{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:20:24Z","timestamp":1793110824034,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1038\/s41372-021-01030-9","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T09:11:24Z","timestamp":1615540284000},"page":"2337-2344","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Maximum vasoactive-inotropic score and mortality in extremely premature, extremely low birth weight infants"],"prefix":"10.1038","volume":"41","author":[{"given":"Khyzer B.","family":"Aziz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8829-4979","authenticated-orcid":false,"given":"Orlyn C.","family":"Lavilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-4836","authenticated-orcid":false,"given":"James L.","family":"Wynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison C.","family":"Lure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gipson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9508-5507","authenticated-orcid":false,"given":"Diomel","family":"de la Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"key":"1030_CR1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jpeds.2019.08.028","volume":"217","author":"PL Watkins","year":"2020","unstructured":"Watkins PL, Dagle JM, Bell EF, Colaizy TT. Outcomes at 18 to 22 months of corrected age for infants born at 22 to 25 weeks of gestation in a center practicing active management. J Pediatr. 2020;217:52\u20138.e1.","journal-title":"J Pediatr"},{"key":"1030_CR2","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1001\/jama.2015.10244","volume":"314","author":"BJ Stoll","year":"2015","unstructured":"Stoll BJ, Hansen NI, Bell EF, Walsh MC, Carlo WA, Shankaran S, et al. Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993\u20132012. JAMA. 2015;314:1039\u201351.","journal-title":"JAMA"},{"key":"1030_CR3","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1056\/NEJMoa1403489","volume":"372","author":"RM Patel","year":"2015","unstructured":"Patel RM, Kandefer S, Walsh MC, Bell EF, Carlo WA, Laptook AR, et al. Causes and timing of death in extremely premature infants from 2000 through 2011. N Engl J Med. 2015;372:331\u201340.","journal-title":"N Engl J Med"},{"key":"1030_CR4","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s00246-012-0193-z","volume":"33","author":"RJ Butts","year":"2012","unstructured":"Butts RJ, Scheurer MA, Atz AM, Zyblewski SC, Hulsey TC, Bradley SM, et al. Comparison of maximum vasoactive inotropic score and low cardiac output syndrome as markers of early postoperative outcomes after neonatal cardiac surgery. Pediatr Cardiol. 2012;33:633\u20138.","journal-title":"Pediatr Cardiol"},{"key":"1030_CR5","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1161\/01.CIR.92.8.2226","volume":"92","author":"G Wernovsky","year":"1995","unstructured":"Wernovsky G, Wypij D, Jonas RA, Mayer JE Jr., Hanley FL, Hickey PR, et al. Postoperative course and hemodynamic profile after the arterial switch operation in neonates and infants. A comparison of low-flow cardiopulmonary bypass and circulatory arrest. Circulation. 1995;92:2226\u201335.","journal-title":"Circulation"},{"key":"1030_CR6","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1097\/PCC.0b013e3181b806fc","volume":"11","author":"MG Gaies","year":"2010","unstructured":"Gaies MG, Gurney JG, Yen AH, Napoli ML, Gajarski RJ, Ohye RG, et al. Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatr Crit Care Med. 2010;11:234\u20138.","journal-title":"Pediatr Crit Care Med"},{"key":"1030_CR7","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/PCC.0000000000000153","volume":"15","author":"MG Gaies","year":"2014","unstructured":"Gaies MG, Jeffries HE, Niebler RA, Pasquali SK, Donohue JE, Yu S, et al. Vasoactive-inotropic score is associated with outcome after infant cardiac surgery: an analysis from the Pediatric Cardiac Critical Care Consortium and Virtual PICU System Registries. Pediatr Crit Care Med. 2014;15:529\u201337.","journal-title":"Pediatr Crit Care Med"},{"key":"1030_CR8","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1097\/PCC.0000000000001191","volume":"18","author":"AM McIntosh","year":"2017","unstructured":"McIntosh AM, Tong S, Deakyne SJ, Davidson JA, Scott HF. Validation of the vasoactive-inotropic score in pediatric sepsis. Pediatr Crit Care Med. 2017;18:750\u20137.","journal-title":"Pediatr Crit Care Med"},{"key":"1030_CR9","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1007\/s00134-012-2544-x","volume":"38","author":"J Davidson","year":"2012","unstructured":"Davidson J, Tong S, Hancock H, Hauck A, da Cruz E, Kaufman J. Prospective validation of the vasoactive-inotropic score and correlation to short-term outcomes in neonates and infants after cardiothoracic surgery. Intensive Care Med. 2012;38:1184\u201390.","journal-title":"Intensive Care Med"},{"key":"1030_CR10","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.jpainsymman.2016.12.333","volume":"53","author":"DA Brand","year":"2017","unstructured":"Brand DA, Patrick PA, Berger JT, Ibrahim M, Matela A, Upadhyay S, et al. Intensity of vasopressor therapy for septic shock and the risk of in-hospital death. J Pain Symptom Manag. 