{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:06:07Z","timestamp":1793502367664,"version":"4.5.0"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL144712"],"award-info":[{"award-number":["R01HL144712"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL141950"],"award-info":[{"award-number":["R01HL141950"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK110108"],"award-info":[{"award-number":["R01DK110108"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA204044"],"award-info":[{"award-number":["R01CA204044"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1038\/s41375-020-0906-x","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T11:02:37Z","timestamp":1591700557000},"page":"2295-2304","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["CTCF-mediated genome organization and leukemogenesis"],"prefix":"10.1038","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3282-6072","authenticated-orcid":false,"given":"Yi","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-2085","authenticated-orcid":false,"given":"Suming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"906_CR1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.gde.2016.03.008","volume":"36","author":"AL Valton","year":"2016","unstructured":"Valton AL, Dekker J. TAD disruption as oncogenic driver. Curr Opin Genet Dev. 2016;36:34\u201340.","journal-title":"Curr Opin Genet Dev"},{"key":"906_CR2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cell.2014.02.019","volume":"157","author":"S Groschel","year":"2014","unstructured":"Groschel S, Sanders MA, Hoogenboezem R, de Wit E, Bouwman BAM, Erpelinck C, et al. A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia. Cell. 2014;157:369\u201381.","journal-title":"Cell"},{"key":"906_CR3","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1101\/gr.201517.115","volume":"26","author":"PC Taberlay","year":"2016","unstructured":"Taberlay PC, Achinger-Kawecka J, Lun AT, Buske FA, Sabir K, Gould CM, et al. Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations. Genome Res. 2016;26:719\u201331.","journal-title":"Genome Res"},{"key":"906_CR4","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1182\/blood-2017-11-814319","volume":"132","author":"H Luo","year":"2018","unstructured":"Luo H, Wang F, Zha J, Li H, Yan B, Du Q, et al. CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia. Blood. 2018;132:837\u201348.","journal-title":"Blood"},{"key":"906_CR5","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1126\/science.1262088","volume":"347","author":"V Narendra","year":"2015","unstructured":"Narendra V, Rocha PP, An D, Raviram R, Skok JA, Mazzoni EO, et al. CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation. Science. 2015;347:1017\u201321.","journal-title":"Science"},{"key":"906_CR6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF00333519","volume":"62","author":"T Cremer","year":"1982","unstructured":"Cremer T, Cremer C, Schneider T, Baumann H, Hens L, Kirsch-Volders M. Analysis of chromosome positions in the interphase nucleus of Chinese hamster cells by laser-UV-microirradiation experiments. Hum Genet. 1982;62:201\u20139.","journal-title":"Hum Genet"},{"key":"906_CR7","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ceb.2006.04.007","volume":"18","author":"T Cremer","year":"2006","unstructured":"Cremer T, Cremer M, Dietzel S, Muller S, Solovei I, Fakan S. Chromosome territories-a functional nuclear landscape. Curr Opin Cell Biol. 2006;18:307\u201316.","journal-title":"Curr Opin Cell Biol"},{"key":"906_CR8","doi-asserted-by":"crossref","first-page":"e1000016","DOI":"10.1371\/journal.pgen.1000016","volume":"4","author":"D Noordermeer","year":"2008","unstructured":"Noordermeer D, Branco MR, Splinter E, Klous P, van Ijcken W, Swagemakers S, et al. Transcription and chromatin organization of a housekeeping gene cluster containing an integrated beta-globin locus control region. PLoS Genet. 2008;4:e1000016.","journal-title":"PLoS Genet"},{"key":"906_CR9","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2009.06.001","volume":"137","author":"JE Phillips","year":"2009","unstructured":"Phillips JE, Corces VG. CTCF: master weaver of the genome. Cell. 2009;137:1194\u2013211.","journal-title":"Cell"},{"key":"906_CR10","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41576-018-0060-8","volume":"19","author":"MJ Rowley","year":"2018","unstructured":"Rowley MJ, Corces VG. Organizational principles of 3D genome architecture. Nat Rev Genet. 