{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:04:12Z","timestamp":1790643852390,"version":"4.1.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1038\/s41372-025-02407-w","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:50:37Z","timestamp":1756947037000},"page":"1327-1334","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Physiology-guided vasoactive therapy in neonates: rethinking dopamine as first-line"],"prefix":"10.1038","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5412-9526","authenticated-orcid":false,"given":"Audrey","family":"H\u00e9bert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-2155","authenticated-orcid":false,"given":"Satyan","family":"Lakshminrusimha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2766-9244","authenticated-orcid":false,"given":"Danielle R.","family":"Rios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4581-246X","authenticated-orcid":false,"given":"Shazia","family":"Bhombal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-0104","authenticated-orcid":false,"given":"Shiran Sara","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0493-640X","authenticated-orcid":false,"given":"Stephanie","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5141-0964","authenticated-orcid":false,"given":"Gabriel","family":"Altit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"2407_CR1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.jpeds.2014.06.009","volume":"165","author":"DR Rios","year":"2014","unstructured":"Rios DR, Moffett BS, Kaiser JR. Trends in pharmacotherapy for neonatal hypotension. J Pediatr. 2014;165:697\u2013701.e1.","journal-title":"J Pediatr"},{"key":"2407_CR2","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00431-022-04758-4","volume":"182","author":"S Nissimov","year":"2023","unstructured":"Nissimov S, Joye S, Kharrat A, Zhu F, Ripstein G, Baczynski M, et al. Dopamine or norepinephrine for sepsis-related hypotension in preterm infants: a retrospective cohort study. Eur J Pediatr. 2023;182:1029\u201338.","journal-title":"Eur J Pediatr"},{"key":"2407_CR3","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.jpeds.2014.12.027","volume":"166","author":"DR Rios","year":"2015","unstructured":"Rios DR, Kaiser JR. Vasopressin versus dopamine for treatment of hypotension in extremely low birth weight infants: a randomized, blinded pilot study. J Pediatr. 2015;166:850\u20135. https:\/\/doi.org\/10.1016\/j.jpeds.2014.12.027.","journal-title":"J Pediatr"},{"key":"2407_CR4","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1038\/s41390-023-02995-3","volume":"95","author":"S Ouellet","year":"2024","unstructured":"Ouellet S, Drolet C, Morissette G, Pellerin A, H\u00e9bert A. Vasopressin in newborns with refractory acute pulmonary hypertension. Pediatr Res. 2024;95:1572\u20137.","journal-title":"Pediatr Res"},{"key":"2407_CR5","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1136\/archdischild-2022-324935","volume":"109","author":"R Mullaly","year":"2024","unstructured":"Mullaly R, El-Khuffash AF. Haemodynamic assessment and management of hypotension in the preterm. Arch Dis Child Fetal Neonatal Ed. 2024;109:120\u20137.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2407_CR6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0022-3476(78)80033-X","volume":"92","author":"DJ Driscoll","year":"1978","unstructured":"Driscoll DJ, Gillette PC, McNamara DG. The use of dopamine in children. J Pediatr. 1978;92:309\u201314.","journal-title":"J Pediatr"},{"key":"2407_CR7","doi-asserted-by":"crossref","first-page":"F99","DOI":"10.1136\/fn.81.2.F99","volume":"81","author":"J Zhang","year":"1999","unstructured":"Zhang J, Penny DJ, Kim NS, Yu VY, Smolich JJ. Mechanisms of blood pressure increase induced by dopamine in hypotensive preterm neonates. Arch Dis Child Fetal Neonatal Ed. 1999;81:F99\u2013F104.