{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T09:35:44Z","timestamp":1768037744155,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":954,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["4I01BX000574"],"award-info":[{"award-number":["4I01BX000574"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01BX003031"],"award-info":[{"award-number":["1I01BX003031"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005440","name":"U.S. Department of Health & Human Services | NIH | Center for Scientific Review","doi-asserted-by":"publisher","award":["DK108959"],"award-info":[{"award-number":["DK108959"]}],"id":[{"id":"10.13039\/100005440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1038\/s41374-020-0405-8","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T09:03:03Z","timestamp":1581584583000},"page":"837-848","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase\/histamine signaling"],"prefix":"10.1016","volume":"100","author":[{"given":"Lindsey","family":"Kennedy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vik","family":"Meadows","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Demieville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Hargrove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohaib","family":"Virani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianhao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan","family":"Rinehart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Jaeger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantina","family":"Kyritsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linh","family":"Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Alpini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Francis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/s41374-020-0405-8_bib1","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/hep.28704","article-title":"Inhibition of mast cell-secreted histamine decreases biliary proliferation and fibrosis in primary sclerosing cholangitis Mdr2(\u2212\/\u2212) mice","volume":"64","author":"Jones","year":"2016","journal-title":"Hepatology"},{"key":"10.1038\/s41374-020-0405-8_bib2","doi-asserted-by":"crossref","unstructured":"Kennedy L, Hargrove L, Demieville J, Karstens W, Jones H, DeMorrow S, et al. Blocking H1\/H2 histamine receptors inhibits damage\/fibrosis in Mdr2(\u2212\/\u2212) mice and human cholangiocarcinoma tumorigenesis. Hepatology. 2018. https:\/\/doi.org\/10.1002\/hep.29898.","DOI":"10.1002\/hep.29898"},{"key":"10.1038\/s41374-020-0405-8_bib3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.suc.2018.11.003","article-title":"Autoimmune diseases of the biliary tract: a review","volume":"99","author":"Lee","year":"2019","journal-title":"Surg Clin North Am"},{"key":"10.1038\/s41374-020-0405-8_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4291\/wjgp.v10.i1.1","article-title":"Current therapies and novel approaches for biliary diseases","volume":"10","author":"Rajapaksha","year":"2019","journal-title":"World J Gastrointest Pathophysiol"},{"key":"10.1038\/s41374-020-0405-8_bib5","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1007\/s00261-017-1328-8","article-title":"Cholangiocarcinoma and its mimickers in primary sclerosing cholangitis","volume":"42","author":"Lee","year":"2017","journal-title":"Abdom Radiol (NY)"},{"key":"10.1038\/s41374-020-0405-8_bib6","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1053\/j.gastro.2013.10.013","article-title":"Pathogenesis, diagnosis, and management of cholangiocarcinoma","volume":"145","author":"Rizvi","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1038\/s41374-020-0405-8_bib7","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jhep.2011.09.023","article-title":"Histamine regulation of biliary proliferation","volume":"56","author":"Francis","year":"2012","journal-title":"J Hepatol"},{"key":"10.1038\/s41374-020-0405-8_bib8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4291\/wjgp.v1.i2.38","article-title":"Histamine regulation of hyperplastic and neoplastic cell growth in cholangiocytes","volume":"1","author":"Onori","year":"2010","journal-title":"World J Gastrointest Pathophysiol"},{"key":"10.1038\/s41374-020-0405-8_bib9","doi-asserted-by":"crossref","first-page":"C499","DOI":"10.1152\/ajpcell.00369.2007","article-title":"Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3\/CaMK I\/CREB pathway","volume":"295","author":"Francis","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1038\/s41374-020-0405-8_bib10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/labinvest.2011.158","article-title":"Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3\/Ca2+ and cAMP-dependent signaling mechanisms","volume":"92","author":"Francis","year":"2012","journal-title":"Lab Invest"},{"key":"10.1038\/s41374-020-0405-8_bib11","doi-asserted-by":"crossref","first-page":"G813","DOI":"10.1152\/ajpgi.00188.2014","article-title":"Knockout of histidine decarboxylase decreases bile duct ligation-induced biliary hyperplasia via downregulation of the histidine decarboxylase\/VEGF axis through PKA-ERK1\/2 signaling","volume":"307","author":"Graf","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1038\/s41374-020-0405-8_bib12","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ajpath.2017.11.016","article-title":"Knockout of l-histidine decarboxylase prevents cholangiocyte damage and hepatic fibrosis in mice subjected to high-fat diet feeding via disrupted histamine\/leptin signaling","volume":"188","author":"Kennedy","year":"2018","journal-title":"Am J