{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:38:04Z","timestamp":1787002684432,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1038\/s41375-024-02165-2","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T05:02:43Z","timestamp":1707282163000},"page":"851-864","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Znf687 recruits Brd4-Smrt complex to regulate gfi1aa during neutrophil development"],"prefix":"10.1038","volume":"38","author":[{"given":"Lin","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuiyi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1113-4472","authenticated-orcid":false,"given":"Hugues","family":"de Th\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7983-3130","authenticated-orcid":false,"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0472-3188","authenticated-orcid":false,"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"2165_CR1","doi-asserted-by":"publisher","first-page":"e00057","DOI":"10.1128\/MMBR.00057-17","volume":"82","author":"SM Lawrence","year":"2018","unstructured":"Lawrence SM, Corriden R, Nizet V. The Ontogeny of a Neutrophil: Mechanisms of Granulopoiesis and Homeostasis. Microbiol Mol Biol Rev MMBR. 2018;82:e00057\u201317.","journal-title":"Microbiol Mol Biol Rev MMBR"},{"key":"2165_CR2","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.it.2019.05.004","volume":"40","author":"L Yvan-Charvet","year":"2019","unstructured":"Yvan-Charvet L, Ng LG. Granulopoiesis and Neutrophil Homeostasis: A Metabolic, Daily Balancing Act. Trends Immunol. 2019;40:598\u2013612.","journal-title":"Trends Immunol"},{"key":"2165_CR3","first-page":"57","volume":"2","author":"K Fiedler","year":"2012","unstructured":"Fiedler K, Brunner C. The role of transcription factors in the guidance of granulopoiesis. Am J Blood Res. 2012;2:57\u201365.","journal-title":"Am J Blood Res"},{"key":"2165_CR4","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00223-019-00522-3","volume":"104","author":"L Gennari","year":"2019","unstructured":"Gennari L, Rendina D, Falchetti A, Merlotti D. Paget\u2019s Disease of Bone. Calcif Tissue Int. 2019;104:483\u2013500.","journal-title":"Calcif Tissue Int"},{"key":"2165_CR5","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41586-018-0623-z","volume":"562","author":"JW Tyner","year":"2018","unstructured":"Tyner JW, Tognon CE, Bottomly D, Wilmot B, Kurtz SE, Savage SL, et al. Functional genomic landscape of acute myeloid leukaemia. Nature 2018;562:526\u201331.","journal-title":"Nature"},{"key":"2165_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02403-5","volume":"8","author":"JE Lee","year":"2017","unstructured":"Lee JE, Park YK, Park S, Jang Y, Waring N, Dey A, et al. Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis. Nat Commun. 2017;8:2217.","journal-title":"Nat Commun"},{"key":"2165_CR7","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1093\/nar\/gkw826","volume":"45","author":"Z Najafova","year":"2017","unstructured":"Najafova Z, Tirado-Magallanes R, Subramaniam M, Hossan T, Schmidt G, Nagarajan S, et al. BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire. Nucleic Acids Res. 2017;45:127\u201341.","journal-title":"Nucleic Acids Res"},{"key":"2165_CR8","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1182\/blood-2014-10-607309","volume":"125","author":"AJ Stonestrom","year":"2015","unstructured":"Stonestrom AJ, Hsu SC, Jahn KS, Huang P, Keller CA, Giardine BM, et al. Functions of BET proteins in erythroid gene expression. Blood. 2015;125:2825\u201334.","journal-title":"Blood"},{"key":"2165_CR9","doi-asserted-by":"publisher","first-page":"e111473","DOI":"10.15252\/embj.2022111473","volume":"42","author":"L Zhao","year":"2023","unstructured":"Zhao L, Wang Y, Jaganathan A, Sun Y, Ma N, Li N, et al. BRD4-PRC2 represses transcription of T-helper 2-specific negative regulators during T-cell differentiation. EMBO J. 2023;42:e111473.","journal-title":"EMBO J"},{"key":"2165_CR10","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1101\/sqb.2016.81.031039","volume":"81","author":"JS Roe","year":"2016","unstructured":"Roe JS, Vakoc CR. The Essential Transcriptional Function of BRD4 in Acute Myeloid Leukemia. Cold Spring Harb Symp Quant Biol. 2016;81:61\u20136.","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"2165_CR11","doi-asserted-by":"publisher","first-page":"13141","DOI":"10.1074\/jbc.R700001200","volume":"282","author":"SY Wu","year":"2007","unstructured":"Wu SY, Chiang CM. The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation. J Biol Chem. 2007;282:13141\u20135.","journal-title":"J Biol Chem"},{"key":"2165_CR12","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1189\/jlb.2RI0616-250R","volume":"100","author":"BN Devaiah","year":"2016","unstructured":"Devaiah BN, Gegonne A, Singer DS. Bromodomain 4: a cellular Swiss army knife. J Leukoc Biol. 2016;100:679\u201386.","journal-title":"J Leukoc Biol"},{"key":"2165_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20378-8","volume":"12","author":"AL Latif","year":"2021","unstructured":"Latif AL, Newcombe A, Li S, Gilroy K, Robertson NA, Lei X, et al. BRD4-mediated repression of p53 is a target for combination therapy in AML. Nat Commun. 