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2407_CR8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF00442581","volume":"142","author":"I Seri","year":"1984","unstructured":"Seri I, Tulassay T, Kiszel J, Machay T, Cs\u00f6m\u00f6r S. Cardiovascular response to dopamine in hypotensive preterm neonates with severe hyaline membrane disease. Eur J Pediatr. 1984;142:3\u20139.","journal-title":"Eur J Pediatr"},{"key":"2407_CR9","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1203\/00006450-199312000-00009","volume":"34","author":"I Seri","year":"1993","unstructured":"Seri I, Rudas G, Bors Z, Kanyicska B, Tulassay T. Effects of low-dose dopamine infusion on cardiovascular and renal functions, cerebral blood flow, and plasma catecholamine levels in sick preterm neonates. Pediatr Res. 1993;34:742\u20139.","journal-title":"Pediatr Res"},{"key":"2407_CR10","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.smrv.2013.06.002","volume":"18","author":"KL Fyfe","year":"2014","unstructured":"Fyfe KL, Yiallourou SR, Wong FY, Horne RS. The development of cardiovascular and cerebral vascular control in preterm infants. Sleep Med Rev. 2014;18:299\u2013310.","journal-title":"Sleep Med Rev"},{"key":"2407_CR11","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/ar.a.10110","volume":"274","author":"JH Burrell","year":"2003","unstructured":"Burrell JH, Boyn AM, Kumarasamy V, Hsieh A, Head SI, Lumbers ER. Growth and maturation of cardiac myocytes in fetal sheep in the second half of gestation. Anat Rec A Discov Mol Cell Evol Biol. 2003;274:952\u201361.","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"2407_CR12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0033-0620(72)90006-0","volume":"15","author":"WF Friedman","year":"1972","unstructured":"Friedman WF. The intrinsic physiologic properties of the developing heart. Prog Cardiovasc Dis. 1972;15:87\u2013111.","journal-title":"Prog Cardiovasc Dis"},{"key":"2407_CR13","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1203\/00006450-198509000-00017","volume":"19","author":"DF Teitel","year":"1985","unstructured":"Teitel DF, Sidi D, Chin T, Brett C, Heymann MA, Rudolph AM. Developmental changes in myocardial contractile reserve in the lamb. Pediatr Res. 1985;19:948\u201355.","journal-title":"Pediatr Res"},{"key":"2407_CR14","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1476-5381.1990.tb14704.x","volume":"99","author":"M Kojima","year":"1990","unstructured":"Kojima M, Ishima T, Taniguchi N, Kimura K, Sada H, Sperelakis N. Developmental changes in beta-adrenoceptors, muscarinic cholinoceptors and Ca2+ channels in rat ventricular muscles. Br J Pharmacol. 1990;99:334\u20139.","journal-title":"Br J Pharmacol"},{"key":"2407_CR15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1139\/y94-053","volume":"72","author":"A Inayatulla","year":"1994","unstructured":"Inayatulla A, Li DY, Chemtob S, Varma DR. Ontogeny of positive inotropic responses to sympathomimetic agents and of myocardial adrenoceptors in rats. Can J Physiol Pharmcol. 1994;72:361\u20137.","journal-title":"Can J Physiol Pharmcol"},{"key":"2407_CR16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000211667","volume":"96","author":"A Patel","year":"2009","unstructured":"Patel A, Lakshminrusimha S, Ryan RM, Swartz DD, Wang H, Wynn KA, et al. Exposure to supplemental oxygen downregulates antioxidant enzymes and increases pulmonary arterial contractility in premature lambs. Neonatology. 2009;96:182\u201392.","journal-title":"Neonatology"},{"key":"2407_CR17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1203\/01.pdr.0000191136.69142.8c","volume":"59","author":"S Lakshminrusimha","year":"2006","unstructured":"Lakshminrusimha S, Russell JA, Steinhorn RH, Ryan RM, Gugino SF, Morin FC, et al. Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation. Pediatr Res. 2006;59:137\u201341.","journal-title":"Pediatr Res"},{"key":"2407_CR18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0022-3476(95)70445-0","volume":"126","author":"I Seri","year":"1995","unstructured":"Seri I. Cardiovascular, renal, and endocrine actions of dopamine in neonates and children. J Pediatr. 