{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:28:43Z","timestamp":1793507323860,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1038\/s41375-025-02603-9","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T10:57:34Z","timestamp":1744714654000},"page":"1425-1434","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Molecular landscape of distinct follicular lymphoma histologic grades: insights from genomic and transcriptome analyses"],"prefix":"10.1038","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9373-8175","authenticated-orcid":false,"given":"Cong","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchen","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzi","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weicheng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Pan-Hammarstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7663-2923","authenticated-orcid":false,"given":"Xianhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0091-0026","authenticated-orcid":false,"given":"Huilai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"2603_CR1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3322\/caac.21357","volume":"66","author":"LR Teras","year":"2016","unstructured":"Teras LR, DeSantis CE, Cerhan JR, Morton LM, Jemal A, Flowers CR. 2016 us lymphoid malignancy statistics by world health organization subtypes. Ca Cancer J Clin. 2016;66:443\u201359.","journal-title":"Ca Cancer J Clin"},{"key":"2603_CR2","unstructured":"Swerdlow S, Campo E, Harris N, Jaffe E, Pileri S, Stein H, et al. WHO classification of tumours of haematopoietic and lymphoid tissues, 4th ed. Lyon: International Agency for Research on Cancer, 2017."},{"key":"2603_CR3","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.3324\/haematol.12754","volume":"93","author":"PP Piccaluga","year":"2008","unstructured":"Piccaluga PP, Califano A, Klein U, Agostinelli C, Bellosillo B, Gimeno E, et al. Gene expression analysis provides a potential rationale for revising the histological grading of follicular lymphomas. Haematologica. 2008;93:1033\u20138.","journal-title":"Haematologica"},{"key":"2603_CR4","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.3324\/haematol.2017.181024","volume":"103","author":"H Horn","year":"2018","unstructured":"Horn H, Kohler C, Witzig R, Kreuz M, Leich E, Klapper W, et al. Gene expression profiling reveals a close relationship between follicular lymphoma grade 3a and 3b, but distinct profiles of follicular lymphoma grade 1 and 2. Haematologica. 2018;103:1182\u201390.","journal-title":"Haematologica"},{"key":"2603_CR5","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","volume":"36","author":"R Alaggio","year":"2022","unstructured":"Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBDO, Berti E, et al. The 5th edition of the world health organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia. 2022;36:1720\u201348.","journal-title":"Leukemia"},{"key":"2603_CR6","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1182\/blood.2022015851","volume":"140","author":"E Campo","year":"2022","unstructured":"Campo E, Jaffe ES, Cook JR, Quintanilla-Martinez L, Swerdlow SH, Anderson KC, et al. The international consensus classification of mature lymphoid neoplasms: a report from the clinical advisory committee. Blood. 2022;140:1229\u201353.","journal-title":"Blood"},{"key":"2603_CR7","unstructured":"WHO Classification of Tumours Editorial Board. Haematolymphoid tumours. Lyon (France): International Agency for Research on Cancer; 2024. (WHO classification of tumours series, 5th ed.; vol. 11)."},{"key":"2603_CR8","first-page":"83","volume":"102","author":"E Sabattini","year":"2010","unstructured":"Sabattini E, Bacci F, Sagramoso C, Pileri SA. Who classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview. Pathologica. 2010;102:83\u201387.","journal-title":"Pathologica"},{"key":"2603_CR9","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1200\/JCO.1999.17.4.1244","volume":"17","author":"BD Cheson","year":"1999","unstructured":"Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM, et al. Report of an international workshop to standardize response criteria for non-Hodgkin\u2019s lymphomas. NCI sponsored an International working group. J Clin Oncol. 1999;17:1244.","journal-title":"J Clin Oncol"},{"key":"2603_CR10","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","volume":"127","author":"SH Swerdlow","year":"2016","unstructured":"Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al. The 2016 revision of the world health organization classification of lymphoid neoplasms. Blood. 