fam Reprod Health. 2015;9:125\u20138.","journal-title":"J Fam Reprod Health"},{"key":"33_CR16","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1039\/an9962100189","volume":"121","author":"I Harrison","year":"1996","unstructured":"Harrison I, Littlejohn D, Fell GS. Distribution of selenium in human blood plasma and serum. Analyst. 1996;121:189\u201394.","journal-title":"Analyst"},{"key":"33_CR17","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/00005176-199803000-00005","volume":"26","author":"LA Daniels","year":"1998","unstructured":"Daniels LA, Gibson RA, Simmer K. Glutathione peroxidase is not a functional marker of selenium status in the neonatal period. J Pediatr Gastroenterol Nutr. 1998;26:263\u20138.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"33_CR18","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1111\/ped.12698","volume":"57","author":"A Asci","year":"2015","unstructured":"Asci A, Surmeli-Onay O, Erkekoglu P, Yigit S, Yurdakok M, Kocer-Gumusel B. Oxidant and antioxidant status in neonatal proven and clinical sepsis according to selenium status. Pediatr Int. 2015;57:1131\u20137.","journal-title":"Pediatr Int"},{"key":"33_CR19","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s004080000006","volume":"178","author":"V Bhandari","year":"2000","unstructured":"Bhandari V, Maulik N, Kresch M. Hyperoxia causes an increase in antioxidant enzyme activity in adult and fetal rat type II pneumocytes. Lung. 2000;178:53\u201360.","journal-title":"Lung"},{"key":"33_CR20","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1093\/jn\/122.9.1760","volume":"122","author":"HY Kim","year":"1992","unstructured":"Kim HY, Picciano MF, Wallig MA. Postnatal selenium repletion protects lungs of neonatal rats from hyperoxia. J Nutr. 1992;122:1760\u20137.","journal-title":"J Nutr"},{"key":"33_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/PL00007623","volume":"177","author":"JC Lavoie","year":"1999","unstructured":"Lavoie JC, Spalinger M, Chessex P. Glutathione synthetic activity in the lungs in newborn guinea pigs. Lung. 1999;177:1\u20137.","journal-title":"Lung"},{"key":"33_CR22","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12917-017-1040-5","volume":"13","author":"C Delesalle","year":"2017","unstructured":"Delesalle C, de Bruijn M, Wilmink S, Vandendriessche H, Mol G, Boshuizen B, et al. White muscle disease in foals: focus on selenium soil content. A case series. BMC Vet Res. 2017;13:121.","journal-title":"BMC Vet Res"},{"key":"33_CR23","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jtemb.2014.09.011","volume":"31","author":"M Oropeza-Moe","year":"2015","unstructured":"Oropeza-Moe M, Wisl\u00f8ff H, Bernhoft A. Selenium deficiency associated porcine and human cardiomyopathies. J Trace Elem Med Biol. 2015;31:148\u201356.","journal-title":"J Trace Elem Med Biol"},{"key":"33_CR24","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.3892\/mmr.2017.6377","volume":"15","author":"M Vinceti","year":"2017","unstructured":"Vinceti M, Filippini T, Cilloni S, Bargellini A, Vergoni AV, Tsatsakis A, et al. Health risk assessment of environmental selenium: emerging evidence and challenges (Review). Mol Med Rep. 2017;15:3323\u201335.","journal-title":"Mol Med Rep."},{"key":"33_CR25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/BF03041947","volume":"92","author":"T Zimmermann","year":"1997","unstructured":"Zimmermann T, Albrecht S, K\u00fchne H, Vogelsang U, Gr\u00fctzmann R, Kopprasch S. Selenium administration in patients with sepsis syndrome. A prospective randomized study. Med Klin. 1997;92:3\u20134.","journal-title":"Med Klin."},{"key":"33_CR26","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.pedneo.2012.08.008","volume":"53","author":"H Boskabadi","year":"2012","unstructured":"Boskabadi H, Maamouri G, Omran F. Effect of Prenatal Selenium Supplementation on Cord Blood Selenium and Lipid Profile. Pediatr Neonatol. 