2018;19:789\u2013800.","journal-title":"Nat Rev Genet"},{"key":"906_CR11","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cell.2014.09.030","volume":"159","author":"JM Dowen","year":"2014","unstructured":"Dowen JM, Fan ZP, Hnisz D, Ren G, Abraham BJ, Zhang LN, et al. Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes. Cell. 2014;159:374\u201387.","journal-title":"Cell"},{"key":"906_CR12","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.cell.2015.11.024","volume":"163","author":"Z Tang","year":"2015","unstructured":"Tang Z, Luo OJ, Li X, Zheng M, Zhu JJ, Szalaj P, et al. CTCF-mediated human 3D genome architecture reveals chromatin topology for transcription. Cell. 2015;163:1611\u201327.","journal-title":"Cell"},{"key":"906_CR13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0092-8674(00)81967-4","volume":"98","author":"AC Bell","year":"1999","unstructured":"Bell AC, West AG, Felsenfeld G. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell. 1999;98:387\u201396.","journal-title":"Cell"},{"key":"906_CR14","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0092-8674(93)80052-G","volume":"74","author":"JH Chung","year":"1993","unstructured":"Chung JH, Whiteley M, Felsenfeld G. A 5\u2019 element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell. 1993;74:505\u201314.","journal-title":"Cell"},{"key":"906_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2008.08.017","volume":"32","author":"AM Bushey","year":"2008","unstructured":"Bushey AM, Dorman ER, Corces VG. Chromatin insulators: regulatory mechanisms and epigenetic inheritance. Mol Cell. 2008;32:1\u20139.","journal-title":"Mol Cell"},{"key":"906_CR16","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrg1925","volume":"7","author":"M Gaszner","year":"2006","unstructured":"Gaszner M, Felsenfeld G. Insulators: exploiting transcriptional and epigenetic mechanisms. Nat Rev Genet. 2006;7:703\u201313.","journal-title":"Nat Rev Genet"},{"key":"906_CR17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1101\/gad.954702","volume":"16","author":"AG West","year":"2002","unstructured":"West AG, Gaszner M, Felsenfeld G. Insulators: many functions, many mechanisms. Genes Dev. 2002;16:271\u201388.","journal-title":"Genes Dev"},{"key":"906_CR18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1101\/gr.082800.108","volume":"19","author":"S Cuddapah","year":"2009","unstructured":"Cuddapah S, Jothi R, Schones DE, Roh TY, Cui K, Zhao K. Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res. 2009;19:24\u201332.","journal-title":"Genome Res"},{"key":"906_CR19","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1242\/jcs.039990","volume":"122","author":"J Zlatanova","year":"2009","unstructured":"Zlatanova J, Caiafa P. CTCF and its protein partners: divide and rule? J Cell Sci. 2009;122:1275\u201384.","journal-title":"J Cell Sci"},{"key":"906_CR20","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1097-2765(04)00029-2","volume":"13","author":"TM Yusufzai","year":"2004","unstructured":"Yusufzai TM, Tagami H, Nakatani Y, Felsenfeld G. CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species. Mol Cell. 2004;13:291\u20138.","journal-title":"Mol Cell"},{"key":"906_CR21","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.cell.2016.02.007","volume":"164","author":"J Dekker","year":"2016","unstructured":"Dekker J, Mirny L. The 3D genome as moderator of chromosomal communication. Cell. 2016;164:1110\u201321.","journal-title":"Cell"},{"key":"906_CR22","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/s41586-019-1910-z","volume":"578","author":"Y Li","year":"2020","unstructured":"Li Y, Haarhuis JHI, Sedeno Cacciatore A, Oldenkamp R, van Ruiten MS, Willems L, et al. The structural basis for cohesin-CTCF-anchored loops. Nature. 2020;578:472\u20136.","journal-title":"Nature"},{"key":"906_CR23","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.cell.2008.01.011","volume":"132","author":"V Parelho","year":"2008","unstructured":"Parelho V, Hadjur S, Spivakov M, Leleu M, Sauer S, Gregson HC, et al. Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell. 2008;132:422\u201333.","journal-title":"Cell"},{"key":"906_CR24","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nature06634","volume":"451","author":"KS Wendt","year":"2008","unstructured":"Wendt KS, Yoshida K, Itoh T, Bando M, Koch B, Schirghuber E, et al. Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature. 2008;451:796\u2013801.","journal-title":"Nature"},{"key":"906_CR25","doi-asserted-by":"crossref","first-page":"8309","DOI":"10.1073\/pnas.0801273105","volume":"105","author":"ED Rubio","year":"2008","unstructured":"Rubio ED, Reiss DJ, Welcsh PL, Disteche CM, Filippova GN, Baliga NS, et al. CTCF physically links cohesin to chromatin. Proc Natl Acad Sci USA. 2008;105:8309\u201314.","journal-title":"Proc Natl Acad Sci USA"},{"key":"906_CR26","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.celrep.2016.04.085","volume":"15","author":"G Fudenberg","year":"2016","unstructured":"Fudenberg G, Imakaev M, Lu C, Goloborodko A, Abdennur N, Mirny LA. Formation of chromosomal domains by loop extrusion. Cell Rep. 2016;15:2038\u201349.","journal-title":"Cell Rep"},{"key":"906_CR27","doi-asserted-by":"crossref","first-page":"E6697","DOI":"10.1073\/pnas.1717730115","volume":"115","author":"J Nuebler","year":"2018","unstructured":"Nuebler J, Fudenberg G, Imakaev M, Abdennur N, Mirny LA. Chromatin organization by an interplay of loop extrusion and compartmental segregation. Proc Natl Acad Sci USA. 2018;115:E6697\u2013706.","journal-title":"Proc Natl Acad Sci USA"},{"key":"906_CR28","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1073\/pnas.1317788111","volume":"111","author":"J Zuin","year":"2014","unstructured":"Zuin J, Dixon JR, van der Reijden MI, Ye Z, Kolovos P, Brouwer RW, et al. Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells. Proc Natl Acad Sci USA. 2014;111:996\u20131001.","journal-title":"Proc Natl Acad Sci USA"},{"key":"906_CR29","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nature08079","volume":"460","author":"S Hadjur","year":"2009","unstructured":"Hadjur S, Williams LM, Ryan NK, Cobb BS, Sexton T, Fraser P, et al. Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature. 2009;460:410\u20133.","journal-title":"Nature"},{"key":"906_CR30","doi-asserted-by":"crossref","first-page":"e1000739","DOI":"10.1371\/journal.pgen.1000739","volume":"5","author":"R Nativio","year":"2009","unstructured":"Nativio R, Wendt KS, Ito Y, Huddleston JE, Uribe-Lewis S, Woodfine K, et al. Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus. PLoS Genet. 2009;5:e1000739.","journal-title":"PLoS Genet"},{"key":"906_CR31","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41594-018-0070-4","volume":"25","author":"A Kojic","year":"2018","unstructured":"Kojic A, Cuadrado A, De Koninck M, Gimenez-Llorente D, Rodriguez-Corsino M, Gomez-Lopez G, et al. Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization. Nat Struct Mol Biol. 2018;25:496\u2013504.","journal-title":"Nat Struct Mol Biol"},{"key":"906_CR32","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.cell.2013.04.053","volume":"153","author":"JE Phillips-Cremins","year":"2013","unstructured":"Phillips-Cremins JE, Sauria ME, Sanyal A, Gerasimova TI, Lajoie BR, Bell JS, et al. Architectural protein subclasses shape 3D organization of genomes during lineage commitment. Cell. 2013;153:1281\u201395.","journal-title":"Cell"},{"key":"906_CR33","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.cell.2013.07.034","volume":"154","author":"J Yan","year":"2013","unstructured":"Yan J, Enge M, Whitington T, Dave K, Liu J, Sur I, et al. Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites. Cell. 2013;154:801\u201313.","journal-title":"Cell"},{"key":"906_CR34","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1101\/gad.1967810","volume":"24","author":"H Yao","year":"2010","unstructured":"Yao H, Brick K, Evrard Y, Xiao T, Camerini-Otero RD, Felsenfeld G. Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA. Genes Dev. 2010;24:2543\u201355.","journal-title":"Genes Dev"},{"key":"906_CR35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.molcel.2014.12.006","volume":"57","author":"JT Kung","year":"2015","unstructured":"Kung JT, Kesner B, An JY, Ahn JY, Cifuentes-Rojas C, Colognori D, et al. Locus-specific targeting to the X chromosome revealed by the RNA interactome of CTCF. Mol Cell. 2015;57:361\u201375.","journal-title":"Mol Cell"},{"key":"906_CR36","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.cell.2013.02.016","volume":"152","author":"JT Lee","year":"2013","unstructured":"Lee JT, Bartolomei MS. X-inactivation, imprinting, and long noncoding RNAs in health and disease. Cell. 2013;152:1308\u201323.","journal-title":"Cell"},{"key":"906_CR37","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.molcel.2019.08.015","volume":"76","author":"R Saldana-Meyer","year":"2019","unstructured":"Saldana-Meyer R, Rodriguez-Hernaez J, Escobar T, Nishana M, Jacome-Lopez K, Nora EP, et al. RNA interactions are essential for CTCF-mediated genome organization. Mol Cell. 2019;76:412\u201322.e415","journal-title":"Mol Cell"},{"key":"906_CR38","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.molcel.2019.07.039","volume":"76","author":"AS Hansen","year":"2019","unstructured":"Hansen AS, Hsieh TS, Cattoglio C, Pustova I, Saldana-Meyer R, Reinberg D, et al. Distinct classes of chromatin loops revealed by deletion of an RNA-binding region in CTCF. Mol Cell. 2019;76:395\u2013411.e313.","journal-title":"Mol Cell"},{"key":"906_CR39","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ccell.2019.10.011","volume":"36","author":"H Luo","year":"2019","unstructured":"Luo H, Zhu G, Xu J, Lai Q, Yan B, Guo Y, et al. HOTTIP lncRNA promotes hematopoietic stem cell self-renewal leading to AML-like disease in mice. Cancer Cell. 2019;36:645\u201359.e648.","journal-title":"Cancer Cell"},{"key":"906_CR40","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nature09819","volume":"472","author":"KC Wang","year":"2011","unstructured":"Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, et al. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature. 2011;472:120\u20134.","journal-title":"Nature"},{"key":"906_CR41","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/sj.leu.2402354","volume":"16","author":"HA Drabkin","year":"2002","unstructured":"Drabkin HA, Parsy C, Ferguson K, Guilhot F, Lacotte L, Roy L, et al. Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia. Leukemia. 2002;16:186\u201395.","journal-title":"Leukemia"},{"key":"906_CR42","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1038\/leu.2008.198","volume":"22","author":"M Andreeff","year":"2008","unstructured":"Andreeff M, Ruvolo V, Gadgil S, Zeng C, Coombes K, Chen W, et al. HOX expression patterns identify a common signature for favorable AML. Leukemia. 2008;22:2041\u20137.","journal-title":"Leukemia"},{"key":"906_CR43","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/ncb3354","volume":"18","author":"DR Dou","year":"2016","unstructured":"Dou DR, Calvanese V, Sierra MI, Nguyen AT, Minasian A, Saarikoski P, et al. Medial HOXA genes demarcate haematopoietic stem cell fate during human development. Nat Cell Biol. 2016;18:595\u2013606.","journal-title":"Nat Cell Biol"},{"key":"906_CR44","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1182\/blood-2005-05-2003","volume":"106","author":"HJ Lawrence","year":"2005","unstructured":"Lawrence HJ, Christensen J, Fong S, Hu YL, Weissman I, Sauvageau G, et al. Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells. Blood. 2005;106:3988\u201394.","journal-title":"Blood"},{"key":"906_CR45","doi-asserted-by":"crossref","first-page":"e1003524","DOI":"10.1371\/journal.pgen.1003524","volume":"9","author":"C Deng","year":"2013","unstructured":"Deng C, Li Y, Liang S, Cui K, Salz T, Yang H, et al. USF1 and hSET1A mediated epigenetic modifications regulate lineage differentiation and HoxB4 transcription. PLoS Genet. 2013;9:e1003524.","journal-title":"PLoS Genet"},{"key":"906_CR46","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/leu.2012.356","volume":"27","author":"RA Alharbi","year":"2013","unstructured":"Alharbi RA, Pettengell R, Pandha HS, Morgan R. The role of HOX genes in normal hematopoiesis and acute leukemia. Leukemia. 2013;27:1000\u20138.","journal-title":"Leukemia"},{"key":"906_CR47","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/leu.2015.6","volume":"29","author":"DH Spencer","year":"2015","unstructured":"Spencer DH, Young MA, Lamprecht TL, Helton NM, Fulton R, O\u2019Laughlin M, et al. Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells. Leukemia. 2015;29:1279\u201389.","journal-title":"Leukemia"},{"key":"906_CR48","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature11082","volume":"485","author":"JR Dixon","year":"2012","unstructured":"Dixon JR, Selvaraj S, Yue F, Kim A, Li Y, Shen Y, et al. Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature. 2012;485:376\u201380.","journal-title":"Nature"},{"key":"906_CR49","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/ng.857","volume":"43","author":"L Handoko","year":"2011","unstructured":"Handoko L, Xu H, Li G, Ngan CY, Chew E, Schnapp M, et al. CTCF-mediated functional chromatin interactome in pluripotent cells. Nat Genet. 2011;43:630\u20138.","journal-title":"Nat Genet"},{"key":"906_CR50","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ng1891","volume":"38","author":"Z Zhao","year":"2006","unstructured":"Zhao Z, Tavoosidana G, Sjolinder M, Gondor A, Mariano P, Wang S, et al. Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Nat Genet. 2006;38:1341\u20137.","journal-title":"Nat Genet"},{"key":"906_CR51","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.gde.2007.08.005","volume":"17","author":"JA Wallace","year":"2007","unstructured":"Wallace JA, Felsenfeld G. We gather together: insulators and genome organization. Curr Opin Genet Dev. 2007;17:400\u20137.","journal-title":"Curr Opin Genet Dev"},{"key":"906_CR52","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nature11049","volume":"485","author":"EP Nora","year":"2012","unstructured":"Nora EP, Lajoie BR, Schulz EG, Giorgetti L, Okamoto I, Servant N, et al. Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature. 2012;485:381\u20135.","journal-title":"Nature"},{"key":"906_CR53","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/nprot.2012.071","volume":"7","author":"T Sexton","year":"2012","unstructured":"Sexton T, Kurukuti S, Mitchell JA, Umlauf D, Nagano T, Fraser P. Sensitive detection of chromatin coassociations using enhanced chromosome conformation capture on chip. Nat Protoc. 2012;7:1335\u201350.","journal-title":"Nat Protoc"},{"key":"906_CR54","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.molcel.2017.08.026","volume":"67","author":"G Ren","year":"2017","unstructured":"Ren G, Jin W, Cui K, Rodrigez J, Hu G, Zhang Z, et al. CTCF-mediated enhancer-promoter interaction is a critical regulator of cell-to-cell variation of gene expression. Mol Cell. 2017;67:1049\u201358.e1046.","journal-title":"Mol Cell"},{"key":"906_CR55","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.stem.2019.08.003","volume":"25","author":"AD Viny","year":"2019","unstructured":"Viny AD, Bowman RL, Liu Y, Lavallee VP, Eisman SE, Xiao W, et al. Cohesin members Stag1 and Stag2 display distinct roles in chromatin accessibility and topological control of HSC self-renewal and differentiation. Cell Stem Cell. 2019;25:682\u201396.e688.","journal-title":"Cell Stem Cell"},{"key":"906_CR56","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1101\/gad.307769.117","volume":"31","author":"E Rodriguez-Carballo","year":"2017","unstructured":"Rodriguez-Carballo E, Lopez-Delisle L, Zhan Y, Fabre PJ, Beccari L, El-Idrissi I, et al. The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes. Genes Dev. 2017;31:2264\u201381.","journal-title":"Genes Dev"},{"key":"906_CR57","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1101\/gad.288324.116","volume":"30","author":"V Narendra","year":"2016","unstructured":"Narendra V, Bulajic M, Dekker J, Mazzoni EO, Reinberg D. CTCF-mediated topological boundaries during development foster appropriate gene regulation. Genes Dev. 2016;30:2657\u201362.","journal-title":"Genes Dev"},{"key":"906_CR58","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2015.07.038","volume":"162","author":"Y Guo","year":"2015","unstructured":"Guo Y, Xu Q, Canzio D, Shou J, Li J, Gorkin DU, et al. CRISPR inversion of CTCF sites alters genome topology and enhancer\/promoter function. Cell. 2015;162:900\u201310.","journal-title":"Cell"},{"key":"906_CR59","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.molcel.2015.09.023","volume":"60","author":"E de Wit","year":"2015","unstructured":"de Wit E, Vos ES, Holwerda SJ, Valdes-Quezada C, Verstegen MJ, Teunissen H, et al. CTCF binding polarity determines chromatin looping. Mol Cell. 2015;60:676\u201384.","journal-title":"Mol Cell"},{"key":"906_CR60","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41576-019-0128-0","volume":"20","author":"S Schoenfelder","year":"2019","unstructured":"Schoenfelder S, Fraser P. Long-range enhancer-promoter contacts in gene expression control. Nat Rev Genet. 