{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:06:40Z","timestamp":1774397200252,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["RO1HD67270"],"award-info":[{"award-number":["RO1HD67270"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD067270"],"award-info":[{"award-number":["R01HD067270"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD067270"],"award-info":[{"award-number":["R01HD067270"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD067270"],"award-info":[{"award-number":["R01HD067270"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1038\/s41372-021-01003-y","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T08:03:51Z","timestamp":1614585831000},"page":"2408-2416","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of maternal fertility status and receipt of fertility treatment with healthcare utilization in infants up to age four"],"prefix":"10.1038","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3327-2996","authenticated-orcid":false,"given":"Dmitry","family":"Dukhovny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2661-4049","authenticated-orcid":false,"given":"Sunah S.","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daksha","family":"Gopal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1185-8331","authenticated-orcid":false,"given":"Howard J.","family":"Cabral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3654-9674","authenticated-orcid":false,"given":"Hafsatou","family":"Diop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7672-3913","authenticated-orcid":false,"given":"Judy E.","family":"Stern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"1003_CR1","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.fertnstert.2018.06.039","volume":"110","author":"GD Adamson","year":"2018","unstructured":"Adamson GD, de Mouzon J, Chambers GM, Zegers-Hochschild F, Mansour R, Ishihara O. et al. International Committee for Monitoring Assisted Reproductive Technology: world report on assisted reproductive technology, 2011. Fertil Steril. 2018;110:1067\u201379. https:\/\/doi.org\/10.1016\/j.fertnstert.2018.06.039.","journal-title":"Fertil Steril"},{"key":"1003_CR2","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1056\/NEJMoa010035","volume":"346","author":"M Hansen","year":"2002","unstructured":"Hansen M, Kurinczuk JJ, Bower C, Webb S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N. Engl J Med. 2002;346:725\u201330.","journal-title":"N. Engl J Med"},{"key":"1003_CR3","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1136\/bmj.37957.560278.EE","volume":"328","author":"FM Helmerhorst","year":"2004","unstructured":"Helmerhorst FM, Perquin DAM, Donker D, Keirse JNC. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ. 2004;328:261\u20136.","journal-title":"BMJ"},{"key":"1003_CR4","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1093\/humrep\/deh593","volume":"20","author":"M Hansen","year":"2005","unstructured":"Hansen M, Bower C, Milne E, de Klerk N, Kurinczuk JJ. Assisted reproductive technologies and the risk of birth defects\u2014a systematic review. Hum Reprod. 2005;20:328\u201338.","journal-title":"Hum Reprod"},{"key":"1003_CR5","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1093\/humrep\/den387","volume":"24","author":"J Reefhuis","year":"2009","unstructured":"Reefhuis J, Honein MA, Schieve LA, Correa A, Hobbs CA, Rasmussen SA.the National Birth Defects Prevention Study. Assisted reproductive technology and major structural birth defects in the United States. Hum Reprod. 2009;24:360\u20136.","journal-title":"Hum Reprod"},{"key":"1003_CR6","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1016\/j.fertnstert.2008.08.080","volume":"92","author":"D El-Chaar","year":"2009","unstructured":"El-Chaar D, Yang Q, Gao J, Bottomley J, Leader A, Wen SW, et al. Risk of birth defects increased in pregnancies conceived by assisted human reproduction. Fertil Steril. 2009;92:1557\u201361.","journal-title":"Fertil Steril"},{"key":"1003_CR7","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1097\/01.AOG.0000127037.12652.76","volume":"103","author":"LA Schieve","year":"2004","unstructured":"Schieve LA, Ferre C, Peterson HB, Macaluso M, Reynolds MA, Wright VC. Perinatal outcome among singleton infants conceived through assisted reproductive technology in the United States. Obstet Gynecol. 2004;103:1144\u201311538.","journal-title":"Obstet Gynecol"},{"key":"1003_CR8","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0140-6736(07)60456-5","volume":"370","author":"AG Sutcliffe","year":"2007","unstructured":"Sutcliffe AG, Ludwig M. Outcome of assisted reproduction. Lancet. 2007;370:351\u20139.","journal-title":"Lancet."},{"key":"1003_CR9","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.fertnstert.2010.07.1075","volume":"95","author":"AK Henningsen","year":"2011","unstructured":"Henningsen AK, Pinborg A, Lidegaard O, Vestergaard C, Forman JL, Andersen AN. Perinatal outcome of singleton siblings born after assisted reproductive technology and spontaneous conception: Danish national sibling cohort study. Fertil Steril. 