{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:49:16Z","timestamp":1788446956705,"version":"build-2803163510"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1038\/s41372-025-02247-8","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T08:17:32Z","timestamp":1741249052000},"page":"951-956","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A prospective randomized pilot trial comparing weekly vs. biweekly Darbepoetin administration to preterm infants"],"prefix":"10.1038","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7946-0290","authenticated-orcid":false,"given":"Timothy M.","family":"Bahr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5872-582X","authenticated-orcid":false,"given":"Robert D.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberlee A.","family":"Weaver-Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4600-8828","authenticated-orcid":false,"given":"Danielle M.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Gerday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5088-1086","authenticated-orcid":false,"given":"Jared J.","family":"Tuttle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2865-8878","authenticated-orcid":false,"given":"Robin K.","family":"Ohls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"2247_CR1","volume":"16","author":"D Khullar","year":"2024","unstructured":"Khullar D, Muchhala SS, Abhishek T. Advancing anemia management in chronic kidney disease: Assessing the superiority of darbepoetin alfa over erythropoietin alpha. Cureus. 2024;16:e51613.","journal-title":"Cureus"},{"key":"2247_CR2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00431-022-04650-1","volume":"182","author":"R Mazahir","year":"2023","unstructured":"Mazahir R, Anand K, Pruthi PK. Comparison of darbepoetin alpha and recombinant human erythropoietin for treatment of anemia in pediatric chronic kidney disease: a non-inferiority trial from India. Eur J Pediatr. 2023;182:101\u20139.","journal-title":"Eur J Pediatr"},{"key":"2247_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.clp.2004.03.006","volume":"31","author":"RK Ohls","year":"2004","unstructured":"Ohls RK, Dai A. Long-acting erythropoietin: clinical studies and potential uses in neonates. Clin Perinatol. 2004;31:77\u201389.","journal-title":"Clin Perinatol"},{"key":"2247_CR4","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1542\/peds.2013-0143","volume":"132","author":"RK Ohls","year":"2013","unstructured":"Ohls RK, Christensen RD, Kamath-Rayne BD, Rosenberg A, Wiedmeier SE, Roohi M, et al. A randomized, masked, placebo-controlled study of darbepoetin alfa in preterm infants. Pediatrics. 2013;132:e119\u201327.","journal-title":"Pediatrics"},{"key":"2247_CR5","doi-asserted-by":"publisher","first-page":"e976","DOI":"10.1016\/S2352-3026(23)00285-5","volume":"10","author":"IMC Ree","year":"2023","unstructured":"Ree IMC, de Haas M, van Geloven N, Juul SE, de Winter D, Verweij EJT, et al. Darbepoetin alfa to reduce transfusion episodes in infants with haemolytic disease of the fetus and newborn who are treated with intrauterine transfusions in the Netherlands: an open-label, single-centre, phase 2, randomised, controlled trial. Lancet Haematol. 2023;10:e976\u201384.","journal-title":"Lancet Haematol"},{"key":"2247_CR6","doi-asserted-by":"publisher","unstructured":"Ohls RK, Bahr TM, Peterson TG, Christensen RD. A practical guide to reducing\/eliminating red blood cell transfusions in the neonatal intensive care unit. Semin Fetal Neonatal Med. 2024:101545. https:\/\/doi.org\/10.1016\/j.siny.2024.101545.","DOI":"10.1016\/j.siny.2024.101545"},{"key":"2247_CR7","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/sj.jp.7211387","volume":"25","author":"TL Warwood","year":"2005","unstructured":"Warwood TL, Ohls RK, Wiedmeier SE, Lambert DK, Jones C, Scoffield SH, et al. Single dose darbepoetin administration to anemic preterm neonates. J Perinatol. 2005;25:725\u201330.","journal-title":"J Perinatol"},{"key":"2247_CR8","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1016\/j.xphs.2017.02.001","volume":"106","author":"G An","year":"2017","unstructured":"An G, Ohls RK, Christensen RD, Widness JA, Mock DM, Veng-Pedersen P. Population pharmacokinetics of Darbepoetin in infants following single intravenous and subcutaneous dosing. J Pharm Sci. 2017;106:1644\u20139.","journal-title":"J Pharm Sci"},{"key":"2247_CR9","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1681\/ASN.V10112392","volume":"10","author":"IC Macdougall","year":"1999","unstructured":"Macdougall IC, Gray SJ, Elston O, Breen C, Jenkins B, Browne J, et al. Pharmacokinetics of novel erythropoiesis stimulating protein compared with epoetin alfa in dialysis patients. J Am Soc Nephrol. 