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Infants were randomly assigned to study group with receive orally 2\u2009ml breast milk (<jats:italic>n<\/jats:italic>\u2009=\u200945) or a control group with no intervention (<jats:italic>n<\/jats:italic>\u2009=\u200945). A near-infrared spectroscopy device was used to monitor regional cerebral oxygen saturation (rScO<jats:sub>2<\/jats:sub>), while neonatal pain expression was assessed by Neonatal Pain, Agitation, and Sedation Scale (N-PASS).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The N-PASS score (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) and the crying time (<jats:italic>p<\/jats:italic>\u2009=\u20090.017) were significantly lower in the study group compared to the control group. Although the mean rScO<jats:sub>2<\/jats:sub> values decreased in both groups during the procedure, the percent change in rScO<jats:sub>2<\/jats:sub> was not significant difference between two groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Breast milk administration decreases behavioral responses to a noxious stimulus without reducing the cortical response to pain.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical trial registration<\/jats:title>\n                <jats:p>This trial was registered under ClinicalTrials.gov identifier no. NCT05961904.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41372-024-02081-4","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T15:02:19Z","timestamp":1723474939000},"page":"1675-1681","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of breast milk on cortical pain response in newborns during the heel prick procedure: a randomized controlled trial"],"prefix":"10.1038","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9939-7375","authenticated-orcid":false,"given":"Ozgul","family":"Bulut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-4393","authenticated-orcid":false,"given":"Seyma Cagla","family":"Topaloglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7247-6302","authenticated-orcid":false,"given":"Nurgul","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1832-9993","authenticated-orcid":false,"given":"Meryem","family":"Hocaoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1636-9991","authenticated-orcid":false,"given":"Sertac","family":"Arslanoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"2081_CR1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1001\/jama.300.1.60","volume":"300","author":"R Carbajal","year":"2008","unstructured":"Carbajal R, Rousset A, Danan C, Coquery S, Nolent P, Ducrocq S, et al. 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