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Serial hemodynamic assessments and physiology-centric care have been shown to be safe and effective in the acute transitional and peri-operative care of these neonates and will likely be informative in the discussion of chronic pulmonary hypertension as well. Herein, we discuss the epidemiology, contributors, and proposed physiology-based phenotypes of chronic pulmonary hypertension in neonates with CDH. Further investigation is needed to contribute to our understanding and treatment of chronic pulmonary hypertension in this complex, heterogeneous population.<\/jats:p>","DOI":"10.1038\/s41372-026-02582-4","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T09:58:31Z","timestamp":1771840711000},"page":"1100-1108","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A hemodynamic-driven approach to chronic pulmonary hypertension in congenital diaphragmatic hernia"],"prefix":"10.1038","volume":"46","author":[{"given":"Carly E.","family":"Byrd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John T.","family":"Wren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneetha","family":"Desiraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7648-8872","authenticated-orcid":false,"given":"Patrick J.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"2582_CR1","doi-asserted-by":"publisher","first-page":"114,119.e1","DOI":"10.1016\/j.jpeds.2012.12.036","volume":"163","author":"J Wynn","year":"2013","unstructured":"Wynn J, Krishnan U, Aspelund G, Zhang Y, Duong J, Stolar CJH, et al. 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