{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:35:39Z","timestamp":1783488939893,"version":"3.55.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:00:00Z","timestamp":1547683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National University of Ireland Galway Perinatal Fund."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1038\/s41372-019-0312-2","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T09:02:38Z","timestamp":1547715758000},"page":"439-444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Maternal parity and functional contractility of human myometrium in vitro in the third trimester of pregnancy"],"prefix":"10.1038","volume":"39","author":[{"given":"Gillian A.","family":"Ryan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0381-9719","authenticated-orcid":false,"given":"Denis J.","family":"Crankshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"key":"312_CR1","unstructured":"National Institute for Health and Care Excellence. Intrapartum care: care of healthy women and their babies during childbirth (clinical guideline 190), 2014. \n                    www.nice.org.uk\/guidance\/cg190\n                    \n                  ."},{"key":"312_CR2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/01.AOG.0000226862.78768.5c","volume":"357","author":"T Lavender","year":"2006","unstructured":"Lavender T, Alfirevic Z, Walkinshaw S. Effect of different partogram lines on birth outcomes: a randomized controlled trial. Obstet Gynecol. 2006;357:295\u2013302.","journal-title":"Obstet Gynecol"},{"key":"312_CR3","doi-asserted-by":"publisher","first-page":"j2469","DOI":"10.1136\/bmj.j2469","volume":"357","author":"S Kenyon","year":"2017","unstructured":"Kenyon S, Sanders J, Middleton L, Johnston T. What is the best treatment to reduce the need for caesarean section in nulliparous women at term with delayed first stage of labor? BMJ. 2017;357:j2469.","journal-title":"BMJ"},{"key":"312_CR4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ejogrb.2009.08.015","volume":"147","author":"V Sharma","year":"2009","unstructured":"Sharma V, Colleran G, Dineen B, Hession MB, Avalos G, Morrison JJ. Factors influencing delivery mode for nulliparous women with a singleton gestation and cephalic presentation during a 17-year period. Eur J Obstet Gynecol Reprod Biol. 2009;147:173\u20137.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"312_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/jpm-2017-0018","volume":"46","author":"WR Cohen","year":"2018","unstructured":"Cohen WR, Friedman FA. The assessment of labor: a brief history. J Perinat Med. 2018;46:1\u20138.","journal-title":"J Perinat Med"},{"key":"312_CR6","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/ijgo.12270","volume":"139","author":"WR Cohen","year":"2017","unstructured":"Cohen WR. Clinical assessment of uterine contractions. Int J Gynecol Obstet. 2017;139:137\u201342.","journal-title":"Int J Gynecol Obstet"},{"key":"312_CR7","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1113\/EP085131","volume":"100","author":"S Wray","year":"2015","unstructured":"Wray S. Insights from physiology into myometrial function and dysfunction. Exp Physiol. 2015;100:1468\u201372.","journal-title":"Exp Physiol"},{"key":"312_CR8","doi-asserted-by":"publisher","first-page":"155E1","DOI":"10.1016\/j.ajog.2011.03.014","volume":"205","author":"DJ Crankshaw","year":"2011","unstructured":"Crankshaw DJ, Morrison JJ. Methodology and pharmacological effects of uterotonic compounds in human myometrium in vitro. Am J Obstet Gynecol. 2011;205:155E1\u20136.","journal-title":"Am J Obstet Gynecol"},{"key":"312_CR9","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1177\/1933719115572483","volume":"22","author":"DJ Crankshaw","year":"2015","unstructured":"Crankshaw DJ, O\u2019Brien YM, Crosby DA, Morrison JJ. Maternal age and contractility of human myometrium in pregnancy. Reprod Sci. 2015;22:1229\u201335.","journal-title":"Reprod Sci"},{"key":"312_CR10","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/jp.2016.271","volume":"35","author":"DJ Crankshaw","year":"2017","unstructured":"Crankshaw DJ, O\u2019Brien YM, Crosby DA, Morrison JJ. Maternal body mass index and spontaneous contractility of human myometrium in pregnancy. J Perinatol. 2017;35:492\u20137.","journal-title":"J Perinatol"},{"key":"312_CR11","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.ajog.2017.10.319","volume":"218","author":"GA Ryan","year":"2018","unstructured":"Ryan GA, Nicholson SM, Crankshaw DJ, Morrison JJ. Human uterine contractility at term in relation to parity. Am J Obstet Gynecol. 