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Brain injury was assessed according to the Kidokoro scale. Moreover, 17 term-born infants with hypoxic-ischemic encephalopathy (HIE) were scanned. The metabolic profile of the central nervous system was obtained from the bilateral thalamus.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Result<\/jats:title>\n            <jats:p>The Lipids\/Creatine, Choline\/Creatine, N-acetyl aspartate\/Choline, Lactate\/N-acetyl aspartate, and Lactate\/Creatine ratios differed between VP infants with moderate+severe brain damage and those without brain injury. Moreover, VP infants with moderate+severe brain damage had higher Lactate\/ N-acetyl aspartate and Lactate\/Creatine ratios than HIE group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>There were significant differences in the cerebral metabolite profile at TEA between VP infants with and without brain injury. The <jats:sup>1<\/jats:sup>H-MRS profile of VP infants with moderate+severe brain damage may reflect profound chronic metabolic alterations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1038\/s41372-024-02172-2","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T16:36:25Z","timestamp":1732811785000},"page":"194-201","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cerebral magnetic resonance spectroscopy \u2013 insights into preterm brain injury"],"prefix":"10.1038","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0459-7046","authenticated-orcid":false,"given":"Magdalena","family":"Zasada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Karcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Olszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Kowalik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6996-2879","authenticated-orcid":false,"given":"Wojciech","family":"Zasada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Herman-Sucharska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemko","family":"Kwinta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"2172_CR1","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00429-014-0921-7","volume":"221","author":"Y Lao","year":"2016","unstructured":"Lao Y, Wang Y, Shi J, Ceschin R, Nelson MD, Panigrahy A, et al. 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Written informed consent was obtained from the participants\u2019 parents for participation in the study. All methods were performed in accordance with the relevant guidelines and regulations.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of ethics"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}