{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:42:34Z","timestamp":1766137354506,"version":"3.37.3"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>To examine the effects of 30% oral dextrose on biochemical markers of pain, adenosine triphosphate (ATP) degradation, and oxidative stress in preterm neonates experiencing a clinically required heel lance.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Study design<\/jats:title>\n<jats:p>Utilizing a prospective study design, preterm neonates that met study criteria (<jats:italic>n<\/jats:italic>\u2009=\u2009169) were randomized to receive either (1) 30% oral dextrose, (2) facilitated tucking, or (3) 30% oral dextrose and facilitated tucking 2\u2009min before heel lance. Plasma markers of ATP degradation (hypoxanthine, uric acid) and oxidative stress (allantoin) were measured before and after the heel lance. Pain was measured using the premature infant pain profile-revised (PIPP-R).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Oral dextrose, administered alone or with facilitated tucking, did not alter plasma markers of ATP utilization and oxidative stress.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>A single dose of 30% oral dextrose, given before a clinically required heel lance, decreased signs of pain without increasing ATP utilization and oxidative stress in premature neonates.<\/jats:p>\n<\/jats:sec>","DOI":"10.1038\/s41372-020-0634-0","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T10:03:03Z","timestamp":1582711383000},"page":"888-895","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Oral dextrose reduced procedural pain without altering cellular ATP metabolism in preterm neonates: a prospective randomized trial"],"prefix":"10.1038","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0997-0295","authenticated-orcid":false,"given":"Danilyn M.","family":"Angeles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6919-3726","authenticated-orcid":false,"given":"Danilo S.","family":"Boskovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Shih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Hoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-2955","authenticated-orcid":false,"given":"Dorothy","family":"Forde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raylene M.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1482-740X","authenticated-orcid":false,"given":"Andrew","family":"Hopper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1751-5188","authenticated-orcid":false,"given":"Douglas D.","family":"Deming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giang","family":"Truong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aprille","family":"Febre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Pegis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Lavery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munaf","family":"Kadri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anamika","family":"Banerji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iman","family":"Mousselli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vora","family":"Farha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elba","family":"Fayard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"key":"634_CR1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/ejp.757","volume":"20","author":"MD Cruz","year":"2016","unstructured":"Cruz MD, Fernandes AM, Oliveira CR. Epidemiology of painful procedures performed in neonates: a systematic review of observational studies. Eur J Pain. 2016;20:489\u201398.","journal-title":"Eur J Pain"},{"key":"634_CR2","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.jpain.2012.03.010","volume":"13","author":"L Slater","year":"2012","unstructured":"Slater L, Asmerom Y, Boskovic DS, Bahjri K, Plank MS, Angeles KR, et al. Procedural pain and oxidative stress in premature neonates. J Pain. 2012;13:590\u20137.","journal-title":"J Pain"},{"key":"634_CR3","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1111\/apa.14567","volume":"107","author":"L Kristoffersen","year":"2018","unstructured":"Kristoffersen L, Malahleha M, Duze Z, Tegnander E, Kapongo N, Stoen R, et al. Randomised controlled trial showed that neonates received better pain relief from a higher dose of sucrose during venepuncture. Acta Paediatr. 