{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:47:45Z","timestamp":1792259265555,"version":"4.4.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["13R\/2019"],"award-info":[{"award-number":["13R\/2019"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We performed a questionnaire-based cross-sectional study to analyze Acute Myeloid Leukemia (AML) long-term survivor (LTS) outcomes, including psychosocial well-being and somatic health status. Four-hundred-twenty-seven former AML patients participated (response rate, 63%) \u22655 years[y] and up to 18.6\u2009y past their leukemia diagnosis (median, 11.3\u2009y). Median age at study participation was 61\u2009y (range 28y\u201393y), 23% had experienced disease relapse, and 63% had received allogeneic hematopoietic stem cell transplantation (alloHSCT). Overall, quality of life (QoL) and general life satisfaction (gLS) summary scores were higher in AML LTS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) compared to age-\/sex-matched reference cohorts, although differences were small and likely not clinically relevant. However, we identified subgroups of survivors reporting impaired QoL (27%), gLS (13%) and health-related life satisfaction (hrLS; 17%). Using multivariable regression models, we identified predisposing and protective factors for each of these outcomes. Treatment with alloHSCT did not adversely impact QoL, gLS, or hrLS. In summary, global QoL and LS in AML LTS are comparable to the general population, irrespective of treatment modality, although some survivors report clinically significant impairment of global QoL and\/or in specific domains. We identified factors associated with impaired outcomes (e.g., comorbidity and fatigue), delineating a subgroup of survivors with unmet needs \u22655\u2009y after their AML diagnosis.\n                  <\/jats:p>","DOI":"10.1038\/s41375-025-02735-y","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T10:22:09Z","timestamp":1755858129000},"page":"2663-2672","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quality of life and life satisfaction in long-term survivors of acute myeloid leukemia"],"prefix":"10.1038","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2060-7730","authenticated-orcid":false,"given":"Eva","family":"Telzerow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-9419","authenticated-orcid":false,"given":"Dennis","family":"G\u00f6rlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8748-8218","authenticated-orcid":false,"given":"Cristina","family":"Sauerland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Rothenberg-Thurley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Sophia","family":"Moret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8514-5500","authenticated-orcid":false,"given":"Simon M.","family":"Krau\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike H. A.","family":"Mumm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Amler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3030-6567","authenticated-orcid":false,"given":"Wolfgang E.","family":"Berdel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2273-5502","authenticated-orcid":false,"given":"Bernhard J.","family":"W\u00f6rmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utz","family":"Krug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6528-2078","authenticated-orcid":false,"given":"Jan","family":"Braess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Heu\u00dfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hiddemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5139-4957","authenticated-orcid":false,"given":"Karsten","family":"Spiekermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3920-7490","authenticated-orcid":false,"given":"Klaus H.","family":"Metzeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"2735_CR1","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1080\/07357900600896323","volume":"25","author":"GT Deimling","year":"2007","unstructured":"Deimling GT, Bowman KF, Wagner LJ. Cancer survivorship and identity among long-term survivors. Cancer Invest. 2007;25:758\u201365.","journal-title":"Cancer Invest"},{"key":"2735_CR2","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3324\/haematol.12304","volume":"93","author":"D Pulte","year":"2008","unstructured":"Pulte D, Gondos A, Brenner H. Improvements in survival of adults diagnosed with acute myeloblastic leukemia in the early 21st century. Haematologica. 2008;93:594\u2013600.","journal-title":"Haematologica"},{"key":"2735_CR3","doi-asserted-by":"publisher","first-page":"3666","DOI":"10.1182\/blood-2008-09-179341","volume":"113","author":"AR Derolf","year":"2009","unstructured":"Derolf AR, Kristinsson SY, Andersson TM, Landgren O, Dickman PW, Bj\u00f6rkholm M. Improved patient survival for acute myeloid leukemia: a population-based study of 9729 patients diagnosed in Sweden between 1973 and 2005. Blood. 