1995;126:333\u201344.","journal-title":"J Pediatr"},{"key":"2407_CR19","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/cc1016","volume":"5","author":"PY Cheung","year":"2001","unstructured":"Cheung PY, Barrington KJ. The effects of dopamine and epinephrine on hemodynamics and oxygen metabolism in hypoxic anesthetized piglets. Crit Care. 2001;5:158\u201366.","journal-title":"Crit Care"},{"key":"2407_CR20","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jpeds.2008.06.014","volume":"153","author":"A Bouissou","year":"2008","unstructured":"Bouissou A, Rakza T, Klosowski S, Tourneux P, Vanderborght M, Storme L. Hypotension in preterm infants with significant patent ductus arteriosus: effects of dopamine. J Pediatr. 2008;153:790\u20134.","journal-title":"J Pediatr"},{"key":"2407_CR21","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/s41372-024-01958-8","volume":"44","author":"AM Vasquez","year":"2024","unstructured":"Vasquez AM, Bischoff AR, Giesinger RE, McNamara PJ. Impact of therapeutic hypothermia (TH) on echocardiography indices of pulmonary hemodynamics among neonates with hypoxic ischemic encephalopathy (HIE). J Perinatol. 2024;44:1212\u20135.","journal-title":"J Perinatol"},{"key":"2407_CR22","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jpeds.2022.03.022","volume":"246","author":"PJ McNamara","year":"2022","unstructured":"McNamara PJ, Giesinger RE, Lakshminrusimha S. Dopamine and neonatal pulmonary hypertension-pressing need for a better pressor?. J Pediatr. 2022;246:242\u201350.","journal-title":"J Pediatr"},{"key":"2407_CR23","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.clp.2012.06.006","volume":"39","author":"S Lakshminrusimha","year":"2012","unstructured":"Lakshminrusimha S. The pulmonary circulation in neonatal respiratory failure. Clin Perinatol. 2012;39:655\u201383.","journal-title":"Clin Perinatol"},{"key":"2407_CR24","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1152\/japplphysiol.00711.2011","volume":"111","author":"S Lakshminrusimha","year":"2011","unstructured":"Lakshminrusimha S, Steinhorn RH, Wedgwood S, Savorgnan F, Nair J, Mathew B, et al. Pulmonary hemodynamics and vascular reactivity in asphyxiated term lambs resuscitated with 21 and 100% oxygen. J Appl Physiol. 2011;111:1441\u20137.","journal-title":"J Appl Physiol"},{"key":"2407_CR25","doi-asserted-by":"crossref","first-page":"F117","DOI":"10.1136\/archdischild-2011-301488","volume":"98","author":"RS Garner","year":"2013","unstructured":"Garner RS, Burchfield DJ. Treatment of presumed hypotension in very low birthweight neonates: effects on regional cerebral oxygenation. Arch Dis Child Fetal Neonatal Ed. 2013;98:F117\u2013121.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2407_CR26","doi-asserted-by":"crossref","first-page":"e1502","DOI":"10.1542\/peds.2010-3791","volume":"128","author":"HJ Bonestroo","year":"2011","unstructured":"Bonestroo HJ, Lemmers PM, Baerts W, van Bel F. Effect of antihypotensive treatment on cerebral oxygenation of preterm infants without PDA. Pediatrics. 2011;128:e1502\u201310.","journal-title":"Pediatrics"},{"key":"2407_CR27","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1542\/peds.2004-1073","volume":"114","author":"MJ Munro","year":"2004","unstructured":"Munro MJ, Walker AM, Barfield CP. Hypotensive extremely low birth weight infants have reduced cerebral blood flow. Pediatrics. 2004;114:1591\u20136.","journal-title":"Pediatrics"},{"key":"2407_CR28","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1111\/apa.12817","volume":"103","author":"VR Eriksen","year":"2014","unstructured":"Eriksen VR, Hahn GH, Greisen G. Dopamine therapy is associated with impaired cerebral autoregulation in preterm infants. Acta Paediatr. 