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PEEP was increased stepwise by 2 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O from 4 to 10\u2009cmH\n                      <jats:sub>2<\/jats:sub>\n                      O. The PEEP with the lowest lung ultrasound score was recorded along with vital parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 10 of 11 infants (91%; 95% confidence interval 62\u201399,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), the LRM identified a PEEP with a lower lung ultrasound score than the clinically set level; five infants required a higher and five a lower PEEP. Clinical parameters were stable or improved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this pilot cohort, lung ultrasound-guided PEEP adjustment appeared feasible and was associated with favourable short-term changes in lung aeration. Larger studies are required to validate these preliminary findings and determine clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41372-026-02831-6","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:36:21Z","timestamp":1785245781000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of lung ultrasound-guided positive end-expiratory pressure adjustment in newborns"],"prefix":"10.1038","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3398-172X","authenticated-orcid":false,"given":"Anna Holst","family":"M\u00f8ller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Heiring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian Pornpakdee","family":"Feldskou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Klebermass-Schrehof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-0670","authenticated-orcid":false,"given":"Mette H\u00f8j","family":"Lauridsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper Jacobsen","family":"Kyng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"2831_CR1","doi-asserted-by":"publisher","first-page":"e2020038505E","DOI":"10.1542\/peds.2020-038505E","volume":"147","author":"K Aziz","year":"2021","unstructured":"Aziz K, Lee HC, Escobedo MB, Hoover AV, Kamath-Rayne BD, et al. 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