{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:35:19Z","timestamp":1793831719880,"version":"4.6.1"},"reference-count":71,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":1624,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1038\/s41374-018-0063-2","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T12:44:37Z","timestamp":1527857077000},"page":"1105-1121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Cisplatin nephrotoxicity as a model of chronic kidney disease"],"prefix":"10.1016","volume":"98","author":[{"given":"Mingjun","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L.","family":"McMillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Gillings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orson W.","family":"Moe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3235-8301","authenticated-orcid":false,"given":"Ming Chang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41374-018-0063-2_bib1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2215\/CJN.04961107","article-title":"Epidemiology of acute kidney injury","volume":"3","author":"Cerda","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib2","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.2215\/CJN.00710113","article-title":"World incidence of AKI: a meta-analysis","volume":"8","author":"Susantitaphong","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000445091","article-title":"Acute kidney injury in western countries","volume":"2","author":"Bouchard","year":"2016","journal-title":"Kidney Dis"},{"key":"10.1038\/s41374-018-0063-2_bib4","first-page":"479730","article-title":"Epidemiology of acute kidney injury in the intensive care unit","volume":"2013","author":"Case","year":"2013","journal-title":"Crit Care Res Pract"},{"key":"10.1038\/s41374-018-0063-2_bib5","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1681\/ASN.2006070756","article-title":"Incidence and outcomes in acute kidney injury: a comprehensive population-based study","volume":"18","author":"Ali","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib6","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1681\/ASN.2012030222","article-title":"Yes, AKI truly leads to CKD","volume":"23","author":"Hsu","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/ki.2011.405","article-title":"Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury","volume":"81","author":"Bucaloiu","year":"2012","journal-title":"Kidney Int"},{"key":"10.1038\/s41374-018-0063-2_bib8","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1681\/ASN.2015060613","article-title":"AlphaKlotho mitigates progression of AKI to CKD through activation of autophagy","volume":"27","author":"Shi","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1681\/ASN.2009121311","article-title":"Klotho deficiency causes vascular calcification in chronic kidney disease","volume":"22","author":"Hu","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib10","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1681\/ASN.2014050465","article-title":"Klotho and phosphate are modulators of pathologic uremic cardiac remodeling","volume":"26","author":"Hu","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib11","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.kint.2016.10.034","article-title":"Recombinant alpha-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy","volume":"91","author":"Hu","year":"2017","journal-title":"Kidney Int"},{"key":"10.1038\/s41374-018-0063-2_bib12","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/bcp.12554","article-title":"Drug-induced acute kidney injury in children","volume":"80","author":"Faught","year":"2015","journal-title":"Br J Clin Pharmacol"},{"key":"10.1038\/s41374-018-0063-2_bib13","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-016-2271-8","article-title":"Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors","volume":"16","author":"Sato","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1038\/s41374-018-0063-2_bib14","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2215\/CJN.08070715","article-title":"Long-term renal outcomes after cisplatin treatment","volume":"11","author":"Latcha","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib15","first-page":"397","article-title":"Methods of reduction of cisplatin nephrotoxicity","volume":"11","author":"Walker","year":"1981","journal-title":"Ann Clin Lab Sci"},{"key":"10.1038\/s41374-018-0063-2_bib16","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00109-015-1366-z","article-title":"CD4 T cell knockout does not protect against kidney injury and worsens cancer","volume":"94","author":"Ravichandran","year":"2016","journal-title":"J Mol Med"},{"key":"10.1038\/s41374-018-0063-2_bib17","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/ki.2015.327","article-title":"Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition","volume":"89","author":"Katagiri","year":"2016","journal-title":"Kidney Int"},{"key":"10.1038\/s41374-018-0063-2_bib18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1155\/MI.2005.139","article-title":"Lipid peroxides and antioxidant enzymes in cisplatin-induced chronic nephrotoxicity in rats","volume":"2005","author":"Gonzalez","year":"2005","journal-title":"Mediat