{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:03:08Z","timestamp":1789984988552,"version":"4.0.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Identify clinical predictors of bloodstream (BSI) and urinary tract infections (UTI) in infants with gastroschisis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Retrospective analysis of infants with gastroschisis admitted to 47 neonatal intensive care units (NICUs) contributing to the Children\u2019s Hospitals Neonatal Database (CHND) from 2010\u201323. Outcomes were occurrence of BSI or UTI before discharge. Generalized linear models with generalized estimating equation (GEE) to account for hospitals as clusters utilized to identify factors independently related to the outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Of 3987 eligible infants, rates of early BSI (within 3 days of birth) were 0.4%, any BSI 7.6% and UTI 3.5%. Median age of infection was 32 days for BSI and 39 days for UTI. Bowel atresia, silo\/staged closure, patch closure, and additional anomalies were independently associated with these infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We identified clinical predictors of BSI and UTI, which should facilitate limitation of antibiotic use in low risk patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41372-026-02880-x","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:30:56Z","timestamp":1789983056000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predicting risk of infection in infants with gastroschisis"],"prefix":"10.1038","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-6689","authenticated-orcid":false,"given":"Stefanie","family":"Riddle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1234-3468","authenticated-orcid":false,"given":"Isabella","family":"Zaniletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karna","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6776-6383","authenticated-orcid":false,"given":"Alaina","family":"Pyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5367-3039","authenticated-orcid":false,"given":"Ellen","family":"Bendel-Stenzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Grover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3813-3189","authenticated-orcid":false,"given":"Heidi","family":"Karpen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-7990","authenticated-orcid":false,"given":"Franscesca","family":"Miquel-Verges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadie","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-218X","authenticated-orcid":false,"given":"Jennifer","family":"Rumpel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2050-5930","authenticated-orcid":false,"given":"Michael A.","family":"Padula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the CHNC Gastroschisis Focus Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"2880_CR1","first-page":"170","volume":"8","author":"IN Bielicki","year":"2021","unstructured":"Bielicki IN, Somme S, Frongia G, Holland-Cunz SG, Vuille-Dit-Bille RN. 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TG is a board member of CHNC; a portion of faculty effort is supported by CHNC in Dr. Grover\u2019s role as Associate Executive Director of CHNC. MP is Board member of CHNC. All other authors have no conflicts of interest to disclose.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"Each contributing hospital obtained IRB oversight to participate in the CHND. The Stanley Manne Research Institute Institutional Review Board, affiliated with Ann & Robert H. Lurie Children\u2019s Hospital of Chicago Research Center\u2019s approved this study (#2011-14673).","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Ethics"}}]}}