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This research has been reviewed by the Mayo Clinic Conflict of Interest Review Board and was conducted in compliance with Mayo Clinic conflict of interest policies.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All methods described in this manuscript were performed in accordance with the relevant guidelines and regulations. The human study protocols reported in this manuscript were conducted in accordance with the Declaration of Helsinki. Patients who donated bone marrow aspiration samples and peripheral plasma provided written informed consent in accordance with the biobanking study protocol, which was approved by the Mayo Clinic Institutional Review Board under the number 521-93. Analyses of these samples was approved by the Mayo Clinic Institutional Review Board under the number 20-002263. Trephine iliac crest bone biopsies from MGUS, SMM, and NDMM patients were obtained from Danish pathological biobanks under approval from the Danish National Committee on Biomedical Research Ethics (S-20190110) and in compliance with the Declaration of Helsinki. All patients provided written informed consent. Bone biopsies from healthy individuals were included from a previous study approved by the Danish National Committee on Biomedical Research Ethics under protocol number 1-10-72-223-20, with informed consent obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}