2018;218:236. \n                    https:\/\/doi.org\/10.1016\/j.ajog.2017.10.319","journal-title":"Am J Obstet Gynecol"},{"key":"312_CR12","doi-asserted-by":"publisher","first-page":"453.e1","DOI":"10.1016\/j.ajog.2010.03.023","volume":"202","author":"MD O\u2019Sullivan","year":"2010","unstructured":"O\u2019Sullivan MD, Hehir MP, O\u2019Brien YM, Morrison JJ. 17 alpha-hydroxyprogesterone caproate vehicle, castor oil, enhances the contractile effect of oxytocin in human myometrium in pregnancy. Am J Obstet Gynecol. 2010;202:453.e1\u20134.","journal-title":"Am J Obstet Gynecol"},{"key":"312_CR13","doi-asserted-by":"publisher","first-page":"167.e1","DOI":"10.1016\/j.ajog.2008.01.002","volume":"199","author":"AT Moynihan","year":"2008","unstructured":"Moynihan AT, Hehir MP, Sharkey AM, Robson SC, Europe-Finner GN, Morrison JJ. Histone deacetylase inhibitors and a functional potent inhibitory effect on human uterine contractility. Am J Obstet Gynecol. 2008;199:167.e1\u20137.","journal-title":"Am J Obstet Gynecol"},{"key":"312_CR14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.lfs.2014.08.018","volume":"116","author":"DJ Crankshaw","year":"2014","unstructured":"Crankshaw DJ, Walsh JM, Morrison JJ. The effects of methyl palmitate, a putative regulator from perivascular fat, on the contractility of pregnant human myometrium. Life Sci. 2014;116:25\u201330.","journal-title":"Life Sci"},{"key":"312_CR15","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ejogrb.2018.02.026","volume":"223","author":"E Abalos","year":"2018","unstructured":"Abalos E, Oladapo OT, Chamillard M, D\u00edaz V, Pasquale J, Bonet M, et al. Duration of spontaneous labour in \u2018low-risk\u2019 women with \u2018normal\u2019 perinatal outcomes: a systematic review. Eur J Obstet Gynecol Reprod Biol. 2018;223:123\u201332.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"312_CR16","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1111\/aogs.13167","volume":"96","author":"U Waldenstr\u00f6m","year":"2017","unstructured":"Waldenstr\u00f6m U, Ek\u00e9us C. Risk of labor dystocia increases with maternal age irrespective of parity: a population-based register study. Acta Obstet Gynecol Scand. 2017;96:1063\u20139.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"312_CR17","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1111\/j.1471-0528.2012.03502.x","volume":"119","author":"A Sandstr\u00f6m","year":"2012","unstructured":"Sandstr\u00f6m A, Cnattingius S, Wikstr\u00f6m AK, Stephansson O. Labour dystocia\u2014risk of recurrence and instrumental delivery in following labour\u2014a population-based cohort study. BJOG. 2012;119:1648\u201356.","journal-title":"BJOG"},{"key":"312_CR18","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1111\/j.1471-0528.2011.03064.x","volume":"118","author":"S Quenby","year":"2011","unstructured":"Quenby S, Matthew A, Zhang J, Dawood F, Wray S. In vitro myometrial contractility reflects indication for caesarean section. BJOG. 2011;118:1499\u2013506.","journal-title":"BJOG"},{"key":"312_CR19","doi-asserted-by":"publisher","first-page":"32.e1","DOI":"10.1016\/j.ajog.2013.04.004","volume":"209","author":"CC Heuser","year":"2013","unstructured":"Heuser CC, Knight S, Esplin MS, Eller AG, Holmgren CM, Manuck TA, et al. Tachysystole in term labor: incidence, risk factors, outcomes, and effect on fetal heart tracings. Am J Obstet Gynecol. 2013;209:32.e1\u20136.","journal-title":"Am J Obstet Gynecol"},{"key":"312_CR20","doi-asserted-by":"publisher","first-page":"3335","DOI":"10.3109\/14767058.2015.1125463","volume":"29","author":"AI Ahmed","year":"2016","unstructured":"Ahmed AI, Zhu L, Aldhaheri S, Sakr S, Minkoff H, Haberman S. Uterine tachysystole in spontaneous labor at term. J Matern Fetal Neonatal Med. 2016;29:3335\u20139.","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41372-019-0312-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41372-019-0312-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41372-019-0312-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:27:51Z","timestamp":1684618071000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41372-019-0312-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,17]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["312"],"URL":"https:\/\/doi.org\/10.1038\/s41372-019-0312-2","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,17]]},"assertion":[{"value":"11 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}