2012;53:334\u20139.","journal-title":"Pediatr Neonatol"},{"key":"33_CR27","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.pedneo.2012.11.001","volume":"53","author":"HC Chao","year":"2012","unstructured":"Chao HC. Impact of maternal selenium supplementation on neonates. Pediatr Neonatol. 2012;53:327\u20138.","journal-title":"Pediatr Neonatol"},{"key":"33_CR28","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1515\/jpm.2010.068","volume":"38","author":"F Tara","year":"2010","unstructured":"Tara F, Rayman MP, Boskabadi H, Ghayour-Mobarhan M, Sahebkar A, Alamdari DH, et al. Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controlled trial of selenium supplementation. J Perinat Med. 2010;38:473\u20138.","journal-title":"J Perinat Med."},{"key":"33_CR29","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1740-8709.2012.00430.x","volume":"10","author":"H Mistry","year":"2014","unstructured":"Mistry H, Kurlak L, Young S. Maternal selenium, copper, and zinc concentrations in pregnancy associated with small-for-gestational-age infants. Matern Child Nutr. 2014;10:327\u201334.","journal-title":"Matern Child Nutr."},{"key":"33_CR30","doi-asserted-by":"crossref","unstructured":"Xu M, Guo D, Gu H, Zhang L, Lv S. Selenium and preeclampsia: a systematic review and meta-analysis. Biol. Trace Element Res.; 2015;171;283\u2013292.","DOI":"10.1007\/s12011-015-0545-7"},{"key":"33_CR31","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/BF02916547","volume":"7","author":"PA Bayliss","year":"1985","unstructured":"Bayliss PA, Buchanan BE, Hancock RG, Zlotkin SH. Tissue selenium accretion in premature and full-term human infants and children. Biol Trace Elem Res. 1985;7:55\u201361.","journal-title":"Biol Trace Elem Res."},{"key":"33_CR32","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.jtemb.2013.03.006","volume":"27","author":"A Peirovifar","year":"2013","unstructured":"Peirovifar A, Gharehbaghi MM, Abdulmohammad-Zadeh H, Sadegi GH, Jouyban A. Serum selenium levels of the very low birth weight premature newborn infants with bronchopulmonary dysplasia. J Trace Elem Med Biol. 2013;27:317\u201321.","journal-title":"J Trace Elem Med Biol."},{"key":"33_CR33","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.earlhumdev.2005.01.007","volume":"81","author":"A Galinier","year":"2005","unstructured":"Galinier A, P\u00e9riquet B, Lambert W, Garcia J, Assouline C, Rolland M, et al. Reference range for micronutrients and nutritional marker proteins in cord blood of neonates appropriated for gestational ages. Early Hum Dev. 2005;81:583\u201393.","journal-title":"Early Hum Dev."},{"key":"33_CR34","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1177\/0884533614563353","volume":"30","author":"C Finch","year":"2015","unstructured":"Finch C. Review of trace mineral requirements for preterm infants: what are the current recommendations for clinical practice? Nutr Clin Pract. 2015;30:44\u201358.","journal-title":"Nutr Clin Pract."},{"key":"33_CR35","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/S0946-672X(01)80005-5","volume":"14","author":"E Sievers","year":"2001","unstructured":"Sievers E, Arpe T, Schleyerbach U, Garbe-Sch\u00f6nberg D, Schaub J. Plasma selenium in preterm and term infants during the first 12 months of life. J Trace Elem Med Biol. 2001;14:218\u201322.","journal-title":"J Trace Elem Med Biol"},{"key":"33_CR36","doi-asserted-by":"publisher","first-page":"F158","DOI":"10.1136\/fn.74.3.F158","volume":"74","author":"L Daniels","year":"1996","unstructured":"Daniels L, Gibson R, Simmer K. Randomised clinical trial of parenteral selenium supplementation in preterm infants. Arch Dis Child Fetal Neonatal Ed. 1996;74:F158\u2013164.","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"33_CR37","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1177\/0148607191015005556","volume":"15","author":"RK Huston","year":"1991","unstructured":"Huston RK, Jelen BJ, Vidgoff J. Selenium supplementation in low-birthweight premature infants: relationship to trace metals and antioxidant enzymes. JPEN J Parenter Enter Nutr. 1991;15:556\u20139.","journal-title":"JPEN J Parenter Enter Nutr."