2009;113:3666\u201372.","journal-title":"Blood"},{"key":"2735_CR4","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/bjh.12425","volume":"162","author":"A Shah","year":"2013","unstructured":"Shah A, Andersson TM, Rachet B, Bj\u00f6rkholm M, Lambert PC. Survival and cure of acute myeloid leukaemia in England, 1971-2006: a population-based study. Br J Haematol. 2013;162:509\u201316.","journal-title":"Br J Haematol"},{"key":"2735_CR5","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1111\/j.1365-2141.2012.09213.x","volume":"158","author":"RK Hills","year":"2012","unstructured":"Hills RK. The contribution of randomized trials to the cure of haematological disorders from Bradford Hill onwards. Br J Haematol. 2012;158:691\u20139.","journal-title":"Br J Haematol"},{"key":"2735_CR6","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1002\/pon.5652","volume":"30","author":"DR Richardson","year":"2021","unstructured":"Richardson DR, Oakes AH, Crossnohere NL, Rathsmill G, Reinhart C, O\u2019Donoghue B, et al. Prioritizing the worries of AML patients: Quantifying patient experience using best-worst scaling. Psychooncology. 2021;30:1104\u201311.","journal-title":"Psychooncology"},{"key":"2735_CR7","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1007\/s00277-019-03760-5","volume":"98","author":"KJ Suh","year":"2019","unstructured":"Suh KJ, Shin D-Y, Kim I, Yoon S-S, Lee J-O, Bang S-M, et al. Comparison of quality of life and health behaviors in survivors of acute leukemia and the general population. Ann Hematol. 2019;98:2357\u201366.","journal-title":"Ann Hematol"},{"key":"2735_CR8","doi-asserted-by":"publisher","first-page":"826","DOI":"10.3324\/haematol.11987","volume":"93","author":"D Messerer","year":"2008","unstructured":"Messerer D, Engel J, Hasford J, Schaich M, Ehninger G, Sauerland C, et al. Impact of different post-remission strategies on quality of life in patients with acute myeloid leukemia. Haematologica. 2008;93:826\u201333.","journal-title":"Haematologica"},{"key":"2735_CR9","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s11899-022-00680-6","volume":"17","author":"G Granroth","year":"2022","unstructured":"Granroth G, Khera N, Arana Yi C. Progress and Challenges in Survivorship After Acute Myeloid Leukemia in Adults. Curr Hematol Malig Rep. 2022;17:243\u201353.","journal-title":"Curr Hematol Malig Rep"},{"key":"2735_CR10","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1038\/leu.2010.210","volume":"24","author":"KS Baker","year":"2010","unstructured":"Baker KS, Ness KK, Weisdorf D, Francisco L, Sun CL, Forman S, et al. Late effects in survivors of acute leukemia treated with hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study. Leukemia. 2010;24:2039\u201347.","journal-title":"Leukemia"},{"key":"2735_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-015-0222-8","volume":"13","author":"S Amler","year":"2015","unstructured":"Amler S, Sauerland MC, Deiters C, B\u00fcchner T, Schumacher A. Factors influencing life satisfaction in acute myeloid leukemia survivors following allogeneic stem cell transplantation: a cross-sectional study. Health Qual Life Outcomes. 2015;13:28.","journal-title":"Health Qual Life Outcomes"},{"key":"2735_CR12","first-page":"4993","volume":"24","author":"KH Chang","year":"2016","unstructured":"Chang KH, Hwang WL, Muo CH, Hsu CY, Teng CJ. Outcome and late effects among acute myeloid leukemia survivors: a nationwide population-based study. Support Care Cancer. 2016;24:4993\u20135000.","journal-title":"Support Care Cancer"},{"key":"2735_CR13","doi-asserted-by":"crossref","unstructured":"Cheng MJ, Hourigan CS, Smith TJ. Adult Acute Myeloid Leukemia Long-term Survivors. J Leuk (Los Angel). 2014;2:26855.","DOI":"10.4172\/2329-6917.1000135"},{"key":"2735_CR14","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1038\/leu.2016.25","volume":"30","author":"U Krug","year":"2016","unstructured":"Krug U, Berdel WE, Gale RP, Haferlach C, Schnittger S, M\u00fcller-Tidow C, et al. Increasing intensity of therapies assigned at diagnosis does not improve survival of adults with acute myeloid leukemia. Leukemia. 2016;30:1230\u20136.","journal-title":"Leukemia"},{"key":"2735_CR15","doi-asserted-by":"publisher","first-page":"3903","DOI":"10.1182\/blood-2008-07-162842","volume":"113","author":"J Braess","year":"2009","unstructured":"Braess J, Spiekermann K, Staib P, Gr\u00fcneisen A, W\u00f6rmann B, Ludwig WD, et al. Dose-dense induction with sequential high-dose cytarabine and mitoxantone (S-HAM) and pegfilgrastim results in a high efficacy and a short duration of critical neutropenia in de novo acute myeloid leukemia: a pilot study of the AMLCG. Blood. 