{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:58:58Z","timestamp":1740124738922,"version":"3.37.3"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1038\/s41372-021-00981-3","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T13:03:51Z","timestamp":1614603831000},"page":"1278-1284","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying neonatal early-onset sepsis test and treatment decision thresholds"],"prefix":"10.1038","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8577-478X","authenticated-orcid":false,"given":"Sharla","family":"Rent","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly","family":"Brine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5864-3808","authenticated-orcid":false,"given":"Maria Fernanda","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1967-9861","authenticated-orcid":false,"given":"Ruth","family":"Guinsburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligia","family":"Rugolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Mosca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Trevisanuto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-6149","authenticated-orcid":false,"given":"Gary","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"981_CR1","doi-asserted-by":"publisher","first-page":"e20182894","DOI":"10.1542\/peds.2018-2894","volume":"142","author":"KM Puopolo","year":"2018","unstructured":"Puopolo KM, Benitz WE, Zaoutis TE, AAP Committee on Fetus and Newborn, AAP Committee on Infectious Diseases. Management of neonates born at \u226535 0\/7 weeks\u2019 gestation with suspected or proven early-onset bacterial sepsis. Pediatrics. 2018;142:e20182894.","journal-title":"Pediatrics"},{"key":"981_CR2","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1097\/INF.0b013e318223bad2","volume":"30","author":"EJ Weston","year":"2011","unstructured":"Weston EJ, Pondo T, Lewis MM, Martell-Cleary P, Morin C, Jewell B, et al. The burden of invasive early-onset neonatal sepsis in the United States, 2005-2008. Pediatr Infect Dis J. 2011;30:937\u201341.","journal-title":"Pediatr Infect Dis J"},{"key":"981_CR3","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1542\/peds.2010-2217","volume":"127","author":"BJ Stoll","year":"2011","unstructured":"Stoll BJ, Hansen NI, Sanchez PJ, Faix RG, Poindexter BB, Van Meurs KP, et al. Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues. Pediatrics. 2011;127:817\u201326.","journal-title":"Pediatrics"},{"key":"981_CR4","first-page":"1","volume":"59","author":"JR Verani","year":"2010","unstructured":"Verani JR, McGee L, Schrag SJ, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC). Prevention of perinatal group B streptococcal disease-revised guidelines from CDC, 2010. MMWR Recomm Rep. 2010;59:1\u201336.","journal-title":"MMWR Recomm Rep"},{"key":"981_CR5","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/jp.2012.96","volume":"33","author":"S Mukhopadhyay","year":"2013","unstructured":"Mukhopadhyay S, Eichenwald EC, Puopolo KM. Neonatal early-onset sepsis evaluations among well-appearing infants: projected impact of changes in CDC GBS guidelines. J Perinatol. 2013;33:198\u2013205.","journal-title":"J Perinatol"},{"key":"981_CR6","first-page":"232","volume":"42","author":"MW Kuzniewicz","year":"2016","unstructured":"Kuzniewicz MW, Walsh EM, Li S, Fischer A, Escobar GJ. Development and implementation of an early-onset sepsis calculator to guide antibiotic management in late preterm and term neonates. Jt Comm J Qual Patient Saf. 2016;42:232\u20139.","journal-title":"Jt Comm J Qual Patient Saf"},{"key":"981_CR7","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1080\/1040841X.2016.1211088","volume":"43","author":"LF Stinson","year":"2017","unstructured":"Stinson LF, Payne MS, Keelan JA. Planting the seed: origins, composition, and postnatal health significance of the fetal gastrointestinal microbiota. Crit Rev Microbiol. 