2017;53:938\u201343.","journal-title":"J Pain Symptom Manag"},{"key":"1030_CR11","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1053\/j.semperi.2015.12.005","volume":"40","author":"RE Giesinger","year":"2016","unstructured":"Giesinger RE, McNamara PJ. Hemodynamic instability in the critically ill neonate: an approach to cardiovascular support based on disease pathophysiology. Semin Perinatol. 2016;40:174\u201388.","journal-title":"Semin Perinatol"},{"key":"1030_CR12","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s13312-015-0630-1","volume":"52","author":"A Haque","year":"2015","unstructured":"Haque A, Siddiqui NR, Munir O, Saleem S, Mian A. Association between vasoactive-inotropic score and mortality in pediatric septic shock. Indian Pediatr. 2015;52:311\u20133.","journal-title":"Indian Pediatr"},{"key":"1030_CR13","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.clp.2008.09.003","volume":"36","author":"EM Dempsey","year":"2009","unstructured":"Dempsey EM, Barrington KJ. Evaluation and treatment of hypotension in the preterm infant. Clin Perinatol. 2009;36:75\u201385.","journal-title":"Clin Perinatol"},{"key":"1030_CR14","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/S0022-3476(05)82418-7","volume":"119","author":"RD Uauy","year":"1991","unstructured":"Uauy RD, Fanaroff AA, Korones SB, Phillips EA, Phillips JB, Wright LL. Necrotizing enterocolitis in very low birth weight infants: biodemographic and clinical correlates. National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr. 1991;119:630\u20138.","journal-title":"J Pediatr"},{"key":"1030_CR15","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/S0022-3468(98)90475-4","volume":"33","author":"EE Adderson","year":"1998","unstructured":"Adderson EE, Pappin A, Pavia AT. Spontaneous intestinal perforation in premature infants: a distinct clinical entity associated with systemic candidiasis. J Pediatr Surg. 1998;33:1463\u20137.","journal-title":"J Pediatr Surg"},{"key":"1030_CR16","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0031-3955(16)34975-6","volume":"33","author":"MC Walsh","year":"1986","unstructured":"Walsh MC, Kliegman RM. Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am. 1986;33:179\u2013201.","journal-title":"Pediatr Clin North Am"},{"key":"1030_CR17","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/01.PCC.0000149131.72248.E6","volume":"6","author":"B Goldstein","year":"2005","unstructured":"Goldstein B, Giroir B, Randolph A. International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6:2\u20138.","journal-title":"Pediatr Crit Care Med"},{"key":"1030_CR18","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315:801\u201310.","journal-title":"JAMA"},{"key":"1030_CR19","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1097\/PCC.0b013e31816689a8","volume":"9","author":"E Kermorvant-Duchemin","year":"2008","unstructured":"Kermorvant-Duchemin E, Laborie S, Rabilloud M, Lapillonne A, Claris O. Outcome and prognostic factors in neonates with septic shock. Pediatr Crit Care Med. 2008;9:186\u201391.","journal-title":"Pediatr Crit Care Med"},{"key":"1030_CR20","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.clp.2017.02.001","volume":"44","author":"A El-Khuffash","year":"2017","unstructured":"El-Khuffash A, McNamara PJ. Hemodynamic assessment and monitoring of premature infants. Clin Perinatol. 2017;44:377\u201393.","journal-title":"Clin Perinatol"},{"key":"1030_CR21","first-page":"151","volume":"16","author":"M Vento","year":"2015","unstructured":"Vento M, Lista G. Managing preterm infants in the first minutes of life. Paediatr Respir Rev. 2015;16:151\u20136.","journal-title":"Paediatr Respir Rev"},{"key":"1030_CR22","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1038\/sj.jp.7211464","volume":"26","author":"I Seri","year":"2006","unstructured":"Seri I. Management of hypotension and low systemic blood flow in the very low birth weight neonate during the first postnatal week. J Perinatol. 