{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:17:02Z","timestamp":1787314622338,"version":"build-2736575974"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA107476"],"award-info":[{"award-number":["R01 CA107476"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA168762"],"award-info":[{"award-number":["R01 CA168762"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R25 CA092049"],"award-info":[{"award-number":["R25 CA092049"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["P50 CA186781"],"award-info":[{"award-number":["P50 CA186781"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1038\/s41375-018-0246-2","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T10:18:54Z","timestamp":1536574734000},"page":"499-507","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Risk of MGUS in relatives of multiple myeloma cases by clinical and tumor characteristics"],"prefix":"10.1038","volume":"33","author":[{"given":"Alyssa I.","family":"Clay-Gilmour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5392-9284","authenticated-orcid":false,"given":"Shaji","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Vincent","family":"Rajkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Rishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Kyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry A.","family":"Katzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron D.","family":"Norman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra J.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk R","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"O\u2019Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Slager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine M.","family":"Vachon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,10]]},"reference":[{"key":"246_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.92","volume":"5","author":"AM Rajan","year":"2015","unstructured":"Rajan AM, Rajkumar SV. Interpretation of cytogenetic results in multiple myeloma for clinical practice. Blood Cancer J. 2015;5:e365.","journal-title":"Blood Cancer J"},{"key":"246_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.cancergencyto.2010.11.002","volume":"204","author":"JR Sawyer","year":"2011","unstructured":"Sawyer JR. The prognostic significance of cytogenetics and molecular profiling in multiple myeloma. Cancer Genet. 2011;204:3\u201312.","journal-title":"Cancer Genet"},{"key":"246_CR3","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1158\/1078-0432.CCR-10-1843","volume":"17","author":"NFlsd1C Munshi","year":"2011","unstructured":"Munshi NFlsd1C, Avet-Loiseau H. Genomics in multiple myeloma. Clin Cancer Res. 2011;17:1234\u201342.","journal-title":"Clin Cancer Res"},{"key":"246_CR4","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1056\/NEJMoa054494","volume":"354","author":"RA Kyle","year":"2006","unstructured":"Kyle RA, Therneau TM, Rajkumar SV, Larson DR, Plevak MF, Offord JR, et al. Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med. 2006;354:1362\u20139.","journal-title":"N Engl J Med"},{"key":"246_CR5","doi-asserted-by":"publisher","first-page":"5412","DOI":"10.1182\/blood-2008-12-194241","volume":"113","author":"O Landgren","year":"2009","unstructured":"Landgren O, Kyle RA, Pfeiffer RM, Katzmann JA, Caporaso NE, Hayes RB, et al. Monoclonal gammopathy of undetermined significance (mgus) consistently precedes multiple myeloma: a prospective study. Blood. 2009;113:5412\u20137.","journal-title":"Blood"},{"key":"246_CR6","doi-asserted-by":"publisher","first-page":"933","DOI":"10.4065\/mcp.2010.0337","volume":"85","author":"RK Wadhera","year":"2010","unstructured":"Wadhera RK, Rajkumar SV. Prevalence of monoclonal gammopathy of undetermined significance: a systematic review. Mayo Clin Proc. 2010;85:933\u201342.","journal-title":"Mayo Clin Proc"},{"key":"246_CR7","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1056\/NEJMoa01133202","volume":"346","author":"RA Kyle","year":"2002","unstructured":"Kyle RA, Therneau TM, Rajkumar SV, Offord JR, Larson DR, Plevak MF, et al. A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med. 2002;346:564\u20139.","journal-title":"N Engl J Med"},{"key":"246_CR8","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1182\/blood-2008-12-192575","volume":"114","author":"CM Vachon","year":"2009","unstructured":"Vachon CM, Kyle RA, Therneau TM, Foreman BJ, Larson DR, Colby CL, et al. Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance. Blood. 2009;114:785\u201390.","journal-title":"Blood"},{"key":"246_CR9","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/BF00051914","volume":"3","author":"M Eriksson","year":"1992","unstructured":"Eriksson M, Hallberg B. Familial occurrence of hematologic malignancies and other diseases in multiple myeloma: a case-control study. Cancer Causes Control. 1992;3:63\u201367.","journal-title":"Cancer Causes Control"},{"key":"246_CR10","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/j.1365-2141.1985.tb07452.x","volume":"60","author":"IR Judson","year":"1985","unstructured":"Judson IR, Wiltshaw E, Newland AC. Multiple myeloma in a pair of monozygotic twins: the first reported case. Br J Haematol. 1985;60:551\u20134.","journal-title":"Br J Haematol"},{"key":"246_CR11","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1056\/NEJMoa0708704","volume":"359","author":"HT Lynch","year":"2008","unstructured":"Lynch HT, Ferrara K, Barlogie B, Coleman EA, Lynch JF, Weisenburger D, et al. Familial myeloma. N Engl J Med. 2008;359:152\u20137.","journal-title":"N Engl J Med"},{"key":"246_CR12","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1093\/jnci\/93.19.1479","volume":"93","author":"HT Lynch","year":"2001","unstructured":"Lynch HT, Sanger WG, Pirruccello S, Quinn-Laquer B, Weisenburger DD. Familial multiple myeloma: a family study and review of the literature. J Natl Cancer Inst. 2001;93:1479\u201383.","journal-title":"J Natl Cancer Inst"},{"key":"246_CR13","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1200\/JCO.2005.10.126","volume":"23","author":"HT Lynch","year":"2005","unstructured":"Lynch HT, Watson P, Tarantolo S, Wiernik PH, Quinn-Laquer B, Isgur Bergsagel K, et al. Phenotypic heterogeneity in multiple myeloma families. J Clin Oncol. 2005;23:685\u201393.","journal-title":"J Clin Oncol"},{"key":"246_CR14","first-page":"58","volume":"75","author":"N Bizzaro","year":"1990","unstructured":"Bizzaro N, Pasini P. Familial occurrence of multiple myeloma and monoclonal gammopathy of undetermined significance in 5 siblings. Haematologica. 1990;75:58\u201363.","journal-title":"Haematologica"},{"key":"246_CR15","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1002\/1097-0142(197711)40:5<2094::AID-CNCR2820400518>3.0.CO;2-5","volume":"40","author":"ZA Zawadzki","year":"1977","unstructured":"Zawadzki ZA, Aizawa Y, Kraj MA, Haradin AR, Fisher B. Familial immunopathies: report of nine families and survey of literature. Cancer. 1977;40:2094\u2013101.","journal-title":"Cancer"},{"key":"246_CR16","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3816\/CLM.2009.n.005","volume":"9","author":"HM Ogmundsdottir","year":"2009","unstructured":"Ogmundsdottir HM, Einarsdottir HK, Steingrimsdottir H, Haraldsdottir V. Familial predisposition to monoclonal gammopathy of unknown significance, Waldenstrom\u2019s macroglobulinemia, and multiple myeloma. Clin Lymphoma Myeloma. 2009;9:27\u201329.","journal-title":"Clin Lymphoma Myeloma"},{"key":"246_CR17","first-page":"66","volume":"90","author":"HM Ogmundsdottir","year":"2005","unstructured":"Ogmundsdottir HM, Haraldsdottirm V, Johannesson GM, Olafsdottir G, Bjarnadottir K, Sigvaldason H, et al. Familiality of benign and malignant paraproteinemias. A population-based cancer-registry study of multiple myeloma families. Haematologica. 2005;90:66\u201371.","journal-title":"Haematologica"},{"key":"246_CR18","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1002\/ijc.21745","volume":"118","author":"O Landgren","year":"2006","unstructured":"Landgren O, Linet MS, McMaster ML, Gridley G, Hemminki K, Goldin LR. Familial characteristics of autoimmune and hematologic disorders in 8406 multiple myeloma patients: a population-based case-control study. Int J Cancer. 