{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T10:58:28Z","timestamp":1793703508899,"version":"4.5.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1038\/s41372-018-0109-8","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T15:28:03Z","timestamp":1525274883000},"page":"1114-1122","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Quality improvement initiative to improve inpatient outcomes for Neonatal Abstinence Syndrome"],"prefix":"10.1038","volume":"38","author":[{"given":"Elisha M.","family":"Wachman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davida M.","family":"Schiff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara L.","family":"Philipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Minear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Hutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley","family":"Saia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FNU","family":"Nikita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Khattab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Nolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginny","family":"Combs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Stickney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Driscoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Humphreys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Farrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonny L.","family":"Whalen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,8]]},"reference":[{"key":"109_CR1","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1001\/jama.2012.3951","volume":"307","author":"SW Patrick","year":"2012","unstructured":"Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM. Neonatal abstinence syndrome and associated healthcare expenditures\u2014United States, 2000\u22122009. JAMA. 2012;307:1934\u201340.","journal-title":"JAMA"},{"key":"109_CR2","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/jp.2015.63","volume":"35","author":"SW Patrick","year":"2015","unstructured":"Patrick SW, Davis MM, Lehman CU, Cooper WO. Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009 to 2012. J Perinatol. 2015;35:667.","journal-title":"J Perinatol"},{"key":"109_CR3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1542\/hpeds.2017-0077","volume":"8","author":"CE Milliren","year":"2018","unstructured":"Milliren CE, Gupta M, Graham DA, Melvin P, Jorina M, Ozonoff A. Hospital variation in neonatal abstinence syndrome incidence, treatment modalities, resource use, and costs across pediatric hospitals in the United States, 2013 to 2016. Hosp Pediatr. 2018;8:15\u201320.","journal-title":"Hosp Pediatr"},{"key":"109_CR4","unstructured":"Massachusetts Department of Public Health. 2017. Data brief: an assessment of opioid-related overdoses in Massachusetts 2011\u22122015 [Homepage on the Internet]. http:\/\/www.mass.gov\/eohhs\/docs\/dph\/stop-addiction\/data-brief-chapter-55-aug-2017.pdf (Accessed August 2017)."},{"key":"109_CR5","doi-asserted-by":"publisher","first-page":"e540","DOI":"10.1542\/peds.2011-3212","volume":"129","author":"ML Hudak","year":"2012","unstructured":"Hudak ML, Tan RC. From the American Academy of Pediatrics: Neonatal drug withdrawal. Pediatrics. 2012;129:e540\u2013560.","journal-title":"Pediatrics"},{"key":"109_CR6","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1056\/NEJMoa1614835","volume":"376","author":"WK Kraft","year":"2017","unstructured":"Kraft WK, Adeniyi-Jones SC, Chervoneva I, Greenspan JS, Abatemarco D, Kaltenbach K, et al. Buprenorphine for the treatment of the neonatal abstinence syndrome. N Engl J Med. 2017;376:2341\u20138.","journal-title":"N Engl J Med"},{"key":"109_CR7","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/jp.2014.194","volume":"35","author":"MS Brown","year":"2015","unstructured":"Brown MS, Hayes MJ, Thornton LM. Methadone versus morphine for treatment of neonatal abstinence syndrome: a prospective randomized clinical trial. J Perinatol. 