2006;26:S8\u201313. discussion S22-13","journal-title":"J Perinatol"},{"key":"1030_CR23","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1542\/peds.2004-1396","volume":"115","author":"A Pellicer","year":"2005","unstructured":"Pellicer A, Valverde E, Elorza MD, Madero R, Gaya F, Quero J, et al. Cardiovascular support for low birth weight infants and cerebral hemodynamics: a randomized, blinded, clinical trial. Pediatrics. 2005;115:1501\u201312.","journal-title":"Pediatrics"},{"key":"1030_CR24","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1053\/siny.2000.0034","volume":"6","author":"I Seri","year":"2001","unstructured":"Seri I. Circulatory support of the sick preterm infant. Semin Neonatol. 2001;6:85\u201395.","journal-title":"Semin Neonatol"},{"key":"1030_CR25","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1159\/000180113","volume":"95","author":"J Kuint","year":"2009","unstructured":"Kuint J, Barak M, Morag I, Maayan-Metzger A. Early treated hypotension and outcome in very low birth weight infants. Neonatology. 2009;95:311\u20136.","journal-title":"Neonatology"},{"key":"1030_CR26","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.5152\/TurkPediatriArs.2018.01801","volume":"53","author":"D Dilli","year":"2018","unstructured":"Dilli D, Soylu H, Tekin N. Neonatal hemodynamics and management of hypotension in newborns. Turk Pediatr Ars. 2018;53:S65\u201375.","journal-title":"Turk Pediatr Ars"},{"key":"1030_CR27","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.siny.2010.05.001","volume":"16","author":"AF El-Khuffash","year":"2011","unstructured":"El-Khuffash AF, McNamara PJ. Neonatologist-performed functional echocardiography in the neonatal intensive care unit. Semin Fetal Neonatal Med. 2011;16:50\u201360.","journal-title":"Semin Fetal Neonatal Med"},{"key":"1030_CR28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1055\/s-0034-1368090","volume":"4","author":"DE Weisz","year":"2014","unstructured":"Weisz DE, Poon WB, James A, McNamara PJ. Low cardiac output secondary to a malpositioned umbilical venous catheter: value of targeted neonatal echocardiography. AJP Rep. 2014;4:23\u20138.","journal-title":"AJP Rep"},{"key":"1030_CR29","doi-asserted-by":"publisher","first-page":"i3","DOI":"10.1093\/bja\/aep299","volume":"103","author":"JM Murkin","year":"2009","unstructured":"Murkin JM, Arango M. Near-infrared spectroscopy as an index of brain and tissue oxygenation. Br J Anaesth. 2009;103:i3\u201313.","journal-title":"Br J Anaesth"},{"key":"1030_CR30","doi-asserted-by":"publisher","first-page":"F340","DOI":"10.1136\/fetalneonatal-2011-301090","volume":"97","author":"S Noori","year":"2012","unstructured":"Noori S, Drabu B, Soleymani S, Seri I. Continuous non-invasive cardiac output measurements in the neonate by electrical velocimetry: a comparison with echocardiography. Arch Dis Child Fetal Neonatal Ed. 2012;97:F340\u20133.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"1030_CR31","first-page":"470","volume":"15","author":"AB Zubrow","year":"1995","unstructured":"Zubrow AB, Hulman S, Kushner H, Falkner B. Determinants of blood pressure in infants admitted to neonatal intensive care units: a prospective multicenter study. Philadelphia Neonatal Blood Pressure Study Group. J Perinatol. 1995;15:470\u20139.","journal-title":"J Perinatol"},{"key":"1030_CR32","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/jp.2014.6","volume":"34","author":"B Batton","year":"2014","unstructured":"Batton B, Li L, Newman NS, Das A, Watterberg KL, Yoder BA, et al. Evolving blood pressure dynamics for extremely preterm infants. J Perinatol. 2014;34:301\u20135.","journal-title":"J Perinatol"},{"key":"1030_CR33","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.clp.2011.12.010","volume":"39","author":"S Noori","year":"2012","unstructured":"Noori S, Seri I. Neonatal blood pressure support: the use of inotropes, lusitropes, and other vasopressor agents. Clin Perinatol. 2012;39:221\u201338.","journal-title":"Clin Perinatol"},{"key":"1030_CR34","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41390-019-0517-2","volume":"88","author":"JL Wynn","year":"2020","unstructured":"Wynn JL, Polin RA. A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants. Pediatr Res. 2020;88:85\u201390.","journal-title":"Pediatr Res"},{"key":"1030_CR35","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1542\/peds.2011-2820","volume":"130","author":"SA Lorch","year":"2012","unstructured":"Lorch SA, Baiocchi M, Ahlberg CE, Small DS. The differential impact of delivery hospital on the outcomes of premature infants. Pediatrics. 