{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:05:42Z","timestamp":1789743942519,"version":"4.0.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Monitoring bilirubin in preterm neonates is essential to prevent neurotoxicity. Total serum bilirubin (TSB) remains the diagnostic standard, while transcutaneous bilirubinometry (TcB) offers a rapid, non-invasive, and cost-effective alternative. However, TcB\u2019s accuracy in preterm infants, especially during phototherapy and across racial or gestational groups, remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess concordance between TcB and TSB in preterm neonates across gestational ages, racial\/ethnic groups, and phototherapy exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 330 paired TcB-TSB readings from 113 preterm infants (postnatal age 5\u2013408\u2009h, mean\u2009\u00b1\u2009SD: 91.8\u2009\u00b1\u200964.2) in a NICU. Infants were categorized by gestational age (&lt;28, 28\u201332, 32\u201336 weeks), including self-reported maternal race and ethnicity. We employed correlation analysis, paired t-tests, linear regression, and Bland-Altman plots. TcB was evaluated under phototherapy (exposed vs. patched skin) in relation to escalation of care thresholds (ECT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TcB and TSB were strongly correlated overall (r\u2009=\u20090.822), but the level of agreement varied by gestational age and phototherapy exposure. Accuracy declined with phototherapy, especially on exposed skin. Bland-Altman analysis showed that TSB and TcB are not interchangeable. Finally, TcB-ECT concordance was low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TcB correlates with TSB but lacks sufficient accuracy for standalone use in preterm infants, particularly during phototherapy. Caution is called for in clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41372-025-02558-w","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T13:29:52Z","timestamp":1767619792000},"page":"1720-1725","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcutaneous bilirubin measurements in preterm infants: the impact of race, age, and phototherapy"],"prefix":"10.1038","volume":"46","author":[{"given":"Natasha","family":"Cordero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Petrova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrryn","family":"Halari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9919-1043","authenticated-orcid":false,"given":"Thomas","family":"Hegyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"2558_CR1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1542\/peds.65.2.195","volume":"65","author":"I Yamanouchi","year":"1980","unstructured":"Yamanouchi I, Yamauchi Y, Igarashi I. 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The Rutgers University Office of Research IRB approved this project, reference number Pro2023000044. Informed consent was obtained from a parent of all enrolled infants.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Ethics"}}]}}