Pathol"},{"key":"10.1038\/s41374-020-0405-8_bib13","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1002\/hep.29079","article-title":"Bile duct ligation-induced biliary hyperplasia, hepatic injury, and fibrosis are reduced in mast cell-deficient Kit(W-sh) mice","volume":"65","author":"Hargrove","year":"2017","journal-title":"Hepatology"},{"key":"10.1038\/s41374-020-0405-8_bib14","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/j.ajpath.2018.06.015","article-title":"The secretin\/secretin receptor axis modulates ductular reaction and liver fibrosis through changes in transforming growth factor-beta1-mediated biliary senescence","volume":"188","author":"Wu","year":"2018","journal-title":"Am J Pathol"},{"key":"10.1038\/s41374-020-0405-8_bib15","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S0016-5085(96)70081-1","article-title":"Hepatic microcirculation and peribiliary plexus in experimental biliary cirrhosis: a morphological study","volume":"111","author":"Gaudio","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1038\/s41374-020-0405-8_bib16","doi-asserted-by":"crossref","unstructured":"Kyritsi K, Chen L, O'Brien A, Francis H, Hein TW, Venter J, et al. Modulation of the TPH1\/MAO-A\/5HT\/5HTR2A\/2B\/2C axis regulates biliary proliferation and liver fibrosis during cholestasis. Hepatology. 2019. https:\/\/doi.org\/10.1002\/hep.30880. [Epub ahead of print].","DOI":"10.1002\/hep.30880"},{"key":"10.1038\/s41374-020-0405-8_bib17","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jhep.2005.06.025","article-title":"Mdr2 (Abcb4)\u2212\/\u2212 mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes","volume":"43","author":"Popov","year":"2005","journal-title":"J Hepatol"},{"key":"10.1038\/s41374-020-0405-8_bib18","doi-asserted-by":"crossref","unstructured":"Kennedy L, Francis H, Invernizzi P, Venter J, Wu N, Carbone M, et al. Secretin\/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis. FASEB J. 2019. https:\/\/doi.org\/10.1096\/fj.201802606R.","DOI":"10.1096\/fj.201802606R"},{"key":"10.1038\/s41374-020-0405-8_bib19","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1096\/fj.201700097R","article-title":"Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation","volume":"31","author":"Wu","year":"2017","journal-title":"FASEB J"},{"key":"10.1038\/s41374-020-0405-8_bib20","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/hep.29145","article-title":"The role of long noncoding RNA H19 in gender disparity of cholestatic liver injury in multidrug resistance 2 gene knockout mice","volume":"66","author":"Li","year":"2017","journal-title":"Hepatology"},{"key":"10.1038\/s41374-020-0405-8_bib21","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1478-3231.2003.00876.x","article-title":"Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice","volume":"23","author":"Ueno","year":"2003","journal-title":"Liver Int"},{"key":"10.1038\/s41374-020-0405-8_bib22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1136\/gutjnl-2011-300007","article-title":"Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma","volume":"61","author":"Francis","year":"2012","journal-title":"Gut"},{"key":"10.1038\/s41374-020-0405-8_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0014-5793(01)02663-1","article-title":"Mice lacking histidine decarboxylase exhibit abnormal mast cells","volume":"502","author":"Ohtsu","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1038\/s41374-020-0405-8_bib24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.dld.2014.12.006","article-title":"Histamine restores biliary mass following carbon tetrachloride-induced damage in a cholestatic rat model","volume":"47","author":"Johnson","year":"2015","journal-title":"Dig Liver Dis"},{"key":"10.1038\/s41374-020-0405-8_bib25","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/labinvest.2014.129","article-title":"Inhibition of mast cell-derived histamine secretion by cromolyn sodium treatment decreases biliary hyperplasia in cholestatic rodents","volume":"94","author":"Kennedy","year":"2014","journal-title":"Lab Invest"},{"key":"10.1038\/s41374-020-0405-8_bib26","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1002\/hep.30698","article-title":"Long noncoding RNA H19 contributes to cholangiocyte proliferation and cholestatic liver fibrosis in biliary atresia","volume":"70","author":"Xiao","year":"2019","journal-title":"Hepatology"},{"key":"10.1038\/s41374-020-0405-8_bib27","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.jaci.2014.10.044","article-title":"The sphingosine-1-phosphate\/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses","volume":"135","author":"Oskeritzian","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/s41374-020-0405-8_bib28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10238-018-0537-y","article-title":"Serum histamine and acetylcholine variations as new noninvasive biochemical markers in staging of experimental hepatocellular carcinoma","volume":"19","author":"Abdel-Hamid","year":"2019","journal-title":"Clin Exp Med"},{"key":"10.1038\/s41374-020-0405-8_bib29","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.dld.2016.05.001","article-title":"Histamine is correlated with liver fibrosis in biliary atresia","volume":"48","author":"Zhou","year":"2016","journal-title":"Dig Liver Dis"},{"key":"10.1038\/s41374-020-0405-8_bib30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuron.2013.10.052","article-title":"Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice","volume":"81","author":"Baldan","year":"2014","journal-title":"Neuron"},{"key":"10.1038\/s41374-020-0405-8_bib31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/164_2016_127","article-title":"Histidine