{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:44:40Z","timestamp":1790628280697,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:00:00Z","timestamp":1536105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000402","name":"Kay Kendall Leukaemia Fund (KKLF)","doi-asserted-by":"publisher","award":["KKL698"],"award-info":[{"award-number":["KKL698"]}],"id":[{"id":"10.13039\/501100000402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000402","name":"Kay Kendall Leukaemia Fund (KKLF)","doi-asserted-by":"publisher","award":["KKL501"],"award-info":[{"award-number":["KKL501"]}],"id":[{"id":"10.13039\/501100000402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000402","name":"Kay Kendall Leukaemia Fund (KKLF)","doi-asserted-by":"publisher","award":["KKL698"],"award-info":[{"award-number":["KKL698"]}],"id":[{"id":"10.13039\/501100000402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000402","name":"Kay Kendall Leukaemia Fund (KKLF)","doi-asserted-by":"publisher","award":["1069"],"award-info":[{"award-number":["1069"]}],"id":[{"id":"10.13039\/501100000402","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SULSA | Scottish Universities Life Sciences Alliance"},{"DOI":"10.13039\/501100000265","name":"Medical Research Council (MRC)","doi-asserted-by":"publisher","award":["MR\/K014854\/1"],"award-info":[{"award-number":["MR\/K014854\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK (CRUK)","doi-asserted-by":"publisher","award":["C596\/A18076"],"award-info":[{"award-number":["C596\/A18076"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bloodwise Specialist Programme (14033) the Howat Foundation Friends of Paul O&apos;Gorman"},{"DOI":"10.13039\/501100004101","name":"Lady Tata Memorial Trust","doi-asserted-by":"publisher","award":["International Award for Research in Leukaemia"],"award-info":[{"award-number":["International Award for Research in Leukaemia"]}],"id":[{"id":"10.13039\/501100004101","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Leuka: John Goldman Fellowship The Howat Foundation Friends of Paul O&apos;Gorman Leukaemia Research Centre"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1038\/s41375-018-0252-4","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T04:49:19Z","timestamp":1536122959000},"page":"981-994","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Targeting quiescent leukemic stem cells using second generation autophagy inhibitors"],"prefix":"10.1038","volume":"33","author":[{"given":"Pablo","family":"Baquero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunima","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie M.","family":"Kuntz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orianne","family":"Olivares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Ianniciello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary T.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Nicastri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5404-475X","authenticated-orcid":false,"given":"Alison M.","family":"Michie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Halsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin P.","family":"Keaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon O.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi K.","family":"Amaravadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa L.","family":"Holyoake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1616-132X","authenticated-orcid":false,"given":"G. Vignir","family":"Helgason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,5]]},"reference":[{"key":"252_CR1","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1056\/NEJMoa062867","volume":"355","author":"BJ Druker","year":"2006","unstructured":"Druker BJ, Guilhot F, O\u2019Brien SG, Gathmann I, Kantarjian H, Gattermann N, et al. 5-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med. 2006;355:2408\u201317.","journal-title":"N Engl J Med"},{"key":"252_CR2","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1182\/blood-2016-09-696013","volume":"129","author":"TL Holyoake","year":"2017","unstructured":"Holyoake TL, Vetrie D. The chronic myeloid leukemia stem cell: stemming the tide of persistence. Blood. 2017;129:1595\u2013606.","journal-title":"Blood"},{"key":"252_CR3","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1172\/JCI35721","volume":"121","author":"AS Corbin","year":"2011","unstructured":"Corbin AS, Agarwal A, Loriaux M, Cortes J, Deininger MW, Druker BJ. Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J Clin Invest. 