{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:00:02Z","timestamp":1785517202891,"version":"3.56.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Internalizing disorders in children and adolescents include anxiety, depression, and somatic symptoms. Early identification is essential to prevent long-term mental health challenges. Hypoxic-ischemic encephalopathy (HIE) has been associated with an increased risk of internalizing disorders in early life. This scoping review summarized the literature on internalizing disorders in HIE survivors, highlighting the assessment methods and psychological outcomes. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for scoping reviews and included peer-reviewed studies reporting internalizing symptoms in HIE survivors. Five major databases were searched, and study quality was assessed using the Newcastle\u2013Ottawa Scale. Of the 2917 studies screened, twelve met the inclusion criteria. Our review revealed variability in internalizing symptoms, but nine of the 12 studies showed that HIE survivors had higher internalizing symptoms. This review revealed substantial variability across studies, underscoring the need for more standardized assessment tools and early screening during early childhood.<\/jats:p>","DOI":"10.1038\/s41372-026-02834-3","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:28:01Z","timestamp":1785313681000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Silent struggles of internalizing disorders in survivors of neonatal hypoxic ischemic encephalopathy: a scoping review"],"prefix":"10.1038","author":[{"given":"Nursena","family":"Yabalar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6652-3927","authenticated-orcid":false,"given":"Irem","family":"Isik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7947-9496","authenticated-orcid":false,"given":"Nur","family":"Aycan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-388X","authenticated-orcid":false,"given":"Mary","family":"Hitchcock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Elizabeth","family":"Nigro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0116-8422","authenticated-orcid":false,"given":"Alanna M.","family":"Kessler-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Cengiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1410-7883","authenticated-orcid":false,"given":"Jonathan J.","family":"Mietchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"2834_CR1","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1001\/archpsyc.60.8.837","volume":"60","author":"EJ Costello","year":"2003","unstructured":"Costello EJ, Mustillo S, Erkanli A, Keeler G, Angold A. Prevalence and development of psychiatric disorders in childhood and adolescence. Arch Gen Psychiatry. 2003;60:837\u201344.","journal-title":"Arch Gen Psychiatry"},{"key":"2834_CR2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/1469-7610.00303","volume":"39","author":"M Kovacs","year":"1998","unstructured":"Kovacs M, Devlin B. Internalizing disorders in childhood. J Child Psychol Psychiatry, Allied Discip. 1998;39:47\u201363.","journal-title":"J Child Psychol Psychiatry, Allied Discip"},{"key":"2834_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.31887\/DCNS.2009.11.1\/krmerikangas","volume":"11","author":"KR Merikangas","year":"2009","unstructured":"Merikangas KR, Nakamura EF, Kessler RC. Epidemiology of mental disorders in children and adolescents. Dialogues Clin Neurosci. 2009;11:7\u201320.","journal-title":"Dialogues Clin Neurosci"},{"key":"2834_CR4","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","volume":"62","author":"RC Kessler","year":"2005","unstructured":"Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62:593\u2013602.","journal-title":"Arch Gen Psychiatry"},{"key":"2834_CR5","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.psc.2009.06.002","volume":"32","author":"K Beesdo","year":"2009","unstructured":"Beesdo K, Knappe S, Pine DS. Anxiety and anxiety disorders in children and adolescents: developmental issues and implications for DSM-V. Psychiatr Clin North Am. 2009;32:483\u2013524.","journal-title":"Psychiatr Clin North Am"},{"key":"2834_CR6","doi-asserted-by":"crossref","unstructured":"Cainelli E, Vedovelli L, Mastretta E, Gregori D, Suppiej A, Bisiacchi PS. Long-term outcomes after neonatal hypoxic-ischemic encephalopathy in the era of therapeutic hypothermia: a longitudinal, prospective, multicenter case-control study in children without overt brain damage. Children. 