{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:40:25Z","timestamp":1792172425076,"version":"4.4.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1038\/s41372-024-01982-8","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T01:02:00Z","timestamp":1714525320000},"page":"1652-1657","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Feasibility of intranasal human milk as stem cell therapy in preterm infants with intraventricular hemorrhage"],"prefix":"10.1038","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9457-8791","authenticated-orcid":false,"given":"Rebecca","family":"Hoban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Gallipoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Signorile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Mander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andree","family":"Gauthier-Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford","family":"Librach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8091-5742","authenticated-orcid":false,"given":"Sharon","family":"Unger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"1982_CR1","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1542\/peds.2015-0944","volume":"136","author":"A Mukerji","year":"2015","unstructured":"Mukerji A, Shah V, Shah PS. Periventricular\/intraventricular hemorrhage and neurodevelopmental outcomes: a meta-analysis. Pediatrics. 2015;136:1132\u201343.","journal-title":"Pediatrics"},{"key":"1982_CR2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3345\/kjp.2014.57.6.251","volume":"57","author":"SY Ahn","year":"2014","unstructured":"Ahn SY, Chang YS, Park WS. Mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage. Korean J Pediatr. 2014;57:251\u20136.","journal-title":"Korean J Pediatr"},{"key":"1982_CR3","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1097\/ANC.0000000000000338","volume":"16","author":"C Briere","year":"2016","unstructured":"Briere C, McGrath J, Jensen T, Matson A, Finck C. Breast milk stem cells: current science and implications for preterm infants. Adv Neonatal Care. 2016;16:410\u20139.","journal-title":"Adv Neonatal Care"},{"key":"1982_CR4","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.jpeds.2013.11.036","volume":"164","author":"CM Cotten","year":"2014","unstructured":"Cotten CM, Murtha AP, Goldberg RN, Grotegut CA, Smith PB, Goldstein RF, et al. Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy. J Pediatr. 2014;164:973\u2013979.e1.","journal-title":"J Pediatr"},{"key":"1982_CR5","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1053\/j.semperi.2015.12.002","volume":"40","author":"SA Mitsialis","year":"2015","unstructured":"Mitsialis SA, Kourembanas S. Stem cell\u2013based therapies for the newborn lung and brain: possibilities and challenges. Semin Perinatol. 2015;40:138\u201351.","journal-title":"Semin Perinatol"},{"key":"1982_CR6","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.neuroscience.2017.05.006","volume":"355","author":"T Mukai","year":"2017","unstructured":"Mukai T, Mori Y, Shimazu T, Takahashi A, Tsunoda H, Yamaguchi S, et al. Intravenous injection of umbilical cord-derived mesenchymal stromal cells attenuates reactive gliosis and hypomyelination in a neonatal intraventricular hemorrhage model. Neuroscience. 2017;355:175\u201387.","journal-title":"Neuroscience"},{"key":"1982_CR7","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3727\/096368916X694193","volume":"26","author":"WS Park","year":"2017","unstructured":"Park WS, Ahn SY, Sung SI, Ahn J, Chang YS. Mesenchymal stem cells: the magic cure for intraventricular hemorrhage? Cell Transpl. 2017;26:439\u201348.","journal-title":"Cell Transpl"},{"key":"1982_CR8","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1177\/0890334413475528","volume":"29","author":"A Twigger","year":"2013","unstructured":"Twigger A, Hodgetts S, Filgueira L, Hartmann PE, Hassiotou F. From breast milk to brains. J Hum Lact. 2013;29:136\u20139.","journal-title":"J Hum Lact"},{"key":"1982_CR9","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/pr.2017.260","volume":"83","author":"M Nabetani","year":"2018","unstructured":"Nabetani M, Shintaku H, Hamazaki T. Future perspectives of cell therapy for neonatal hypoxic\u2013ischemic encephalopathy. Pediatr Res. 2018;83:356\u201363.","journal-title":"Pediatr Res"},{"key":"1982_CR10","doi-asserted-by":"publisher","first-page":"807896","DOI":"10.1155\/2014\/807896","volume":"2014","author":"SM Hosseini","year":"2014","unstructured":"Hosseini SM, Talaei-Khozani T, Sani M, Owrangi B. Differentiation of human breast-milk stem cells to neural stem cells and neurons. Neurol Res Int. 2014;2014:807896\u20138.","journal-title":"Neurol Res Int"},{"key":"1982_CR11","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1002\/cyto.b.21748","volume":"96","author":"T Keller","year":"2019","unstructured":"Keller T, Wengenroth L, Smorra D, Probst K, Kurian L, Kribs A, et al. Novel DRAQ5\u2122\/SYTOX\u00ae blue based flow cytometric strategy to identify and characterize stem cells in human breast milk. Cytom B Clin Cytom. 