2015;35:278\u201383.","journal-title":"J Perinatol"},{"key":"109_CR8","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1056\/NEJMsa1500439","volume":"372","author":"VN Tolia","year":"2015","unstructured":"Tolia VN, Patrick SW, Bennett MM, Murthy K, Sousa J, Smith PB, et al. Increasing incidence of the neonatal abstinence syndrome in U.S. neonatal ICUs. N Engl J Med. 2015;372:2118\u201326.","journal-title":"N Engl J Med"},{"key":"109_CR9","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/sj.jp.7211427","volume":"26","author":"S Sarkar","year":"2006","unstructured":"Sarkar S, Donn SM. Management of neonatal abstinence syndrome in neonatal intensive care units: a national survey. J Perinatol. 2006;26:15\u201317.","journal-title":"J Perinatol"},{"key":"109_CR10","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1542\/hpeds.2012-0079","volume":"3","author":"A Mehta","year":"2013","unstructured":"Mehta A, Forbes KD, Kuppala VS. Neonatal abstinence syndrome management from prenatal counseling to post-discharge follow-up care: results of a national survey. Hosp Pediatr. 2013;3:317\u201323.","journal-title":"Hosp Pediatr"},{"key":"109_CR11","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.acap.2016.10.003","volume":"17","author":"DL Bogen","year":"2017","unstructured":"Bogen DL, Whalen BL, Kair LR, Vining M, King BA. Wide variation found in care of opioid-exposed newborns. Acad Pediatr. 2017;17:374\u201380.","journal-title":"Acad Pediatr"},{"key":"109_CR12","first-page":"141","volume":"2","author":"LP Finnegan","year":"1975","unstructured":"Finnegan LP, Connaughton JF Jr, Kron RE, Emich JP. Neonatal abstinence syndrome: assessment and management. Addict Dis. 1975;2:141\u201358.","journal-title":"Addict Dis"},{"key":"109_CR13","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/ajad.12388","volume":"25","author":"HE Jones","year":"2016","unstructured":"Jones HE, Seashore C, Johnson E, Horton E, O\u2019Grady KE, Andringa K, et al. Psychometric assessment of the Neonatal Abstinence Scoring System and the MOTHER NAS Scale. Am J Addict. 2016;25:370\u20133.","journal-title":"Am J Addict"},{"key":"109_CR14","doi-asserted-by":"publisher","first-page":"e20163360","DOI":"10.1542\/peds.2016-3360","volume":"139","author":"M Grossman","year":"2017","unstructured":"Grossman M, Berkwitt A, Osborn R, Xu Y, Esserman DA, Shapiro ED. et al. An initiative to improve the quality of care of infants with neonatal abstinence syndrome. Pediatrics. 2017;139:e20163360","journal-title":"Pediatrics"},{"key":"109_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/hpeds.2017-0128","volume":"8","author":"MR Grossman","year":"2018","unstructured":"Grossman MR, Lipshaw MJ, Osborn RR, Berkwitt AK. A novel approach to assessing infants with neonatal abstinence syndrome. Hosp Pediatr. 2018;8:1\u20136.","journal-title":"Hosp Pediatr"},{"key":"109_CR16","doi-asserted-by":"publisher","first-page":"e20152929","DOI":"10.1542\/peds.2015-2929","volume":"137","author":"AV Holmes","year":"2016","unstructured":"Holmes AV, Atwood EC, Whalen B, Beliveau J, Jarvis JD, Matulis J. et al. Rooming-in to treat neonatal abstinence syndrome: improved family-centered care at lower cost. Pediatrics. 2016;137:e20152929","journal-title":"Pediatrics"},{"key":"109_CR17","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1940-0640-9-19","volume":"9","author":"SM Bagley","year":"2014","unstructured":"Bagley SM, Wachman EM, Holland E, Brogly SB. Review of the assessment and management of neonatal abstinence syndrome. Addict Sci Clin Pract. 2014;9:19.","journal-title":"Addict Sci Clin Pract"},{"key":"109_CR18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1542\/hpeds.2016-0147","volume":"7","author":"MB Howard","year":"2017","unstructured":"Howard MB, Schiff MD, Penwill N, Si W, Rai A, Wolfgang T, et al. Impact of parental presence at infants\u2019 bedside on neonatal abstinence syndrome. Hosp Pediatr. 