{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:18:28Z","timestamp":1792592308646,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2023R1A2C1003952"],"award-info":[{"award-number":["2023R1A2C1003952"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2024-00437643"],"award-info":[{"award-number":["RS-2024-00437643"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1038\/s41375-025-02768-3","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T05:56:50Z","timestamp":1759298210000},"page":"2935-2945","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Regulation of metabolic adaptation and leukemia progression by MUSASHI2-DEPTOR-KIF11 axis"],"prefix":"10.1038","volume":"39","author":[{"given":"Tania","family":"Setiawan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jabir Aliyu","family":"Muhammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadya","family":"Marcelina Julianto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence Mario","family":"Wirawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoung","family":"Jun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-7992","authenticated-orcid":false,"given":"Ita Novita","family":"Sari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian G.","family":"Oehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3967-4267","authenticated-orcid":false,"given":"Dong-Wook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1663-5118","authenticated-orcid":false,"given":"Hyog Young","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"2768_CR1","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s41375-023-01822-2","volume":"37","author":"S Sembill","year":"2023","unstructured":"Sembill S, Ampatzidou M, Chaudhury S, Dworzak M, Kalwak K, Karow A, et al. Management of children and adolescents with chronic myeloid leukemia in blast phase: International pediatric CML expert panel recommendations. Leukemia. 2023;37:505\u201317.","journal-title":"Leukemia"},{"key":"2768_CR2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40164-024-00479-6","volume":"13","author":"J Liu","year":"2024","unstructured":"Liu J, Jiang P, Lu Z, Yu Z, Qian P. Decoding leukemia at the single-cell level: clonal architecture, classification, microenvironment, and drug resistance. Experimental Hematol Oncol. 2024;13:12.","journal-title":"Experimental Hematol Oncol"},{"key":"2768_CR3","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.blre.2019.04.005","volume":"36","author":"RM Shallis","year":"2019","unstructured":"Shallis RM, Wang R, Davidoff A, Ma X, Zeidan AM. Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges. Blood Rev. 2019;36:70\u201387.","journal-title":"Blood Rev"},{"key":"2768_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.694526","volume":"11","author":"A Bhingarkar","year":"2021","unstructured":"Bhingarkar A, Vangapandu HV, Rathod S, Hoshitsuki K, Fernandez CA. Amino acid metabolic vulnerabilities in acute and chronic myeloid leukemias. Front Oncol. 2021;11:694526.","journal-title":"Front Oncol"},{"key":"2768_CR5","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1038\/s41591-018-0233-1","volume":"24","author":"DA Pollyea","year":"2018","unstructured":"Pollyea DA, Stevens BM, Jones CL, Winters A, Pei S, Minhajuddin M, et al. Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia. Nat Med. 2018;24:1859\u201366.","journal-title":"Nat Med"},{"key":"2768_CR6","doi-asserted-by":"crossref","unstructured":"Gr\u00f8nnings\u00e6ter IS, Fredly HK, Gjertsen BT, Hatfield KJ, Bruserud \u00d8. Systemic metabolomic profiling of acute myeloid leukemia patients before and during disease-stabilizing treatment based on all-trans retinoic acid, valproic acid, and low-dose chemotherapy. Cells. 2019;8:1229.","DOI":"10.3390\/cells8101229"},{"key":"2768_CR7","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.tem.2021.03.003","volume":"32","author":"M Butler","year":"2021","unstructured":"Butler M, van der Meer LT, van Leeuwen FN. Amino acid depletion therapies: starving cancer cells to death. Trends Endocrinol Metab. 