{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:41:05Z","timestamp":1788946865428,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":528,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"This work was supported by General Program of National Natural Science Foundation of China"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1038\/s41374-021-00598-2","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T07:03:09Z","timestamp":1618815789000},"page":"1071-1083","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["LncRNA GAS5 activates the HIF1A\/VEGF pathway by binding to TAF15 to promote wound healing in diabetic foot ulcers"],"prefix":"10.1016","volume":"101","author":[{"given":"Wei-Xia","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Xiang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Qin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Da","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41374-021-00598-2_bib1","doi-asserted-by":"crossref","first-page":"107622","DOI":"10.1016\/j.jdiacomp.2020.107622","article-title":"Surgical treatment of diabetic foot ulcers during the COVID-19 pandemic in China","volume":"34","author":"Tao","year":"2020","journal-title":"J Diabetes Complicat"},{"key":"10.1038\/s41374-021-00598-2_bib2","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.enfcli.2019.07.107","article-title":"Nurses' perspectives on diabetic foot ulcer's odor: a qualitative study","volume":"30","author":"Samad","year":"2020","journal-title":"Enferm Clin"},{"key":"10.1038\/s41374-021-00598-2_bib3","doi-asserted-by":"crossref","first-page":"108147","DOI":"10.1016\/j.diabres.2020.108147","article-title":"Long-term diabetic complications as predictors of foot ulcers healing failure: a retrospective study in a tertiary-care center","volume":"163","author":"Caruso","year":"2020","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1038\/s41374-021-00598-2_bib4","doi-asserted-by":"crossref","first-page":"117813","DOI":"10.1016\/j.lfs.2020.117813","article-title":"Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing","volume":"254","author":"Seraphim","year":"2020","journal-title":"Life Sci"},{"key":"10.1038\/s41374-021-00598-2_bib5","doi-asserted-by":"crossref","first-page":"109705","DOI":"10.1016\/j.cellsig.2020.109705","article-title":"MeCP2 inactivation of LncRNA GAS5 triggers cardiac fibroblasts activation in cardiac fibrosis","volume":"74","author":"Tao","year":"2020","journal-title":"Cell Signal"},{"key":"10.1038\/s41374-021-00598-2_bib6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.gene.2019.04.014","article-title":"Transcriptome analysis to identify long non coding RNA (lncRNA) and characterize their functional role in back fat tissue of pig","volume":"703","author":"Kumar","year":"2019","journal-title":"Gene"},{"key":"10.1038\/s41374-021-00598-2_bib7","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.omtn.2019.11.034","article-title":"The MSC-derived exosomal lncRNA H19 promotes wound healing in diabetic foot ulcers by upregulating PTEN via microRNA-152-3p","volume":"19","author":"Li","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1038\/s41374-021-00598-2_bib8","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.omtn.2019.05.020","article-title":"lncRNA MALAT1 accelerates wound healing of diabetic mice transfused with modified autologous blood via the HIF-1\u03b1 signaling pathway","volume":"17","author":"Liu","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1038\/s41374-021-00598-2_bib9","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbacli.2015.09.001","article-title":"Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus","volume":"4","author":"Carter","year":"2015","journal-title":"BBA Clin"},{"key":"10.1038\/s41374-021-00598-2_bib10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.chembiol.2018.11.012","article-title":"Stabilization of lncRNA GAS5 by a small molecule and its implications in diabetic adipocytes","volume":"26","author":"Shi","year":"2019","journal-title":"Cell Chem Biol"},{"key":"10.1038\/s41374-021-00598-2_bib11","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1074\/jbc.M117.811240","article-title":"Topical mevastatin promotes wound healing by inhibiting the transcription factor c-Myc via the glucocorticoid receptor and the long non-coding RNA Gas5","volume":"293","author":"Sawaya","year":"2018","journal-title":"J Biol Chem"},{"key":"10.1038\/s41374-021-00598-2_bib12","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.omtn.2020.05.003","article-title":"lncRNA LINC00665 stabilized by TAF15 impeded the malignant biological behaviors of glioma cells via STAU1-mediated mRNA degradation","volume":"20","author":"Ruan","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1038\/s41374-021-00598-2_bib13","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1038\/onc.2012.490","article-title":"TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs","volume":"32","author":"Ballarino","year":"2013","journal-title":"Oncogene"},{"key":"10.1038\/s41374-021-00598-2_bib14","doi-asserted-by":"crossref","first-page":"105683","DOI":"10.1016\/j.biocel.2019.105683","article-title":"TRPM2-AS promotes cancer cell proliferation through control of TAF15","volume":"120","author":"Pan","year":"2020","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1038\/s41374-021-00598-2_bib15","article-title":"USF1-induced upregulation of LINC01048 promotes cell proliferation and apoptosis in cutaneous squamous cell carcinoma by binding to TAF15 to transcriptionally activate YAP1","volume":"10","author":"Chen","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1038\/s41374-021-00598-2_bib16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mce.2014.04.008","article-title":"Distinct roles of HIF1A in endothelial adaptations to physiological and ambient oxygen","volume":"391","author":"Jiang","year":"2014","journal-title":"Mol Cell Endocrinol"},{"key":"10.1038\/s41374-021-00598-2_bib17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.biopha.2017.09.113","article-title":"lncRNAs HIF1A-AS2 facilitates the up-regulation of HIF-1\u03b1 by sponging to miR-153-3p, whereby promoting angiogenesis in HUVECs in hypoxia","volume":"96","author":"Li","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"10.1038\/s41374-021-00598-2_bib18","doi-asserted-by":"crossref","first-page":"e21423","DOI":"10.1002\/arch.21423","article-title":"Inhibition