2021;12:241.","journal-title":"Nat Commun"},{"key":"2165_CR14","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.molcel.2017.04.027","volume":"66","author":"JI Sakamaki","year":"2017","unstructured":"Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O\u2019Prey J, Clark W, et al. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Mol Cell. 2017;66:517\u201332.e9.","journal-title":"Mol Cell"},{"key":"2165_CR15","doi-asserted-by":"publisher","first-page":"e2109133119","DOI":"10.1073\/pnas.2109133119","volume":"119","author":"B Liu","year":"2022","unstructured":"Liu B, Liu X, Han L, Chen X, Wu X, Wu J, et al. BRD4-directed super-enhancer organization of transcription repression programs links to chemotherapeutic efficacy in breast cancer. Proc Natl Acad Sci USA. 2022;119:e2109133119.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2165_CR16","first-page":"253","volume":"203","author":"CB Kimmel","year":"1995","unstructured":"Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF. Stages of embryonic development of the zebrafish. Dev Dyn Publ Am Assoc Anat. 1995;203:253\u2013310.","journal-title":"Dev Dyn Publ Am Assoc Anat"},{"key":"2165_CR17","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1097\/00062752-200107000-00011","volume":"8","author":"K Hsu","year":"2001","unstructured":"Hsu K, Kanki JP, Look AT. Zebrafish myelopoiesis and blood cell development. Curr Opin Hematol. 2001;8:245\u201351.","journal-title":"Curr Opin Hematol"},{"key":"2165_CR18","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0070-2153(03)53004-6","volume":"53","author":"JL Galloway","year":"2003","unstructured":"Galloway JL, Zon LI. Ontogeny of hematopoiesis: examining the emergence of hematopoietic cells in the vertebrate embryo. Curr Top Dev Biol. 2003;53:139\u201358.","journal-title":"Curr Top Dev Biol"},{"key":"2165_CR19","doi-asserted-by":"publisher","first-page":"2876","DOI":"10.1182\/blood.V86.8.2876.2876","volume":"86","author":"LI Zon","year":"1995","unstructured":"Zon LI. Developmental biology of hematopoiesis. Blood. 1995;86:2876\u201391.","journal-title":"Blood"},{"key":"2165_CR20","first-page":"4147","volume":"134","author":"JY Bertrand","year":"2007","unstructured":"Bertrand JY, Kim AD, Violette EP, Stachura DL, Cisson JL, Traver D. Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo. Dev Camb Engl. 2007;134:4147\u201356.","journal-title":"Dev Camb Engl"},{"key":"2165_CR21","first-page":"1853","volume":"135","author":"JY Bertrand","year":"2008","unstructured":"Bertrand JY, Kim AD, Teng S, Traver D. CD41 + cmyb + precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis. Dev Camb Engl. 2008;135:1853\u201362.","journal-title":"Dev Camb Engl"},{"key":"2165_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2017.63","volume":"6","author":"T Zhang","year":"2017","unstructured":"Zhang T, Huang Y, Liu W, Meng W, Zhao H, Yang Q, et al. Overexpression of zinc finger protein 687 enhances tumorigenic capability and promotes recurrence of hepatocellular carcinoma. Oncogenesis. 2017;6:e363.","journal-title":"Oncogenesis"},{"key":"2165_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2020.05.031","volume":"489","author":"F Scotto di Carlo","year":"2020","unstructured":"Scotto di Carlo F, Whyte MP, Gianfrancesco F. The two faces of giant cell tumor of bone. Cancer Lett. 2020;489:1\u20138.","journal-title":"Cancer Lett"},{"key":"2165_CR24","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1128\/MCB.22.6.1804-1818.2002","volume":"22","author":"A Melnick","year":"2002","unstructured":"Melnick A, Carlile G, Ahmad KF, Kiang CL, Corcoran C, Bardwell V, et al. Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors. Mol Cell Biol. 2002;22:1804\u201318.","journal-title":"Mol Cell Biol"},{"key":"2165_CR25","doi-asserted-by":"publisher","first-page":"e1009693","DOI":"10.1371\/journal.pgen.1009693","volume":"17","author":"S Gao","year":"2021","unstructured":"Gao S, Wang Z, Wang L, Wang H, Yuan H, Liu X, et al. Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish. PLoS Genet. 2021;17:e1009693.","journal-title":"PLoS Genet"},{"key":"2165_CR26","first-page":"dev199516","volume":"148","author":"M Wu","year":"2021","unstructured":"Wu M, Xu Y, Li J, Lian J, Chen Q, Meng P, et al. Genetic and epigenetic orchestration of Gfi1aa-Lsd1-cebpa in zebrafish neutrophil development. Dev Camb Engl. 2021;148:dev199516.","journal-title":"Dev Camb Engl"},{"key":"2165_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.critrevonc.2011.04.007","volume":"82","author":"C Vicente","year":"2012","unstructured":"Vicente C, Conchillo A, Garc\u00eda-S\u00e1nchez MA, Odero MD. The role of the GATA2 transcription factor in normal and malignant hematopoiesis. Crit Rev Oncol Hematol. 