2016;127:2375\u201390.","journal-title":"Blood"},{"key":"2603_CR11","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41572-019-0132-x","volume":"5","author":"A Carbone","year":"2019","unstructured":"Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, Lopez-Guillermo A, et al. Follicular lymphoma. Nat Rev Dis Prim. 2019;5:83.","journal-title":"Nat Rev Dis Prim"},{"key":"2603_CR12","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.7150\/ijbs.80401","volume":"19","author":"T Xu","year":"2023","unstructured":"Xu T, Zheng Z, Zhao W. Advances in the multi-omics landscape of follicular lymphoma. Int J Biol Sci. 2023;19:1955\u201367.","journal-title":"Int J Biol Sci"},{"key":"2603_CR13","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.cell.2016.08.032","volume":"167","author":"M Boice","year":"2016","unstructured":"Boice M, Salloum D, Mourcin F, Sanghvi V, Amin R, Oricchio E, et al. Loss of the hvem tumor suppressor in lymphoma and restoration by modified car-t cells. Cell. 2016;167:405\u201318.","journal-title":"Cell"},{"key":"2603_CR14","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/modpathol.2016.51","volume":"29","author":"IN Siddiqi","year":"2016","unstructured":"Siddiqi IN, Friedman J, Barry-Holson KQ, Ma C, Thodima V, Kang I, et al. Characterization of a variant of t(14;18) negative nodal diffuse follicular lymphoma with cd23 expression, 1p36\/tnfrsf14 abnormalities, and stat6 mutations. Mod Pathol. 2016;29:570\u201381.","journal-title":"Mod Pathol"},{"key":"2603_CR15","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1182\/blood-2013-05-500595","volume":"123","author":"A Bouska","year":"2014","unstructured":"Bouska A, McKeithan TW, Deffenbacher KE, Lachel C, Wright GW, Iqbal J, et al. Genome-wide copy-number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma. Blood. 2014;123:1681\u201390.","journal-title":"Blood"},{"key":"2603_CR16","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.celrep.2013.12.027","volume":"6","author":"L Pasqualucci","year":"2014","unstructured":"Pasqualucci L, Khiabanian H, Fangazio M, Vasishtha M, Messina M, Holmes AB, et al. Genetics of follicular lymphoma transformation. Cell Rep. 2014;6:130\u201340.","journal-title":"Cell Rep."},{"key":"2603_CR17","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3906\/biy-1810-2","volume":"43","author":"D Kursun","year":"2019","unstructured":"Kursun D, Kucuk C. Systematic analysis of the frequently amplified 2p15-p16.1 locus reveals papolg as a potential proto-oncogene in follicular and transformed follicular lymphoma. Turk J Biol. 2019;43:124\u201332.","journal-title":"Turk J Biol"},{"key":"2603_CR18","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.immuni.2017.11.021","volume":"47","author":"K Man","year":"2017","unstructured":"Man K, Gabriel SS, Liao Y, Gloury R, Preston S, Henstridge DC, et al. Transcription factor irf4 promotes cd8(+) t cell exhaustion and limits the development of memory-like t cells during chronic infection. Immunity. 2017;47:1129\u201341.","journal-title":"Immunity"},{"key":"2603_CR19","doi-asserted-by":"publisher","first-page":"863","DOI":"10.5858\/2004-128-863-ACEOFL","volume":"128","author":"ED Hsi","year":"2004","unstructured":"Hsi ED, Mirza I, Lozanski G, Hill J, Pohlman B, Karafa MT, et al. A clinicopathologic evaluation of follicular lymphoma grade 3a versus grade 3b reveals no survival differences. Arch Pathol Lab Med. 2004;128:863\u20138.","journal-title":"Arch Pathol Lab Med"},{"key":"2603_CR20","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1093\/annonc\/mdq574","volume":"22","author":"J Shustik","year":"2011","unstructured":"Shustik J, Quinn M, Connors JM, Gascoyne RD, Skinnider B, Sehn LH. Follicular non-Hodgkin lymphoma grades 3a and 3b have a similar outcome and appear incurable with anthracycline-based therapy. Ann Oncol. 2011;22:1164\u20139.","journal-title":"Ann Oncol"},{"key":"2603_CR21","first-page":"2444","volume":"108","author":"A Barraclough","year":"2023","unstructured":"Barraclough A, England JT, Villa D, Wight J, Hapgood G, Conn J, et al. Outcomes in grade 3b follicular lymphoma: an international study led by the Australasian Lymphoma Alliance. Haematologica. 2023;108:2444\u201353.","journal-title":"Haematologica"},{"key":"2603_CR22","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1093\/annonc\/mdw185","volume":"27","author":"K Koch","year":"2016","unstructured":"Koch K, Hoster E, Ziepert M, Unterhalt M, Ott G, Rosenwald A, et al. Clinical, pathological and genetic features of follicular lymphoma grade 3a: a joint analysis of the german low-grade and high-grade lymphoma study groups GLSG and DSHNHL. Ann Oncol. 