{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:12:49Z","timestamp":1793059969141,"version":"4.5.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>Glucose-6-phosphate dehydrogenase deficiency (G6PDD) being highly prevalent in the Middle East, the primary objective was to estimate the incidence of neonatal jaundice among G6PD-deficient neonates and to explore its association with various risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study includes 7 years data of neonates diagnosed with G6PDD between 1st January 2015, and 30 September 2022, from Al Wakra Hospital, HMC Qatar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 40,305 total births, 1013 had G6PDD with an incidence of 2.51%. Of all the G6PDD babies, 24.6% (249\/1013) received phototherapy and three babies required exchange transfusion. Statistically significant associations were noted between the need for phototherapy and gestational age, gestational age groups, birth weight, and birth weight groups, but logistic regression analysis showed significant association for phototherapy only with the gestational age group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Universal screening and proper follow-up is essential for G6PDD as it plays crucial role in neonatal jaundice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41372-024-01927-1","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:05:53Z","timestamp":1710338753000},"page":"1035-1041","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Glucose-6-phosphate dehydrogenase deficiency and neonatal indirect hyperbilirubinemia: a retrospective cohort study among 40,305 consecutively born babies"],"prefix":"10.1038","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3760-2422","authenticated-orcid":false,"given":"Rajai Rofail Raja","family":"Al-Bedaywi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil Mohd Khalil","family":"Salameh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarfrazul","family":"Abedin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brijroy","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abedalkhalik Ahmad","family":"Khedr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina Hussain M.","family":"Habboub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"1927_CR1","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/BF00216453","volume":"92","author":"YE Hsia","year":"1993","unstructured":"Hsia YE, Miyakawa F, Baltazar J, Ching NS, Yuen J, Westwood B, et al. Frequency of glucose-6-phosphate dehydrogenase (G6PD) mutations in Chinese, Filipinos, and Laotians from Hawaii. Hum Genet. 1993;92:470\u20136.","journal-title":"Hum Genet"},{"key":"1927_CR2","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1056\/NEJM199101173240306","volume":"324","author":"Beutler","year":"1991","unstructured":"Beutler. Glucose-6-phosphate dehydrogenase deficiency. N Engl J Med. 1991;324:169\u201374.","journal-title":"N Engl J Med"},{"key":"1927_CR3","doi-asserted-by":"publisher","first-page":"3613","DOI":"10.1182\/blood.V84.11.3613.bloodjournal84113613","volume":"84","author":"E Beutler","year":"1994","unstructured":"Beutler E. G6PD deficiency. Blood. 1994;84:3613\u201336.","journal-title":"Blood"},{"key":"1927_CR4","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S0140-6736(08)60073-2","volume":"371","author":"MD Cappellini","year":"2008","unstructured":"Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet (London, England). 2008;371:64\u201374.","journal-title":"Lancet (London, England)"},{"key":"1927_CR5","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.bcmd.2008.12.005","volume":"42","author":"ET Nkhoma","year":"2009","unstructured":"Nkhoma ET, Poole C, Vannappagari V, Hall SA, Beutler E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol Dis. 2009;42:267\u201378.","journal-title":"Blood Cells Mol Dis"},{"key":"1927_CR6","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1182\/blood.2019000944","volume":"136","author":"L Luzzatto","year":"2020","unstructured":"Luzzatto L, Ally M, Notaro R. Glucose-6-phosphate dehydrogenase deficiency. Blood. 