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All newborns treated with TH between 2018 and 2022 were included. The primary outcome was the incidence of SCFN. Secondary outcomes included associated risk factors and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SCFN occurred in 4% of newborns (20\/499) undergoing TH. Factors associated with SCFN included elevated maternal BMI, maternal preeclampsia\/hypertension, pyrexia during labor, earlier initiation of active cooling, thrombocytopenia, and blood product administration. Half of the SCFN cases developed hypercalcemia. SCFN was associated with longer hospital stay (median 11.5 vs. 8 days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this large, contemporary cohort, SCFN occurred in 4% of newborns with NE treated with TH. Enhanced monitoring and risk stratification may facilitate early diagnosis and improve management outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41372-026-02772-0","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:39:35Z","timestamp":1783323575000},"page":"1801-1809","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence and risk factor profile for subcutaneous fat necrosis among newborns undergoing therapeutic hypothermia: a multi-center regional cohort"],"prefix":"10.1038","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4665-6884","authenticated-orcid":false,"given":"Brian H.","family":"Walsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5662-1661","authenticated-orcid":false,"given":"Hoda","family":"El-Shibiny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Cherkerzian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara V.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munish","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7766-5188","authenticated-orcid":false,"given":"Anne","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-4543","authenticated-orcid":false,"given":"Emily","family":"Herzberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet S.","family":"Soul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrie","family":"Inder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6979-7407","authenticated-orcid":false,"given":"Mohamed","family":"El-Dib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"2772_CR1","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1111\/j.1365-2133.2007.07782.x","volume":"156","author":"E Mah\u00e9","year":"2007","unstructured":"Mah\u00e9 E, Girszyn N, Hadj-Rabia S, Bodemer C, Hamel-Teillac D, De Prost Y. 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