2021;8:1076\u201384.","DOI":"10.3390\/children8111076"},{"key":"2834_CR7","doi-asserted-by":"publisher","first-page":"e0263055","DOI":"10.1371\/journal.pone.0263055","volume":"17","author":"M \u00c1lvarez-Garc\u00eda","year":"2022","unstructured":"\u00c1lvarez-Garc\u00eda M, Cu\u00e9llar-Flores I, Sierra-Garc\u00eda P, Mart\u00ednez-Orgado J. Mood disorders in children following neonatal hypoxic-ischemic encephalopathy. PLoS ONE. 2022;17:e0263055.","journal-title":"PLoS ONE"},{"key":"2834_CR8","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1093\/jpepsy\/jsp049","volume":"35","author":"M van Handel","year":"2010","unstructured":"van Handel M, Swaab H, de Vries LS, Jongmans MJ. Behavioral outcome in children with a history of neonatal encephalopathy following perinatal asphyxia. J Pediatr Psychol. 2010;35:286\u201395.","journal-title":"J Pediatr Psychol"},{"key":"2834_CR9","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s00431-007-0437-8","volume":"166","author":"M van Handel","year":"2007","unstructured":"van Handel M, Swaab H, de Vries LS, Jongmans MJ. Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a review. Eur J Pediatrics. 2007;166:645\u201354.","journal-title":"Eur J Pediatrics"},{"key":"2834_CR10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00431-017-3028-3","volume":"177","author":"BC Hayes","year":"2018","unstructured":"Hayes BC, Doherty E, Grehan A, Madigan C, McGarvey C, Mulvany S, et al. Neurodevelopmental outcome in survivors of hypoxic ischemic encephalopathy without cerebral palsy. Eur J Pediatrics. 2018;177:19\u201332.","journal-title":"Eur J Pediatrics"},{"key":"2834_CR11","doi-asserted-by":"publisher","first-page":"F380","DOI":"10.1136\/adc.2004.067520","volume":"90","author":"N Marlow","year":"2005","unstructured":"Marlow N, Rose AS, Rands CE, Draper ES. Neuropsychological and educational problems at school age associated with neonatal encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2005;90:F380\u20137.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2834_CR12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ijdevneu.2007.08.020","volume":"26","author":"S Rees","year":"2008","unstructured":"Rees S, Harding R, Walker D. An adverse intrauterine environment: implications for injury and altered development of the brain. Int J Dev Neurosci. 2008;26:3\u201311.","journal-title":"Int J Dev Neurosci"},{"key":"2834_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-018-0611-x","volume":"18","author":"Z Munn","year":"2018","unstructured":"Munn Z, Peters MDJ, Stern C, Tufanaru C, McArthur A, Aromataris E. Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Med Res Methodol. 2018;18:143.","journal-title":"BMC Med Res Methodol"},{"key":"2834_CR14","doi-asserted-by":"publisher","first-page":"467","DOI":"10.7326\/M18-0850","volume":"169","author":"AC Tricco","year":"2018","unstructured":"Tricco AC, Lillie E, Zarin W, O\u2019Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169:467\u201373.","journal-title":"Ann Intern Med"},{"key":"2834_CR15","doi-asserted-by":"crossref","unstructured":"Kromm GH, Patankar H, Nagalotimath S, Wong H, Austin T. Socioemotional and psychological outcomes of hypoxic-ischemic encephalopathy: a systematic review. Pediatrics. 2024;153:e2023063399\u2013e2023063419.","DOI":"10.1542\/peds.2023-063399"},{"key":"2834_CR16","unstructured":"Covidence systematic review software, VHI, Melbourne, Australia. Available from: www.covidence.org."},{"key":"2834_CR17","unstructured":"Wells GA SB, O\u2019Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of non-randomised studies in meta-analyses. 2000. Available from: https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"2834_CR18","unstructured":"Achenbach TM, Rescorla L. Manual for the ASEBA School-Age Forms & Profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, & Families.2001."