2011;95:959\u201363.","journal-title":"Fertil Steril"},{"key":"1003_CR10","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/humupd\/dms044","volume":"19","author":"A Pinborg","year":"2013","unstructured":"Pinborg A, Wennerholm UB, Romundstad LB, Loft A, Aittomaki K, Soderstrom-Antilla V, et al. Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis. Hum Reprod Update. 2013;19:87\u2013104.","journal-title":"Hum Reprod Update"},{"key":"1003_CR11","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.fertnstert.2015.01.015","volume":"103","author":"GL Dunetz","year":"2015","unstructured":"Dunetz GL, Holzman C, McKane P, Li C, Boulet SL, Todem D, et al. Assisted reproductive technology and the risk of preterm birth among primiparas. Fertil Steril. 2015;103:974\u20139. https:\/\/doi.org\/10.1016\/j.fertnstert.2015.01.015.","journal-title":"Fertil Steril"},{"key":"1003_CR12","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1111\/apa.13880","volume":"106","author":"TNK Raju","year":"2017","unstructured":"Raju TNK, Buist AS, Blaisdell CJ, Moxey-Mims M, Saigal S. Adults born preterm: a review of general health and system-specific outcomes. Acta Paediatr. 2017;106:1409\u201337. https:\/\/doi.org\/10.1111\/apa.13880.","journal-title":"Acta Paediatr"},{"key":"1003_CR13","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.fertnstert.2014.12.119","volume":"103","author":"E Declercq","year":"2015","unstructured":"Declercq E, Luke B, Belanoff C, Cabral H, Diop H, Gopal D, et al. Perinatal outcomes associated with assisted reproductive technology: the Massachusetts outcomes study of assisted reproductive technologies (MOSART). Fertil Steril. 2015;103:888\u201395.","journal-title":"Fertil Steril"},{"key":"1003_CR14","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.ajog.2017.03.012","volume":"217","author":"B Luke","year":"2017","unstructured":"Luke B, Gopal D, Cabral H, Stern JE, Diop H. Pregnancy, birth, and infant outcomes by maternal fertility status: the Massachusetts outcomes study of assisted reproductive technology. AM J Obstet Gynecol. 2017;217:e1\u201314.","journal-title":"AM J Obstet Gynecol"},{"key":"1003_CR15","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1017\/S2040174417000228","volume":"8","author":"M Chen","year":"2017","unstructured":"Chen M, Heilbronn LK. The health outcomes of human offspring conceived by assisted reproductive technologies (ART). J Dev Orig Health Dis. 2017;8:388\u2013402.","journal-title":"J Dev Orig Health Dis"},{"key":"1003_CR16","doi-asserted-by":"publisher","unstructured":"Bergh C, Wennerholm UB. Long-term health of children conceived after assisted reproductive technology. J Med Sci. 2020:125. https:\/\/doi.org\/10.1080\/03009734.2020.1729904.","DOI":"10.1080\/03009734.2020.1729904"},{"key":"1003_CR17","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1093\/humrep\/deg257","volume":"18","author":"A Pinborg","year":"2003","unstructured":"Pinborg A, Loft A, Schmidt L, Andersen AN. Morbidity in a Danish National cohort of 472 IVF\/ICSI twins, 1132 non-IVF\/ICSI twins and 634 IVF\/ICSI singletons: health-related and social implications for the children and their families. Hum Reprod. 2003;18:1234\u201343.","journal-title":"Hum Reprod"},{"key":"1003_CR18","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1111\/andr.12369","volume":"5","author":"SR Catford","year":"2017","unstructured":"Catford SR, McLachlan RI, O\u2019Bryan MK, Halliday JL. Long-term follow-up of intra-cytoplasmic sperm injection conceived offspring compared with in vitro fertilization-conceived offspring: a systematic review of health outcomes beyond the neonatal period. Andrology. 2017;5:610\u201321.","journal-title":"Andrology"},{"key":"1003_CR19","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1093\/humrep\/dey246","volume":"33","author":"H Zandstra","year":"2018","unstructured":"Zandstra H, Brentjens LBPM, Spauwen B, Touwslager RNH, Bons JAP, Mulder AL, et al. Association of culture medium with growth, weight and cardiovascular development of IVF children at the age of 9 years. Hum Reprod. 2018;33:1645\u201356.","journal-title":"Hum Reprod"},{"key":"1003_CR20","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.fertnstert.2019.01.035","volume":"111","author":"M Heijligers","year":"2019","unstructured":"Heijligers M, Peeters A, van Montfoort A, Nijsten J, Janssen E, Gunnewiek FK, et al. Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis. Fertil Steril. 2019;111:1151\u20138.","journal-title":"Fertil Steril"},{"key":"1003_CR21","doi-asserted-by":"publisher","first-page":"e20174069","DOI":"10.1542\/peds.2017-4069","volume":"142","author":"SS Hwang","year":"2018","unstructured":"Hwang SS, Dukhovny D, Gopal D, Cabral H, Missmer SA, Diop H, et al. Health of infants following ART-treated, subfertile and fertile deliveries in Massachusetts. Pediatrics. 