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Five sequential Plan-Do-Study-Act cycles incorporated guidelines to decrease transfusions. Statistical Process Control charts (QI Macros SPC Software for Microsoft Excel) were used to track time-ordered data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>pRBC transfusions decreased from 28\/1000 patient days to 18.3\/1000 patient days below the target of 21\/1000 patient days over a 16-month period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A transition to more restrictive transfusion thresholds was done successfully in our unit with a robust framework leading to fewer pRBC transfusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41372-026-02699-6","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T09:49:26Z","timestamp":1776937766000},"page":"868-873","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decreasing packed red blood cell (pRBC) transfusions in neonates through quality improvement"],"prefix":"10.1038","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7054-0858","authenticated-orcid":false,"given":"Valerie","family":"Elberson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4679-7307","authenticated-orcid":false,"given":"Kavya","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheetal","family":"Chepuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8727-3017","authenticated-orcid":false,"given":"Praveen","family":"Chandrasekharan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"2699_CR1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1111\/vox.13036","volume":"116","author":"A Villeneuve","year":"2021","unstructured":"Villeneuve A, Arsenault V, Lacroix J, Tucci M. 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