2019;96:480\u20139.","journal-title":"Cytom B Clin Cytom"},{"key":"1982_CR12","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1177\/0890334413477242","volume":"29","author":"F Hassiotou","year":"2013","unstructured":"Hassiotou F, Geddes DT, Hartmann PE. Cells in human milk. J Hum Lact. 2013;29:171\u201382.","journal-title":"J Hum Lact"},{"key":"1982_CR13","doi-asserted-by":"publisher","first-page":"14289","DOI":"10.1038\/s41598-018-32715-5","volume":"8","author":"MS Aydin","year":"2018","unstructured":"Aydin MS, Yigit EN, Vatandaslar E, Erdogan E, Ozturk G. Transfer and integration of breast milk stem cells to the brain of suckling pups. Sci Rep. 2018;8:14289\u20139.","journal-title":"Sci Rep."},{"key":"1982_CR14","doi-asserted-by":"publisher","first-page":"187","DOI":"10.5152\/TurkArchPediatr.2021.21006","volume":"56","author":"SG Kersin","year":"2021","unstructured":"Kersin SG, \u00d6zek E. Breast milk stem cells: are they magic bullets in neonatology? Turk Arch Pediatr. 2021;56:187\u201391.","journal-title":"Turk Arch Pediatr"},{"key":"1982_CR15","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00431-018-3279-7","volume":"178","author":"T Keller","year":"2019","unstructured":"Keller T, K\u00f6rber F, Oberthuer A, Schafmeyer L, Mehler K, Kuhr K, et al. Intranasal breast milk for premature infants with severe intraventricular hemorrhage\u2014an observation. Eur J Pediatr. 2019;178:199\u2013206","journal-title":"Eur J Pediatr"},{"key":"1982_CR16","doi-asserted-by":"publisher","first-page":"3215","DOI":"10.1016\/j.apsb.2022.04.001","volume":"12","author":"Y Li","year":"2022","unstructured":"Li Y, Wu H, Jiang X, Dong Y, Zheng J, Gao J. New idea to promote the clinical applications of stem cells or their extracellular vesicles in central nervous system disorders: Combining with intranasal delivery. Acta Pharm Sin B. 2022;12:3215\u201332.","journal-title":"Acta Pharm Sin B"},{"key":"1982_CR17","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1002\/stem.3456","volume":"39","author":"S Herman","year":"2021","unstructured":"Herman S, Fishel I, Offen D. Intranasal delivery of mesenchymal stem cells\u2010derived extracellular vesicles for the treatment of neurological diseases. Stem Cells. 2021;39:1589\u20131600.","journal-title":"Stem Cells"},{"key":"1982_CR18","doi-asserted-by":"publisher","first-page":"131","DOI":"10.31616\/asj.2019.0026","volume":"14","author":"M Borhani-Haghighi","year":"2020","unstructured":"Borhani-Haghighi M, Navid S, Mohamadi Y. The therapeutic potential of conditioned medium from human breast milk stem cells in treating spinal cord injury. Asian Spine J. 2020;14:131\u20138.","journal-title":"Asian Spine J"},{"key":"1982_CR19","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.pcl.2012.10.002","volume":"60","author":"O Ballard","year":"2013","unstructured":"Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors. Pediatr Clin North Am. 2013;60:49\u201374.","journal-title":"Pediatr Clin North Am"},{"key":"1982_CR20","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","volume":"92","author":"LA Papile","year":"1978","unstructured":"Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92:529\u201334.","journal-title":"J Pediatr"},{"key":"1982_CR21","doi-asserted-by":"publisher","first-page":"770","DOI":"10.3945\/an.114.006924","volume":"5","author":"F Hassiotou","year":"2014","unstructured":"Hassiotou F, Hartmann PE. At the dawn of a new discovery: the potential of breast milk stem cells. Adv Nutr. 2014;5:770\u20138.","journal-title":"Adv Nutr"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41372-024-01982-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-024-01982-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-024-01982-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T15:04:25Z","timestamp":1730127865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41372-024-01982-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["1982"],"URL":"https:\/\/doi.org\/10.1038\/s41372-024-01982-8","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,30]]},"assertion":[{"value":"7 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no conflicts of interest to declare related to the study. RH is currently on the scientific advisory board for Medela, USA (was not at the time of the study).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Study approval statement: This study protocol was reviewed and approved by the Ontario provincial research ethics board Clinical Trials Ontario (CTO), Project ID 1911. Consent to participate statement Written informed consent was obtained from the guardian(s) of eligible participants prior to participation in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}}]}}