},{"key":"33_CR38","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0022-3476(05)82058-X","volume":"119","author":"AM Smith","year":"1991","unstructured":"Smith AM, Chan GM, Moyer-Mileur LJ, Johnson CE, Gardner BR. Selenium status of preterm infants fed human milk, preterm formula, or selenium-supplemented preterm formula. J Pediatr. 1991;119:429\u201333.","journal-title":"J Pediatr."},{"key":"33_CR39","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1093\/ajcn\/42.5.829","volume":"42","author":"J Kumpulainen","year":"1985","unstructured":"Kumpulainen J, Salmenper\u00e4 L, Siimes MA, Koivistoinen P, Perheentupa J. Selenium status of exclusively breast-fed infants as influenced by maternal organic or inorganic selenium supplementation. Am J Clin Nutr. 1985;42:829\u201335.","journal-title":"Am J Clin Nutr."},{"key":"33_CR40","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/sj.jp.7200273","volume":"19","author":"G Klinger","year":"1999","unstructured":"Klinger G, Shamir R, Singer P, Diamond EM, Josefsberg Z, Sirota L. Parenteral selenium supplementation in extremely low birth weight infants: inadequate dosage but no correlation with hypothyroidism. J Perinatol. 1999;19:568\u201372.","journal-title":"J Perinatol."},{"key":"33_CR41","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S0022-3476(00)90010-6","volume":"136","author":"BA Darlow","year":"2000","unstructured":"Darlow BA, Winterbourn CC, Inder TE, Graham PJ, Harding JE, Weston PJ, et al. The effect of selenium supplementation on outcome in very low birth weight infants: a randomized controlled trial. The New Zealand Neonatal Study Group. J Pediatr. 2000;136:473\u201380.","journal-title":"J Pediatr."},{"key":"33_CR42","doi-asserted-by":"crossref","unstructured":"Darlow BA, Austin NC. Selenium supplementation to prevent short-term morbidity in preterm neonates. Cochrane Database Syst Rev. 2003: CD003312.","DOI":"10.1002\/14651858.CD003312"},{"key":"33_CR43","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/j.1440-1754.1995.tb00824.x","volume":"31","author":"BA Darlow","year":"1995","unstructured":"Darlow BA, Inder TE, Sluis KB, Nuthall G, Mogridge N, Winterbourn CC. Selenium status of New Zealand infants fed either a selenium supplemented or a standard formula. J Paediatr Child Health. 1995;31:339\u201344.","journal-title":"J Paediatr Child Health."},{"key":"33_CR44","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1542\/peds.96.2.314","volume":"96","author":"BA Darlow","year":"1995","unstructured":"Darlow BA, Inder TE, Graham PJ, Sluis KB, Malpas TJ, Taylor BJ, et al. The relationship of selenium status to respiratory outcome in the very low birth weight infant. Pediatrics. 1995;96:314\u20139.","journal-title":"Pediatrics."},{"key":"33_CR45","first-page":"203","volume":"202","author":"U Merz","year":"1998","unstructured":"Merz U, Peschgens T, Dott W, H\u00f6rnchen H. Selenium status and bronchopulmonary dysplasia in premature infants <1500\u2009g. Z Geburtshilfe Neonatol. 1998;202:203\u20136.","journal-title":"Z Geburtshilfe Neonatol."}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41372-017-0033-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-017-0033-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-017-0033-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:48:53Z","timestamp":1744159733000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41372-017-0033-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,3]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["33"],"URL":"https:\/\/doi.org\/10.1038\/s41372-017-0033-3","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,3]]},"assertion":[{"value":"22 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}