2014;103:1221\u20136.","journal-title":"Acta Paediatr"},{"key":"2407_CR29","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/s41390-020-0790-0","volume":"88","author":"NS Solanki","year":"2020","unstructured":"Solanki NS, Hoffman SB. Association between dopamine and cerebral autoregulation in preterm neonates. Pediatr Res. 2020;88:618\u201322.","journal-title":"Pediatr Res"},{"key":"2407_CR30","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.jpeds.2013.12.042","volume":"164","author":"T Alderliesten","year":"2014","unstructured":"Alderliesten T, Lemmers PM, van Haastert IC, de Vries LS, Bonestroo HJ, Baerts W, et al. Hypotension in preterm neonates: low blood pressure alone does not affect neurodevelopmental outcome. J Pediatr. 2014;164:986\u201391.","journal-title":"J Pediatr"},{"key":"2407_CR31","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113687","volume":"341","author":"IM Inocencio","year":"2021","unstructured":"Inocencio IM, Tran NT, Khor SJ, Wiersma M, Nakamura S, Walker DW, et al. The cerebral haemodynamic response to somatosensory stimulation in preterm newborn lambs is reduced with dopamine or dobutamine infusion. Exp Neurol. 2021;341:113687.","journal-title":"Exp Neurol"},{"key":"2407_CR32","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/BF01957532","volume":"152:","author":"A Greenough","year":"1993","unstructured":"Greenough A, Emery EF. Randomized trial comparing dopamine and dobutamine in preterm infants. Eur J Pediatr. 1993;152:925\u20137.","journal-title":"Eur J Pediatr"},{"key":"2407_CR33","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/jp.2013.20","volume":"33","author":"JL Crouchley","year":"2013","unstructured":"Crouchley JL, Smith PB, Cotten CM, Hornik CD, Goldberg RN, Foreman JW, et al. Effects of low-dose dopamine on urine output in normotensive very low birth weight neonates. J Perinatol. 2013;33:619\u201321.","journal-title":"J Perinatol"},{"key":"2407_CR34","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0169-409X(03)00030-9","volume":"55","author":"J Alcorn","year":"2003","unstructured":"Alcorn J, McNamara PJ. Pharmacokinetics in the newborn. Adv Drug Deliv Rev. 2003;55:667\u201386.","journal-title":"Adv Drug Deliv Rev"},{"key":"2407_CR35","doi-asserted-by":"crossref","first-page":"e207","DOI":"10.1542\/neo.25-4-e207","volume":"25","author":"MA Prideaux","year":"2024","unstructured":"Prideaux MA, Guillet R. The use of low-dose dopamine in the neonatal intensive care unit. Neoreviews. 2024;25:e207\u2013e215.","journal-title":"Neoreviews"},{"key":"2407_CR36","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1136\/archdischild-2020-320241","volume":"106","author":"EM Dempsey","year":"2021","unstructured":"Dempsey EM, Barrington KJ, Marlow N, O\u2019Donnell CPF, Miletin J, Naulaers G, et al. Hypotension in preterm infants (HIP) randomised trial. Arch Dis Child Fetal Neonatal Ed. 2021;106:398\u2013403.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2407_CR37","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00431-018-3195-x","volume":"177","author":"K Baske","year":"2018","unstructured":"Baske K, Saini SS, Dutta S, Sundaram V. Epinephrine versus dopamine in neonatal septic shock: a double-blind randomized controlled trial. Eur J Pediatr. 2018;177:1335\u201342.","journal-title":"Eur J Pediatr"},{"key":"2407_CR38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/01.PCC.0000216680.22950.D9","volume":"7","author":"L Filippi","year":"2006","unstructured":"Filippi L, Pezzati M, Cecchi A, Poggi C. Dopamine infusion: a possible cause of undiagnosed congenital hypothyroidism in preterm infants. Pediatr Crit Care Med. 2006;7:249\u201351.","journal-title":"Pediatr Crit Care Med"},{"key":"2407_CR39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/tropej\/fmv007","volume":"61","author":"X Shi","year":"2015","unstructured":"Shi X, Sun Y, Qiang R. Undiagnosed congenital hypothyroidism in a newborn treated with dopamine infusion. J Trop Pediatr. 