{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:30:37Z","timestamp":1780497037933,"version":"3.54.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1038\/s41372-021-01046-1","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T10:04:19Z","timestamp":1617271459000},"page":"1142-1148","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of standard versus high-dose ibuprofen for the treatment of hemodynamically significant patent ductus arteriosus in preterm infants"],"prefix":"10.1038","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5966-4256","authenticated-orcid":false,"given":"Katelyn","family":"Hillier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlee","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"MacInnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7477-7264","authenticated-orcid":false,"given":"Souvik","family":"Mitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"key":"1046_CR1","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1001\/jama.2018.1896","volume":"319","author":"S Mitra","year":"2018","unstructured":"Mitra S, Florez I, Tamayo M, Mbuagbaw L, Vanniyasingam T, Veroniki A, et al. Association of placebo, indomethacin, ibuprofen, and acetaminophen with closure of hemodynamically significant patent ductus arteriosus in preterm infants: a systematic review and meta-analysis. JAMA. 2018;319:1221\u201338.","journal-title":"JAMA"},{"key":"1046_CR2","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12887-021-02558-7","volume":"21","author":"S Gupta","year":"2021","unstructured":"Gupta, S. et al. \u2018The Baby-OSCAR Collaborative Group\u2019. Study protocol: baby-OSCAR trial: Outcome after Selective early treatment for Closure of patent ductus ARteriosus in preterm babies, a multicentre, masked, randomised placebo-controlled parallel group trial. BMC Pediatr. 2021;21:100.","journal-title":"BMC Pediatr."},{"key":"1046_CR3","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1097\/00005176-200502000-00019","volume":"40","author":"S Dollberg","year":"2005","unstructured":"Dollberg S, Lusky A, Reichman B. Patent ductus arteriosus, indomethacin and necrotizing enterocolitis in very low birth weight infants: a population-based study. J Pediatr Gastroenterol Nutr. 2005;40:184\u20138.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"1046_CR4","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/S0022-3476(79)80454-0","volume":"95","author":"E Brown","year":"1979","unstructured":"Brown E. Increased risk of bronchopulmonary dysplasia in infants with patent ductus arteriosus. J Pediatr. 1979;95:865\u20136.","journal-title":"J Pediatr"},{"key":"1046_CR5","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.earlhumdev.2016.12.008","volume":"104","author":"J Letshwiti","year":"2017","unstructured":"Letshwiti J, Semberova J, Pichova K, Dempsey E, Franklin O, Miletin J, et al. A conservative treatment of patent ductus arteriosus in very low birth weight infants. Early Hum Dev. 2017;104:45\u20139.","journal-title":"Early Hum Dev"},{"key":"1046_CR6","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1111\/chd.12143","volume":"8","author":"S Mitra","year":"2013","unstructured":"Mitra S, Ronnestad A, Holmstrom H. Management of patent ductus arteriosus in preterm infants\u2014where do we stand? Congenit Heart Dis. 2013;8:500\u201312.","journal-title":"Congenit Heart Dis"},{"key":"1046_CR7","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4103\/2249-4847.134670","volume":"3","author":"D Weisz","year":"2014","unstructured":"Weisz D, McNamara P. Patent ductus arteriosus ligation and adverse outcomes: causality or bias? J Clin Neonatol. 2014;3:67\u201375.","journal-title":"J Clin Neonatol"},{"key":"1046_CR8","doi-asserted-by":"crossref","unstructured":"Ohlsson A, Walia R, Shah S. Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birthweight (or both) infants. Cochrane Database Syst Rev. 2020;2:CD003481.","DOI":"10.1002\/14651858.CD003481.pub8"},{"key":"1046_CR9","doi-asserted-by":"publisher","first-page":"e1024","DOI":"10.1542\/peds.2013-3431","volume":"133","author":"D Weisz","year":"2014","unstructured":"Weisz D, More K, McNamara P, Shah P, et al. PDA ligation and health outcomes: a meta-analysis. Pediatrics. 2014;133:e1024\u201346.","journal-title":"Pediatrics"},{"key":"1046_CR10","first-page":"187","volume":"38","author":"V Khuwuthyakorn","year":"2018","unstructured":"Khuwuthyakorn V, Jatuwattana C, Silvilairat S, Tantiprapha W. Oral indomethacin versus oral ibuprofen for treatment of patent ductus arteriosus: a randomised controlled study in very low-birthweight infants. Paediatr Int Child Health. 2018;38:187\u201392.","journal-title":"Paediatr Int Child Health"},{"key":"1046_CR11","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1111\/j.1365-2125.2008.03118.x","volume":"65","author":"D Hirt","year":"2008","unstructured":"Hirt D, Van Overmeire B, Treluyer JM, Langhendries J, Marguglio A, Eisinger M, et al. An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic study. Br J Clin Pharm. 