2009;113:3903\u201310.","journal-title":"Blood"},{"key":"2735_CR16","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1038\/s41375-018-0268-9","volume":"32","author":"J Braess","year":"2018","unstructured":"Braess J, Amler S, Kreuzer K-A, Spiekermann K, Lindemann HW, Lengfelder E, et al. Sequential high-dose cytarabine and mitoxantrone (S-HAM) versus standard double induction in acute myeloid leukemia\u2014a phase 3 study. Leukemia. 2018;32:2558\u201371.","journal-title":"Leukemia"},{"key":"2735_CR17","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1200\/JCO.1993.11.3.570","volume":"11","author":"DF Cella","year":"1993","unstructured":"Cella DF, Tulsky DS, Gray G, Sarafian B, Linn E, Bonomi A, et al. The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. J Clin Oncol. 1993;11:570\u20139.","journal-title":"J Clin Oncol"},{"key":"2735_CR18","first-page":"S125","volume":"38","author":"P Fayers","year":"2002","unstructured":"Fayers P, Bottomley A. Quality of life research within the EORTC-the EORTC QLQ-C30. Eur Organ Res Treat Cancer Eur J Cancer. 2002;38:S125\u201333.","journal-title":"Eur Organ Res Treat Cancer Eur J Cancer"},{"key":"2735_CR19","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1027\/\/1015-5759.16.3.150","volume":"16","author":"G Henrich","year":"2000","unstructured":"Henrich G, Herschbach P. Questions on Life Satisfaction (FLZM) - A Short Questionnaire for Assessing Subjective Quality of Life. Eur J Psychological Assess. 2000;16:150\u20139.","journal-title":"Eur J Psychological Assess"},{"key":"2735_CR20","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","volume":"67","author":"AS Zigmond","year":"1983","unstructured":"Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67:361\u201370.","journal-title":"Acta Psychiatr Scand"},{"key":"2735_CR21","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/0022-3999(94)00125-O","volume":"39","author":"EM Smets","year":"1995","unstructured":"Smets EM, Garssen B, Bonke B, De Haes JC. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res. 1995;39:315\u201325.","journal-title":"J Psychosom Res"},{"key":"2735_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s40359-018-0249-9","volume":"6","author":"RD Kocalevent","year":"2018","unstructured":"Kocalevent RD, Berg L, Beutel ME, Hinz A, Zenger M, H\u00e4rter M, et al. Social support in the general population: standardization of the Oslo social support scale (OSSS-3). BMC Psychol. 2018;6:31.","journal-title":"BMC Psychol"},{"key":"2735_CR23","unstructured":"(Hrsg) RK-I. Daten und Fakten: Ergebnisse der Studie \u00bbGesundheit in Deutschland aktuell 2012\u00ab. Beitr\u00e4ge zur Gesundheitsberichterstattung des Bundes, RKI, Berlin. 2014."},{"key":"2735_CR24","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.jclinepi.2004.10.018","volume":"58","author":"DL Groll","year":"2005","unstructured":"Groll DL, To T, Bombardier C, Wright JG. The development of a comorbidity index with physical function as the outcome. J Clin Epidemiol. 2005;58:595\u2013602.","journal-title":"J Clin Epidemiol"},{"key":"2735_CR25","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/02841860310023453","volume":"43","author":"B Holzner","year":"2004","unstructured":"Holzner B, Kemmler G, Cella D, De Paoli C, Meraner V, Kopp M, et al. Normative data for functional assessment of cancer therapy-general scale and its use for the interpretation of quality of life scores in cancer survivors. Acta Oncol. 2004;43:153\u201360.","journal-title":"Acta Oncol"},{"key":"2735_CR26","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1026\/1616-3443\/a000099","volume":"40","author":"I Daig","year":"2011","unstructured":"Daig I, Spangenberg L, Henrich G, Herschbach P, Kienast T, Br\u00e4hler E. Alters- und geschlechtspezifische Neunormierung der Fragen zur Lebenszufriedenheit (FLZM) f\u00fcr die Altersspanne von 14 bis 64 Jahre. [Age and gender specific new normative data for the Questions on Life Satisfaction Questionnaire for 14\u201364 years olds.]. Z f\u00fcr Klinische Psychologie und Psychotherapie: Forsch und Prax. 2011;40:172\u20138.","journal-title":"Z f\u00fcr Klinische Psychologie und Psychotherapie: Forsch und Prax"},{"key":"2735_CR27","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41375-018-0162-5","volume":"33","author":"N Timilshina","year":"2019","unstructured":"Timilshina N, Breunis H, Tomlinson GA, Brandwein JM, Buckstein R, Durbano S, et al. Long-term recovery of quality of life and physical function over three years in adult survivors of acute myeloid leukemia after intensive chemotherapy. Leukemia. 