2015;61:215\u20137.","journal-title":"J Trop Pediatr"},{"key":"2407_CR40","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1203\/00006450-199302000-00020","volume":"33","author":"K Barrington","year":"1993","unstructured":"Barrington K, Chan W. The circulatory effects of epinephrine infusion in the anesthesized piglet. Pediatr Res. 1993;33:190\u20134.","journal-title":"Pediatr Res"},{"key":"2407_CR41","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1542\/peds.2004-1396","volume":"115","author":"A Pellicer","year":"2005","unstructured":"Pellicer A, Valverde E, Elorza MD, Madero R, Gay\u00e1 F, Quero J, et al. Cardiovascular support for low birth weight infants and cerebral hemodynamics: a randomized, blinded, clinical trial. Pediatrics. 2005;115:1501\u201312.","journal-title":"Pediatrics"},{"key":"2407_CR42","doi-asserted-by":"publisher","first-page":"e1213","DOI":"10.1542\/peds.2005-2108","volume":"117","author":"E Valverde","year":"2006","unstructured":"Valverde E, Pellicer A, Madero R, Elorza D, Quero J, Caba\u00f1as F. Dopamine versus epinephrine for cardiovascular support in low birth weight infants: analysis of systemic effects and neonatal clinical outcomes. Pediatrics. 2006;117:e1213\u201322. https:\/\/doi.org\/10.1542\/peds.2005-2108.","journal-title":"Pediatrics"},{"key":"2407_CR43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1067\/mpd.2002.120834","volume":"140","author":"D Osborn","year":"2002","unstructured":"Osborn D, Evans N, Kluckow M. Randomized trial of dobutamine versus dopamine in preterm infants with low systemic blood flow. J Pediatr. 2002;140:183\u201391.","journal-title":"J Pediatr"},{"key":"2407_CR44","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40748-015-0015-4","volume":"1","author":"V Sharma","year":"2015","unstructured":"Sharma V, Berkelhamer S, Lakshminrusimha S. Persistent pulmonary hypertension of the newborn. Matern Health Neonatol Perinatol. 2015;1:14.","journal-title":"Matern Health Neonatol Perinatol"},{"key":"2407_CR45","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/SHK.0000000000000388","volume":"44","author":"MO Bianchi","year":"2015","unstructured":"Bianchi MO, Cheung PY, Phillipos E, Aranha-Netto A, Joynt C. The effect of milrinone on splanchnic and cerebral perfusion in infants with congenital heart disease prior to surgery: an observational study. Shock. 2015;44:115\u201320.","journal-title":"Shock"},{"key":"2407_CR46","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1038\/s41372-021-01049-y","volume":"41","author":"AR Bischoff","year":"2021","unstructured":"Bischoff AR, Habib S, McNamara PJ, Giesinger RE. Hemodynamic response to milrinone for refractory hypoxemia during therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy. J Perinatol. 2021;41:2345\u201354.","journal-title":"J Perinatol"},{"key":"2407_CR47","first-page":"145","volume":"41","author":"D Derleth","year":"1997","unstructured":"Derleth D. Clinical experience with norepinephrine (NE) infusions in critically Ill newborns. 856. Pediatr Res. 1997;41:145.","journal-title":"Pediatr Res"},{"key":"2407_CR48","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/apa.14112","volume":"107","author":"MY Rizk","year":"2018","unstructured":"Rizk MY, Lapointe A, Lefebvre F, Barrington KJ. Norepinephrine infusion improves haemodynamics in the preterm infants during septic shock. Acta Paediatr. 2018;107:408\u201313.","journal-title":"Acta Paediatr"},{"key":"2407_CR49","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1007\/s00431-022-04437-4","volume":"181","author":"S Gupta","year":"2022","unstructured":"Gupta S, Agrawal G, Thakur S, Gupta A, Wazir S. The effect of norepinephrine on clinical and hemodynamic parameters in neonates with shock: a retrospective cohort study. Eur J Pediatr. 