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For each time period, means and percentages were calculated. <jats:italic>P<\/jats:italic> values for trend were calculated using linear and logistic regression.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>HbA1c in each trimester was unchanged across the analysis period. The prevalence of nephropathy decreased from 4.8% to 0% (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). Excessive gestational weight gain increased (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). Gestation length also increased (<jats:italic>P<\/jats:italic>\u2009=\u20090.01), as did vaginal deliveries (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). There were no change in birthweight over time (<jats:italic>P<\/jats:italic>\u2009=\u20090.07) and the percentage of neonates with macrosomia and large for gestational age (LGA) neonates also remained unchanged.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Obstetric guideline changes may have improved gestation length and mode of delivery; however, other outcomes need more attention, including excessive gestational weight gain, macrosomia, and LGA.<\/jats:p>\n<\/jats:sec>","DOI":"10.1038\/s41372-020-0698-x","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T19:08:59Z","timestamp":1591124939000},"page":"1145-1153","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Time trends in pregnancy-related outcomes among women with type 1 diabetes mellitus, 2004\u20132017"],"prefix":"10.1038","volume":"40","author":[{"given":"Sarit","family":"Helman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamarra M.","family":"James-Todd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zifan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bellavia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Wyckoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanti","family":"Serdy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Halprin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Takoudes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munish","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"McElrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"698_CR1","doi-asserted-by":"publisher","first-page":"177 e171","DOI":"10.1016\/j.ajog.2016.10.007","volume":"216","author":"TY Peng","year":"2017","unstructured":"Peng TY, Ehrlich SF, Crites Y, Kitzmiller JL, Kuzniewicz MW, Hedderson MM, et al. 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