2006;118:3095\u20138.","journal-title":"Int J Cancer"},{"key":"246_CR19","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1056\/NEJMc081677","volume":"359","author":"NJ Camp","year":"2008","unstructured":"Camp NJ, Werner TL, Cannon-Albright LA. Familial myeloma. N Engl J Med. 2008;359:1734\u20135. author reply 1735","journal-title":"N Engl J Med"},{"key":"246_CR20","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2385::AID-CNCR13>3.0.CO;2-A","volume":"85","author":"LM Brown","year":"1999","unstructured":"Brown LM, Linet MS, Greenberg RS, Silverman DT, Hayes RB, Swanson GM, et al. Multiple myeloma and family history of cancer among blacks and whites in the u.S. Cancer. 1999;85:2385\u201390.","journal-title":"Cancer"},{"key":"246_CR21","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1002\/1097-0142(19851015)56:8<2133::AID-CNCR2820560842>3.0.CO;2-F","volume":"56","author":"CC Bourguet","year":"1985","unstructured":"Bourguet CC, Grufferman S, Delzell E, DeLong ER, Cohen HJ. Multiple myeloma and family history of cancer. A case-control study. Cancer. 1985;56:2133\u20139.","journal-title":"Cancer"},{"key":"246_CR22","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1093\/jnci\/86.21.1600","volume":"86","author":"DE Goldgar","year":"1994","unstructured":"Goldgar DE, Easton DF, Cannon-Albright LA, Skolnick MH. Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands. J Natl Cancer Inst. 1994;86:1600\u20138.","journal-title":"J Natl Cancer Inst"},{"key":"246_CR23","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1182\/blood-2008-12-191676","volume":"114","author":"O Landgren","year":"2009","unstructured":"Landgren O, Kristinsson SY, Goldin LR, Caporaso NE, Blimark C, Mellqvist UH, et al. Risk of plasma cell and lymphoproliferative disorders among 14621 first-degree relatives of 4458 patients with monoclonal gammopathy of undetermined significance in sweden. Blood. 2009;114:791\u20135.","journal-title":"Blood"},{"key":"246_CR24","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1002\/ijc.24514","volume":"125","author":"SY Kristinsson","year":"2009","unstructured":"Kristinsson SY, Bjorkholm M, Goldin LR, Blimark C, Mellqvist UH, Wahlin A, et al. Patterns of hematologic malignancies and solid tumors among 37,838 first-degree relatives of 13,896 patients with multiple myeloma in sweden. Int J Cancer. 2009;125:2147\u201350.","journal-title":"Int J Cancer"},{"issue":"Suppl 12","key":"246_CR25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/ijc.22718","volume":"120","author":"DD Alexander","year":"2007","unstructured":"Alexander DD, Mink PJ, Adami HO, Cole P, Mandel JS, Oken MM, et al. Multiple myeloma: a review of the epidemiologic literature. Int J Cancer. 2007;120(Suppl 12):40\u201361.","journal-title":"Int J Cancer"},{"key":"246_CR26","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/leu.2015.279","volume":"30","author":"C Frank","year":"2016","unstructured":"Frank C, Fallah M, Chen T, Mai EK, Sundquist J, Forsti A, et al. Search for familial clustering of multiple myeloma with any cancer. Leukemia. 2016;30:627\u201332.","journal-title":"Leukemia"},{"key":"246_CR27","doi-asserted-by":"publisher","first-page":"5359","DOI":"10.1182\/blood-2011-11-387324","volume":"119","author":"AJ Greenberg","year":"2012","unstructured":"Greenberg AJ, Rajkumar SV, Vachon CM. Familial monoclonal gammopathy of undetermined significance and multiple myeloma: epidemiology, risk factors, and biological characteristics. Blood. 2012;119:5359\u201366.","journal-title":"Blood"},{"key":"246_CR28","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2147\/TACG.S35605","volume":"6","author":"DG Evans","year":"2013","unstructured":"Evans DG, Ingham SL. Reduced life expectancy seen in hereditary diseases which predispose to early-onset tumors. Appl Clin Genet. 2013;6:53\u201361.","journal-title":"Appl Clin Genet"},{"key":"246_CR29","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1136\/jmedgenet-2011-100562","volume":"49","author":"A Wilding","year":"2012","unstructured":"Wilding A, Ingham SL, Lalloo F, Clancy T, Huson SM, Moran A, et al. Life expectancy in hereditary cancer predisposing diseases: an observational study. J Med Genet. 