2012;82:1\u201317.","journal-title":"Crit Rev Oncol Hematol"},{"key":"2165_CR28","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.molcel.2018.11.006","volume":"73","author":"JP Lambert","year":"2019","unstructured":"Lambert JP, Picaud S, Fujisawa T, Hou H, Savitsky P, Uusk\u00fcla-Reimand L, et al. Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol Cell. 2019;73:621\u201338.e17.","journal-title":"Mol Cell"},{"key":"2165_CR29","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1038\/s41388-020-01625-0","volume":"40","author":"KP Eagen","year":"2021","unstructured":"Eagen KP, French CA. Supercharging BRD4 with NUT in carcinoma. Oncogene. 2021;40:1396\u2013408.","journal-title":"Oncogene"},{"key":"2165_CR30","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1182\/blood-2013-11-541391","volume":"124","author":"Y Wei","year":"2014","unstructured":"Wei Y, Ma D, Gao Y, Zhang C, Wang L, Liu F. Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish. Blood. 2014;124:1578\u201385.","journal-title":"Blood"},{"key":"2165_CR31","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/s41593-018-0311-1","volume":"22","author":"W Zhou","year":"2019","unstructured":"Zhou W, He Y, Rehman AU, Kong Y, Hong S, Ding G, et al. Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. Nat Neurosci. 2019;22:205\u201317.","journal-title":"Nat Neurosci"},{"key":"2165_CR32","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.ajhg.2015.12.016","volume":"98","author":"G Divisato","year":"2016","unstructured":"Divisato G, Formicola D, Esposito T, Merlotti D, Pazzaglia L, Del Fattore A, et al. ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor. Am J Hum Genet. 2016;98:275\u201386.","journal-title":"Am J Hum Genet"},{"key":"2165_CR33","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1002\/gcc.20355","volume":"45","author":"TT Nguyen","year":"2006","unstructured":"Nguyen TT, Ma LN, Slovak ML, Bangs CD, Cherry AM, Arber DA. Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia. Genes Chromosomes Cancer. 2006;45:918\u201332.","journal-title":"Genes Chromosomes Cancer"},{"key":"2165_CR34","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.stemcr.2015.01.012","volume":"4","author":"T Wu","year":"2015","unstructured":"Wu T, Pinto HB, Kamikawa YF, Donohoe ME. The BET family member BRD4 interacts with OCT4 and regulates pluripotency gene expression. Stem Cell Rep. 2015;4:390\u2013403.","journal-title":"Stem Cell Rep"},{"key":"2165_CR35","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1038\/cdd.2014.124","volume":"21","author":"W Liu","year":"2014","unstructured":"Liu W, Stein P, Cheng X, Yang W, Shao NY, Morrisey EE, et al. BRD4 regulates Nanog expression in mouse embryonic stem cells and preimplantation embryos. Cell Death Differ. 2014;21:1950\u201360.","journal-title":"Cell Death Differ"},{"key":"2165_CR36","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0915-9","volume":"17","author":"B Donati","year":"2018","unstructured":"Donati B, Lorenzini E, Ciarrocchi A. BRD4 and Cancer: going beyond transcriptional regulation. Mol Cancer. 2018;17:164.","journal-title":"Mol Cancer"},{"key":"2165_CR37","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nature18288","volume":"534","author":"SA Abraham","year":"2016","unstructured":"Abraham SA, Hopcroft LEM, Carrick E, Drotar ME, Dunn K, Williamson AJK, et al. Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells. Nature. 2016;534:341\u20136.","journal-title":"Nature"},{"key":"2165_CR38","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/nature10334","volume":"478","author":"J Zuber","year":"2011","unstructured":"Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 2011;478:524\u20138.","journal-title":"Nature"},{"key":"2165_CR39","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/s41375-018-0166-1","volume":"33","author":"J Fraszczak","year":"2019","unstructured":"Fraszczak J, Vadnais C, Rashkovan M, Ross J, Beauchemin H, Chen R, et al. Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice. Leukemia. 2019;33:110\u201321.","journal-title":"Leukemia"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41375-024-02165-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-024-02165-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-024-02165-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T11:03:03Z","timestamp":1712314983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41375-024-02165-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,7]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["2165"],"URL":"https:\/\/doi.org\/10.1038\/s41375-024-02165-2","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,7]]},"assertion":[{"value":"28 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was approved by the Ethics Committee of Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. Zebrafish experimental procedures were conducted in accordance with the protocols approved by the Institutional Animal Care and Use Committee (IACUC) of Shanghai Jiao Tong University (2020-3#).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}}]}}