{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:07:12Z","timestamp":1789744032907,"version":"4.0.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Preterm infants are vulnerable to bilirubin neurotoxicity. We evaluated whether time-stratified transcutaneous bilirubin (TcB) and kinetic indices improve the prediction of the risk of phototherapy and escalation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a cohort of preterm infants, only pre-phototherapy TcB values were analyzed. TcB values were grouped by postnatal age (\u226424\u2009h, 25\u201348\u2009h, 49\u201372\u2009h, \u226573\u2009h), and sequential measurements were used to calculate bilirubin increase rates (RBIa, RBIb) and absolute percent change (APC%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Infants requiring phototherapy had higher TcB levels within 72\u2009h, particularly at \u226424\u2009h and 25\u201348\u2009h. Independent predictors included TcB (OR 2.11), gestational age (OR 0.37), and postnatal age (OR 0.30; AUC 0.827). Treated infants showed faster bilirubin accumulation, and early RBIa correlated with peak TcB (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.334). APC% independently predicted proximity to the escalation threshold.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Time-standardized TcB measurements and dynamic kinetic indices may facilitate earlier identification of preterm infants at increased risk for phototherapy and warrant prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41372-026-02886-5","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:27:12Z","timestamp":1788186432000},"page":"1747-1753","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bilirubin kinetics in preterm infants"],"prefix":"10.1038","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9919-1043","authenticated-orcid":false,"given":"Thomas","family":"Hegyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Cordero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrryn","family":"Halari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Petrova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"2886_CR1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.clp.2016.01.006","volume":"43","author":"C Olds","year":"2016","unstructured":"Olds C, Oghalai JS. 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The Rutgers University Office of Research IRB approved this project, reference number Pro2023000044. Informed consent was obtained from a parent of all enrolled infants.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Ethics"}}]}}