2018;107:2071\u20138.","journal-title":"Acta Paediatr"},{"key":"634_CR4","first-page":"CD001069","volume":"7","author":"B Stevens","year":"2016","unstructured":"Stevens B, Yamada J, Ohlsson A, Haliburton S, Shorkey A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2016;7:CD001069.","journal-title":"Cochrane Database Syst Rev"},{"key":"634_CR5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jpeds.2012.12.088","volume":"163","author":"Y Asmerom","year":"2013","unstructured":"Asmerom Y, Slater L, Boskovic DS, Bahjri K, Holden MS, Phillips R, et al. Oral sucrose for heel lance increases adenosine triphosphate use and oxidative stress in preterm neonates. J Pediatr. 2013;163:29\u201335.e1.","journal-title":"J Pediatr"},{"key":"634_CR6","doi-asserted-by":"publisher","first-page":"205031211561143","DOI":"10.1177\/2050312115611431","volume":"3","author":"DM Angeles","year":"2015","unstructured":"Angeles DM, Asmerom Y, Boskovic DS, Slater L, Bacot-Carter S, Bahjri K, et al. Oral sucrose for heel lance enhances adenosine triphosphate use in preterm neonates with respiratory distress. SAGE Open Med. 2015;3:2050312115611431.","journal-title":"SAGE Open Med"},{"key":"634_CR7","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1111\/j.1523-536X.2010.00389.x","volume":"37","author":"B Dilen","year":"2010","unstructured":"Dilen B, Elseviers M. Oral glucose solution as pain relief in newborns: results of a clinical trial. Birth. 2010;37:98\u2013105.","journal-title":"Birth"},{"key":"634_CR8","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1155\/2013\/956549","volume":"18","author":"M Bueno","year":"2013","unstructured":"Bueno M, Yamada J, Harrison D, Khan S, Ohlsson A, Adams-Webber T, et al. A systematic review and meta-analyses of nonsucrose sweet solutions for pain relief in neonates. Pain Res Manag. 2013;18:153\u201361.","journal-title":"Pain Res Manag"},{"issue":"5 Suppl","key":"634_CR9","doi-asserted-by":"publisher","first-page":"754S","DOI":"10.1093\/ajcn\/58.5.754S","volume":"58","author":"PA Mayes","year":"1993","unstructured":"Mayes PA. Intermediary metabolism of fructose. Am J Clin Nutr. 1993;58 5 Suppl:754S\u201365S.","journal-title":"Am J Clin Nutr"},{"key":"634_CR10","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1007\/s11095-011-0492-8","volume":"28","author":"DC Liemburg-Apers","year":"2011","unstructured":"Liemburg-Apers DC, Imamura H, Forkink M, Nooteboom M, Swarts HG, Brock R, et al. Quantitative glucose and ATP sensing in mammalian cells. Pharm Res. 2011;28:2745\u201357.","journal-title":"Pharm Res"},{"key":"634_CR11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3233\/PRM-130233","volume":"6","author":"B Sundaram","year":"2013","unstructured":"Sundaram B, Shrivastava S, Pandian JS, Singh VP. Facilitated tucking on pain in pre-term newborns during neonatal intensive care: a single blinded randomized controlled cross-over pilot trial. J Pediatr Rehabil Med. 2013;6:19\u201327.","journal-title":"J Pediatr Rehabil Med"},{"key":"634_CR12","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1097\/JPN.0b013e3181bdcf77","volume":"23","author":"H Obeidat","year":"2009","unstructured":"Obeidat H, Kahalaf I, Callister LC, Froelicher ES. Use of facilitated tucking for nonpharmacological pain management in preterm infants: a systematic review. J Perinat Neonatal Nurs. 2009;23:372\u20137.","journal-title":"J Perinat Neonatal Nurs"},{"key":"634_CR13","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1542\/pir.35-10-417","volume":"35","author":"S Reuter","year":"2014","unstructured":"Reuter S, Moser C, Baack M. Respiratory distress in the newborn. Pediatr Rev. 2014;35:417\u201328. quiz 29","journal-title":"Pediatr Rev"},{"key":"634_CR14","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.earlhumdev.2014.01.005","volume":"90","author":"S Gibbins","year":"2014","unstructured":"Gibbins