of translation initiation factor eIF4A is required for apoptosis mediated by Microplitis bicoloratus bracovirus","volume":"96","author":"Dong","year":"2017","journal-title":"Arch Insect Biochem Physiol"},{"key":"10.1038\/s41374-021-00598-2_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.dci.2019.02.010","article-title":"Microplitis bicoloratus bracovirus modulates innate immune suppression through the eIF4E\u2013eIF4A axis in the insect Spodoptera litura","volume":"95","author":"Cui","year":"2019","journal-title":"Dev Comp Immunol"},{"key":"10.1038\/s41374-021-00598-2_bib20","doi-asserted-by":"crossref","DOI":"10.1186\/1476-4598-13-92","article-title":"Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer","volume":"13","author":"Liu","year":"2014","journal-title":"Mol Cancer"},{"key":"10.1038\/s41374-021-00598-2_bib21","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.1002\/jcp.27260","article-title":"Long noncoding RNA-antisense noncoding RNA in the INK4 locus accelerates wound healing in diabetes by promoting lymphangiogenesis via regulating miR-181a\/Prox1 axis","volume":"234","author":"He","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1038\/s41374-021-00598-2_bib22","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.prp.2018.12.022","article-title":"HIF1A and VEGF regulate each other by competing endogenous RNA mechanism and involve in the pathogenesis of peritoneal fibrosis","volume":"215","author":"Li","year":"2019","journal-title":"Pathol Res Pract"},{"key":"10.1038\/s41374-021-00598-2_bib23","doi-asserted-by":"crossref","first-page":"107403","DOI":"10.1016\/j.jdiacomp.2019.06.008","article-title":"Amino acids and wound healing in people with limb-threatening diabetic foot ulcers","volume":"33","author":"Hung","year":"2019","journal-title":"J Diabetes Complicat"},{"key":"10.1038\/s41374-021-00598-2_bib24","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neuint.2019.02.014","article-title":"Neurovascular interactions in skin wound healing","volume":"125","author":"Kiya","year":"2019","journal-title":"Neurochem Int"},{"key":"10.1038\/s41374-021-00598-2_bib25","doi-asserted-by":"crossref","first-page":"117888","DOI":"10.1016\/j.lfs.2020.117888","article-title":"Circular RNA COL1A2 promotes angiogenesis via regulating miR-29b\/VEGF axis in diabetic retinopathy","volume":"256","author":"Zou","year":"2020","journal-title":"Life Sci"},{"key":"10.1038\/s41374-021-00598-2_bib26","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.yexcr.2018.12.014","article-title":"LncRNA GAS5 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition in oral squamous cell carcinoma by regulating the miR-21\/PTEN axis","volume":"374","author":"Zeng","year":"2019","journal-title":"Exp Cell Res"},{"key":"10.1038\/s41374-021-00598-2_bib27","doi-asserted-by":"crossref","first-page":"104754","DOI":"10.1016\/j.phrs.2020.104754","article-title":"Phytochemicals as modulators of \u03b2-cells and immunity for the therapy of type 1 diabetes: Recent discoveries in pharmacological mechanisms and clinical potential","volume":"156","author":"Apaya","year":"2020","journal-title":"Pharmacol Res"},{"key":"10.1038\/s41374-021-00598-2_bib28","doi-asserted-by":"crossref","first-page":"152510","DOI":"10.1016\/j.prp.2019.152510","article-title":"Key genes associated with diabetes mellitus and hepatocellular carcinoma","volume":"215","author":"Liu","year":"2019","journal-title":"Pathol Res Pract"},{"key":"10.1038\/s41374-021-00598-2_bib29","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.2337\/db15-0863","article-title":"NETosis Delays diabetic wound healing in mice and humans","volume":"65","author":"Fadini","year":"2016","journal-title":"Diabetes"},{"key":"10.1038\/s41374-021-00598-2_bib30","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181740","article-title":"Danggui buxue tang inhibited mesangial cell proliferation and extracellular matrix accumulation through GAS5\/NF-kappaB pathway","volume":"39","author":"Zhang","year":"2019","journal-title":"Biosci Rep"},{"key":"10.1038\/s41374-021-00598-2_bib31","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.2147\/DMSO.S228654","article-title":"lncRNA GAS5\/miR-452-5p reduces oxidative stress and pyroptosis of high-glucose-stimulated renal tubular cells","volume":"12","author":"Xie","year":"2019","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1038\/s41374-021-00598-2_bib32","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.omtn.2020.05.003","article-title":"lncRNA LINC00665 stabilized by TAF15 impeded the malignant biological behaviors of glioma cells via STAU1-mediated mRNA degradation","volume":"20","author":"Ruan","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1038\/s41374-021-00598-2_bib33","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12943-018-0916-8","article-title":"LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cell proliferation and tumorigenesis by promoting cell-cycle progression","volume":"17","author":"Wang","year":"2018","journal-title":"Mol Cancer"}],"updated-by":[{"DOI":"10.1038\/s41374-021-00603-8","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000}}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41374-021-00598-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41374-021-00598-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722005992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722005992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41374-021-00598-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T09:10:19Z","timestamp":1676106619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722005992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S0023683722005992"],"URL":"https:\/\/doi.org\/10.1038\/s41374-021-00598-2","relation":{"erratum":[{"id-type":"doi","id":"10.1038\/s41374-021-00603-8","asserted-by":"object"}]},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LncRNA GAS5 activates the HIF1A\/VEGF pathway by binding to TAF15 to promote wound healing in diabetic foot ulcers","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41374-021-00598-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/s41374-021-00603-8","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}