},{"key":"2834_CR19","doi-asserted-by":"crossref","unstructured":"Goodman R. The strengths and difficulties questionnaire: a research note. J Child Psychol Psychiatry Allied Disciplin. 1997;38:581\u20136.","DOI":"10.1111\/j.1469-7610.1997.tb01545.x"},{"key":"2834_CR20","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1097\/00005650-200108000-00006","volume":"39","author":"JW Varni","year":"2001","unstructured":"Varni JW, Seid M, Kurtin PS. PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. Med Care. 2001;39:800\u201312.","journal-title":"Med Care"},{"key":"2834_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2022.105541","volume":"165","author":"S Halpin","year":"2022","unstructured":"Halpin S, McCusker C, Fogarty L, White J, Cavaliere E, Boylan G, et al. Long-term neuropsychological and behavioral outcome of mild and moderate hypoxic ischemic encephalopathy. Early Hum Dev. 2022;165:105541.","journal-title":"Early Hum Dev"},{"key":"2834_CR22","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1159\/000490369","volume":"114","author":"WS Kalteren","year":"2018","unstructured":"Kalteren WS, Ter Horst HJ, den Heijer AE, de Vetten L, Kooi EMW, Bos AF. Perinatal anemia is associated with neonatal and neurodevelopmental outcomes in infants with moderate-to-severe perinatal asphyxia. Neonatology. 2018;114:315\u201322.","journal-title":"Neonatology"},{"key":"2834_CR23","first-page":"104","volume":"100","author":"MM Hortiguela","year":"2024","unstructured":"Hortiguela MM, Mart\u00ednez-Biarge M, Conejo D, Vega-Del-Val C, Arnaez J. Grupo A. Motor, cognitive and behavioural outcomes after neonatal hypoxic-ischaemic encephalopathy. Pediatrics. 2024;100:104\u201314.","journal-title":"Pediatrics"},{"key":"2834_CR24","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1111\/apa.15902","volume":"110","author":"Z Zareen","year":"2021","unstructured":"Zareen Z, Allen J, Kelly LA, McDonald D, Sweetman D, Molloy EJ. An observational study of sleep in childhood post-neonatal encephalopathy. Acta Paediatr. 2021;110:2352\u20136.","journal-title":"Acta Paediatr"},{"key":"2834_CR25","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1136\/archdischild-2018-316509","volume":"105","author":"R Lee-Kelland","year":"2020","unstructured":"Lee-Kelland R, Jary S, Tonks J, Cowan FM, Thoresen M, Chakkarapani E. School-age outcomes of children without cerebral palsy cooled for neonatal hypoxic-ischaemic encephalopathy in 2008-10. Arch Dis Child Fetal Neonatal Ed. 2020;105:8\u201313.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2834_CR26","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ejpn.2020.04.003","volume":"27","author":"CJ Edmonds","year":"2020","unstructured":"Edmonds CJ, Helps SK, Hart D, Zatorska A, Gupta N, Cianfaglione R, et al. Minor neurological signs and behavioural function at age 2 years in neonatal hypoxic-ischaemic encephalopathy (HIE). Eur J Paediatr Neurol Off J Eur Paediatr Neurol Soc. 2020;27:78\u201385.","journal-title":"Eur J Paediatr Neurol Off J Eur Paediatr Neurol Soc"},{"key":"2834_CR27","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1080\/13854046.2020.1833987","volume":"35","author":"A Danguecan","year":"2021","unstructured":"Danguecan A, El Shahed AI, Somerset E, Fan CS, Ly LG, Williams T. Towards a biopsychosocial understanding of neurodevelopmental outcomes in children with hypoxic-ischemic encephalopathy: a mixed-methods study. Clin Neuropsychol. 2021;35:925\u201347.","journal-title":"Clin Neuropsychol"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41372-026-02834-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-026-02834-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41372-026-02834-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:08:58Z","timestamp":1785514138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41372-026-02834-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":27,"alternative-id":["2834"],"URL":"https:\/\/doi.org\/10.1038\/s41372-026-02834-3","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"assertion":[{"value":"21 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}