S, Stevens BJ, Yamada J, Dionne K, Campbell-Yeo M, Lee G, et al. Validation of the premature infant pain profile-revised (PIPP-R). Early Hum Dev. 2014;90:189\u201393.","journal-title":"Early Hum Dev"},{"key":"634_CR15","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.pain.2008.02.031","volume":"139","author":"NB Freire","year":"2008","unstructured":"Freire NB, Garcia JB, Lamy ZC. Evaluation of analgesic effect of skin-to-skin contact compared to oral glucose in preterm neonates. Pain. 2008;139:28\u201333.","journal-title":"Pain"},{"key":"634_CR16","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1651-2227.1997.tb08872.x","volume":"86","author":"Y Skogsdal","year":"1997","unstructured":"Skogsdal Y, Eriksson M, Schollin J. Analgesia in newborns given oral glucose. Acta Paediatr. 1997;86:217\u201320.","journal-title":"Acta Paediatr"},{"key":"634_CR17","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1542\/peds.110.6.1053","volume":"110","author":"M Gradin","year":"2002","unstructured":"Gradin M, Eriksson M, Holmqvist G, Holstein A, Schollin J. Pain reduction at venipuncture in newborns: oral glucose compared with local anesthetic cream. Pediatrics. 2002;110:1053\u20137.","journal-title":"Pediatrics"},{"key":"634_CR18","doi-asserted-by":"crossref","unstructured":"Plank MS, Calderon TC, Asmerom Y, Boskovic DS, Angeles DM. Biochemical measurement of neonatal hypoxia. J Vis Exp. 2011;54:2948.1\u20137.","DOI":"10.3791\/2948"},{"key":"634_CR19","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1089\/ars.2008.2364","volume":"11","author":"J Gruber","year":"2009","unstructured":"Gruber J, Tang SY, Jenner AM, Mudway I, Blomberg A, Behndig A, et al. Allantoin in human plasma, serum, and nasal-lining fluids as a biomarker of oxidative stress: avoiding artifacts and establishing real in vivo concentrations. Antioxid Redox Signal. 2009;11:1767\u201376.","journal-title":"Antioxid Redox Signal"},{"key":"634_CR20","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0009-8981(01)00805-1","volume":"318","author":"DV Pavitt","year":"2002","unstructured":"Pavitt DV, de Fonseka S, Al-Khalaf N, Cam JM, Reaveley DA. Assay of serum allantoin in humans by gas chromatography-mass spectrometry. Clin Chim Acta. 2002;318:63\u201370.","journal-title":"Clin Chim Acta"},{"key":"634_CR21","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/S0140-6736(67)90494-1","volume":"2","author":"J Perheentupa","year":"1967","unstructured":"Perheentupa J, Raivio K. Fructose-induced hyperuricaemia. Lancet. 1967;2:528\u201331.","journal-title":"Lancet"},{"key":"634_CR22","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.jhep.2016.12.025","volume":"66","author":"A Mosca","year":"2017","unstructured":"Mosca A, Nobili V, De Vito R, Crudele A, Scorletti E, Villani A, et al. Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents. J Hepatol. 2017;66:1031\u20136.","journal-title":"J Hepatol"},{"key":"634_CR23","doi-asserted-by":"publisher","first-page":"364","DOI":"10.3390\/metabo5020364","volume":"5","author":"V Varma","year":"2015","unstructured":"Varma V, Boros LG, Nolen GT, Chang CW, Wabitsch M, Beger RD, et al. Fructose alters intermediary metabolism of glucose in human adipocytes and diverts glucose to serine oxidation in the one-carbon cycle energy producing pathway. Metabolites. 2015;5:364\u201385.","journal-title":"Metabolites"},{"key":"634_CR24","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1007\/s10495-015-1128-y","volume":"20","author":"N Jaiswal","year":"2015","unstructured":"Jaiswal N, Maurya CK, Arha D, Avisetti DR, Prathapan A, Raj PS, et al. Fructose induces mitochondrial dysfunction and triggers apoptosis in skeletal muscle cells by provoking oxidative stress. Apoptosis. 2015;20:930\u201347.","journal-title":"Apoptosis"},{"key":"634_CR25","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1681\/ASN.2008060576","volume":"20","author":"P Cirillo","year":"2009","unstructured":"Cirillo P, Gersch MS, Mu W, Scherer PM, Kim KM, Gesualdo L, et al. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol. 2009;20:545\u201353.","journal-title":"J Am Soc Nephrol"},{"key":"634_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14181","volume":"8","author":"A Andres-Hernando","year":"2017","unstructured":"Andres-Hernando A, Li N, Cicerchi C, Inaba S, Chen W, Roncal-Jimenez C, et al. Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice. Nat Commun. 2017;8:14181.","journal-title":"Nat Commun"},{"key":"634_CR27","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3945\/an.112.002998","volume":"4","author":"RH Lustig","year":"2013","unstructured":"Lustig RH. Fructose: it\u2019s \u201calcohol without the buzz\u201d. Adv Nutr. 2013;4:226\u201335.","journal-title":"Adv Nutr"},{"key":"634_CR28","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.cbi.2008.10.011","volume":"178","author":"O Lee","year":"2009","unstructured":"Lee O, Bruce WR, Dong Q, Bruce J, Mehta R, O\u2019Brien PJ. Fructose and carbonyl metabolites as endogenous toxins. Chem Biol Interact. 2009;178:332\u20139.","journal-title":"Chem Biol Interact"},{"key":"634_CR29","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1194\/jlr.M900022-JLR200","volume":"50","author":"MK Pickens","year":"2009","unstructured":"Pickens MK, Yan JS, Ng RK, Ogata H, Grenert JP, Beysen C, et al. Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis. J Lipid Res. 2009;50:2072\u201382.","journal-title":"J Lipid Res"},{"key":"634_CR30","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1097\/00006199-200211000-00005","volume":"51","author":"S Gibbins","year":"2002","unstructured":"Gibbins S, Stevens B, Hodnett E, Pinelli J, Ohlsson A, Darlington G. Efficacy and safety of sucrose for procedural pain relief in preterm and term neonates. Nurs Res. 2002;51:375\u201382.","journal-title":"Nurs Res"},{"key":"634_CR31","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1542\/peds.110.3.523","volume":"110","author":"CC Johnston","year":"2002","unstructured":"Johnston CC, Filion F, Snider L, Majnemer A, Limperopoulos C, Walker CD, et al. Routine sucrose analgesia during the first week of life in neonates younger than 31 weeks\u2019 postconceptional age. Pediatrics. 2002;110:523\u20138.","journal-title":"Pediatrics"},{"key":"634_CR32","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1097\/j.pain.0000000000000961","volume":"158","author":"S Tremblay","year":"2017","unstructured":"Tremblay S, Ranger M, Chau CMY, Ellegood J, Lerch JP, Holsti L, et al. Repeated exposure to sucrose for procedural pain in mouse pups leads to long-term widespread brain alterations. Pain. 2017;158:1586\u201398.","journal-title":"Pain"},{"key":"634_CR33","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.3389\/fpsyg.2018.02394","volume":"9","author":"M Ranger","year":"2018","unstructured":"Ranger M, Tremblay S, Chau CMY, Holsti L, Grunau RE, Goldowitz D. Adverse behavioral changes in adult mice following neonatal repeated exposure to pain and sucrose. Front Psychol. 2018;9:2394.","journal-title":"Front Psychol"},{"key":"634_CR34","first-page":"SC10","volume":"9","author":"SS Harsha","year":"2015","unstructured":"Harsha SS, Archana BR. SNAPPE-II (Score for Neonatal Acute Physiology with Perinatal Extension-II) in predicting mortality and morbidity in NICU. J Clin Diagn Res. 2015;9:SC10\u20132.","journal-title":"J Clin Diagn Res"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41372-020-0634-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41372-020-0634-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41372-020-0634-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:30:57Z","timestamp":1684618257000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41372-020-0634-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,26]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["634"],"URL":"https:\/\/doi.org\/10.1038\/s41372-020-0634-0","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"type":"print","value":"0743-8346"},{"type":"electronic","value":"1476-5543"}],"subject":[],"published":{"date-parts":[[2020,2,26]]},"assertion":[{"value":"29 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}