2022;181:2379\u201387.","journal-title":"Eur J Pediatr"},{"key":"2407_CR50","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jpeds.2008.03.007","volume":"153","author":"P Tourneux","year":"2008","unstructured":"Tourneux P, Rakza T, Bouissou A, Krim G, Storme L. Pulmonary circulatory effects of norepinephrine in newborn infants with persistent pulmonary hypertension. J Pediatr. 2008;153:345\u20139.","journal-title":"J Pediatr"},{"key":"2407_CR51","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1093\/bja\/aeh278","volume":"93:","author":"S Jaillard","year":"2004","unstructured":"Jaillard S, Elbaz F, Bresson-Just S, Riou Y, Houfflin-Debarge V, Rakza T, et al. Pulmonary vasodilator effects of norepinephrine during the development of chronic pulmonary hypertension in neonatal lambs. Br J Anaesth. 2004;93:818\u201324.","journal-title":"Br J Anaesth"},{"key":"2407_CR52","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2024.1443990","volume":"12","author":"R Garegrat","year":"2024","unstructured":"Garegrat R, Patnaik S, Suryawanshi S, Chetan C, Banait N, Singh P, et al. A pilot randomized controlled trial comparing noradrenaline and adrenaline as a first-line vasopressor for fluid-refractory septic shock in neonates. Front Pediatr. 2024;12:1443990.","journal-title":"Front Pediatr"},{"key":"2407_CR53","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/PCC.0000000000000716","volume":"17","author":"SL Siehr","year":"2016","unstructured":"Siehr SL, Feinstein JA, Yang W, Peng LF, Ogawa MT, Ramamoorthy C. Hemodynamic effects of phenylephrine, vasopressin, and epinephrine in children with pulmonary hypertension: a pilot study. Pediatr Crit Care Med. 2016;17:428\u201337.","journal-title":"Pediatr Crit Care Med"},{"key":"2407_CR54","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1080\/14767058.2020.1757642","volume":"35","author":"AA Mohamed","year":"2022","unstructured":"Mohamed AA, Louis D, Surak A, Weisz DE, McNamara PJ, Jain A. Vasopressin for refractory persistent pulmonary hypertension of the newborn in preterm neonates - a case series. J Matern Fetal Neonatal Med. 2022;35:1475\u201383.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2407_CR55","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jpeds.2010.04.038","volume":"157","author":"M Bidegain","year":"2010","unstructured":"Bidegain M, Greenberg R, Simmons C, Dang C, Cotten CM, Smith PB. Vasopressin for refractory hypotension in extremely low birth weight infants. J Pediatr. 2010;157:502\u20134.","journal-title":"J Pediatr"},{"key":"2407_CR56","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.trsl.2010.07.011","volume":"156","author":"OJ How","year":"2010","unstructured":"How OJ, R\u00f8sner A, Kildal AB, Stenberg TA, Gjessing PF, Hermansen SE, et al. Dobutamine-norepinephrine, but not vasopressin, restores the ventriculoarterial matching in experimental cardiogenic shock. Transl Res. 2010;156:273\u201381.","journal-title":"Transl Res"},{"key":"2407_CR57","doi-asserted-by":"crossref","first-page":"1465785","DOI":"10.3389\/fped.2024.1465785","volume":"12","author":"K Patel","year":"2024","unstructured":"Patel K, Thomson S, Vijayan M, Makoni M, Johnson PN, Stephens K, et al. Vasopressin induced hyponatremia in infants <3 months of age in the neonatal intensive care unit. Front Pediatr. 2024;12:1465785.","journal-title":"Front Pediatr"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41372-025-02407-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-025-02407-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-025-02407-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:09:43Z","timestamp":1759144183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41372-025-02407-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,4]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["2407"],"URL":"https:\/\/doi.org\/10.1038\/s41372-025-02407-w","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,4]]},"assertion":[{"value":"7 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}