{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:16:38Z","timestamp":1788322598657,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1038\/s41374-021-00664-9","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T08:04:38Z","timestamp":1641801878000},"page":"691-701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Induction of cancer cell stemness in glioma through glycolysis and the long noncoding RNA HULC-activated FOXM1\/AGR2\/HIF-1\u03b1 axis"],"prefix":"10.1016","volume":"102","author":[{"given":"You-Ping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3192-6020","authenticated-orcid":false,"given":"Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Min","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ke","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Er-Xing","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Er-Ming","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1468-4357","authenticated-orcid":false,"given":"Chun-Hua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41374-021-00664-9_bib1","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1093\/neuonc\/now207","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2009\u20132013","volume":"18","author":"Ostrom","year":"2016","journal-title":"Neuro. Oncol"},{"key":"10.1038\/s41374-021-00664-9_bib2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s11060-017-2607-5","article-title":"Epidemiology of glioma: clinical characteristics, symptoms, and predictors of glioma patients grade I-IV in the the Danish Neuro-Oncology Registry","volume":"135","author":"Rasmussen","year":"2017","journal-title":"J. Neurooncol."},{"key":"10.1038\/s41374-021-00664-9_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev-pathol-121808-102109","article-title":"The pathobiology of glioma tumors","volume":"5","author":"Gladson","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"10.1038\/s41374-021-00664-9_bib4","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s13311-017-0519-x","article-title":"Glioma subclassifications and their clinical significance","volume":"14","author":"Chen","year":"2017","journal-title":"Neurotherapeutics"},{"key":"10.1038\/s41374-021-00664-9_bib5","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1101\/gad.261982.115","article-title":"Cancer stem cells in glioblastoma","volume":"29","author":"Lathia","year":"2015","journal-title":"Genes Dev."},{"key":"10.1038\/s41374-021-00664-9_bib6","doi-asserted-by":"crossref","first-page":"27582","DOI":"10.18632\/oncotarget.15175","article-title":"Long non-coding RNA in glioma: signaling pathways","volume":"8","author":"Shi","year":"2017","journal-title":"Oncotarget"},{"key":"10.1038\/s41374-021-00664-9_bib7","doi-asserted-by":"crossref","first-page":"9071","DOI":"10.1002\/jcp.29765","article-title":"Highly upregulated in liver cancer (HULC): An update on its role in carcinogenesis","volume":"235","author":"Ghafouri-Fard","year":"2020","journal-title":"J. Cell Physiol"},{"key":"10.1038\/s41374-021-00664-9_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/14728222.2019.1570499","article-title":"Involvement of long non-coding RNA HULC (highly up-regulated in liver cancer) in pathogenesis and implications for therapeutic intervention","volume":"23","author":"Klec","year":"2019","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1038\/s41374-021-00664-9_bib9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2147\/OTT.S124614","article-title":"High expression of long noncoding RNA HULC is a poor predictor of prognosis and regulates cell proliferation in glioma","volume":"10","author":"Yan","year":"2017","journal-title":"Onco. Targets Ther."},{"key":"10.1038\/s41374-021-00664-9_bib10","doi-asserted-by":"crossref","first-page":"14429","DOI":"10.18632\/oncotarget.7418","article-title":"HULC long noncoding RNA silencing suppresses angiogenesis by regulating ESM-1 via the PI3K\/Akt\/mTOR signaling pathway in human gliomas","volume":"7","author":"Zhu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1038\/s41374-021-00664-9_bib11","doi-asserted-by":"crossref","first-page":"109720","DOI":"10.1016\/j.cellsig.2020.109720","article-title":"Liver X receptor inhibits the growth of hepatocellular carcinoma cells via regulating HULC\/miR-134-5p\/FOXM1 axis","volume":"74","author":"He","year":"2020","journal-title":"Cell Signal"},{"key":"10.1038\/s41374-021-00664-9_bib12","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1007\/s00432-019-03015-w","article-title":"METase\/lncRNA HULC\/FoxM1 reduced cisplatin resistance in gastric cancer by suppressing autophagy","volume":"145","author":"Xin","year":"2019","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1038\/s41374-021-00664-9_bib13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13046-017-0573-6","article-title":"Akt\/FoxM1 signaling pathway-mediated upregulation of MYBL2 promotes progression of human glioma","volume":"36","author":"Zhang","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1038\/s41374-021-00664-9_bib14","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1007\/s12013-013-9650-4","article-title":"AGR2 expression is regulated by HIF-1 and contributes to growth and angiogenesis of glioblastoma","volume":"67","author":"Hong","year":"2013","journal-title":"Cell Biochem Biophys."