2019;33:15\u201325.","journal-title":"Leukemia"},{"key":"2735_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-50289-9","volume":"13","author":"J Baum","year":"2023","unstructured":"Baum J, Lax H, Lehmann N, Merkel-Jens A, Beelen DW, J\u00f6ckel KH, et al. Impairment of vocational activities and financial problems are frequent among German blood cancer survivors. Sci Rep. 2023;13:22856.","journal-title":"Sci Rep"},{"key":"2735_CR29","doi-asserted-by":"crossref","unstructured":"Korszun A, Sarker S-J, Chowdhury K, Clark C, Greaves P, Johnson R, et al. Psychosocial factors associated with impact of cancer in longterm haematological cancer survivors. British Journal of Haematology. 2014;164.","DOI":"10.1111\/bjh.12698"},{"key":"2735_CR30","doi-asserted-by":"publisher","first-page":"18354","DOI":"10.1002\/cam4.6435","volume":"12","author":"V Osmani","year":"2023","unstructured":"Osmani V, H\u00f6rner L, Klug SJ, Tanaka LF. Prevalence and risk of psychological distress, anxiety and depression in adolescent and young adult (AYA) cancer survivors: A systematic review and meta-analysis. Cancer Med. 2023;12:18354\u201367.","journal-title":"Cancer Med"},{"key":"2735_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-11-46","volume":"11","author":"J Dunn","year":"2013","unstructured":"Dunn J, Ng SK, Breitbart W, Aitken J, Youl P, Baade PD, et al. Health-related quality of life and life satisfaction in colorectal cancer survivors: trajectories of adjustment. Health Qual Life Outcomes. 2013;11:46.","journal-title":"Health Qual Life Outcomes"},{"key":"2735_CR32","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.1007\/s11136-021-02846-w","volume":"30","author":"A Vanier","year":"2021","unstructured":"Vanier A, Oort FJ, McClimans L, Ow N, Gulek BG, B\u00f6hnke JR, et al. Response shift in patient-reported outcomes: definition, theory, and a revised model. Qual Life Res. 2021;30:3309\u201322.","journal-title":"Qual Life Res"},{"key":"2735_CR33","doi-asserted-by":"publisher","first-page":"3278","DOI":"10.1200\/JCO.21.02829","volume":"40","author":"SH Armenian","year":"2022","unstructured":"Armenian SH, Chen Y, Hageman L, Wu J, Landier W, Bosworth A, et al. Burden of long-term morbidity borne by survivors of acute myeloid leukemia treated with blood or marrow transplantation: the results of the BMT survivor study. J Clin Oncol. 2022;40:3278\u201388.","journal-title":"J Clin Oncol"},{"key":"2735_CR34","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1158\/1055-9965.EPI-21-1388","volume":"31","author":"AM Berkman","year":"2022","unstructured":"Berkman AM, Andersen CR, Cuglievan B, McCall DC, Lupo PJ, Parsons SK, et al. Long-term outcomes among adolescent and young adult survivors of acute leukemia: a surveillance, epidemiology, and end results analysis. Cancer Epidemiol Biomark Prev. 2022;31:1176\u201384.","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"2735_CR35","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1097\/COC.0000000000000665","volume":"43","author":"AD Parekh","year":"2020","unstructured":"Parekh AD, Bates JE, Amdur RJ. Response Rate and Nonresponse Bias in Oncology Survey Studies. Am J Clin Oncol. 2020;43:229\u201330.","journal-title":"Am J Clin Oncol"},{"key":"2735_CR36","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/insr.12100","volume":"84","author":"R Nishimura","year":"2016","unstructured":"Nishimura R, Wagner J, Elliott MR. Alternative indicators for the risk of non-response bias: a simulation study. Int Stat Rev. 2016;84:43\u201362.","journal-title":"Int Stat Rev"},{"key":"2735_CR37","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1182\/blood.2022016867","volume":"140","author":"H Dohner","year":"2022","unstructured":"Dohner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, et al. Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood. 2022;140:1345\u201377.","journal-title":"Blood"},{"key":"2735_CR38","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1002\/ijc.34152","volume":"151","author":"ME Schmidt","year":"2022","unstructured":"Schmidt ME, Goldschmidt S, Hermann S, Steindorf K. Late effects, long-term problems and unmet needs of cancer survivors. Int J Cancer. 2022;151:1280\u201390.","journal-title":"Int J Cancer"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41375-025-02735-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-025-02735-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-025-02735-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:34:53Z","timestamp":1762331693000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41375-025-02735-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["2735"],"URL":"https:\/\/doi.org\/10.1038\/s41375-025-02735-y","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,22]]},"assertion":[{"value":"24 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was approved by the ethics committee at LMU Munich (no. 17-444). All participants provided written informed consent. This study has been registered in the German Clinical Trials Registry (DRKS00023991).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}