2012;130:270\u20138.","journal-title":"Pediatrics"},{"key":"1030_CR36","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1542\/peds.106.5.1070","volume":"106","author":"SK Lee","year":"2000","unstructured":"Lee SK, McMillan DD, Ohlsson A, Pendray M, Synnes A, Whyte R, et al. Variations in practice and outcomes in the Canadian NICU network: 1996\u20131997. Pediatrics. 2000;106:1070\u20139.","journal-title":"Pediatrics"},{"key":"1030_CR37","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/sj.jp.7211263","volume":"25","author":"PJ McNamara","year":"2005","unstructured":"McNamara PJ, Mak W, Whyte HE. Dedicated neonatal retrieval teams improve delivery room resuscitation of outborn premature infants. J Perinatol. 2005;25:309\u201314.","journal-title":"J Perinatol"},{"key":"1030_CR38","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1542\/peds.2009-2959","volume":"126","author":"BJ Stoll","year":"2010","unstructured":"Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. 2010;126:443\u201356.","journal-title":"Pediatrics"},{"key":"1030_CR39","doi-asserted-by":"crossref","unstructured":"Osborn DA, Evans N. Early volume expansion for prevention of morbidity and mortality in very preterm infants. Cochrane Database Syst Rev. 2004;2004:CD002055.","DOI":"10.1002\/14651858.CD002055.pub2"},{"key":"1030_CR40","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1159\/000357553","volume":"105","author":"EM Dempsey","year":"2014","unstructured":"Dempsey EM, Barrington KJ, Marlow N, O\u2019Donnell CP, Miletin J, Naulaers G, et al. Management of hypotension in preterm infants (The HIP Trial): a randomised controlled trial of hypotension management in extremely low gestational age newborns. Neonatology. 2014;105:275\u201381.","journal-title":"Neonatology"},{"key":"1030_CR41","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/sj.jp.7211579","volume":"26","author":"EM Dempsey","year":"2006","unstructured":"Dempsey EM, Barrington KJ. Diagnostic criteria and therapeutic interventions for the hypotensive very low birth weight infant. J Perinatol. 2006;26:677\u201381.","journal-title":"J Perinatol"},{"key":"1030_CR42","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1542\/peds.2006-1138","volume":"119","author":"M Laughon","year":"2007","unstructured":"Laughon M, Bose C, Allred E, O\u2019Shea TM, Van Marter LJ, Bednarek F, et al. Factors associated with treatment for hypotension in extremely low gestational age newborns during the first postnatal week. Pediatrics. 2007;119:273\u201380.","journal-title":"Pediatrics"},{"key":"1030_CR43","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/sj.jp.7211774","volume":"27","author":"EM Dempsey","year":"2007","unstructured":"Dempsey EM, Barrington KJ. Treating hypotension in the preterm infant: when and with what: a critical and systematic review. J Perinatol. 2007;27:469\u201378.","journal-title":"J Perinatol"},{"key":"1030_CR44","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1159\/000452616","volume":"111","author":"D St Peter","year":"2017","unstructured":"St Peter D, Gandy C, Hoffman SB. Hypotension and adverse outcomes in prematurity: comparing definitions. Neonatology. 2017;111:228\u201333.","journal-title":"Neonatology"},{"key":"1030_CR45","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/s41372-020-0628-y","volume":"40","author":"S Gogcu","year":"2020","unstructured":"Gogcu S, Washburn L, O\u2019Shea TM. Treatment for hypotension in the first 24 postnatal hours and the risk of hearing loss among extremely low birth weight infants. J Perinatol. 2020;40:774\u201380.","journal-title":"J Perinatol"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41372-021-01030-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-021-01030-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-021-01030-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T15:05:14Z","timestamp":1631631914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41372-021-01030-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,12]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["1030"],"URL":"https:\/\/doi.org\/10.1038\/s41372-021-01030-9","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,12]]},"assertion":[{"value":"19 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Institutional Review Board at the University Of Florida (IRB201902780). The study was performed in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}