2017;7:63\u201369.","journal-title":"Hosp Pediatr"},{"issue":"4","key":"109_CR19","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1001\/jamapediatrics.2017.5195","volume":"172","author":"Kathryn Dee L. MacMillan","year":"2018","unstructured":"MacMillan KD, Rendon CP, Verma K, Riblet N, Washer DB, Holmes AV. Rooming-in for neonatal abstinence syndrome: a systematic review and meta-analysis. JAMA Pediatrics. Feb. 5. https:\/\/doi.org\/10.1001\/jamapediatrics.2017.5195 [Epub ahead of print].","journal-title":"JAMA Pediatrics"},{"key":"109_CR20","unstructured":"Neo Advances [homepage on the Internet]. Karen D\u2019Apilito. Available from: https:\/\/www.neoadvances.com\/index.html ."},{"key":"109_CR21","unstructured":"Clinical Trials.Gov: improving outcomes in neonatal abstinence syndrome [homepage on the Internet]. First posted October 2013, updated December 2017. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01958476 ."},{"key":"109_CR22","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1136\/bmjqs-2013-001862","volume":"23","author":"MJ Taylor","year":"2014","unstructured":"Taylor MJ, McNicholas C, Nicolay C, Darzi A, Bell D, Reed JE. Systematic review of the application of the plan-do-study-act method to improve quality in healthcare. BMJ Qual Saf. 2014;23:290\u20138.","journal-title":"BMJ Qual Saf"},{"key":"109_CR23","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1097\/ADM.0b013e3182266a3a","volume":"5","author":"EM Wachman","year":"2011","unstructured":"Wachman EM, Newby PK, Vreeland J, Byun J, Bonzagni A, Bauchner H, et al. The relationship between maternal opioid agonists and psychiatric medications on length of hospitalization for neonatal abstinence syndrome. J Addict Med. 2011;5:293\u20139.","journal-title":"J Addict Med"},{"key":"109_CR24","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.drugalcdep.2012.11.019","volume":"131","author":"HE Jones","year":"2013","unstructured":"Jones HE, Heil SH, Tuten M, Chisolm MS, Foster JM, O\u2019Grady KE, et al. Cigarette smoking in opioiddependent pregnant women: neonatal and maternal outcomes. Drug Alcohol Depend. 2013;131:271\u20137.","journal-title":"Drug Alcohol Depend"},{"key":"109_CR25","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1542\/peds.2014-3299","volume":"135","author":"SW Patrick","year":"2015","unstructured":"Patrick SW, Dudley J, Martin PR, Harrell FE, Warren MD, Hartmann KE, et al. Prescription opioid epidemic and infant outcomes. Pediatrics. 2015;135:842\u201350.","journal-title":"Pediatrics"},{"key":"109_CR26","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.jpeds.2015.09.038","volume":"167","author":"ES Hall","year":"2015","unstructured":"Hall ES, Meinzen-Derr J, Wexelblatt SL. Cohort analysis of a pharmacokinetic-modeled methadone weaning optimization for neonatal abstinence syndrome. J Pediatr. 2015;167:1221\u20135.e1.","journal-title":"J Pediatr"},{"key":"109_CR27","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1136\/qhc.12.6.458","volume":"12","author":"JC Benneyan","year":"2003","unstructured":"Benneyan JC, Lloyd RC, Plsek PE. Statistical process control as a tool for research and healthcare improvement. BMJ Qual Saf. 2003;12:458\u201364.","journal-title":"BMJ Qual Saf"},{"key":"109_CR28","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13722-016-0070-9","volume":"12","author":"K Saia","year":"2017","unstructured":"Saia K, Bagley SM, Wachman EM, Patel PP, Nadas MD, Brogly SB. Prenatal treatment for opioid dependency: observations from a large inner-city clinic. Addict Sci Clin Pract. 2017;12:5.","journal-title":"Addict Sci Clin Pract"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41372-018-0109-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41372-018-0109-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41372-018-0109-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:26:32Z","timestamp":1684617992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41372-018-0109-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,8]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["109"],"URL":"https:\/\/doi.org\/10.1038\/s41372-018-0109-8","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,8]]},"assertion":[{"value":"6 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}