2012;49:264\u20139.","journal-title":"J Med Genet"},{"key":"246_CR30","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/leu.2013.258","volume":"28","author":"AJ Greenberg","year":"2014","unstructured":"Greenberg AJ, Rajkumar SV, Therneau TM, Singh PP, Dispenzieri A, Kumar SK. Relationship between initial clinical presentation and the molecular cytogenetic classification of myeloma. Leukemia. 2014;28:398\u2013403.","journal-title":"Leukemia"},{"key":"246_CR31","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3324\/haematol.2011.060632","volume":"98","author":"M Schmidt-Hieber","year":"2013","unstructured":"Schmidt-Hieber M, Gutierrez ML, Perez-Andres M, Paiva B, Rasillo A, Tabernero MD, et al. Cytogenetic profiles in multiple myeloma and monoclonal gammopathy of undetermined significance: a study in highly purified aberrant plasma cells. Haematologica. 2013;98:279\u201387.","journal-title":"Haematologica"},{"key":"246_CR32","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1182\/blood-2011-11-390658","volume":"119","author":"S Kumar","year":"2012","unstructured":"Kumar S, Fonseca R, Ketterling RP, Dispenzieri A, Lacy MQ, Gertz MA, et al. Trisomies in multiple myeloma: Impact on survival in patients with high-risk cytogenetics. Blood. 2012;119:2100\u20135.","journal-title":"Blood"},{"key":"246_CR33","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1002\/ajh.24402","volume":"91","author":"SV Rajkumar","year":"2016","unstructured":"Rajkumar SV. Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management. Am J Hematol. 2016;91:719\u201334.","journal-title":"Am J Hematol"},{"key":"246_CR34","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.3324\/haematol.2012.081083","volume":"98","author":"S Van Wier","year":"2013","unstructured":"Van Wier S, Braggio E, Baker A, Ahmann G, Levy J, Carpten JD, et al. Hypodiploid multiple myeloma is characterized by more aggressive molecular markers than non-hyperdiploid multiple myeloma. Haematologica. 2013;98:1586\u201392.","journal-title":"Haematologica"},{"key":"246_CR35","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/ejh.12133","volume":"91","author":"AJ Greenberg","year":"2013","unstructured":"Greenberg AJ, Cousin M, Kumar S, Ketterling RP, Knudson RA, Larson D, et al. Differences in the distribution of cytogenetic subtypes between multiple myeloma patients with and without a family history of monoclonal gammopathy and multiple myeloma. Eur J Haematol. 2013;91:193\u20135.","journal-title":"Eur J Haematol"},{"key":"246_CR36","doi-asserted-by":"crossref","unstructured":"World Medical Association. World medical association declaration of helsinki: ethical principles for medical research involving human subjects. JAMA 2013;310:2191\u20134.","DOI":"10.1001\/jama.2013.281053"},{"key":"246_CR37","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.clml.2012.05.003","volume":"12","author":"H Dong","year":"2012","unstructured":"Dong H, Yang HS, Jagannath S, Stephenson CF, Brenholz P, Mazumder A, et al. Risk stratification of plasma cell neoplasm: Insights from plasma cell-specific cytoplasmic immunoglobulin fluorescence in situ hybridization (cig fish) vs. Conventional fish. Clin Lymphoma Myeloma Leuk. 2012;12:366\u201374.","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"246_CR38","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.4065\/mcp.2009.0603","volume":"84","author":"SK Kumar","year":"2009","unstructured":"Kumar SK, Mikhael JR, Buadi FK, Dingli D, Dispenzieri A, Fonseca R, et al. Management of newly diagnosed symptomatic multiple myeloma: updated mayo stratification of myeloma and risk-adapted therapy (msmart) consensus guidelines. Mayo Clin Proc. 2009;84:1095\u2013110.","journal-title":"Mayo Clin Proc"},{"key":"246_CR39","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.mayocp.2015.11.007","volume":"91","author":"SV Rajkumar","year":"2016","unstructured":"Rajkumar SV, Kumar S. Multiple myeloma: diagnosis and treatment. Mayo Clin Proc. 2016;91:101\u201319.","journal-title":"Mayo Clin Proc"},{"key":"246_CR40","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1016\/j.ejca.2005.11.033","volume":"42","author":"A Altieri","year":"2006","unstructured":"Altieri A, Chen B, Bermejo JL, Castro F, Hemminki K. Familial risks and temporal incidence trends of multiple myeloma. Eur J Cancer. 