Inflamm"},{"key":"10.1038\/s41374-018-0063-2_bib19","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1681\/ASN.2015010079","article-title":"Three-dimensional morphology by multiphoton microscopy with clearing in a model of cisplatin-induced CKD","volume":"27","author":"Torres","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib20","doi-asserted-by":"crossref","first-page":"F560","DOI":"10.1152\/ajprenal.00512.2015","article-title":"Repeated administration of low-dose cisplatin in mice induces fibrosis","volume":"310","author":"Sharp","year":"2016","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1038\/s41374-018-0063-2_bib21","doi-asserted-by":"crossref","first-page":"F835","DOI":"10.1152\/ajprenal.00285.2017","article-title":"Developing better mouse models to study cisplatin-induced kidney injury","volume":"313","author":"Sharp","year":"2017","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1038\/s41374-018-0063-2_bib22","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/ki.2010.328","article-title":"Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective","volume":"78","author":"Hu","year":"2010","journal-title":"Kidney Int"},{"key":"10.1038\/s41374-018-0063-2_bib23","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1096\/fj.10-154765","article-title":"Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule","volume":"24","author":"Hu","year":"2010","journal-title":"FASEB J"},{"key":"10.1038\/s41374-018-0063-2_bib24","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/ki.2013.489","article-title":"Klotho has dual protective effects on cisplatin-induced acute kidney injury","volume":"85","author":"Panesso","year":"2014","journal-title":"Kidney Int"},{"key":"10.1038\/s41374-018-0063-2_bib25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/ndt\/gfu291","article-title":"The demonstration of alphaKlotho deficiency in human chronic kidney disease with a novel synthetic antibody","volume":"30","author":"Barker","year":"2015","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/s41374-018-0063-2_bib26","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0022-3476(98)70223-9","article-title":"The late histologic findings in diarrhea-associated hemolytic uremic syndrome","volume":"133","author":"Moghal","year":"1998","journal-title":"J Pediatr"},{"key":"10.1038\/s41374-018-0063-2_bib27","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrneph.2012.92","article-title":"Klotho as a potential biomarker and therapy for acute kidney injury","volume":"8","author":"Hu","year":"2012","journal-title":"Nat Rev Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib28","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1038\/s41374-018-0063-2_bib29","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1681\/ASN.2013101121","article-title":"Fluorescence microangiography for quantitative assessment of peritubular capillary changes after AKI in mice","volume":"25","author":"Kramann","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib30","doi-asserted-by":"crossref","first-page":"818","DOI":"10.5812\/numonthly.10128","article-title":"Gender difference in cisplatin-induced nephrotoxicity in a rat model: greater intensity of damage in male than female","volume":"5","author":"Nematbakhsh","year":"2013","journal-title":"Nephrourol Mon"},{"key":"10.1038\/s41374-018-0063-2_bib31","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1681\/ASN.2012080865","article-title":"Loss of Klotho contributes to kidney injury by derepression of Wnt\/beta-catenin signaling","volume":"24","author":"Zhou","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0300-483X(84)90086-6","article-title":"Age differences in cisplatinum nephrotoxicity","volume":"32","author":"Appenroth","year":"1984","journal-title":"Toxicology"},{"key":"10.1038\/s41374-018-0063-2_bib33","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0002-9343(84)90280-8","article-title":"Lack of age-dependent cisplatin nephrotoxicity","volume":"76","author":"Hrushesky","year":"1984","journal-title":"Am J Med"},{"key":"10.1038\/s41374-018-0063-2_bib34","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000197562","article-title":"Phosphate-the silent stealthy cardiorenal culprit in all stages of chronic kidney disease: a systematic review","volume":"27","author":"Kanbay","year":"2009","journal-title":"Blood Purif"},{"key":"10.1038\/s41374-018-0063-2_bib35","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.2215\/CJN.01660309","article-title":"Phosphate levels and cardiovascular disease in the general population","volume":"4","author":"Foley","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib36","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/ATVBAHA.111.231928","article-title":"Phosphate and CVD: it's all in what's on the table","volume":"31","author":"Striker","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1038\/s41374-018-0063-2_bib37","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1440-1797.2012.01618.x","article-title":"Phosphate in early chronic kidney disease: associations with clinical outcomes and a target to reduce cardiovascular risk","volume":"17","author":"Toussaint","year":"2012","journal-title":"Nephrology"},{"key":"10.1038\/s41374-018-0063-2_bib38","doi-asserted-by":"crossref","first-page":"e102276","DOI":"10.1371\/journal.pone.0102276","article-title":"Can