2019;20:437\u201355.","journal-title":"Nat Rev Genet"},{"key":"906_CR61","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nature12716","volume":"504","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Wong CH, Birnbaum RY, Li G, Favaro R, Ngan CY, et al. Chromatin connectivity maps reveal dynamic promoter-enhancer long-range associations. Nature. 2013;504:306\u201310.","journal-title":"Nature"},{"key":"906_CR62","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature11279","volume":"489","author":"A Sanyal","year":"2012","unstructured":"Sanyal A, Lajoie BR, Jain G, Dekker J. The long-range interaction landscape of gene promoters. Nature. 2012;489:109\u201313.","journal-title":"Nature"},{"key":"906_CR63","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41586-019-1778-y","volume":"576","author":"H Zhang","year":"2019","unstructured":"Zhang H, Emerson DJ, Gilgenast TG, Titus KR, Lan Y, Huang P, et al. Chromatin structure dynamics during the mitosis-to-G1 phase transition. Nature. 2019;576:158\u201362.","journal-title":"Nature"},{"key":"906_CR64","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cell.2007.01.028","volume":"128","author":"T Misteli","year":"2007","unstructured":"Misteli T. Beyond the sequence: cellular organization of genome function. Cell. 2007;128:787\u2013800.","journal-title":"Cell"},{"key":"906_CR65","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1182\/blood-2015-07-604496","volume":"127","author":"D Grimwade","year":"2016","unstructured":"Grimwade D, Ivey A, Huntly BJ. Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance. Blood. 2016;127:29\u201341.","journal-title":"Blood"},{"key":"906_CR66","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1056\/NEJMoa1112304","volume":"366","author":"JP Patel","year":"2012","unstructured":"Patel JP, Gonen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med. 2012;366:1079\u201389.","journal-title":"N Engl J Med"},{"key":"906_CR67","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","volume":"368","author":"N Cancer Genome Atlas Research","year":"2013","unstructured":"Cancer Genome Atlas Research N, Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, et al. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013;368:2059\u201374.","journal-title":"N Engl J Med"},{"key":"906_CR68","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.stem.2018.04.003","volume":"22","author":"S Haas","year":"2018","unstructured":"Haas S, Trumpp A, Milsom MD. Causes and consequences of hematopoietic stem cell heterogeneity. Cell Stem Cell. 2018;22:627\u201338.","journal-title":"Cell Stem Cell"},{"key":"906_CR69","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1016\/j.celrep.2019.11.065","volume":"29","author":"C Chen","year":"2019","unstructured":"Chen C, Yu W, Tober J, Gao P, He B, Lee K, et al. Spatial genome re-organization between fetal and adult hematopoietic stem cells. Cell Rep. 2019;29:4200\u201311.e4207.","journal-title":"Cell Rep"},{"key":"906_CR70","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/leu.2013.158","volume":"28","author":"B Patel","year":"2014","unstructured":"Patel B, Kang Y, Cui K, Litt M, Riberio MS, Deng C, et al. Aberrant TAL1 activation is mediated by an interchromosomal interaction in human T-cell acute lymphoblastic leukemia. Leukemia. 2014;28:349\u201361.","journal-title":"Leukemia"},{"key":"906_CR71","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.1182\/blood-2013-02-483875","volume":"122","author":"Y Zhou","year":"2013","unstructured":"Zhou Y, Kurukuti S, Saffrey P, Vukovic M, Michie AM, Strogantsev R, et al. Chromatin looping defines expression of TAL1, its flanking genes, and regulation in T-ALL. Blood. 2013;122:4199\u2013209.","journal-title":"Blood"},{"key":"906_CR72","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1093\/nar\/gkaa098","volume":"48","author":"Y Li","year":"2020","unstructured":"Li Y, Liao Z, Luo H, Benyoucef A, Kang Y, Lai Q, et al. Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis. Nucleic Acids Res. 2020;48:3119\u201333.","journal-title":"Nucleic Acids Res"},{"key":"906_CR73","doi-asserted-by":"crossref","first-page":"6699","DOI":"10.1093\/nar\/gkz462","volume":"47","author":"J Hyle","year":"2019","unstructured":"Hyle J, Zhang Y, Wright S, Xu B, Shao Y, Easton J, et al. Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping. Nucleic Acids Res. 2019;47:6699\u2013713.","journal-title":"Nucleic Acids Res"},{"key":"906_CR74","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1126\/science.aad9024","volume":"351","author":"D Hnisz","year":"2016","unstructured":"Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH, et al. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science. 2016;351:1454\u20138.","journal-title":"Science"},{"key":"906_CR75","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/ng.3335","volume":"47","author":"R Katainen","year":"2015","unstructured":"Katainen R, Dave K, Pitkanen E, Palin K, Kivioja T, Valimaki N, et al. CTCF\/cohesin-binding sites are frequently mutated in cancer. Nat Genet. 2015;47:818\u201321.","journal-title":"Nat Genet"},{"key":"906_CR76","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2011.07.049","volume":"147","author":"R Chiarle","year":"2011","unstructured":"Chiarle R, Zhang Y, Frock RL, Lewis SM, Molinie B, Ho YJ, et al. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell. 2011;147:107\u201319.","journal-title":"Cell"},{"key":"906_CR77","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.ccr.2012.10.017","volume":"22","author":"BB Zeisig","year":"2012","unstructured":"Zeisig BB, Kulasekararaj AG, Mufti GJ, So CW. SnapShot: acute myeloid leukemia. Cancer Cell. 2012;22:698\u2013e691.","journal-title":"Cancer Cell"},{"key":"906_CR78","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fped.2017.00004","volume":"5","author":"AC Winters","year":"2017","unstructured":"Winters AC, Bernt KM. MLL-rearranged leukemias\u2014an update on science and clinical approaches. Front Pediatr. 2017;5:4.","journal-title":"Front Pediatr"},{"key":"906_CR79","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1172\/JCI31861","volume":"117","author":"KL Rice","year":"2007","unstructured":"Rice KL, Licht JD. HOX deregulation in acute myeloid leukemia. J Clin Investig. 2007;117:865\u20138.","journal-title":"J Clin Investig"},{"key":"906_CR80","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/leu.2009.33","volume":"23","author":"C Meyer","year":"2009","unstructured":"Meyer C, Kowarz E, Hofmann J, Renneville A, Zuna J, Trka J, et al. New insights to the MLL recombinome of acute leukemias. Leukemia. 2009;23:1490\u20139.","journal-title":"Leukemia"},{"key":"906_CR81","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/ng.2731","volume":"45","author":"A Kon","year":"2013","unstructured":"Kon A, Shih LY, Minamino M, Sanada M, Shiraishi Y, Nagata Y, et al. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat Genet. 2013;45:1232\u20137.","journal-title":"Nat Genet"},{"key":"906_CR82","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/leu.2017.30","volume":"31","author":"EM Heath","year":"2017","unstructured":"Heath EM, Chan SM, Minden MD, Murphy T, Shlush LI, Schimmer AD. Biological and clinical consequences of NPM1 mutations in AML. Leukemia. 2017;31:798\u2013807.","journal-title":"Leukemia"},{"key":"906_CR83","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ccell.2018.08.005","volume":"34","author":"L Brunetti","year":"2018","unstructured":"Brunetti L, Gundry MC, Sorcini D, Guzman AG, Huang YH, Ramabadran R, et al. Mutant NPM1 maintains the leukemic state through HOX expression. Cancer Cell. 2018;34:499\u2013512.e499.","journal-title":"Cancer Cell"},{"key":"906_CR84","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/s41375-019-0681-8","volume":"34","author":"AJ Wang","year":"2020","unstructured":"Wang AJ, Han Y, Jia N, Chen P, Minden MD. NPM1c impedes CTCF functions through cytoplasmic mislocalization in acute myeloid leukemia. Leukemia. 2020;34:1278\u201390.","journal-title":"Leukemia"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41375-020-0906-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41375-020-0906-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41375-020-0906-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:41:01Z","timestamp":1684618861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41375-020-0906-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,9]]},"references-count":84,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["906"],"URL":"https:\/\/doi.org\/10.1038\/s41375-020-0906-x","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,9]]},"assertion":[{"value":"11 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}