{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:26:32Z","timestamp":1780068392287,"version":"3.54.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1038\/s41372-019-0432-8","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T07:02:57Z","timestamp":1563865377000},"page":"1569-1576","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Decrease in the frequency of treatment for patent ductus arteriosus after implementation of consensus guidelines: a 15-year experience"],"prefix":"10.1038","volume":"39","author":[{"given":"Lara","family":"Pavageau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc P.","family":"Brion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9208-6539","authenticated-orcid":false,"given":"Charles R.","family":"Rosenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Steven","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Ramaciotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Jeannette","family":"Burchfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mambarambath A.","family":"Jaleel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"432_CR1","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1542\/peds.104.6.1345","volume":"104","author":"DD Marshall","year":"1999","unstructured":"Marshall DD, Kotelchuck M, Young TE, Bose CL, Kruyer L, O\u2019Shea TM. Risk factors for chronic lung disease in the surfactant era: a North Carolina population-based study of very low birth weight infants. Pediatrics. 1999;104:1345\u201350.","journal-title":"Pediatrics"},{"key":"432_CR2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/oxfordjournals.aje.a112960","volume":"112","author":"RW Ryder","year":"1980","unstructured":"Ryder RW, Shelton JD, Guinan ME. Necrotizing enterocolitis: a prospective multicenter investigation. Am J Epidemiol. 1980;112:113\u201323.","journal-title":"Am J Epidemiol"},{"key":"432_CR3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1542\/peds.66.1.42","volume":"66","author":"FD Dykes","year":"1980","unstructured":"Dykes FD, Lazzara A, Ahmann P, Blumenstein B, Schwartz J, Brann AW. Intraventricular hemorrhage: a prospective evaluation of etiopathogenesis. Pediatrics. 1980;66:42\u201349.","journal-title":"Pediatrics"},{"key":"432_CR4","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1067\/mpd.2001.110528","volume":"138","author":"B Van Overmeire","year":"2001","unstructured":"Van Overmeire B, Van de Broek H, Van Laer P, Weyler J, Vanhaesebrouch P. Early versus late indomethacin treatment for patent ductus arteriosus in premature infants with respiratory distress syndrome. J Pedia. 2001;138:205\u201311.","journal-title":"J Pedia"},{"key":"432_CR5","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S0022-3476(78)80910-X","volume":"93","author":"RB Cotton","year":"1978","unstructured":"Cotton RB, Stahlman MT, Berder HW, Graham TP, Catterton WZ, Kover I. Randomized trial of early closure of symptomatic patent ductus arteriosus in small preterm infants. J Pedia. 1978;93:647\u201351.","journal-title":"J Pedia"},{"key":"432_CR6","doi-asserted-by":"publisher","first-page":"F45","DOI":"10.1136\/adc.2009.168682","volume":"96","author":"LJ Jones","year":"2011","unstructured":"Jones LJ, Craven PD, Attia J, Thakkinstian A, Wright I. Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2011;96:F45\u2013F52.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"432_CR7","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4103\/2249-4847.134670","volume":"3","author":"DE Weisz","year":"2014","unstructured":"Weisz DE, McNamara PJ. Patent ductus arteriosus ligation and adverse outcomes: causality or bias? J Clin Neonatol. 2014;3:67\u201375.","journal-title":"J Clin Neonatol"},{"key":"432_CR8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.jpeds.2006.11.039","volume":"150","author":"NS Kabra","year":"2007","unstructured":"Kabra NS, Schmidt B, Roberts RS, Doyle LW, Papile L, Fanroff A. Neurosensory impairment after surgical closure of patent ductus arteriosus in ELBW infants: results from the TIPP. Pediatrics. 2007;150:229\u201334.","journal-title":"Pediatrics"},{"key":"432_CR9","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1542\/peds.2007-2781","volume":"123","author":"JC Madan","year":"2009","unstructured":"Madan JC, Kendrick D, Hagadorn JI, Frantz IV. Patent ductus arteriosus therapy: impact on neonatal and 18-month outcome. Pediatrics. 2009;123:674\u201381.","journal-title":"Pediatrics"},{"key":"432_CR10","unstructured":"Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Generic database of very low birth weight infants (GDB). NCT00063063. http:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT00063063."