serum levels of alkaline phosphatase and phosphate predict cardiovascular diseases and total mortality in individuals with preserved renal function? A systemic review and meta-analysis","volume":"9","author":"Li","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1038\/s41374-018-0063-2_bib39","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1681\/ASN.2015020117","article-title":"Rationale and approaches to phosphate and fibroblast growth factor 23 reduction in CKD","volume":"26","author":"Isakova","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib40","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1139\/apnm-2015-0176","article-title":"Phosphate excretion is decreased in older cardiac patients with normal kidney function: an emerging dietary risk factor?","volume":"41","author":"Jozefacki","year":"2016","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1038\/s41374-018-0063-2_bib41","doi-asserted-by":"crossref","first-page":"e0150093","DOI":"10.1371\/journal.pone.0150093","article-title":"Phosphate-induced renal fibrosis requires the prolyl isomerase pin1","volume":"11","author":"Shen","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1038\/s41374-018-0063-2_bib42","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nrneph.2016.164","article-title":"The role of phosphate in kidney disease","volume":"13","author":"Vervloet","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib43","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s40618-014-0158-6","article-title":"Alpha Klotho and phosphate homeostasis","volume":"37","author":"Bian","year":"2014","journal-title":"J Endocrinol Invest"},{"key":"10.1038\/s41374-018-0063-2_bib44","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/sj.ki.5002191","article-title":"Gender-specific association of adiponectin as a predictor of progression of chronic kidney disease: the mild to moderate kidney disease study","volume":"71","author":"Kollerits","year":"2007","journal-title":"Kidney Int"},{"key":"10.1038\/s41374-018-0063-2_bib45","doi-asserted-by":"crossref","first-page":"F1169","DOI":"10.1152\/ajprenal.00676.2013","article-title":"Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats","volume":"307","author":"Diwan","year":"2014","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1038\/s41374-018-0063-2_bib46","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1042\/CS20160047","article-title":"Sex and gender differences in chronic kidney disease: progression to end-stage renal disease and haemodialysis","volume":"130","author":"Cobo","year":"2016","journal-title":"Clin Sci"},{"key":"10.1038\/s41374-018-0063-2_bib47","doi-asserted-by":"crossref","first-page":"e4203","DOI":"10.1097\/MD.0000000000004203","article-title":"Risk factors of gender for renal progression in patients with early chronic kidney disease","volume":"95","author":"Chang","year":"2016","journal-title":"Medicine"},{"key":"10.1038\/s41374-018-0063-2_bib48","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.semnephrol.2017.02.009","article-title":"Chronic kidney disease, gender, and access to care: a global perspective","volume":"37","author":"Carrero","year":"2017","journal-title":"Semin Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib49","first-page":"363","article-title":"Cis-diamminedichloroplatinum (II)-induced acute renal failure in the rat. Correlation of structural and functional alterations","volume":"52","author":"Jones","year":"1985","journal-title":"Lab Invest"},{"key":"10.1038\/s41374-018-0063-2_bib50","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/ki.1982.8","article-title":"Cis-diamminedichlorplatinum-induced acute renal failure in the rat","volume":"21","author":"Chopra","year":"1982","journal-title":"Kidney Int"},{"key":"10.1038\/s41374-018-0063-2_bib51","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2119\/molmed.2010.00002","article-title":"MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival","volume":"16","author":"Bhatt","year":"2010","journal-title":"Mol Med"},{"key":"10.1038\/s41374-018-0063-2_bib52","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s10157-010-0324-x","article-title":"Self-eating for death or survival during cisplatin nephrotoxicity?","volume":"14","author":"Jiang","year":"2010","journal-title":"Clin Exp Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib53","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1007\/s00204-014-1239-1","article-title":"Mitochondrial dysregulation and protection in cisplatin nephrotoxicity","volume":"88","author":"Yang","year":"2014","journal-title":"Arch Toxicol"},{"key":"10.1038\/s41374-018-0063-2_bib54","first-page":"F175","article-title":"Cisplatin nephrotoxicity in rats: defect in papillary hypertonicity","volume":"241","author":"Safirstein","year":"1981","journal-title":"Am J Physiol"},{"key":"10.1038\/s41374-018-0063-2_bib55","first-page":"179","article-title":"Nephrotoxicity of cisplatin in rats","volume":"14","author":"Nakada","year":"1986","journal-title":"Dev Toxicol Environ Sci"},{"key":"10.1038\/s41374-018-0063-2_bib56","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3109\/15376516.2014.948248","article-title":"Renal tight junction proteins are decreased in cisplatin-induced nephrotoxicity