2016;27:1323\u20139.","journal-title":"Ann Oncol"},{"key":"2603_CR23","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1365-2141.2011.08942.x","volume":"156","author":"BE Wahlin","year":"2012","unstructured":"Wahlin BE, Yri OE, Kimby E, Holte H, Delabie J, Smeland EB, et al. Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times. Br J Haematol. 2012;156:225\u201333.","journal-title":"Br J Haematol"},{"key":"2603_CR24","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1093\/annonc\/mdx407","volume":"28","author":"L Magnano","year":"2017","unstructured":"Magnano L, Balagu\u00e9 O, Dlouhy I, Rovira J, Karube K, Pinyol M, et al. Clinicobiological features and prognostic impact of diffuse large B-cell lymphoma component in the outcome of patients with previously untreated follicular lymphoma. Annals Oncol. 2017;28:2799\u2013805.","journal-title":"Annals Oncol"},{"key":"2603_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-023-00462-z","volume":"11","author":"J Zha","year":"2023","unstructured":"Zha J, Chen Q, Ye J, Yu H, Yi S, Zheng Z, et al. Differences in clinical characteristics and outcomes between patients with grade 3a and grades 1-2 follicular lymphoma: a real-world multicenter study. Biomark Res. 2023;11:16.","journal-title":"Biomark Res"},{"key":"2603_CR26","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1111\/bjh.18404","volume":"199","author":"A Naik","year":"2022","unstructured":"Naik A, Gooley T, Loeb K, Soma L, Smith SD, Gopal A, et al. The impact of histological grade on outcomes in follicular lymphoma: an analysis of patients in the seer database in the context of evolving disease classification and treatment. Br J Haematol. 2022;199:696\u2013706.","journal-title":"Br J Haematol"},{"key":"2603_CR27","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.3324\/haematol.2021.279351","volume":"107","author":"K Koch","year":"2022","unstructured":"Koch K, Richter J, Hanel C, Huttmann A, Duhrsen U, Klapper W. Follicular lymphoma grade 3b and diffuse large b-cell lymphoma present a histopathological and molecular continuum lacking features of progression\/transformation. Haematologica. 2022;107:2144\u201353.","journal-title":"Haematologica"},{"key":"2603_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01124-5","volume":"14","author":"B Bai","year":"2024","unstructured":"Bai B, Wise JF, Vodak D, Nakken S, Sharma A, Blaker YN, et al. Multi-omics profiling of longitudinal samples reveals early genomic changes in follicular lymphoma. Blood Cancer J. 2024;14:147.","journal-title":"Blood Cancer J"},{"key":"2603_CR29","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1038\/nm.3940","volume":"21","author":"J Zhang","year":"2015","unstructured":"Zhang J, Dominguez-Sola D, Hussein S, Lee JE, Holmes AB, Bansal M, et al. Disruption of kmt2d perturbs germinal center b cell development and promotes lymphomagenesis. Nat Med. 2015;21:1190\u20138.","journal-title":"Nat Med"},{"key":"2603_CR30","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1158\/2159-8290.CD-23-0111","volume":"13","author":"JG Schroers-Martin","year":"2023","unstructured":"Schroers-Martin JG, Soo J, Brisou G, Scherer F, Kurtz DM, Sworder BJ, et al. Tracing founder mutations in circulating and tissue-resident follicular lymphoma precursors. Cancer Discov. 2023;13:1310\u201323.","journal-title":"Cancer Discov"},{"key":"2603_CR31","doi-asserted-by":"publisher","first-page":"4777","DOI":"10.1158\/1078-0432.CCR-07-0456","volume":"13","author":"CW Ross","year":"2007","unstructured":"Ross CW, Ouillette PD, Saddler CM, Shedden KA, Malek SN. Comprehensive analysis of copy number and allele status identifies multiple chromosome defects underlying follicular lymphoma pathogenesis. Clin Cancer Res. 2007;13:4777\u201385.","journal-title":"Clin Cancer Res"},{"key":"2603_CR32","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1182\/blood-2018-07-865428","volume":"133","author":"X Qu","year":"2019","unstructured":"Qu X, Li H, Braziel RM, Passerini V, Rimsza LM, Hsi ED, et al. Genomic alterations important for the prognosis in patients with follicular lymphoma treated in swog study s0016. Blood. 2019;133:81\u201393.","journal-title":"Blood"},{"key":"2603_CR33","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1097\/PAS.0000000000001726","volume":"45","author":"C Laurent","year":"2021","unstructured":"Laurent C, Adelaide J, Guille A, Tesson B, Gat E, Evrard S, et al. High-grade follicular lymphomas exhibit clinicopathologic, cytogenetic, and molecular diversity extending beyond grades 3a and 3b. Am J Surg Pathol. 2021;45:1324\u201336.","journal-title":"Am J Surg Pathol"},{"key":"2603_CR34","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1182\/blood-2008-02-140616","volume":"113","author":"KJ Cheung","year":"2009","unstructured":"Cheung KJ, Shah SP, Steidl C, Johnson N, Relander T, Telenius A, et al. Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances. Blood. 2009;113:137\u201348.","journal-title":"Blood"},{"key":"2603_CR35","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1182\/blood-2008-08-174953","volume":"113","author":"D O\u2019Shea","year":"2009","unstructured":"O\u2019Shea D, O\u2019Riain C, Gupta M, Waters R, Yang Y, Wrench D, et al. Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation. Blood. 2009;113:2298\u2013301.","journal-title":"Blood"},{"key":"2603_CR36","doi-asserted-by":"publisher","first-page":"9166","DOI":"10.1158\/0008-5472.CAN-10-2460","volume":"70","author":"KJ Cheung","year":"2010","unstructured":"Cheung KJ, Johnson NA, Affleck JG, Severson T, Steidl C, Ben-Neriah S, et al. Acquired tnfrsf14 mutations in follicular lymphoma are associated with worse prognosis. Cancer Res. 2010;70:9166\u201374.","journal-title":"Cancer Res"},{"key":"2603_CR37","doi-asserted-by":"crossref","unstructured":"Dobano-Lopez C, Araujo-Ayala F, Serrat N, Valero JG, Perez-Galan P. Follicular lymphoma microenvironment: an intricate network ready for therapeutic intervention. Cancers 2021;13.","DOI":"10.3390\/cancers13040641"},{"key":"2603_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101443","volume":"5","author":"JE Krull","year":"2024","unstructured":"Krull JE, Wenzl K, Hopper MA, Manske MK, Sarangi V, Maurer MJ, et al. Follicular lymphoma b cells exhibit heterogeneous transcriptional states with associated somatic alterations and tumor microenvironments. Cell Rep. Med. 2024;5:101443.","journal-title":"Cell Rep. Med"},{"key":"2603_CR39","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/ijc.20354","volume":"112","author":"G Pruneri","year":"2004","unstructured":"Pruneri G, Valentini S, Fabris S, Del CB, Laszlo D, Bertolini F, et al. Cyclin d3 immunoreactivity in follicular lymphoma is independent of the t(6;14)(p21.1;q32.3) translocation or cyclin d3 gene amplification and is correlated with histologic grade and ki-67 labeling index. Int J Cancer. 2004;112:71\u201377.","journal-title":"Int J Cancer"},{"key":"2603_CR40","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1182\/blood-2004-06-2298","volume":"105","author":"AM Glas","year":"2005","unstructured":"Glas AM. Gene expression profiling in follicular lymphoma to assess clinical aggressiveness and to guide the choice of treatment. Blood. 2005;105:301\u20137.","journal-title":"Blood"},{"key":"2603_CR41","doi-asserted-by":"publisher","first-page":"205","DOI":"10.5144\/0256-4947.2006.205","volume":"26","author":"WA Mourad","year":"2006","unstructured":"Mourad WA, Rawas F, Shoukri M, Tbakhi A, Al OM, Tulbah A, et al. Grading of follicular lymphoma using flow cytometry. Ann Saudi Med. 2006;26:205\u201310.","journal-title":"Ann Saudi Med"},{"key":"2603_CR42","doi-asserted-by":"crossref","unstructured":"Fauzi MF, Pennell M, Sahiner B, Chen W, Shana\u2019Ah A, Hemminger J, et al. Classification of follicular lymphoma: the effect of computer aid on pathologists grading. BMC Med Inf Decis Mak. 2015;15:115.","DOI":"10.1186\/s12911-015-0235-6"},{"key":"2603_CR43","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1182\/blood.2024024496","volume":"144","author":"C Laurent","year":"2024","unstructured":"Laurent C, Trisal P, Tesson B, Seth S, Beyou A, Roulland S, et al. Follicular lymphoma comprises germinal center-like and memory-like molecular subtypes with prognostic significance. Blood. 2024;144:2503\u201316.","journal-title":"Blood"},{"key":"2603_CR44","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1182\/blood.2022018719","volume":"142","author":"K Dreval","year":"2023","unstructured":"Dreval K, Hilton LK, Cruz M, Shaalan H, Ben-Neriah S, Boyle M, et al. Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns. Blood. 2023;142:561\u201373.","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41375-025-02603-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-025-02603-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-025-02603-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T11:04:51Z","timestamp":1748948691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41375-025-02603-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["2603"],"URL":"https:\/\/doi.org\/10.1038\/s41375-025-02603-9","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,15]]},"assertion":[{"value":"3 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and approved by the institutional review board of the Tianjin Medical University Cancer Institute and Hospital. Informed consent was obtained from all patients.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}