2006;42:1661\u201370.","journal-title":"Eur J Cancer"},{"key":"246_CR41","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/ijc.11478","volume":"108","author":"K Hemminki","year":"2004","unstructured":"Hemminki K, Li X, Czene K. Familial risk of cancer: data for clinical counseling and cancer genetics. Int J Cancer. 2004;108:109\u201314.","journal-title":"Int J Cancer"},{"key":"246_CR42","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1046\/j.1365-2141.1998.01061.x","volume":"103","author":"HA Deshpande","year":"1998","unstructured":"Deshpande HA, Hu XP, Marino P, Jan NA, Wiernik PH. Anticipation in familial plasma cell dyscrasias. Br J Haematol. 1998;103:696\u2013703.","journal-title":"Br J Haematol"},{"key":"246_CR43","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1046\/j.1365-2141.1999.01415.x","volume":"105","author":"B Grosbois","year":"1999","unstructured":"Grosbois B, Jego P, Attal M, Payen C, Rapp MJ, Fuzibet JG, et al. Familial multiple myeloma: report of fifteen families. Br J Haematol. 1999;105:768\u201370.","journal-title":"Br J Haematol"},{"key":"246_CR44","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s10552-015-0685-2","volume":"27","author":"ME VanValkenburg","year":"2016","unstructured":"VanValkenburg ME, Pruitt GI, Brill IK, Costa L, Ehtsham M, Justement IT, et al. Family history of hematologic malignancies and risk of multiple myeloma: differences by race and clinical features. Cancer Causes Control. 2016;27:81\u201391.","journal-title":"Cancer Causes Control"},{"key":"246_CR45","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/bjh.14199","volume":"175","author":"LH Schinasi","year":"2016","unstructured":"Schinasi LH, Brown EE, Camp NJ, Wang SS, Hofmann JN, Chiu BC, et al. Multiple myeloma and family history of lymphohaematopoietic cancers: results from the international multiple myeloma consortium. Br J Haematol. 2016;175:87\u2013101.","journal-title":"Br J Haematol"},{"key":"246_CR46","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1158\/1055-9965.EPI-16-0762-T","volume":"26","author":"BM Birmann","year":"2017","unstructured":"Birmann BM, Andreotti G, De Roos AJ, Camp NJ, Chiu BCH, Spinelli JJ, et al. Young adult and usual adult body mass index and multiple myeloma risk: a pooled analysis in the international multiple myeloma consortium (immc). Cancer Epidemiol Biomark Prev. 2017;26:876\u201385.","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"246_CR47","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12050","volume":"7","author":"JS Mitchell","year":"2016","unstructured":"Mitchell JS, Li N, Weinhold N, Forsti A, Ali M, van Duin M, et al. Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Nat Commun. 2016;7:12050.","journal-title":"Nat Commun"},{"key":"246_CR48","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/leu.2013.344","volume":"28","author":"GJ Morgan","year":"2014","unstructured":"Morgan GJ, Johnson DC, Weinhold N, Goldschmidt H, Landgren O, Lynch HT, et al. Inherited genetic susceptibility to multiple myeloma. Leukemia. 2014;28:518\u201324.","journal-title":"Leukemia"},{"key":"246_CR49","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1038\/ng.2733","volume":"45","author":"D Chubb","year":"2013","unstructured":"Chubb D, Weinhold N, Broderick P, Chen B, Johnson DC, Forsti A, et al. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nat Genet. 2013;45:1221\u20135.","journal-title":"Nat Genet"},{"key":"246_CR50","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/ng.2583","volume":"45","author":"N Weinhold","year":"2013","unstructured":"Weinhold N, Johnson DC, Chubb D, Chen B, Forsti A, Hosking FJ, et al. The ccnd1 c.870g > a polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Nat Genet. 2013;45:522\u20135.","journal-title":"Nat Genet"},{"key":"246_CR51","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/ng.993","volume":"44","author":"P Broderick","year":"2011","unstructured":"Broderick P, Chubb D, Johnson DC, Weinhold N, Forsti A, Lloyd A, et al. Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk. Nat Genet. 2011;44:58\u201361.","journal-title":"Nat Genet"},{"key":"246_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8213","volume":"6","author":"B Swaminathan","year":"2015","unstructured":"Swaminathan B, Thorleifsson G, Joud M, Ali M, Johnsson E, Ajore R, et al. Variants in ell2 influencing immunoglobulin levels associate with multiple myeloma. Nat Commun. 2015;6:7213.","journal-title":"Nat Commun"},{"key":"246_CR53","doi-asserted-by":"publisher","first-page":"36203","DOI":"10.18632\/oncotarget.15874","volume":"8","author":"M Scales","year":"2017","unstructured":"Scales M, Chubb D, Dobbins SE, Johnson DC, Li N, Sternberg MJ, et al. Search for rare protein altering variants influencing susceptibility to multiple myeloma. Oncotarget. 2017;8:36203\u201310.","journal-title":"Oncotarget"},{"key":"246_CR54","unstructured":"Arad\u00f3ttir KLS, Bj\u00f6rkholm M, Goldin LR, Turesson I, Landgren O, Kristinsson SY. Family history of lymphoproliferative disease associated with a superior survival in multiple myeloma: a population-based study.\u00a0European Hematology Association:\u00a0Learning Center. 2015."},{"key":"246_CR55","first-page":"283","volume":"34","author":"RC Rosenlof","year":"1971","unstructured":"Rosenlof RC, Lemon HM, Rigby PG. Familial factors relating to prognosis of leukemia and lymphoma. Natl Cancer Inst Monogr. 1971;34:283\u20139.","journal-title":"Natl Cancer Inst Monogr"},{"key":"246_CR56","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1001\/jamaoncol.2015.23","volume":"1","author":"EE Sigurdardottir","year":"2015","unstructured":"Sigurdardottir EE, Turesson I, Lund SH, Lindqvist EK, Mailankody S, Korde N, et al. The role of diagnosis and clinical follow-up of monoclonal gammopathy of undetermined significance on survival in multiple myeloma. JAMA Oncol. 2015;1:168\u20134.","journal-title":"JAMA Oncol"},{"key":"246_CR57","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.clml.2014.09.004","volume":"15","author":"RS Go","year":"2015","unstructured":"Go RS, Gundrum JD, Neuner JM. Determining the clinical significance of monoclonal gammopathy of undetermined significance: a seer-medicare population analysis. Clin Lymphoma Myeloma Leuk. 2015;15:177\u201386 e174.","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"246_CR58","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/1897-4287-5-2-72","volume":"5","author":"EH Gerkes","year":"2007","unstructured":"Gerkes EH, de Jong MM, Sijmons RH, Vellenga E. Familial multiple myeloma: report on two families and discussion of screening options. Hered Cancer Clin Pract. 2007;5:72\u201378.","journal-title":"Hered Cancer Clin Pract"},{"key":"246_CR59","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.canep.2012.05.002","volume":"36","author":"Q Wang","year":"2012","unstructured":"Wang Q, Wang Y, Ji Z, Chen X, Pan Y, Gao G, et al. Risk factors for multiple myeloma: a hospital-based case-control study in northwest china. Cancer Epidemiol. 2012;36:439\u201344.","journal-title":"Cancer Epidemiol"},{"key":"246_CR60","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/ajh.21325","volume":"84","author":"M Jain","year":"2009","unstructured":"Jain M, Ascensao J, Schechter GP. Familial myeloma and monoclonal gammopathy: a report of eight african american families. Am J Hematol. 2009;84:34\u201338.","journal-title":"Am J Hematol"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41375-018-0246-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41375-018-0246-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41375-018-0246-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T17:35:43Z","timestamp":1684604143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41375-018-0246-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,10]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["246"],"URL":"https:\/\/doi.org\/10.1038\/s41375-018-0246-2","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,10]]},"assertion":[{"value":"13 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}