in rats","volume":"24","author":"Trujillo","year":"2014","journal-title":"Toxicol Mech Methods"},{"key":"10.1038\/s41374-018-0063-2_bib57","first-page":"169","article-title":"Plasma platinum levels: relationship to cisplatin dose and nephrotoxicity","volume":"67","author":"Campbell","year":"1983","journal-title":"Cancer Treat Rep"},{"key":"10.1038\/s41374-018-0063-2_bib58","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1158\/1055-9965.EPI-13-0036","article-title":"Glomerular function time trends in long-term survivors of childhood cancer: a longitudinal study","volume":"22","author":"Mulder","year":"2013","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"10.1038\/s41374-018-0063-2_bib59","doi-asserted-by":"crossref","first-page":"922","DOI":"10.2215\/CJN.09980912","article-title":"Long-term nephrotoxicity in adult survivors of childhood cancer","volume":"8","author":"Dekkers","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib60","first-page":"1087","article-title":"Atubular glomeruli in cisplatin-induced chronic interstitial nephropathy","volume":"98","author":"Marcussen","year":"1990","journal-title":"Exp Stereol Investig APMIS"},{"key":"10.1038\/s41374-018-0063-2_bib61","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1248\/bpb.b17-00499","article-title":"Alterations in cisplatin pharmacokinetics and its acute\/sub-chronic kidney injury over multiple cycles of cisplatin treatment in rats","volume":"40","author":"Okada","year":"2017","journal-title":"Biol Pharm Bull"},{"key":"10.1038\/s41374-018-0063-2_bib62","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.mcna.2004.11.010","article-title":"Gender differences in hypertension and kidney disease","volume":"89","author":"Reyes","year":"2005","journal-title":"Med Clin North Am"},{"key":"10.1038\/s41374-018-0063-2_bib63","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s00467-011-1963-1","article-title":"The influence of gender and sexual hormones on incidence and outcome of chronic kidney disease","volume":"27","author":"Kummer","year":"2012","journal-title":"Pediatr Nephrol"},{"key":"10.1038\/s41374-018-0063-2_bib64","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/sj.ki.5000058","article-title":"The progression of chronic kidney disease: a 10-year population-based study of the effects of gender and age","volume":"69","author":"Eriksen","year":"2006","journal-title":"Kidney Int"},{"key":"10.1038\/s41374-018-0063-2_bib65","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1126\/science.1112766","article-title":"Suppression of aging in mice by the hormone Klotho","volume":"309","author":"Kurosu","year":"2005","journal-title":"Science"},{"key":"10.1038\/s41374-018-0063-2_bib66","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.freeradbiomed.2017.05.008","article-title":"Aging-associated metabolic disorder induces Nox2 activation and oxidative damage of endothelial function","volume":"108","author":"Fan","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"10.1038\/s41374-018-0063-2_bib67","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/ALN.0b013e31825b57c9","article-title":"Age-dependent role of microvascular endothelial and polymorphonuclear cells in lipopolysaccharide-induced acute kidney injury","volume":"117","author":"Wulfert","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1038\/s41374-018-0063-2_bib68","doi-asserted-by":"crossref","first-page":"15358","DOI":"10.3390\/ijms150915358","article-title":"The aging kidney: increased susceptibility to nephrotoxicity","volume":"15","author":"Wang","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1038\/s41374-018-0063-2_bib69","doi-asserted-by":"crossref","first-page":"583","DOI":"10.18632\/aging.101181","article-title":"Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging","volume":"9","author":"Zhou","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"10.1038\/s41374-018-0063-2_bib70","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000452880","article-title":"Klotho\/FGF23 axis in chronic kidney disease and cardiovascular disease","volume":"3","author":"Lu","year":"2017","journal-title":"Kidney Dis"},{"key":"10.1038\/s41374-018-0063-2_bib71","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bone.2017.01.017","article-title":"Potential application of klotho in human chronic kidney disease","volume":"100","author":"Neyra","year":"2017","journal-title":"Bone"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41374-018-0063-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41374-018-0063-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722011084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722011084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41374-018-0063-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:36:08Z","timestamp":1758396968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722011084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":71,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0023683722011084"],"URL":"https:\/\/doi.org\/10.1038\/s41374-018-0063-2","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cisplatin nephrotoxicity as a model of chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41374-018-0063-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}