},{"key":"10.1038\/s41374-021-00664-9_bib15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s13046-019-1181-4","article-title":"Glioma stem cells-derived exosomal miR-26a promotes angiogenesis of microvessel endothelial cells in glioma","volume":"38","author":"Wang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res"},{"key":"10.1038\/s41374-021-00664-9_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-12048-5_1","article-title":"Epidemiology of gliomas","volume":"163","author":"Ostrom","year":"2015","journal-title":"Cancer Treat Res"},{"key":"10.1038\/s41374-021-00664-9_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-018-0843-8","article-title":"Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a","volume":"17","author":"Xin","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1038\/s41374-021-00664-9_bib18","doi-asserted-by":"crossref","first-page":"e7080","DOI":"10.1590\/1414-431x20187080","article-title":"LncRNA HULC mediates radioresistance via autophagy in prostate cancer cells","volume":"51","author":"Chen","year":"2018","journal-title":"Braz J. Med. Biol. Res."},{"key":"10.1038\/s41374-021-00664-9_bib19","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"10.1038\/s41374-021-00664-9_bib20","doi-asserted-by":"crossref","first-page":"5927","DOI":"10.2147\/OTT.S252915","article-title":"Quantitative proteomics analysis indicates that upregulation of lncRNA HULC promotes pathogenesis of glioblastoma cells","volume":"13","author":"Hu","year":"2020","journal-title":"Onco. Targets Ther"},{"key":"10.1038\/s41374-021-00664-9_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.486","article-title":"The lncRNA HULC functions as an oncogene by targeting ATG7 and ITGB1 in epithelial ovarian carcinoma","volume":"8","author":"Chen","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1038\/s41374-021-00664-9_bib22","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ccell.2017.02.013","article-title":"m(6)A demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program","volume":"31","author":"Zhang","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1038\/s41374-021-00664-9_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s40880-019-0424-2","article-title":"Bortezomib inhibits growth and sensitizes glioma to temozolomide (TMZ) via down-regulating the FOXM1-Survivin axis","volume":"39","author":"Tang","year":"2019","journal-title":"Cancer Commun."},{"key":"10.1038\/s41374-021-00664-9_bib24","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ccr.2011.08.016","article-title":"FoxM1 promotes beta-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis","volume":"20","author":"Zhang","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1038\/s41374-021-00664-9_bib25","doi-asserted-by":"crossref","first-page":"e1007097","DOI":"10.1371\/journal.pgen.1007097","article-title":"FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas","volume":"13","author":"Milewski","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1038\/s41374-021-00664-9_bib26","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1007\/s13577-020-00356-4","article-title":"AGR2-induced glucose metabolism facilitated the progression of endometrial carcinoma via enhancing the MUC1\/HIF-1alpha pathway","volume":"33","author":"Gong","year":"2020","journal-title":"Hum Cell"},{"key":"10.1038\/s41374-021-00664-9_bib27","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.3892\/or.2017.5472","article-title":"FOXM1 regulates glycolysis in hepatocellular carcinoma by transactivating glucose transporter 1 expression","volume":"37","author":"Shang","year":"2017","journal-title":"Oncol. Rep"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41374-021-00664-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41374-021-00664-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722002045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722002045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41374-021-00664-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:26:48Z","timestamp":1758396408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722002045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S0023683722002045"],"URL":"https:\/\/doi.org\/10.1038\/s41374-021-00664-9","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Induction of cancer cell stemness in glioma through glycolysis and the long noncoding RNA HULC-activated FOXM1\/AGR2\/HIF-1\u03b1 axis","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41374-021-00664-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}