2011;121:396\u2013409.","journal-title":"J Clin Invest"},{"key":"252_CR4","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1182\/blood-2010-12-326843","volume":"119","author":"A Hamilton","year":"2012","unstructured":"Hamilton A, Helgason GV, Schemionek M, Zhang B, Myssina S, Allan EK, et al. Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival. Blood. 2012;119:1501\u201310.","journal-title":"Blood"},{"key":"252_CR5","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/imr.12234","volume":"263","author":"TL Holyoake","year":"2015","unstructured":"Holyoake TL, Helgason GV. Do we need more drugs for chronic myeloid leukemia? Immunol Rev. 2015;263:106\u201323.","journal-title":"Immunol Rev"},{"key":"252_CR6","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1158\/2159-8290.CD-14-0363","volume":"4","author":"G Karsli-Uzunbas","year":"2014","unstructured":"Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, et al. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov. 2014;4:914\u201327. Aug","journal-title":"Cancer Discov"},{"key":"252_CR7","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1101\/gad.283416.116","volume":"30","author":"JY Guo","year":"2016","unstructured":"Guo JY, Teng X, Laddha SV, Ma S, Van Nostrand SC, Yang Y, et al. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev. 2016;30:1704\u201317.","journal-title":"Genes Dev"},{"key":"252_CR8","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1038\/nature03029","volume":"432","author":"A Kuma","year":"2004","unstructured":"Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, et al. The role of autophagy during the early neonatal starvation period. Nature. 2004;432:1032\u20136.","journal-title":"Nature"},{"key":"252_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/onc.2015.99","volume":"35","author":"VW Rebecca","year":"2016","unstructured":"Rebecca VW, Amaravadi RK. Emerging strategies to effectively target autophagy in cancer. Oncogene. 2016;35:1\u201311.","journal-title":"Oncogene"},{"key":"252_CR10","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1172\/JCI35660","volume":"119","author":"C Bellodi","year":"2009","unstructured":"Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M, et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest. 2009;119:1109\u201323.","journal-title":"J Clin Invest"},{"key":"252_CR11","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1080\/15548627.2016.1162359","volume":"12","author":"M Karvela","year":"2016","unstructured":"Karvela M, Baquero P, Kuntz EM, Mukhopadhyay A, Mitchell R, Allan EK, et al. ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells. Autophagy. 2016;12:936\u201348.","journal-title":"Autophagy"},{"key":"252_CR12","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.4161\/auto.29231","volume":"10","author":"D Mahalingam","year":"2014","unstructured":"Mahalingam D, Mita M, Sarantopoulos J, Wood L, Amaravadi RK, Davis LE, et al. Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors. Autophagy. 2014;10:1403\u201314.","journal-title":"Autophagy"},{"key":"252_CR13","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.4161\/auto.29119","volume":"10","author":"R Rangwala","year":"2014","unstructured":"Rangwala R, Chang YC, Hu J, Algazy KM, Evans TL, Fecher LA, et al. Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma. Autophagy. 2014;10:1391\u2013402.","journal-title":"Autophagy"},{"key":"252_CR14","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.4161\/auto.29118","volume":"10","author":"R Rangwala","year":"2014","unstructured":"Rangwala R, Leone R, Chang YC, Fecher LA, Schuchter LM, Kramer A, et al. Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma. Autophagy. 2014;10:1369\u201379.","journal-title":"Autophagy"},{"key":"252_CR15","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.4161\/auto.28984","volume":"10","author":"MR Rosenfeld","year":"2014","unstructured":"Rosenfeld MR, Ye X, Supko JG, Desideri S, Grossman SA, Brem S, et al. A phase I\/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme. Autophagy. 2014;10:1359\u201368.","journal-title":"Autophagy"},{"key":"252_CR16","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.4161\/auto.29264","volume":"10","author":"DT Vogl","year":"2014","unstructured":"Vogl DT, Stadtmauer EA, Tan KS, Heitjan DF, Davis LE, Pontiggia L, et al. Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed\/refractory myeloma. Autophagy. 2014;10:1380\u201390.","journal-title":"Autophagy"},{"key":"252_CR17","doi-asserted-by":"publisher","first-page":"8253","DOI":"10.1073\/pnas.1118193109","volume":"109","author":"Q McAfee","year":"2012","unstructured":"McAfee Q, Zhang Z, Samanta A, Levi SM, Ma XH, Piao S, et al. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci USA. 2012;109:8253\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"252_CR18","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/nchembio.1681","volume":"10","author":"B Ronan","year":"2014","unstructured":"Ronan B, Flamand O, Vescovi L, Dureuil C, Durand L, Fassy F, et al. A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nat Chem Biol. 2014;10:1013\u20139.","journal-title":"Nat Chem Biol"},{"key":"252_CR19","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1042\/BJ20140889","volume":"463","author":"R Bago","year":"2014","unstructured":"Bago R, Malik N, Munson MJ, Prescott AR, Davies P, Sommer E, et al. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase. Biochem J. 2014;463:413\u201327.","journal-title":"Biochem J"},{"key":"252_CR20","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/ncb3053","volume":"16","author":"WE Dowdle","year":"2014","unstructured":"Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, et al. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat Cell Biol. 2014;16:1069\u201379.","journal-title":"Nat Cell Biol"},{"key":"252_CR21","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1182\/blood-2003-12-4369","volume":"105","author":"S Koschmieder","year":"2005","unstructured":"Koschmieder S, Gottgens B, Zhang P, Iwasaki-Arai J, Akashi K, Kutok JL, et al. Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis. Blood. 2005;105:324\u201334.","journal-title":"Blood"},{"key":"252_CR22","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1091\/mbc.e03-09-0704","volume":"15","author":"N Mizushima","year":"2004","unstructured":"Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell. 2004;15:1101\u201311.","journal-title":"Mol Biol Cell"},{"key":"252_CR23","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1083\/jcb.200412022","volume":"169","author":"M Komatsu","year":"2005","unstructured":"Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol. 2005;169:425\u201334.","journal-title":"J Cell Biol"},{"key":"252_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","volume":"12","author":"DJ Klionsky","year":"2016","unstructured":"Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2016;12:1\u2013222. 3rd edition","journal-title":"Autophagy"},{"key":"252_CR25","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature11895","volume":"494","author":"MR Warr","year":"2013","unstructured":"Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, et al. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature. 2013;494:323\u20137.","journal-title":"Nature"},{"key":"252_CR26","doi-asserted-by":"publisher","first-page":"452","DOI":"10.4161\/auto.4451","volume":"3","author":"S Kimura","year":"2007","unstructured":"Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy. 2007;3:452\u201360.","journal-title":"Autophagy"},{"key":"252_CR27","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.molcel.2009.01.020","volume":"33","author":"V Kirkin","year":"2009","unstructured":"Kirkin V, Lamark T, Sou YS, Bjorkoy G, Nunn JL, Bruun JA, et al. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell. 2009;33:505\u201316.","journal-title":"Mol Cell"},{"key":"252_CR28","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature13148","volume":"509","author":"JD Mancias","year":"2014","unstructured":"Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509:105\u20139.","journal-title":"Nature"},{"key":"252_CR29","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1182\/blood.V94.6.2056","volume":"94","author":"T Holyoake","year":"1999","unstructured":"Holyoake T, Jiang X, Eaves C, Eaves A. Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood. 1999;94:2056\u201364.","journal-title":"Blood"},{"key":"252_CR30","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1634\/stemcells.2006-0581","volume":"25","author":"S Brenner","year":"2007","unstructured":"Brenner S, Ryser MF, Whiting-Theobald NL, Gentsch M, Linton GF, Malech HL. The late dividing population of gamma-retroviral vector transduced human mobilized peripheral blood progenitor cells contributes most to gene-marked cell engraftment in nonobese diabetic\/ severe combined immunodeficient mice. Stem Cells. 2007;25:1807\u201313.","journal-title":"Stem Cells"},{"key":"252_CR31","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ccr.2005.01.007","volume":"7","author":"E Weisberg","year":"2005","unstructured":"Weisberg E, Manley PW, Breitenstein W, Bruggen J, Cowan-Jacob SW, Ray A, et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell. 2005;7:129\u201341.","journal-title":"Cancer Cell"},{"key":"252_CR32","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1182\/blood.V99.1.319","volume":"99","author":"SM Graham","year":"2002","unstructured":"Graham SM, Jorgensen HG, Allan E, Pearson C, Alcorn MJ, Richmond L, et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002;99:319\u201325.","journal-title":"Blood"},{"key":"252_CR33","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.ccr.2012.02.018","volume":"21","author":"B Zhang","year":"2012","unstructured":"Zhang B, Ho YW, Huang Q, Maeda T, Lin A, Lee SU, et al. Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia. Cancer Cell. 2012;21:577\u201392.","journal-title":"Cancer Cell"},{"key":"252_CR34","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nature21388","volume":"543","author":"TT Ho","year":"2017","unstructured":"Ho TT, Warr MR, Adelman ER, Lansinger OM, Flach J, Verovskaya EV, et al. Autophagy maintains the metabolism and function of young and old stem cells. Nature. 2017;543:205\u201310.","journal-title":"Nature"},{"key":"252_CR35","doi-asserted-by":"publisher","first-page":"4806","DOI":"10.1182\/blood-2010-06-288589","volume":"116","author":"F Liu","year":"2010","unstructured":"Liu F, Lee JY, Wei H, Tanabe O, Engel JD, Morrison SJ, et al. FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood. 2010;116:4806\u201314.","journal-title":"Blood"},{"key":"252_CR36","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1084\/jem.20101145","volume":"208","author":"M Mortensen","year":"2011","unstructured":"Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, et al. The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J Exp Med. 2011;208:455\u201367.","journal-title":"J Exp Med"},{"key":"252_CR37","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1172\/JCI70454","volume":"124","author":"XH Ma","year":"2014","unstructured":"Ma XH, Piao SF, Dey S, McAfee Q, Karakousis G, Villanueva J, et al. Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma. J Clin Invest. 2014;124:1406\u201317.","journal-title":"J Clin Invest"},{"key":"252_CR38","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.1182\/blood-2009-04-215376","volume":"115","author":"M Schemionek","year":"2010","unstructured":"Schemionek M, Elling C, Steidl U, Baumer N, Hamilton A, Spieker T, et al. BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells. Blood. 2010;115:3185\u201395.","journal-title":"Blood"},{"key":"252_CR39","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/nature12865","volume":"504","author":"MT Rosenfeldt","year":"2013","unstructured":"Rosenfeldt MT, O\u2019Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, et al. p53 status determines the role of autophagy in pancreatic tumour development. Nature. 2013;504:296\u2013300.","journal-title":"Nature"},{"key":"252_CR40","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1101\/gad.219642.113","volume":"27","author":"JY Guo","year":"2013","unstructured":"Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev. 2013;27:1447\u201361.","journal-title":"Genes Dev"},{"key":"252_CR41","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.cell.2007.01.003","volume":"128","author":"Z Tothova","year":"2007","unstructured":"Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 2007;128:325\u201339.","journal-title":"Cell"},{"key":"252_CR42","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1172\/JCI79196","volume":"126","author":"B Zhang","year":"2016","unstructured":"Zhang B, Li L, Ho Y, Li M, Marcucci G, Tong W, et al. Heterogeneity of leukemia-initiating capacity of chronic myelogenous leukemia stem cells. J Clin Invest. 2016;126:975\u201391.","journal-title":"J Clin Invest"},{"key":"252_CR43","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1182\/blood-2006-03-011239","volume":"109","author":"P Rousselot","year":"2007","unstructured":"Rousselot P, Huguet F, Rea D, Legros L, Cayuela JM, Maarek O, et al. Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years. Blood. 2007;109:58\u201360.","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41375-018-0252-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41375-018-0252-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41375-018-0252-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T17:35:46Z","timestamp":1684604146000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41375-018-0252-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,5]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["252"],"URL":"https:\/\/doi.org\/10.1038\/s41375-018-0252-4","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733947391.793583300","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.733947391.793554355","asserted-by":"object"}]},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,5]]},"assertion":[{"value":"21 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}