2017;43:352\u201369.","journal-title":"Crit Rev Microbiol"},{"key":"981_CR8","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1542\/peds.2007-2171","volume":"121","author":"MJ Bizzarro","year":"2008","unstructured":"Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG. Changing patterns in neonatal Escherichia coli sepsis and ampicillin resistance in the era of intrapartum antibiotic prophylaxis. Pediatrics. 2008;121:689\u201396.","journal-title":"Pediatrics"},{"key":"981_CR9","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1001\/jama.1994.03510330081039","volume":"271","author":"R Jaeschke","year":"1994","unstructured":"Jaeschke R, Guyatt GH, Sackett DL. Users\u2019 guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine Working Group. JAMA. 1994;271:703\u20137.","journal-title":"JAMA"},{"key":"981_CR10","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1056\/NEJM198005153022003","volume":"302","author":"SG Pauker","year":"1980","unstructured":"Pauker SG, Kassirer JP. The threshold approach to clinical decision making. N. Engl J Med. 1980;302:1109\u201317.","journal-title":"N. Engl J Med"},{"key":"981_CR11","doi-asserted-by":"publisher","first-page":"e008155","DOI":"10.1136\/bmjopen-2015-008155","volume":"5","author":"PF Whiting","year":"2015","unstructured":"Whiting PF, Davenport C, Jameson C, Burke M, Sterne JA, Hyde C, et al. How well do health professionals interpret diagnostic information? A systematic review. BMJ Open. 2015;5:e008155.","journal-title":"BMJ Open"},{"key":"981_CR12","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1177\/0272989X8600600406","volume":"6","author":"JG Dolan","year":"1986","unstructured":"Dolan JG, Bordley DR, Mushlin AI. An evaluation of clinicians\u2019 subjective prior probability estimates. Med Decis Mak. 1986;6:216\u201323.","journal-title":"Med Decis Mak"},{"key":"981_CR13","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/pr.2017.134","volume":"82","author":"PY Iroh Tam","year":"2017","unstructured":"Iroh Tam PY, Bendel CM. Diagnostics for neonatal sepsis: current approaches and future directions. Pediatr Res. 2017;82:574\u201383.","journal-title":"Pediatr Res"},{"key":"981_CR14","unstructured":"Kaiser Permanente Sepsis Calculator. https:\/\/neonatalsepsiscalculator.kaiserpermanente.org\/. Accessed June 6 2019."},{"key":"981_CR15","doi-asserted-by":"publisher","first-page":"e1155","DOI":"10.1542\/peds.2010-3464","volume":"128","author":"KM Puopolo","year":"2011","unstructured":"Puopolo KM, Draper D, Wi S, Newman TB, Zupancic J, Lieberman E, et al. Estimating the probability of neonatal early-onset infection on the basis of maternal risk factors. Pediatrics. 2011;128:e1155\u201363.","journal-title":"Pediatrics"},{"key":"981_CR16","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1542\/peds.2013-1689","volume":"133","author":"GJ Escobar","year":"2014","unstructured":"Escobar GJ, Puopolo KM, Wi S, Turk BJ, Kuzniewicz MW, Walsh EM, et al. Stratification of risk of early-onset sepsis in newborns >\/= 34 weeks\u2019 gestation. Pediatrics. 2014;133:30\u20136.","journal-title":"Pediatrics"},{"key":"981_CR17","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1001\/jamapediatrics.2016.4678","volume":"171","author":"MW Kuzniewicz","year":"2017","unstructured":"Kuzniewicz MW, Puopolo KM, Fischer A, Walsh EM, Li S, Newman TB, et al. A quantitative, risk-based approach to the management of neonatal early-onset sepsis. JAMA Pediatr. 2017;171:365\u201371.","journal-title":"JAMA Pediatr"},{"key":"981_CR18","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1093\/qjmed\/hcg122","volume":"96","author":"A Cahan","year":"2003","unstructured":"Cahan A, Gilon D, Manor O, Paltiel O. Probabilistic reasoning and clinical decision-making: do doctors overestimate diagnostic probabilities? QJM. 2003;96:763\u20139.","journal-title":"QJM"},{"key":"981_CR19","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/j.1539-6053.2008.00033.x","volume":"8","author":"G Gigerenzer","year":"2007","unstructured":"Gigerenzer G, Gaissmaier W, Kurz-Milcke E, Schwartz LM, Woloshin S. Helping doctors and patients make sense of health statistics. Psychol Sci Public Interest. 