1999;10:2392\u20135.","journal-title":"J Am Soc Nephrol"},{"key":"2247_CR10","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1542\/peds.2013-4307","volume":"133","author":"RK Ohls","year":"2014","unstructured":"Ohls RK, Kamath-Rayne BD, Christensen RD, Wiedmeier SE, Rosenberg A, Fuller J, et al. Cognitive outcomes of preterm infants randomized to darbepoetin, erythropoietin, or placebo. Pediatrics. 2014;133:1023\u201330.","journal-title":"Pediatrics"},{"key":"2247_CR11","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1159\/000511388","volume":"5","author":"TM Bahr","year":"2020","unstructured":"Bahr TM, Knudsen MC, Lozano-Chinga M, Agarwal AM, Meznarich JA, Ohls RK, et al. Infantile Pyknocytosis: end-tidal CO, %Micro-R measurements, next-generation sequencing, and transfusion avoidance with darbepoetin. Biomed Hub. 2020;5:227\u201334.","journal-title":"Biomed Hub"},{"key":"2247_CR12","first-page":"CD004863","volume":"2","author":"A Ohlsson","year":"2020","unstructured":"Ohlsson A, Aher SM. Early erythropoiesis-stimulating agents in preterm or low birth weight infants. Cochrane Database Syst Rev. 2020;2:CD004863.","journal-title":"Cochrane Database Syst Rev"},{"key":"2247_CR13","doi-asserted-by":"crossref","unstructured":"Bahr TM, Ohls RK, Christensen RD. Treating preterm infants with erythropoietin does not increase the risk of retinopathy of prematurity. J Perinatol. 2025;45:292\u20133.","DOI":"10.1038\/s41372-024-02047-6"},{"key":"2247_CR14","unstructured":"Ohls RK, Schibler KR, Lowe JR, Tan S, Beauman S. Darbepoetin trial to improve red cell mass and neuroprotection in preterm infants. Oral Platform. Annual meeting. Pediatric Academic Society; 2023. https:\/\/2023.pas-meeting.org\/."},{"key":"2247_CR15","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/S0022-3476(00)70105-3","volume":"136","author":"RF Maier","year":"2000","unstructured":"Maier RF, Sonntag J, Walka MM, Liu G, Metze BC, Obladen M. Changing practices of red blood cell transfusions in infants with birth weights less than 1000 g. J Pediatr. 2000;136:220\u20134.","journal-title":"J Pediatr"},{"key":"2247_CR16","doi-asserted-by":"publisher","first-page":"232","DOI":"10.3390\/life14020232","volume":"14","author":"DW Wu","year":"2024","unstructured":"Wu DW, Friedman MT, Lombardi DP, Hwang R, Sender J, Cobaj V, et al. Impact of patient blood management on red blood cell utilization in an urban community teaching hospital: A seven-year retrospective study. Life. 2024;14:232.","journal-title":"Life"},{"key":"2247_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2023.113836","volume":"265","author":"TM Bahr","year":"2024","unstructured":"Bahr TM, Snow GL, Christensen TR, Davenport P, Henry E, Tweddell SM, et al. Can red blood cell and platelet transfusions have a pathogenic role in bronchopulmonary dysplasia? J Pediatr. 2024;265:113836.","journal-title":"J Pediatr"},{"key":"2247_CR18","doi-asserted-by":"publisher","unstructured":"Bahr TM, Ohls RK, Henry E, Davenport P, Ilstrup SJ, Kelley WE, et al. The number of blood transfusions received and the incidence and severity of chronic lung disease among NICU patients born >31 weeks gestation. J Perinatol. 2024. https:\/\/doi.org\/10.1038\/s41372-024-02135-7.","DOI":"10.1038\/s41372-024-02135-7"},{"key":"2247_CR19","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13052-024-01714-w","volume":"50","author":"L Teofili","year":"2024","unstructured":"Teofili L, Papacci P, Dani C, Cresi F, Remaschi G, Pellegrino C, et al. Cord blood transfusions in extremely low gestational age neonates to reduce severe retinopathy of prematurity: results of a prespecified interim analysis of the randomized BORN trial. Ital J Pediatr. 2024;50:142.","journal-title":"Ital J Pediatr"},{"key":"2247_CR20","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1056\/NEJMoa2020248","volume":"383","author":"H Kirpalani","year":"2020","unstructured":"Kirpalani H, Bell EF, Hintz SR, Tan S, Schmidt B, Chaudhary AS, et al. Eunice Kennedy Shriver NICHD Neonatal Research Network. Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants. N Engl J Med. 2020;383:2639\u201351.","journal-title":"N Engl J Med"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41372-025-02247-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-025-02247-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-025-02247-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T07:35:29Z","timestamp":1757144129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41372-025-02247-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["2247"],"URL":"https:\/\/doi.org\/10.1038\/s41372-025-02247-8","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,6]]},"assertion":[{"value":"3 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}