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The association between dose and duration of maternal epidural and fentanyl levels in cord blood and meconium was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 298 mother-infant dyads, median duration of fentanyl epidural was 6.8\u2009hours. There was a strong positive correlation between epidural duration and fentanyl levels in meconium (Spearman rho = 0.70, 95%CI [0.64-0.76]),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Positive predictive value for fentanyl detection in meconium &gt;0.05\u2009ng\/g for epidural exposure of &gt;4\u2009hours was 93.9%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is a strong positive correlation between maternal epidural duration and fentanyl in meconium. Providers can anticipate a positive meconium drug screen for fentanyl in the setting of a maternal epidural.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41372-025-02416-9","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T06:12:40Z","timestamp":1758175960000},"page":"563-568","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective observational study quantifying maternal-fetal fentanyl transmission in epidural analgesia infusion using umbilical cord blood and neonatal meconium"],"prefix":"10.1038","volume":"46","author":[{"given":"Nanyaly M.","family":"Santiago-Aponte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongxiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonya S.","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4169-7396","authenticated-orcid":false,"given":"Tammy E.","family":"Corr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"2416_CR1","doi-asserted-by":"publisher","first-page":"845","DOI":"10.15585\/mmwr.mm6731a1","volume":"67","author":"SC Haight","year":"2018","unstructured":"Haight SC, Ko JY, Tong VT, Bohm MK, Callaghan WM. 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