},{"key":"432_CR11","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/sj.jp.7211662","volume":"27","author":"M Laughon","year":"2007","unstructured":"Laughon M, Bose C, Clark R. Treatment strategies to prevent or close a patent ductus arteriosus in preterm infants and outcomes. J Perinatol. 2007;27:164\u201370.","journal-title":"J Perinatol"},{"key":"432_CR12","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1542\/peds.2005-1528","volume":"117","author":"J Koch","year":"2006","unstructured":"Koch J, Hensley G, Roy L, Brown S, Ramaciotti C, Rosenfeld CR. Prevalence of spontaneous closure of the ductus arteriosus in neonates at a birth weight of 1000 grams or Less. Pediatrics. 2006;117:1113\u201321.","journal-title":"Pediatrics"},{"key":"432_CR13","doi-asserted-by":"publisher","first-page":"F55","DOI":"10.1136\/archdischild-2014-306339","volume":"100","author":"A Rolland","year":"2015","unstructured":"Rolland A, Shankar-Aguilera S, Diomande D, Zupan-Simunek V, Boileau P. Natural Evolution of patent ductus arteriosus in the extremely preterm infant. Arch Dis Child Fetal Neonatal. 2015;100:F55\u20138.","journal-title":"Arch Dis Child Fetal Neonatal"},{"key":"432_CR14","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jpeds.2016.06.046","volume":"177","author":"SI Sung","year":"2016","unstructured":"Sung SI, Chang YS, Chun JY, Yoon SA, Yoo HS, Ahn SY, et al. Mandatory closure versus nonintervention for patent ductus arteriosus in very preterm infants. J Pedia. 2016;177:66\u201371.","journal-title":"J Pedia"},{"key":"432_CR15","doi-asserted-by":"publisher","first-page":"e20164258","DOI":"10.1542\/peds.2016-4258","volume":"140","author":"J Semberova","year":"2017","unstructured":"Semberova J, Sirc J, Miletin J, Kucera J, Berka I, Sebkova S, et al. Spontaneous closure of patent ductus arteriosus in infants \u22641500\u2009g. Pediatrics. 2017;140:e20164258.","journal-title":"Pediatrics"},{"key":"432_CR16","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.earlhumdev.2008.12.007","volume":"85","author":"A Chiruvolu","year":"2009","unstructured":"Chiruvolu A, Jaleel MA. Therapeutic management of patent ductus arteriosus. Early Hum Dev. 2009;85:151\u20135.","journal-title":"Early Hum Dev"},{"key":"432_CR17","unstructured":"Sanchez AM, Mize SG, Jimenez JM, Manroe BL, Rosenfeld CR, Tyson TE. Systems approach to the evaluation of maternal and neonatal care. In: Proceedings of the 12th Hawaii international conference on system sciences, selected papers in medical information processing. 1979. p. 140\u201351."},{"key":"432_CR18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0378-3782(85)90135-5","volume":"12","author":"JA Furzan","year":"1985","unstructured":"Furzan JA, Reishe J, Tyson JE, Laird P, Rosenfeld CR. Incidence and risk factors for symptomatic patent ductus arteriosus among inborn very-low-birth-weight infants. Early Hum Dev. 1985;12:39\u201348.","journal-title":"Early Hum Dev"},{"key":"432_CR19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0378-3782(91)90028-2","volume":"27","author":"AI Mouzinho","year":"1991","unstructured":"Mouzinho AI, Rosenfeld CR, Risser R. Symptomatic patent ductus arteriosus in very-low-birth-weight infants: 1987\u20131989. Early Hum Dev. 1991;27:65\u201377.","journal-title":"Early Hum Dev"},{"key":"432_CR20","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/j.1651-2227.1981.tb05775.x","volume":"70","author":"RB Cotton","year":"1981","unstructured":"Cotton RB, Lindstrom DP, Stahlman MT. Early prediction of symptomatic patent ductus arteriosus from perinatal risk factors: a discriminant analysis model. Acta Paediatr. 1981;70:723\u2013127.","journal-title":"Acta Paediatr"},{"key":"432_CR21","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1651-2227.2011.02468.x","volume":"101","author":"I Zonnenberg","year":"2012","unstructured":"Zonnenberg I, de Waal K. The definition of a haemodynamic significant duct in randomized controlled trials: a systematic literature review. Acta Paediatr. 2012;101:247\u201351.","journal-title":"Acta Paediatr"},{"key":"432_CR22","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1542\/peds.2005-0249","volume":"116","author":"RA Ehrenkranz","year":"2005","unstructured":"Ehrenkranz RA, Walsh MC, Vohr BR, Jobe AH, Wright LL, Fanaroff AA, et al. Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia. Pediatrics. 2005;116:1353\u201360.","journal-title":"Pediatrics"},{"key":"432_CR23","doi-asserted-by":"publisher","first-page":"e682","DOI":"10.1542\/peds.2011-1827","volume":"129","author":"R Bhat","year":"2012","unstructured":"Bhat R, Salas AA, Foster C, Carlo WA, Ambalavanan N. Prospective analysis of pulmonary hypertension in extremely low birth weight infants. Pediatrics. 