2007;8:53\u201396.","journal-title":"Psychol Sci Public Interest"},{"key":"981_CR20","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1056\/NEJMp1303712","volume":"368","author":"P Croskerry","year":"2013","unstructured":"Croskerry P. From mindless to mindful practice-cognitive bias and clinical decision making. N. Engl J Med. 2013;368:2445\u20138.","journal-title":"N. Engl J Med"},{"key":"981_CR21","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1097\/ACM.0b013e3181ace703","volume":"84","author":"P Croskerry","year":"2009","unstructured":"Croskerry P. A universal model of diagnostic reasoning. Acad Med. 2009;84:1022\u20138.","journal-title":"Acad Med"},{"key":"981_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-14-57","volume":"14","author":"RS Mhaskar","year":"2014","unstructured":"Mhaskar RS, Wao H, Mahony H, Kumar A, Djulbegovic B. Concordance between decision analysis and matching systematic review of randomized controlled trials in assessment of treatment comparisons: a systematic review. BMC Med Inf Decis Mak. 2014;14:57.","journal-title":"BMC Med Inf Decis Mak"},{"key":"981_CR23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1136\/ebmed-2014-110140","volume":"20","author":"MH Ebell","year":"2015","unstructured":"Ebell MH, Locatelli I, Senn N. A novel approach to the determination of clinical decision thresholds. Evid Based Med. 2015;20:41\u20137.","journal-title":"Evid Based Med"},{"key":"981_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-10-20","volume":"10","author":"MV Boland","year":"2010","unstructured":"Boland MV, Lehmann HP. A new method for determining physician decision thresholds using empiric, uncertain recommendations. BMC Med Inf Decis Mak. 2010;10:20.","journal-title":"BMC Med Inf Decis Mak"},{"key":"981_CR25","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1086\/420741","volume":"38","author":"JE Fischer","year":"2004","unstructured":"Fischer JE, Harbarth S, Agthe AG, Benn A, Ringer SA, Goldmann DA, et al. Quantifying uncertainty: physicians\u2019 estimates of infection in critically ill neonates and children. Clin Infect Dis. 2004;38:1383\u201390.","journal-title":"Clin Infect Dis"},{"key":"981_CR26","first-page":"200","volume":"92","author":"J Burkell","year":"2004","unstructured":"Burkell J. What are the chances? Evaluating risk and benefit information in consumer health materials. J Med Libr Assoc. 2004;92:200\u20138.","journal-title":"J Med Libr Assoc"},{"key":"981_CR27","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/j.1553-2712.2004.tb02416.x","volume":"11","author":"MA Phelps","year":"2004","unstructured":"Phelps MA, Levitt MA. Pretest probability estimates: a pitfall to the clinical utility of evidence-based medicine? Acad Emerg Med. 2004;11:692\u20134.","journal-title":"Acad Emerg Med"},{"key":"981_CR28","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0002-9343(92)90100-P","volume":"92","author":"L Forrow","year":"1992","unstructured":"Forrow L, Taylor WC, Arnold RM. Absolutely relative: how research results are summarized can affect treatment decisions. Am J Med. 1992;92:121\u20134.","journal-title":"Am J Med"},{"key":"981_CR29","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ijchp.2014.12.001","volume":"15","author":"SC Evans","year":"2015","unstructured":"Evans SC, Roberts MC, Keeley JW, Blossom JB, Amaro CM, Garcia AM, et al. Vignette methodologies for studying clinicians\u2019 decision-making: validity, utility, and application in ICD-11 field studies. Int J Clin Health Psychol. 