decarboxylase knockout mice as a model of the pathophysiology of tourette syndrome and related conditions","volume":"241","author":"Pittenger","year":"2017","journal-title":"Handb Exp Pharmacol"},{"key":"10.1038\/s41374-020-0405-8_bib32","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/labinvest.3700533","article-title":"H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA\/ERK1\/2\/ELK-1 pathway","volume":"87","author":"Francis","year":"2007","journal-title":"Lab Invest"},{"key":"10.1038\/s41374-020-0405-8_bib33","doi-asserted-by":"crossref","first-page":"9862496","DOI":"10.1155\/2016\/9862496","article-title":"Proliferative effects of histamine on primary human pterygium fibroblasts","volume":"2016","author":"Qin","year":"2016","journal-title":"Mediators Inflamm"},{"key":"10.1038\/s41374-020-0405-8_bib34","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/hep.30150","article-title":"Ductular reaction in liver diseases: pathological mechanisms and translational significances","volume":"69","author":"Sato","year":"2019","journal-title":"Hepatology"},{"key":"10.1038\/s41374-020-0405-8_bib35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1053\/j.gastro.2006.07.023","article-title":"Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver","volume":"132","author":"Alvaro","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1038\/s41374-020-0405-8_bib36","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1111\/liv.13083","article-title":"Bile ductal injury and ductular reaction are frequent phenomena with different significance in autoimmune hepatitis","volume":"36","author":"Verdonk","year":"2016","journal-title":"Liver Int"},{"key":"10.1038\/s41374-020-0405-8_bib37","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/hep.29076","article-title":"The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice","volume":"65","author":"Wang","year":"2017","journal-title":"Hepatology"},{"key":"10.1038\/s41374-020-0405-8_bib38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1084\/jem.20091513","article-title":"Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema","volume":"207","author":"Oskeritzian","year":"2010","journal-title":"J Exp Med"},{"key":"10.1038\/s41374-020-0405-8_bib39","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/0016-5085(91)90024-F","article-title":"Activation of mast cells by bile acids","volume":"101","author":"Quist","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1038\/s41374-020-0405-8_bib40","first-page":"68","article-title":"Expression of vascular endothelial growth factors and their receptors by hepatic progenitor cells in human liver diseases","volume":"2","author":"Franchitto","year":"2013","journal-title":"Hepatobiliary Surg Nutr"},{"key":"10.1038\/s41374-020-0405-8_bib41","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1002\/hep.28138","article-title":"Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage","volume":"62","author":"Spirli","year":"2015","journal-title":"Hepatology"},{"key":"10.1038\/s41374-020-0405-8_bib42","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.pharep.2016.11.006","article-title":"The role of histamine in the regulation of the viability, proliferation and transforming growth factor beta1 secretion of rat wound fibroblasts","volume":"69","author":"Wolak","year":"2017","journal-title":"Pharmacol Rep"},{"key":"10.1038\/s41374-020-0405-8_bib43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1096\/fj.14-257550","article-title":"Orphan nuclear receptor TR3\/Nur77 improves wound healing by upregulating the expression of integrin beta4","volume":"29","author":"Niu","year":"2015","journal-title":"FASEB J"},{"key":"10.1038\/s41374-020-0405-8_bib44","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/sj.jid.5700253","article-title":"The accelerating effect of histamine on the cutaneous wound-healing process through the action of basic fibroblast growth factor","volume":"126","author":"Numata","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/s41374-020-0405-8_bib45","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/1871520616666160321115349","article-title":"Histamine and histaminergic receptors in colorectal cancer: from basic science to evidence-based medicine","volume":"18","author":"Losurdo","year":"2018","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1038\/s41374-020-0405-8_bib46","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0046-8177(97)90151-9","article-title":"Peribiliary vascular plexus in primary sclerosing cholangitis and primary biliary cirrhosis","volume":"28","author":"Washington","year":"1997","journal-title":"Hum Pathol"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41374-020-0405-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41374-020-0405-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722004603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722004603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41374-020-0405-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:29:33Z","timestamp":1758396573000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722004603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0023683722004603"],"URL":"https:\/\/doi.org\/10.1038\/s41374-020-0405-8","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase\/histamine signaling","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41374-020-0405-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}