2012;129:e682\u20139.","journal-title":"Pediatrics"},{"key":"432_CR24","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1053\/j.semperi.2011.09.022","volume":"36","author":"RI Clyman","year":"2012","unstructured":"Clyman RI, Couto J, Murphy GM. Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all? Semin Perinatol. 2012;36:123\u20139.","journal-title":"Semin Perinatol"},{"key":"432_CR25","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1056\/NEJM200009073431001","volume":"343","author":"B Van Overmeire","year":"2000","unstructured":"Van Overmeire B, Smets K, Lecoutere D, Van de Broek H, Weyler J, De Groote K, et al. A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus. N Engl J Med. 2000;343:674\u201381.","journal-title":"N Engl J Med"},{"key":"432_CR26","doi-asserted-by":"publisher","first-page":"e20162390","DOI":"10.1542\/peds.2016-2390","volume":"139","author":"S Ngo","year":"2017","unstructured":"Ngo S, Profit J, Gould J, Lee HC. Trends in patent ductus arteriosus diagnosis and management for very low birth weight infants. Pediatrics. 2017;139:e20162390.","journal-title":"Pediatrics"},{"key":"432_CR27","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/pr.2016.166","volume":"80","author":"JI Hagadorn","year":"2016","unstructured":"Hagadorn JI, Brownell EA, Trzaski JM, Johnson KR, Lainwala S, Campbell BT, et al. Trends and variation in management and outcomes of very low-birth-weight infants with patent ductus arteriosus. Pedia Res. 2016;80:785\u201392.","journal-title":"Pedia Res"},{"key":"432_CR28","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1055\/s-0036-1593351","volume":"34","author":"A Lokku","year":"2017","unstructured":"Lokku A, Mirea L, Lee SK, Shah PS. On behalf of the Canadian Neonatal Network. Trends and outcomes of patent ductus arteriosus treatment in very preterm infants in Canada. Am J Perinatol. 2017;34:441\u201350.","journal-title":"Am J Perinatol"},{"key":"432_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.2015-3730","volume":"137","author":"WE Benitz","year":"2016","unstructured":"Benitz WE. Committee on fetus and newborn, American Academy of Pediatrics. Patent ductus arteriosus in preterm infants. Pediatrics. 2016;137:1\u20136.","journal-title":"Pediatrics"},{"key":"432_CR30","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/chd.12287","volume":"11","author":"JJ Elhoff","year":"2016","unstructured":"Elhoff JJ, Ebeling M, Hulsey TC, Atz AM. Potential unintended consequences of a conservative management strategy for patent ductus arteriosus. Congenit Heart Dis 2016;11:52\u20137.","journal-title":"Congenit Heart Dis"},{"key":"432_CR31","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.jpeds.2010.02.062","volume":"157","author":"N Jhaveri","year":"2010","unstructured":"Jhaveri N, Moon-Grady A, Clyman RI. Early surgical ligation versus a conservative approach for management of PDA that fails to close after indomethacin treatment. J Pediatrics. 2010;157:381\u20137.","journal-title":"J Pediatrics"},{"key":"432_CR32","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1056\/NEJMsa0806033","volume":"362","author":"WA Carlo","year":"2010","unstructured":"Carlo WA, Finer NN, Walsh MC, Rich W, Gantz MG, Laptook AR, et al. Target ranges of oxygen saturation in extremely preterm infants. N Engl J Med. 2010;362:1959\u201369.","journal-title":"N Engl J Med"},{"key":"432_CR33","doi-asserted-by":"publisher","first-page":"F386","DOI":"10.1136\/archdischild-2014-306057","volume":"99","author":"JM LeVan","year":"2014","unstructured":"LeVan JM, Brion LP, Wrage LA, Gantz MG, Wyckoff MH, Sanchez PJ, et al. Change in practice after the surfactant, positive pressure and oxygenation randomized trial. Arch Dis Child Fetal Neonatal Ed. 2014;99:F386\u2013F39.","journal-title":"Arch Dis Child Fetal Neonatal Ed"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41372-019-0432-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-019-0432-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-019-0432-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T01:53:20Z","timestamp":1744077200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41372-019-0432-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,23]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["432"],"URL":"https:\/\/doi.org\/10.1038\/s41372-019-0432-8","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,23]]},"assertion":[{"value":"7 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the institutional review board of UTSW and by Parkland Hospital as a QI project and exempt from the need for informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}