2015;15:160\u201370.","journal-title":"Int J Clin Health Psychol"},{"key":"981_CR30","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.clp.2014.10.007","volume":"42","author":"CM Cotten","year":"2015","unstructured":"Cotten CM. Antibiotic stewardship: reassessment of guidelines for management of neonatal sepsis. Clin Perinatol. 2015;42:195\u2013206.","journal-title":"Clin Perinatol"},{"key":"981_CR31","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1001\/jamapediatrics.2019.2825","volume":"173","author":"NB Achten","year":"2019","unstructured":"Achten NB, Klingenberg C, Benitz WE, Stocker M, Schlapbach LJ, Giannoni E, et al. Association of use of the neonatal early-onset sepsis calculator with reduction in antibiotic therapy and safety: a systematic review and meta-analysis. JAMA Pediatr. 2019;173:1032\u201340.","journal-title":"JAMA Pediatr"},{"key":"981_CR32","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1111\/j.0887-378X.2004.00327.x","volume":"82","author":"RL Kravitz","year":"2004","unstructured":"Kravitz RL, Duan N, Braslow J. Evidence-based medicine, heterogeneity of treatment effects, and the trouble with averages. Milbank Q. 2004;82:661\u201387.","journal-title":"Milbank Q"},{"key":"981_CR33","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1136\/archdischild-2019-317165","volume":"105","author":"R Morris","year":"2020","unstructured":"Morris R, Jones S, Banerjee S, Collinson A, Hagan H, Walsh H, et al. Comparison of the management recommendations of the Kaiser Permanente neonatal early-onset sepsis risk calculator (SRC) with NICE guideline CG149 in infants >\/=34 weeks\u2019 gestation who developed early-onset sepsis. Arch Dis Child Fetal Neonatal Ed. 2020;105:581\u20136.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"981_CR34","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1177\/1062860605274520","volume":"20","author":"J Veloski","year":"2005","unstructured":"Veloski J, Tai S, Evans AS, Nash DB. Clinical vignette-based surveys: a tool for assessing physician practice variation. Am J Med Qual. 2005;20:151\u20137.","journal-title":"Am J Med Qual"},{"key":"981_CR35","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.5993\/AJHB.31.s1.7","volume":"31","author":"A Fagerlin","year":"2007","unstructured":"Fagerlin A, Ubel PA, Smith DM, Zikmund-Fisher BJ. Making numbers matter: present and future research in risk communication. Am J Health Behav. 2007;31:S47\u201356.","journal-title":"Am J Health Behav"},{"key":"981_CR36","doi-asserted-by":"publisher","first-page":"ii13","DOI":"10.1093\/ndt\/gfw465","volume":"32","author":"M Noordzij","year":"2017","unstructured":"Noordzij M, van Diepen M, Caskey FC, Jager KJ. Relative risk versus absolute risk: one cannot be interpreted without the other. Nephrol Dial Transpl. 2017;32:ii13\u201318.","journal-title":"Nephrol Dial Transpl"},{"key":"981_CR37","doi-asserted-by":"publisher","first-page":"836","DOI":"10.7326\/M16-0577","volume":"164","author":"K Bibbins-Domingo","year":"2016","unstructured":"Bibbins-Domingo K, Force USPST. Aspirin use for the primary prevention of cardiovascular disease and colorectal cancer: U.S. preventive services task force recommendation statement. Ann Intern Med. 2016;164:836\u201345.","journal-title":"Ann Intern Med"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41372-021-00981-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41372-021-00981-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41372-021-00981-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:32:05Z","timestamp":1684618325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41372-021-00981-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["981"],"URL":"https:\/\/doi.org\/10.1038\/s41372-021-00981-3","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"type":"print","value":"0743-8346"},{"type":"electronic","value":"1476-5543"}],"subject":[],"published":{"date-parts":[[2021,3,1]]},"assertion":[{"value":"11 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}