2008;65:629\u201336.","journal-title":"Br J Clin Pharm"},{"key":"1046_CR12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1365-2710.2005.00630.x","volume":"30","author":"L Desfrere","year":"2005","unstructured":"Desfrere L, Zohar S, Morville P, Brunhes A, Chevret S, Pons G, et al. Dose-finding study of ibuprofen in patent ductus arteriosus using the continual reassessment method. J Clin Pharm Ther. 2005;30:121\u201332.","journal-title":"J Clin Pharm Ther"},{"key":"1046_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","volume":"187","author":"M Bell","year":"1978","unstructured":"Bell M, Ternberg J, Feigin R, Keating J, Marshall R, Barton L, et al. Neonatal necrotizing enterocolitis: therapeutic decisions based upon clinical staging. Ann Surg. 1978;187:1\u20137.","journal-title":"Ann Surg"},{"key":"1046_CR14","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","volume":"163","author":"A Jobe","year":"2001","unstructured":"Jobe A, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;163:1723\u20139.","journal-title":"Am J Respir Crit Care Med"},{"key":"1046_CR15","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","volume":"92","author":"L Papile","year":"1978","unstructured":"Papile L, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1500\u2009gm. J Pediatr. 1978;92:529\u201334.","journal-title":"J Pediatr"},{"key":"1046_CR16","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/clpt.2011.284","volume":"91","author":"C Dani","year":"2012","unstructured":"Dani C, Vangi V, Bertini G, Pratesi S, Lori I, Favelli F, et al. High-dose ibuprofen for patent ductus arteriosus in extremely preterm infants: a randomized controlled study. Clin Pharm Ther. 2012;91:590\u20136.","journal-title":"Clin Pharm Ther"},{"key":"1046_CR17","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1055\/s-0035-1551671","volume":"32","author":"S Pourarian","year":"2015","unstructured":"Pourarian S, Takmil F, Cheriki S, Amoozgar H. The effect of oral high-dose ibuprofen on patent ductus arteriosus closure in preterm infants. Am J Perinatol. 2015;32:1158\u201363.","journal-title":"Am J Perinatol"},{"key":"1046_CR18","first-page":"488","volume":"70","author":"H Fesharaki","year":"2012","unstructured":"Fesharaki H, Nayeri F, Asbaq P, Amini E, Sedagat M. Different doses of ibuprofen in the treatment of patent ductus arteriosus: a randomized controlled trial. Tehran Univ Med J. 2012;70:488\u201393.","journal-title":"Tehran Univ Med J"},{"key":"1046_CR19","doi-asserted-by":"publisher","unstructured":"Sung SI, Lee MH, Ahn SY, Chang YS, Park WS. Effect of nonintervention vs. oral ibuprofen in patent ductus arteriosus in preterm infants: a randomized clinical trial. JAMA Pediatr. 2020. https:\/\/doi.org\/10.1001\/jamapediatrics.2020.1447.","DOI":"10.1001\/jamapediatrics.2020.1447"},{"key":"1046_CR20","doi-asserted-by":"publisher","first-page":"e287","DOI":"10.1542\/peds.2008-2232","volume":"124","author":"J Richards","year":"2009","unstructured":"Richards J, Johnson A, Fox G, Campbell M. A second course of ibuprofen is effective in the closure of a clinically significant PDA in ELBW infants. Pediatrics. 2009;124:e287\u2013e293.","journal-title":"Pediatrics"},{"key":"1046_CR21","first-page":"CD010061","volume":"1","author":"A Ohlsson","year":"2020","unstructured":"Ohlsson A, Shah PS. Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. Cochrane Database Syst Rev. 2020;1:CD010061.","journal-title":"Cochrane Database Syst Rev."},{"key":"1046_CR22","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1055\/s-0037-1601442","volume":"34","author":"V Chock","year":"2017","unstructured":"Chock V, Goel V, Palma J, Luh T, Wang N, Gaskari S, et al. Changing management of the patent ductus arteriosus: effect on neonatal outcomes and resource utilization. Am J Perinatol. 2017;34:990\u20135.","journal-title":"Am J Perinatol"},{"key":"1046_CR23","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.siny.2017.07.004","volume":"22","author":"W Benitz","year":"2017","unstructured":"Benitz W, Bhombal S. The use of non-steroidal anti-inflammatory drugs for patent ductus arteriosus closure in preterm infants. Semin Fetal Neonatal Med. 2017;22:302\u20137.","journal-title":"Semin Fetal Neonatal Med"},{"key":"1046_CR24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/chd.12691","volume":"14","author":"K Willis","year":"2018","unstructured":"Willis K, Weems M. Hemodynamically significant patent ductus arteriosus and the development of bronchopulmonary dysplasia. Congenit Heart Dis. 2018;14:27\u201332.","journal-title":"Congenit Heart Dis"},{"key":"1046_CR25","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41372-019-0444-4","volume":"40","author":"X Chen","year":"2020","unstructured":"Chen X, Qiu X, Sun P, Lin Y, Huang Z, Yang C, et al. Neonatal ibuprofen exposure and bronchopulmonary dysplasia in extremely premature infants. J Perinatol. 2020;40:124\u20139.","journal-title":"J Perinatol"},{"key":"1046_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14767058.2019.1667323","volume":"23","author":"J De Klerka","year":"2019","unstructured":"De Klerka J, van Paassen N, van Beynum I, Flint R, Reiss I, Simons S. Ibuprofen treatment after the first days of life in preterm neonates with patent ductus arteriosus. J Matern-Fetal Neonatal Med. 2019;23:1\u20137.","journal-title":"J Matern-Fetal Neonatal Med"},{"key":"1046_CR27","unstructured":"ClinicalTrials.gov. Relative effectiveness and safety of pharmacotherapeutic agents for patent ductus arteriosus (PDA) in preterm infants: a National Comparative Effectiveness Research (CER) Project. Bethesda, MD: National Library of Medicine (US); 2000. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04347720."}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41372-021-01046-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41372-021-01046-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41372-021-01046-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:32:18Z","timestamp":1684618338000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41372-021-01046-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["1046"],"URL":"https:\/\/doi.org\/10.1038\/s41372-021-01046-1","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]},"assertion":[{"value":"1 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}