2018;142:e20174069. https:\/\/doi.org\/10.1542\/peds.2017-4069.","journal-title":"Pediatrics"},{"key":"1003_CR22","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1007\/s10995-014-1465-4","volume":"18","author":"M Kotelchuck","year":"2014","unstructured":"Kotelchuck M, Hoang L, Stern JE, Diop H, Belanoff C, Declercq E. The MOSART database: linking the SART CORS clinical database to the population-based Massachusetts PELL reproductive public health data system. Matern Child Health J. 2014;18:2167\u201378.","journal-title":"Matern Child Health J"},{"key":"1003_CR23","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.fertnstert.2013.10.028","volume":"101","author":"ER Declercq","year":"2014","unstructured":"Declercq ER, Belanoff C, Diop H, Gopal D, Hornstein MD, Kotelchuk M, et al. Identifying women with indicators of subfertility in a statewide population database: operationalizing the missing link in assisted reproductive technology research. Fertil Steril. 2014;101:463\u201371.","journal-title":"Fertil Steril"},{"key":"1003_CR24","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.fertnstert.2017.06.005","volume":"108","author":"F Zegers-Hochschild","year":"2017","unstructured":"Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, de Mouzon J, Sokol R, et al. The international glossary on infertility and fertility care, 2017. Fertil Steril. 2017;108:393\u2013406.","journal-title":"Fertil Steril"},{"key":"1003_CR25","doi-asserted-by":"publisher","unstructured":"Dukhovny D, Hwang SS, Gopal D, Cabral H, Missmer S, Diop H, et al. Length of stay and cost of birth hospitalization: effects of subfertility and ART. JPerinatol. 2018. https:\/\/doi.org\/10.1038\/s41372-018-0205-9.","DOI":"10.1038\/s41372-018-0205-9"},{"key":"1003_CR26","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1007\/s10815-019-01562-2","volume":"36","author":"JE Stern","year":"2019","unstructured":"Stern JE, Liu CL, Cabral H, Gopal D, Harvey E, Missmer SA, et al. Hospitalization before and after delivery in fertile, subfertile, and ART-treated women. JARG. 2019;36:1989\u201397. https:\/\/doi.org\/10.1007\/s10815-019-01562-2.","journal-title":"JARG."},{"key":"1003_CR27","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.1093\/humrep\/dep273","volume":"24","author":"M Ceelen","year":"2009","unstructured":"Ceelen M, van Weissenbruch MM, Prein J, Smit JJ, Vermeiden JPW, Spreeuwenberg M. et al. Growth during infancy and early childhood in relation to blood pressure and body fat measures at age 8\u201318 years of IVF children and spontaneously conceived controls born to subfertile parents. Hum Reprod. 2009;24:2788\u201395. https:\/\/academic.oup.com\/humrep\/article\/24\/11\/2788\/627120.","journal-title":"Hum Reprod"},{"key":"1003_CR28","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/humupd\/dms062","volume":"19","author":"R Hart","year":"2013","unstructured":"Hart R, Norman RJ. The longer-term health outcomes for children born as a result of IVF treatment: part I\u2013General health outcomes. Hum Reprod Update. 2013;19:232\u201343. https:\/\/academic.oup.com\/humupd\/article\/19\/3\/232\/727781","journal-title":"Hum Reprod Update"},{"key":"1003_CR29","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1542\/peds.111.5.1024","volume":"111","author":"S Dovey","year":"2003","unstructured":"Dovey S, Weitzman M, Fryer G, Green, Lawn B, Lanier D, et al. The ecology of medical care for children in the United States. Pediatrics. 2003;111:1024\u20139. https:\/\/pediatrics.aappublications.org\/content\/111\/5\/1024.","journal-title":"Pediatrics"},{"key":"1003_CR30","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1367\/A04-119R.1","volume":"5","author":"L Simpson","year":"2005","unstructured":"Simpson L, Owens PL, Zodet MW, Chevarley FM, Dougherty D, Elixhauser A, et al. Health care for children and youth in the United States: annual report on patterns of coverage, utilization, quality, and expenditures by income. Ambul Pediatr. 2005;5:6\u201344. https:\/\/doi.org\/10.1367\/A04-119R.1.","journal-title":"Ambul Pediatr."},{"key":"1003_CR31","doi-asserted-by":"crossref","unstructured":"Srebnik N, Miron-Shatz T, Rolison JJ, Hanoch Y, Tsafrir A. Physician recommendation for invasive prenatal testing: the case of the\u2019precious baby. Human Reprod. 2013;28:3007\u201311.","DOI":"10.1093\/humrep\/det354"},{"key":"1003_CR32","doi-asserted-by":"publisher","unstructured":"Bacal V, Russo M, Fell DB, Shapiro H, Walker M, Gaudet LM. A systematic review of database validation studies among fertility populations. Hum Reprod Open. 2019; 1\u201314. https:\/\/doi.org\/10.1093\/hropen\/hoz010.","DOI":"10.1093\/hropen\/hoz010"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41372-021-01003-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-021-01003-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-021-01003-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T09:56:23Z","timestamp":1635155783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41372-021-01003-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["1003"],"URL":"https:\/\/doi.org\/10.1038\/s41372-021-01003-y","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,1]]},"assertion":[{"value":"26 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}