2021;32:367\u201381.","journal-title":"Trends Endocrinol Metab"},{"key":"2768_CR8","doi-asserted-by":"publisher","first-page":"220319","DOI":"10.1098\/rsob.220319","volume":"12","author":"TL Fulton","year":"2022","unstructured":"Fulton TL, Mirth CK, Piper MDW. Restricting a single amino acid cross-protects Drosophila melanogaster from nicotine poisoning through mTORC1 and GCN2 signalling. Open Biol. 2022;12:220319.","journal-title":"Open Biol"},{"key":"2768_CR9","doi-asserted-by":"publisher","first-page":"6193","DOI":"10.1158\/0008-5472.CAN-15-3502","volume":"76","author":"E Timosenko","year":"2016","unstructured":"Timosenko E, Ghadbane H, Silk JD, Shepherd D, Gileadi U, Howson LJ, et al. Nutritional stress induced by tryptophan-degrading enzymes results in ATF4-dependent reprogramming of the amino acid transporter profile in tumor cells. Cancer Res. 2016;76:6193\u2013204.","journal-title":"Cancer Res"},{"key":"2768_CR10","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1038\/leu.2017.81","volume":"31","author":"L Poulain","year":"2017","unstructured":"Poulain L, Sujobert P, Zylbersztejn F, Barreau S, Stuani L, Lambert M, et al. High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells. Leukemia. 2017;31:2326\u201335.","journal-title":"Leukemia"},{"key":"2768_CR11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13046-016-0484-y","volume":"36","author":"V Catena","year":"2017","unstructured":"Catena V, Fanciulli M. Deptor: not only a mTOR inhibitor. J Exp Clin Cancer Res. 2017;36:12.","journal-title":"J Exp Clin Cancer Res"},{"key":"2768_CR12","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.cell.2009.03.046","volume":"137","author":"TR Peterson","year":"2009","unstructured":"Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell. 2009;137:873\u201386.","journal-title":"Cell"},{"key":"2768_CR13","doi-asserted-by":"publisher","first-page":"643","DOI":"10.3892\/ijmm.2020.4831","volume":"47","author":"J Wang","year":"2021","unstructured":"Wang J, Chen J, Qiu D, Zeng Z. Regulatory role of DEPTOR\u2011mediated cellular autophagy and mitochondrial reactive oxygen species in angiogenesis in multiple myeloma. Int J Mol Med. 2021;47:643\u201358.","journal-title":"Int J Mol Med"},{"key":"2768_CR14","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1016\/j.celrep.2015.11.022","volume":"13","author":"N Li","year":"2015","unstructured":"Li N, Yousefi M, Nakauka-Ddamba A, Li F, Vandivier L, Parada K, et al. The Msi family of RNA-binding proteins function redundantly as intestinal oncoproteins. Cell Rep. 2015;13:2440\u201355.","journal-title":"Cell Rep"},{"key":"2768_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-024-03444-9","volume":"24","author":"L Huang","year":"2024","unstructured":"Huang L, Sun J, Ma Y, Chen H, Tian C, Dong M. MSI2 regulates NLK-mediated EMT and PI3K\/AKT\/mTOR pathway to promote pancreatic cancer progression. Cancer Cell Int. 2024;24:273.","journal-title":"Cancer Cell Int"},{"key":"2768_CR16","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.stem.2015.06.006","volume":"17","author":"HY Kwon","year":"2015","unstructured":"Kwon HY, Bajaj J, Ito T, Blevins A, Konuma T, Weeks J, et al. Tetraspanin 3 Is required for the development and propagation of acute myelogenous leukemia. Cell Stem Cell. 2015;17:152\u201364.","journal-title":"Cell Stem Cell"},{"key":"2768_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04106-6","volume":"21","author":"F Li","year":"2023","unstructured":"Li F, Han Y, Chen R, Jiang Y, Chen C, Wang X, et al. MicroRNA-143 acts as a tumor suppressor through Musashi-2\/DLL1\/Notch1 and Musashi-2\/Snail1\/MMPs axes in acute myeloid leukemia. J Transl Med. 2023;21:309.","journal-title":"J Transl Med"},{"key":"2768_CR18","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/nature09171","volume":"466","author":"T Ito","year":"2010","unstructured":"Ito T, Kwon HY, Zimdahl B, Congdon KL, Blum J, Lento WE, et al. Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature. 2010;466:765\u20138.","journal-title":"Nature"},{"key":"2768_CR19","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1038\/nm.2187","volume":"16","author":"MG Kharas","year":"2010","unstructured":"Kharas MG, Lengner CJ, Al-Shahrour F, Bullinger L, Ball B, Zaidi S, et al. Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med. 2010;16:903\u20138.","journal-title":"Nat Med"},{"key":"2768_CR20","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s11248-011-9537-3","volume":"21","author":"A Doyle","year":"2012","unstructured":"Doyle A, McGarry MP, Lee NA, Lee JJ. The construction of transgenic and gene knockout\/knockin mouse models of human disease. Transgenic Res. 2012;21:327\u201349.","journal-title":"Transgenic Res"},{"key":"2768_CR21","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/s41419-020-03382-0","volume":"12","author":"W Hu","year":"2021","unstructured":"Hu W, Xiong H, Ru Z, Zhao Y, Zhou Y, Xie K, et al. Extracellular vesicles-released parathyroid hormone-related protein from Lewis lung carcinoma induces lipolysis and adipose tissue browning in cancer cachexia. Cell Death Dis. 2021;12:134.","journal-title":"Cell Death Dis"},{"key":"2768_CR22","first-page":"2037","volume":"140","author":"A Cunningham","year":"2022","unstructured":"Cunningham A, Erdem A, Alshamleh I, Geugien M, Pruis M, Pereira-Martins DA, et al. Dietary methionine starvation impairs acute myeloid leukemia progression. Blood J Am Soc Hematol. 2022;140:2037\u201352.","journal-title":"Blood J Am Soc Hematol"},{"key":"2768_CR23","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.2147\/OTT.S298438","volume":"14","author":"J Sun","year":"2021","unstructured":"Sun J, Sheng W, Ma Y, Dong M. Potential role of musashi-2 RNA-binding protein in cancer EMT. Onco Targets Ther. 2021;14:1969\u201380.","journal-title":"Onco Targets Ther"},{"key":"2768_CR24","doi-asserted-by":"publisher","first-page":"W361","DOI":"10.1093\/nar\/gku406","volume":"42","author":"I Paz","year":"2014","unstructured":"Paz I, Kosti I, Ares M Jr, Cline M, Mandel-Gutfreund Y. RBPmap: a web server for mapping binding sites of RNA-binding proteins. Nucleic Acids Res. 2014;42:W361\u20137.","journal-title":"Nucleic Acids Res"},{"key":"2768_CR25","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1093\/jn\/nxaa067","volume":"150","author":"BB Rasmussen","year":"2020","unstructured":"Rasmussen BB, Adams CM. ATF4 is a fundamental regulator of nutrient sensing and protein turnover. J Nutr. 2020;150:979\u201380.","journal-title":"J Nutr"},{"key":"2768_CR26","doi-asserted-by":"publisher","first-page":"D882","DOI":"10.1093\/nar\/gkz1062","volume":"48","author":"Y Luo","year":"2020","unstructured":"Luo Y, Hitz BC, Gabdank I, Hilton JA, Kagda MS, Lam B, et al. New developments on the Encyclopedia of DNA Elements (ENCODE) data portal. Nucleic Acids Res. 2020;48:D882\u2013d9.","journal-title":"Nucleic Acids Res"},{"key":"2768_CR27","unstructured":"Hitz BC, Lee J-W, Jolanki O, Kagda MS, Graham K, Sud P, et al. The ENCODE uniform analysis pipelines. bioRxiv. 2023:2023.04.04.535623."},{"key":"2768_CR28","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/s41419-021-04417-w","volume":"12","author":"H-O Jin","year":"2021","unstructured":"Jin H-O, Hong S-E, Kim J-Y, Jang S-K, Park I-C. Amino acid deprivation induces AKT activation by inducing GCN2\/ATF4\/REDD1 axis. Cell Death Dis. 2021;12:1127.","journal-title":"Cell Death Dis"},{"key":"2768_CR29","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.cell.2014.01.024","volume":"156","author":"C Demetriades","year":"2014","unstructured":"Demetriades C, Doumpas N, Teleman Aurelio A. Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell. 2014;156:786\u201399.","journal-title":"Cell"},{"key":"2768_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-020-00679-2","volume":"27","author":"T Takahara","year":"2020","unstructured":"Takahara T, Amemiya Y, Sugiyama R, Maki M, Shibata H. Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes. J Biomed Sci. 2020;27:87.","journal-title":"J Biomed Sci"},{"key":"2768_CR31","doi-asserted-by":"publisher","first-page":"W98","DOI":"10.1093\/nar\/gkx247","volume":"45","author":"Z Tang","year":"2017","unstructured":"Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45:W98\u2013W102.","journal-title":"Nucleic Acids Res"},{"key":"2768_CR32","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/s41388-020-01547-x","volume":"40","author":"IN Sari","year":"2021","unstructured":"Sari IN, Yang Y-G, Wijaya YT, Jun N, Lee S, Kim KS, et al. AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth. Oncogene. 2021;40:603\u201317.","journal-title":"Oncogene"},{"key":"2768_CR33","doi-asserted-by":"crossref","unstructured":"Zhang S, You X, Zheng Y, Shen Y, Xiong X, Sun Y. The UBE2C\/CDH1\/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells. J Clin Investig. 2023;133:e162434.","DOI":"10.1172\/JCI162434"},{"key":"2768_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01398-5","volume":"22","author":"MJ Iqbal","year":"2024","unstructured":"Iqbal MJ, Kabeer A, Abbas Z, Siddiqui HA, Calina D, Sharifi-Rad J, et al. Interplay of oxidative stress, cellular communication and signaling pathways in cancer. Cell Commun Signal. 2024;22:7.","journal-title":"Cell Commun Signal"},{"key":"2768_CR35","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.4161\/cc.5.19.3255","volume":"5","author":"BZ Carter","year":"2006","unstructured":"Carter BZ, Mak DH, Shi Y, Schober WD, Wang R-Y, Konopleva M, et al. Regulation and targeting of Eg5, a mitotic motor protein in blast crisis CML: overcoming imatinib resistance. Cell Cycle. 2006;5:2223\u20139.","journal-title":"Cell Cycle"},{"key":"2768_CR36","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s10637-011-9660-2","volume":"30","author":"HM Kantarjian","year":"2012","unstructured":"Kantarjian HM, Padmanabhan S, Stock W, Tallman MS, Curt GA, Li J, et al. Phase I\/II multicenter study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD4877 in patients with refractory acute myeloid leukemia. Investig N Drugs. 2012;30:1107\u201315.","journal-title":"Investig N Drugs"},{"key":"2768_CR37","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.celrep.2014.01.017","volume":"6","author":"M Eguren","year":"2014","unstructured":"Eguren M, \u00c1lvarez-Fern\u00e1ndez M, Garc\u00eda F, L\u00f3pez-Contreras AJ, Fujimitsu K, Yaguchi H, et al. A synthetic lethal interaction between APC\/C and topoisomerase poisons uncovered by proteomic screens. Cell Rep. 2014;6:670\u201383.","journal-title":"Cell Rep"},{"key":"2768_CR38","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.celrep.2016.03.083","volume":"15","author":"Y Liu","year":"2016","unstructured":"Liu Y, Wang Y, Du Z, Yan X, Zheng P, Liu Y. Fbxo30 regulates mammopoiesis by targeting the bipolar mitotic kinesin Eg5. Cell Rep. 2016;15:1111\u201322.","journal-title":"Cell Rep."},{"key":"2768_CR39","first-page":"705","volume":"43","author":"YG Jang","year":"2020","unstructured":"Jang YG, Choi Y, Jun K, Chung J. Mislocalization of TORC1 to lysosomes caused by KIF11 inhibition leads to aberrant TORC1 activity. Mol Cells. 2020;43:705\u201317.","journal-title":"Mol Cells"},{"key":"2768_CR40","doi-asserted-by":"publisher","first-page":"Fso778","DOI":"10.2144\/fsoa-2021-0116","volume":"8","author":"R Shahin","year":"2022","unstructured":"Shahin R, Aljamal S. Kinesin spindle protein inhibitors in cancer: from high throughput screening to novel therapeutic strategies. Future Sci OA. 2022;8:Fso778.","journal-title":"Future Sci OA"},{"key":"2768_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2024.113975","volume":"436","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Xu M-F, Chen J, Zhang J-L, Wang X-Y, Huang M-H, et al. Loss-of-function of kinesin-5 KIF11 causes microcephaly, chorioretinopathy, and developmental disorders through chromosome instability and cell cycle arrest. Experimental Cell Res. 2024;436:113975.","journal-title":"Experimental Cell Res"},{"key":"2768_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14124","volume":"8","author":"VH Villar","year":"2017","unstructured":"Villar VH, Nguyen TL, Delcroix V, Ter\u00e9s S, Bouchecareilh M, Salin B, et al. mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation. Nat Commun. 