2020;136:1225\u201340.","journal-title":"Blood"},{"key":"1927_CR7","doi-asserted-by":"publisher","first-page":"905","DOI":"10.7205\/milmed.171.9.905","volume":"171","author":"TD Chinevere","year":"2006","unstructured":"Chinevere TD, Murray CK, Grant E Jr, Johnson GA, Duelm F, Hospenthal DR. Prevalence of glucose-6-phosphate dehydrogenase deficiency in U.S. Army personnel. Mil Med. 2006;171:905\u20137. https:\/\/doi.org\/10.7205\/milmed.171.9.905.","journal-title":"Mil Med"},{"key":"1927_CR8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/01.JAA.0000586304.65429.a7","volume":"32","author":"SJ Harcke","year":"2019","unstructured":"Harcke SJ, Rizzolo D, Harcke HT. G6PD deficiency: An update. J Am Acad Physician Assist. 2019;32:21\u201326.","journal-title":"J Am Acad Physician Assist"},{"key":"1927_CR9","first-page":"601","volume":"67","author":"E Beutler","year":"1989","unstructured":"Beutler E, Gaetani G, Der Kaloustian V, Luzzatto L, Sodeinde O. Glucose-6-phosphate dehydrogenase deficiency. Bull World Health Organ. 1989;67:601\u201311.","journal-title":"Bull World Health Organ"},{"key":"1927_CR10","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1111\/apa.12735","volume":"103","author":"BO Olusanya","year":"2014","unstructured":"Olusanya BO, Emokpae AA, Zamora TG, Slusher TM. Addressing the burden of neonatal hyperbilirubinaemia in countries with significant glucose-6-phosphate dehydrogenase deficiency. Acta Paediatr. 2014;103:1102\u20139.","journal-title":"Acta Paediatr"},{"key":"1927_CR11","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3345\/kjp.2017.60.4.106","volume":"60","author":"HM Isa","year":"2017","unstructured":"Isa HM, Mohamed MS, Mohamed AM, Abdulla A, Abdulla F. Neonatal indirect hyperbilirubinemia and glucose-6-phosphate dehydrogenase deficiency. Korean J Pediatr. 2017;60:106\u201311.","journal-title":"Korean J Pediatr"},{"key":"1927_CR12","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1542\/pir.27.12.443","volume":"27","author":"MJ Maisels","year":"2006","unstructured":"Maisels MJ. Neonatal jaundice. Pediatr Rev. 2006;27:443\u201354.","journal-title":"Pediatr Rev"},{"key":"1927_CR13","first-page":"45","volume":"5","author":"A Zipursky","year":"1983","unstructured":"Zipursky A, Brown E, Palko J, Brown EJ. The erythrocyte differential count in newborn infants. Am J Pediatr Hematol Oncol. 1983;5:45\u201351.","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"1927_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.875877","volume":"10","author":"HY Lee","year":"2022","unstructured":"Lee HY, Ithnin A, Azma RZ, Othman A, Salvador A, Cheah FC. Glucose-6-phosphate dehydrogenase deficiency and neonatal hyperbilirubinemia: insights on pathophysiology, diagnosis, and gene variants in disease heterogeneity. Front Pediatr. 2022;10:875877.","journal-title":"Front Pediatr"},{"key":"1927_CR15","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1053\/gast.2002.34173","volume":"123","author":"C-S Huang","year":"2002","unstructured":"Huang C-S, Chang P-F, Huang M-J, Chen E-S, Chen W-C. Glucose-6-phosphate dehydrogenase deficiency, the UDP-glucuronosyl transferase 1A1 gene, and neonatal hyperbilirubinemia. Gastroenterology. 2002;123:127\u201333.","journal-title":"Gastroenterology"},{"key":"1927_CR16","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1651-2227.1994.tb13216.x","volume":"394","author":"T Valaes","year":"1994","unstructured":"Valaes T. Severe neonatal jaundice associated with glucose-6-phosphate dehydrogenase deficiency: pathogenesis and global epidemiology. Acta Paediatr Suppl. 1994;394:58\u201376.","journal-title":"Acta Paediatr Suppl"},{"key":"1927_CR17","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1542\/peds.114.1.297","volume":"114","author":"MJ Maisels","year":"2004","unstructured":"Maisels MJ, Baltz RD, Bhutani VK, Newman TB, Palmer H, Rosenfeld W, et al. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114:297\u2013316. https:\/\/doi.org\/10.1542\/peds.114.1.297.","journal-title":"Pediatrics"},{"key":"1927_CR18","first-page":"424","volume":"48","author":"A Koosha","year":"2007","unstructured":"Koosha A, Rafizadeh B. Evaluation of neonatal indirect hyperbilirubinaemia at Zanjan Province of Iran in 2001-2003: prevalence of glucose-6-phosphate dehydrogenase deficiency. Singapore Med J. 2007;48:424\u20138.","journal-title":"Singapore Med J"},{"key":"1927_CR19","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/tropej\/fmi042","volume":"52","author":"E Atay","year":"2006","unstructured":"Atay E, Bozaykut A, Ipek IO. Glucose-6-phosphate Dehydrogenase Deficiency in Neonatal Indirect Hyperbilirubinemia. J Trop Pediatr. 2006;52:56\u201358.","journal-title":"J Trop Pediatr"},{"key":"1927_CR20","doi-asserted-by":"publisher","first-page":"e1001339","DOI":"10.1371\/journal.pmed.1001339","volume":"9","author":"RE Howes","year":"2012","unstructured":"Howes RE, Piel FB, Patil AP, Nyangiri OA, Gething PW, Dewi M, et al. G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map. PLoS Med. 2012;9:e1001339. https:\/\/doi.org\/10.1371\/journal.pmed.1001339.","journal-title":"PLoS Med"},{"key":"1927_CR21","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/BF02730581","volume":"70","author":"R Iranpour","year":"2003","unstructured":"Iranpour R, Akbar MR, Haghshenas I. Glucose-6-phosphate dehydrogenase deficiency in neonates. Indian J Pediatr. 2003;70:855\u20137.","journal-title":"Indian J Pediatr"},{"key":"1927_CR22","doi-asserted-by":"publisher","first-page":"e213","DOI":"10.1542\/peds.114.2.e213","volume":"114","author":"M Kaplan","year":"2004","unstructured":"Kaplan M, Herschel M, Hammerman C, Hoyer JD, Stevenson DK. Hyperbilirubinemia among African American, glucose-6-phosphate dehydrogenase-deficient neonates. Pediatrics. 2004;114:e213\u20139.","journal-title":"Pediatrics"},{"key":"1927_CR23","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/S0095-5108(18)30098-8","volume":"25","author":"M Kaplan","year":"1998","unstructured":"Kaplan M, Hammerman C. Severe neonatal hyperbilirubinemia. A potential complication of glucose-6-phosphate dehydrogenase deficiency. Clin Perinatol. 1998;25:575\u201390, viii.","journal-title":"Clin Perinatol"},{"key":"1927_CR24","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1093\/tropej\/49.2.74","volume":"49","author":"PAK Nair","year":"2003","unstructured":"Nair PAK, Al Khusaiby SM. Kernicterus and G6PD deficiency-a case series from Oman. J Trop Pediatr. 2003;49:74\u201377.","journal-title":"J Trop Pediatr"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41372-024-01927-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-024-01927-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-024-01927-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T10:34:34Z","timestamp":1720175674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41372-024-01927-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,13]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["1927"],"URL":"https:\/\/doi.org\/10.1038\/s41372-024-01927-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3614278\/v1","asserted-by":"object"}]},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,13]]},"assertion":[{"value":"15 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 February 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The current study was carried out in accordance with the principles of the Declaration of Helsinki, Good Clinical Practice, and following the laws and regulations of MOPH (Ministry of Public Health) in Qatar. The study was conducted after obtaining approval from the institutional review board and ethical committee of the Medical Research Center, HMC, Qatar. The protocol number was MRC-01-21-756. This was a retrospective data collection, and no subjects were recruited for the study; thus, informed consent was not needed, and this was waivered by the institutional review board and ethical committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}