{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:00:23Z","timestamp":1774418423341,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess inter-specialty differences in the management of febrile neonates receiving prostaglandin E1 (PGE1) for duct-dependent congenital heart disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>\n                      A cross-sectional, web-based survey was distributed to 800 neonatologists and pediatric cardiac intensivists in North America, Europe, and the Middle East. Respondents (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009526) were queried regarding their management of a clinical vignette involving a febrile neonate on PGE1, including decisions about sepsis work-up, antibiotic administration, and lumbar puncture. Data were analyzed using chi-square tests and multivariate logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Pediatric cardiac intensivists were significantly more likely to initiate full sepsis work-up and antibiotic therapy (65.6% vs. 38.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Specialty was the only significant predictor of antibiotic administration (OR\u2009=\u20093.07, 95% CI: 1.76\u20134.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No significant differences were found in lumbar puncture practices.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Significant inter-specialty variation exists in the management of febrile neonates on PGE1, highlighting the need for evidence-based guidelines to standardize care and optimize antimicrobial stewardship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41372-025-02512-w","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T09:13:03Z","timestamp":1763975583000},"page":"383-387","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inter-specialty differences in the management of febrile neonates on prostaglandin E1"],"prefix":"10.1038","volume":"46","author":[{"given":"Sharon","family":"Morag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Lowenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiba","family":"Abuelhija","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4575-3888","authenticated-orcid":false,"given":"Uri","family":"Pollak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"2512_CR1","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1161\/01.cir.64.5.899","volume":"64","author":"MD Freed","year":"1981","unstructured":"Freed MD, Heymann MA, Lewis AB, Roehl SL, Kensey RC. 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Participation implied consent, and respondents were informed of the anonymous nature of data handling and publication. All methods were performed in accordance with the relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"ethics"}}]}}