{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:40:24Z","timestamp":1788838824225,"version":"build-2803163510"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["15255"],"award-info":[{"award-number":["15255"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["22759"],"award-info":[{"award-number":["22759"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2019-12368737"],"award-info":[{"award-number":["RF-2019-12368737"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1038\/s41375-024-02168-z","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T09:02:27Z","timestamp":1708160547000},"page":"877-882","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Che-1\/miR-590-3p\/TAZ axis sustains multiple myeloma disease"],"prefix":"10.1038","volume":"38","author":[{"given":"Tiziana","family":"Bruno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Catena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6170-9780","authenticated-orcid":false,"given":"Giacomo","family":"Corleone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9017-6373","authenticated-orcid":false,"given":"Clelia","family":"Cortile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Cappelletto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bellei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"De Nicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Amadio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svitlana","family":"Gumenyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-2272","authenticated-orcid":false,"given":"Francesco","family":"Marchesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ombretta","family":"Annibali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6970-2241","authenticated-orcid":false,"given":"Giovanni","family":"Blandino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5281-4191","authenticated-orcid":false,"given":"Maurizio","family":"Fanciulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3730-1125","authenticated-orcid":false,"given":"Silvia","family":"Di Agostino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"2168_CR1","doi-asserted-by":"publisher","first-page":"353ra113","DOI":"10.1126\/scitranslmed.aad8949","volume":"8","author":"H Liu","year":"2016","unstructured":"Liu H, Liu Z, Du J, He J, Lin P, Amini B, et al. Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma. Sci Transl Med. 2016;8:353ra113.","journal-title":"Sci Transl Med"},{"key":"2168_CR2","doi-asserted-by":"publisher","first-page":"3613","DOI":"10.1182\/bloodadvances.2019000374","volume":"3","author":"S Grieve","year":"2019","unstructured":"Grieve S, Wajnberg G, Lees M, Chacko S, Weir J, Crapoulet N, et al. TAZ functions as a tumor suppressor in multiple myeloma by downregulating MYC. Blood Adv. 2019;3:3613\u201325.","journal-title":"Blood Adv"},{"key":"2168_CR3","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1089\/scd.2007.0074","volume":"16","author":"B Li","year":"2007","unstructured":"Li B, Shi M, Li J, Zhang H, Chen B, Chen L, et al. Elevated tumor necrosis factor-alpha suppresses TAZ expression and impairs osteogenic potential of Flk-1+ mesenchymal stem cells in patients with multiple myeloma. Stem Cells Dev. 2007;16:921\u201330.","journal-title":"Stem Cells Dev"},{"key":"2168_CR4","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3389\/fgene.2015.00141","volume":"6","author":"S Iezzi","year":"2015","unstructured":"Iezzi S, Fanciulli M. Discovering Che-1\/AATF: a new attractive target for cancer therapy. Front Genet. 2015;6:141.","journal-title":"Front Genet"},{"key":"2168_CR5","doi-asserted-by":"publisher","first-page":"5616","DOI":"10.1182\/bloodadvances.2020002566","volume":"4","author":"T Bruno","year":"2020","unstructured":"Bruno T, De Nicola F, Corleone G, Catena V, Goeman F, Pallocca M, et al. Che-1\/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma. Blood Adv. 2020;4:5616\u201330.","journal-title":"Blood Adv"},{"key":"2168_CR6","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.15252\/embj.201489920","volume":"34","author":"A Desantis","year":"2015","unstructured":"Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, et al. Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO J. 2015;34:1214\u201330.","journal-title":"EMBO J"},{"key":"2168_CR7","doi-asserted-by":"publisher","first-page":"e109711","DOI":"10.15252\/embj.2021109711","volume":"41","author":"T Bruno","year":"2022","unstructured":"Bruno T, Corleone G, Catena V, Cortile C, De Nicola F, Fabretti F, et al. AATF\/Che-1 localizes to paraspeckles and suppresses R-loops accumulation and interferon activation in Multiple Myeloma. EMBO J. 2022;41:e109711.","journal-title":"EMBO J"},{"key":"2168_CR8","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/gcc.20668","volume":"48","author":"L Agnelli","year":"2009","unstructured":"Agnelli L, Mosca L, Fabris S, Lionetti M, Andronache A, Kwee I, et al. A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: an integrated genomics approach reveals a wide gene dosage effect. Genes Chromosomes Cancer. 2009;48:603\u201314.","journal-title":"Genes Chromosomes Cancer"},{"key":"2168_CR9","doi-asserted-by":"publisher","first-page":"109858","DOI":"10.1016\/j.cellsig.2020.109858","volume":"78","author":"P Samji","year":"2021","unstructured":"Samji P, Rajendran MK, Warrier VP, Ganesh A, Devarajan K. Regulation of Hippo signaling pathway in cancer: A MicroRNA perspective. Cell Signal. 2021;78:109858.","journal-title":"Cell Signal"},{"key":"2168_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-017-0037-4","volume":"8","author":"E Terpos","year":"2018","unstructured":"Terpos E, Ntanasis-Stathopoulos I, Gavriatopoulou M, Dimopoulos MA. Pathogenesis of bone disease in multiple myeloma: from bench to bedside. Blood Cancer J. 2018;8:7.","journal-title":"Blood Cancer J"},{"key":"2168_CR11","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1242\/dev.102376","volume":"141","author":"X Varelas","year":"2014","unstructured":"Varelas X. The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease. Development. 2014;141:1614\u201326.","journal-title":"Development"},{"key":"2168_CR12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.clml.2019.09.620","volume":"20","author":"A Kyriazoglou","year":"2020","unstructured":"Kyriazoglou A, Ntanasis-Stathopoulos I, Terpos E, Fotiou D, Kastritis E, Dimopoulos MA, et al. Emerging insights into the role of the hippo pathway in multiple myeloma and associated bone disease. Clin Lymphoma Myeloma Leuk. 2020;20:57\u201362.","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"2168_CR13","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ccr.2008.01.007","volume":"13","author":"M Chesi","year":"2008","unstructured":"Chesi M, Robbiani DF, Sebag M, Chng WJ, Affer M, Tiedemann R, et al. AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies. Cancer Cell. 2008;13:167\u201380.","journal-title":"Cancer Cell"},{"key":"2168_CR14","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1038\/leu.2010.173","volume":"24","author":"E Terpos","year":"2010","unstructured":"Terpos E, Dimopoulos MA, Sezer O, Roodman D, Abildgaard N, Vescio R, et al. The use of biochemical markers of bone remodeling in multiple myeloma: a report of the International Myeloma Working Group. Leukemia. 2010;24:1700\u201312.","journal-title":"Leukemia"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41375-024-02168-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-024-02168-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-024-02168-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T11:03:26Z","timestamp":1712315006000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41375-024-02168-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,17]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["2168"],"URL":"https:\/\/doi.org\/10.1038\/s41375-024-02168-z","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3062984\/v1","asserted-by":"object"}]},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,17]]},"assertion":[{"value":"14 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}