2017;8:14124.","journal-title":"Nat Commun"},{"key":"2768_CR43","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1172\/JCI62279","volume":"122","author":"T Hoshii","year":"2012","unstructured":"Hoshii T, Tadokoro Y, Naka K, Ooshio T, Muraguchi T, Sugiyama N, et al. mTORC1 is essential for leukemia propagation but not stem cell self-renewal. J Clin Investig. 2012;122:2114\u201329.","journal-title":"J Clin Investig"},{"key":"2768_CR44","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/leu.2016.223","volume":"31","author":"Y Fang","year":"2017","unstructured":"Fang Y, Yang Y, Hua C, Xu S, Zhou M, Guo H, et al. Rictor has a pivotal role in maintaining quiescence as well as stemness of leukemia stem cells in MLL-driven leukemia. Leukemia. 2017;31:414\u201322.","journal-title":"Leukemia"},{"key":"2768_CR45","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.ccell.2015.12.011","volume":"29","author":"R Lechman Eric","year":"2016","unstructured":"Lechman Eric R, Gentner B, Ng Stanley WK, Schoof Erwin M, van Galen P, Kennedy James A, et al. miR-126 regulates distinct self-renewal outcomes in normal and malignant hematopoietic stem cells. Cancer Cell. 2016;29:214\u201328.","journal-title":"Cancer Cell"},{"key":"2768_CR46","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.exphem.2021.08.009","volume":"103","author":"F Wu","year":"2021","unstructured":"Wu F, Chen Z, Liu J, Hou Y. The Akt\u2013mTOR network at the interface of hematopoietic stem cell homeostasis. Experimental Hematol. 2021;103:15\u201323.","journal-title":"Experimental Hematol"}],"updated-by":[{"DOI":"10.1038\/s41375-026-02909-2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000}}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41375-025-02768-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-025-02768-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-025-02768-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T08:01:41Z","timestamp":1772784101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41375-025-02768-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2768"],"URL":"https:\/\/doi.org\/10.1038\/s41375-025-02768-3","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"assertion":[{"value":"17 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: In this article the author\u2019s name Nadya Marcelina Julianto was incorrectly written as Nadya Marcellina. The original article has been corrected.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2026","order":9,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":10,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41375-026-02909-2","URL":"https:\/\/doi.org\/10.1038\/s41375-026-02909-2","order":12,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Declaration of Generative AI and AI-assisted technologies in the writing process: During the preparation of this work, the author(s) used ChatGPT in order to improve readability and language. After using this tool\/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the publication.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All methods were performed in accordance with the relevant guidelines and regulations. All patients were provided written informed consent to participate in studies and for the research use of their specimens in agreement with the Declaration of Helsinki. Animal protocols were reviewed and approved by Soonchunhyang University Institutional Animal Care and Use Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"This manuscript has not been published previously and is not under consideration for publication elsewhere.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}